818 research outputs found
Simulated moult reduces flight performance but overlap with breeding does not affect breeding success in a long-distance migrant
1.Long-distance migrants are time-constrained as they need to incorporate many annual cycle stages within a year. Migratory passerines moult in the short interval between breeding and migration. To widen this interval, moult may start while still breeding, but this results in flying with moulting wings when food provisioning.2.We experimentally simulated wing gaps in breeding male pied flycatchers by plucking two primary feathers from both wings. We quantified the nest visitations of both parents, proportion of high-quality food brought to the nestlings and adults and nestlings condition. Differences in oxidative damage caused by a possible reduction in flight efficiency were measured in amounts of ROMs and OXY in the blood. We also measured how flight performance was affected with recordings of the male`s escape flight using high-speed cameras. Finally, we collected data on adult survival, clutch size and laying date in the following year.3.“Plucked” males travelled a 5% shorter distance per wingbeat, showing that our treatment reduced flight performance. In line with this, “plucked” males visited their nests less often. Females of “plucked” males, however, visited the nest more often than controls, and fully compensated their partner's reduced visitation rate. As a result, there were no differences between treatments in food quality brought to the nest, adult or chick mass or number of successfully fledged chicks. Males did not differ in their oxidative damage or local survival to the following year. In contrast, females paired with plucked males tended to return less often to breed in the next year in comparison to controls, but this difference was not significant. For the birds that did return, there were no effects on breeding.4.Our results reveal that wing gaps in male pied flycatchers reduce their flight performance, but when it occurs during breeding they prioritise their future reproduction by reducing parental care. As a result, there is no apparent detriment to their condition during breeding. Because non-moulting females are able to compensate their partner's reduced care, there is also no immediate cost to the offspring, but females may pay the cost suffering from a reduced survival
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Vortices enable the complex aerobatics of peregrine falcons
The peregrine falcon (Falco peregrinus) is known for its extremely high speeds during hunting dives or stoop. Here we demonstrate that the superior manoeuvrability of peregrine falcons during stoop is attributed to vortex-dominated flow promoted by their morphology, in the M-shape configuration adopted towards the end of dive. Both experiments and simulations on life-size models, derived from field observations, revealed the presence of vortices emanating from the frontal and dorsal region due to a strong spanwise flow promoted by the forward sweep of the radiale. These vortices enhance mixing for flow reattachment towards the tail. The stronger wing and tail vortices provide extra aerodynamic forces through vortex-induced lift for pitch and roll control. A vortex pair with a sense of rotation opposite to that from conventional planar wings interacts with the main wings vortex to reduce induced drag, which would otherwise decelerate the bird significantly during pull-out. These findings could help in improving aircraft performance and wing suits for human flights
Cadmium accumulation and interactions with zinc, copper, and manganese, analysed by ICP-MS in a long-term Caco-2 TC7 cell model
The influence of long-term exposure to cadmium (Cd) on essential minerals was investigated using a Caco-2
TC7 cells and a multi-analytical tool: microwave digestion and inductively coupled plasma mass spectrometry.
Intracellular levels, effects on cadmium accumulation, distribution, and reference concentration
ranges of the following elements were determined: Na, Mg, Ca, Cr, Fe, Mn, Co, Ni, Cu, Zn, Mo, and Cd.
Results showed that Caco-2 TC7 cells incubated long-term with cadmium concentrations ranging from 0 to
10 lmol Cd/l for 5 weeks exhibited a significant increase in cadmium accumulation. Furthermore, this
accumulation was more marked in cells exposed long-term to cadmium compared with controls, and that
this exposure resulted in a significant accumulation of copper and zinc but not of the other elements
measured. Interactions of Cd with three elements: zinc, copper, and manganese were particularly studied.
Exposed to 30 lmol/l of the element, manganese showed the highest inhibition and copper the lowest on
cadmium intracellular accumulation but Zn, Cu, and Mn behave differently in terms of their mutual
competition with Cd. Indeed, increasing cadmium in the culture medium resulted in a gradual and significant
increase in the accumulation of zinc. There was a significant decrease in manganese from 5 lmol
Cd/l exposure, and no variation was observed with copper.
