Three‐dimensional turbulence‐resolving simulations of the plunge phenomenon in a tilted channel

Hyperpycnal flows are produced when the density of a fluid flowing in a relatively quiescent basin is greater than the density of the fluid in the basin. The density differences can be due to the difference in temperatures, salinity, turbidity, concentration, or a combination of them. When the inflow momentum diminishes, the inflowing fluid eventually plunges under the basin fluid and flows along the bottom floor as an underflow density current. In the present work, 3‐D turbulence‐resolving simulations are performed for an hyperpycnal flow evolving at the bottom floor of a tilted channel. Using advanced numerical techniques designed for supercomputers, the incompressible Navier‐Stokes and transport equations are solved to reproduce numerically the experiments of Lamb et al. (2010, https://doi.org/10.1130/B30125.1) obtained inside a flume with a long tilted ramp. This study focuses on presenting and validating a new numerical framework for the correct reproduction and analysis of the plunge phenomenon and its associated flow features. A very good agreement is found between the experimental data of Lamb et al. (2010), the analytical models of Parker and Toniolo (2007, https://doi.org/10.1061/(ASCE)0733-9429(2007)133:6(690)), and the present turbulence‐resolving simulations. The mixing process between the ambient fluid and the underflow density current is also analyzed thanks to visualizations of vortical structures at the interface

Glucose hypometabolism in the Auditory Pathway in Age Related Hearing Loss in the ADNI cohort

Purpose: Hearing loss (HL) is one of the most common age-related diseases. Here, we investigate the central auditory correlates of HL in people with normal cognition and mild cognitive impairment (MCI) and test their association with genetic markers with the aim of revealing pathogenic mechanisms. / Methods: Brain glucose metabolism based on FDG-PET, self-reported HL status, and genetic data were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. FDG-PET data was analysed from 742 control subjects (non-HL with normal cognition or MCI) and 162 cases (HL with normal cognition or MCI) with age ranges of 72.2 ± 7.1 and 77.4 ± 6.4, respectively. Voxel-wise statistics of FDG uptake differences between cases and controls were computed using the generalised linear model in SPM12. An additional 1515 FDG-PET scans of 618 participants were analysed using linear mixed effect models to assess longitudinal HL effects. Furthermore, a quantitative trait genome-wide association study (GWAS) was conducted on the glucose uptake within regions of interest (ROIs), which were defined by the voxel-wise comparison, using genotyping data with 5,082,878 variants available for HL cases and HL controls (N = 817). / Results: The HL group exhibited hypometabolism in the bilateral Heschl’s gyrus (kleft = 323; kright = 151; Tleft = 4.55; Tright = 4.14; peak Puncorr < 0.001), the inferior colliculus (k = 219;T = 3.53; peak Puncorr < 0.001) and cochlear nucleus (k = 18;T = 3.55; peak Puncorr < 0.001) after age correction and using a cluster forming height threshold P < 0.005 (FWE-uncorrected). Moreover, in an age-matched subset, the cluster comprising the left Heschl’s gyrus survived the FWE-correction (kleft = 1903; Tleft = 4.39; cluster PFWE-corr = 0.001). The quantitative trait GWAS identified no genome-wide significant locus in the three HL ROIs. However, various loci were associated at the suggestive threshold (p < 1e-05). / Conclusion: Compared to the non-HL group, glucose metabolism in the HL group was lower in the auditory cortex, the inferior colliculus, and the cochlear nucleus although the effect sizes were small. The GWAS identified candidate genes that might influence FDG uptake in these regions. However, the specific biological pathway(s) underlying the role of these genes in FDG-hypometabolism in the auditory pathway requires further investigation

A new method for fabrication of nanohydroxyapatite and TCP from the sea snail Cerithium vulgatum

Biphasic bioceramic nanopowders of hydroxyapatite (HA) and β-tricalcium phosphate (TCP) were prepared from shells of the sea snail Cerithium vulgatum (Bruguière, 1792) using a novel chemical method. Calcination of the powders produced was carried out at varying temperatures, specifically at 400°C and 800°C, in air for 4 hours. When compared to the conventional hydrothermal transformation method, this chemical method is very simple, economic, due to the fact that it needs inexpensive and safe equipment, because the transformation of the aragonite and calcite of the shells into the calcium phosphate phases takes place at 80°C under the atmospheric pressure. The powders produced were determined using infrared spectroscopy (FT-IR), X-ray diffraction, and scanning electron microscopy (SEM). The features of the powders produced along with the fact of their biological origin qualify these powders for further consideration and experimentation to fabricate nanoceramic biomaterials. © 2014 O. Gunduz et al

The impact of maternal smoking during pregnancy on depressive and anxiety behaviors in children: the Norwegian Mother and Child Cohort Study.