Abbreviation: AAS – Atomic absorption spectrometry; CRM– Certified reference material; PBS – Phosphate
buffered saline without calcium and magnesium; DMEM – Dubelcco’s modified Eagle’s medium
Rare genetic variation in UNC13A may modify survival in amyotrophic lateral sclerosis
Our objective was to identify whether rare genetic variation in amyotrophic lateral sclerosis (ALS) candidate survival genes modifies ALS survival. Candidate genes were selected based on evidence for modifying ALS survival. Each tail of the extreme 1.5% of survival was selected from the UK MND DNA Bank and all samples available underwent whole genome sequencing. A replication set from the Netherlands was used for validation. Sequences of candidate survival genes were extracted and variants passing quality control with a minor allele frequency ≤0.05 were selected for association testing. Analysis was by burden testing using SKAT. Candidate survival genes UNC13A, KIFAP3, and EPHA4 were tested for association in a UK sample comprising 25 short survivors and 25 long survivors. Results showed that only SNVs in UNC13A were associated with survival (p = 6.57 × 10−3). SNV rs10419420:G > A was found exclusively in long survivors (3/25) and rs4808092:G > A exclusively in short survivors (4/25). These findings were not replicated in a Dutch sample. In conclusion, population specific rare variants of UNC13A may modulate survival in ALS
Male breast cancer: a report of 127 cases at a Moroccan institution
Background: Male breast cancer (MBC) is a rare disease representing less than 1% of all malignancies in men and
only 1% of all incident breast cancers. Our study details clinico-pathological features, treatments and prognostic
factors in a large Moroccan cohort.
Findings: One hundred and twenty-seven patients were collected from 1985 to 2007 at the National Institute of
Oncology in Rabat, Morocco.
Median age was 62 years and median time for consultation 28 months. The main clinical complaint was a mass
beneath the areola in 93, 5% of the cases. Most patients have an advanced disease. Ninety-one percent of tumors
were ductal carcinomas.
Management consisted especially of radical mastectomy; followed by adjuvant radiotherapy and hormonal therapy
with or without chemotherapy. The median of follow-up was 30 months. The evolution has been characterized by
local recurrence; in twenty two cases (17% of all patients). Metastasis occurred in 41 cases (32% of all patients). The
site of metastasis was the bone in twenty cases; lung in twelve cases; liver in seven case; liver and skin in one case
and pleura and skin in one case.
Conclusion: Male breast cancer has many similarities to breast cancer in women, but there are distinct features
that should be appreciated. Future research for better understanding of this disease at national or international
level are needed to improve the management and prognosis of male patients
A quantum magnetic analogue to the critical point of water
At the familiar liquid-gas phase transition in water, the density jumps
discontinuously at atmospheric pressure, but the line of these first-order
transitions defined by increasing pressures terminates at the critical point, a
concept ubiquitous in statistical thermodynamics. In correlated quantum
materials, a critical point was predicted and measured terminating the line of
Mott metal-insulator transitions, which are also first-order with a
discontinuous charge density. In quantum spin systems, continuous quantum phase
transitions (QPTs) have been investigated extensively, but discontinuous QPTs
have received less attention. The frustrated quantum antiferromagnet
SrCu(BO) constitutes a near-exact realization of the paradigmatic
Shastry-Sutherland model and displays exotic phenomena including magnetization
plateaux, anomalous thermodynamics and discontinuous QPTs. We demonstrate by
high-precision specific-heat measurements under pressure and applied magnetic
field that, like water, the pressure-temperature phase diagram of
SrCu(BO) has an Ising critical point terminating a first-order
transition line, which separates phases with different densities of magnetic
particles (triplets). We achieve a quantitative explanation of our data by
detailed numerical calculations using newly-developed finite-temperature
tensor-network methods. These results open a new dimension in understanding the
thermodynamics of quantum magnetic materials, where the anisotropic spin
interactions producing topological properties for spintronic applications drive
an increasing focus on first-order QPTs.Comment: 8+4 pages, 4+3 figure
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