BACKGROUND: Maternal smoking during pregnancy (MSDP) is associated with multiple adverse childhood outcomes including externalizing behaviors. However, the association between MSDP and internalizing (anxiety and depressive) behaviors in offspring has received less investigation. We aimed to assess the association between MSDP and childhood internalizing (anxiety and depressive) behaviors in a very large, well-characterized cohort study. METHODS: We assessed the association between MSDP and internalizing behaviors in offspring utilizing information drawn from 90,040 mother-child pairs enrolled in the Norwegian Mother and Child Cohort Study. Mothers reported smoking information, including status and frequency of smoking, twice during pregnancy. Mothers also reported their child\u27s internalizing behaviors at 18 months, 36 months, and 5 years. Associations between MSDP and childhood internalizing behaviors, including dose-response and timing of smoking in pregnancy, were assessed at each time point. RESULTS: MSDP was associated with increased internalizing behaviors when offspring were aged 18 months (B&thinsp;=&thinsp;0.11, P &lt;0.001) and 36 months (B&thinsp;=&thinsp;0.06, P &lt;0.01), adjusting for numerous potential confounders. Higher rates of smoking (e.g., &gt;20 cigarettes per day) were associated with higher levels of internalizing behaviors. Maternal smoking during early pregnancy appeared to be the critical period for exposure. CONCLUSIONS: We found evidence supporting a potential role for MSDP in increasing internalizing (anxiety and depressive) behaviors in offspring. We also found evidence supportive of a possible causal relationship, including dose-dependency and support for a predominant role of early pregnancy exposure. Further investigation utilizing genetically informed designs are warranted to assess this association

The Impact of United Kingdom and Malaysia's Inherent Health Systems on Their COVID‐19 Responses: A Comparison of Containment Strategies

In March 2020, the outbreak of COVID‐19 was officially declared a global pandemic by the World Health Organization. Given the novelty of the virus, and hence, lack of official guidance on effective containment strategies, individual countries opted for different containment approaches ranging from herd immunity to strict lockdown. The opposing strategies followed by the United Kingdom and its former colony, Malaysia, stand exemplary for this. Real‐time polymerase chain reaction was implemented for testing in both counties. Malaysia acted with strict quarantining rules and infection surveillance. The United Kingdom followed an initially lenient, herd‐immunity approach with strict lockdown only enforced weeks later. Although based on the same health‐care structure historically, Malaysia developed a more unified health system compared with the United Kingdom. We suggest that this more centralized structure could be one possible explanation for why Malaysia was able to react in a more timely and efficient manner, despite its closer geographic proximity to China. We further explore how the differences in testing and quarantining strategy, as well as political situation and societal compliance could account for the discrepancy in the United Kingdom's versus Malaysia's relative success of COVID‐19 containment

The European Federation of Organisations for Medical Physics Policy Statement No. 6.1: Recommended Guidelines on National Registration Schemes for Medical Physicists

This EFOMP Policy Statement is an update of Policy Statement No. 6 first published in 1994. The present version takes into account the European Union Parliament and Council Directive 2013/55/EU that amends Directive 2005/36/EU on the recognition of professional qualifications and the European Union Council Directive 2013/59/EURATOM laying down the basic safety standards for protection against the dangers arising from exposure to ionising radiation. The European Commission Radiation Protection Report No. 174, Guidelines on Medical Physics Expert and the EFOMP Policy Statement No. 12.1, Recommendations on Medical Physics Education and Training in Europe 2014, are also taken into consideration. The EFOMP National Member Organisations are encouraged to update their Medical Physics registration schemes where these exist or to develop registration schemes taking into account the present version of this EFOMP Policy Statement (Policy Statement No. 6.1"Recommended Guidelines on National Registration Schemes for Medical Physicists")

Géomorphologie structurale et risque naturel dans une portion de zone mobile du complexe du Nyong au SW Cameroun : cas de la région Lolodorf-Mvengue

Au cours des trente dernières années, les risques et les catastrophes naturels ont été identifiés et étudiés principalement dans la zone volcano-sédimentaire tertiaire à actuelle. Une analyse de la géomorphologique la région de Lolodorf-Mvengué qui est une portion de la zone mobile éburnéenne appartenant au complexe du Nyong d’âge paléo-protérozoïque au Cameroun montre qu’elle présente aussi bien des risques potentiels pour les populations riveraines et leur bien.Mots-clés: géomorphologie structurale, risques naturels, Lolodorf-Mvengué, complexe du Nyong, SW Cameroun. Structural geomorphology and natural hazard of a portion of mobile belt in the nyong complex, sw cameroon: case of the lolodorf region Natural hazard and disaster identified and studied these last thirty years principally in the regions of tertiary to actual volcano-sedimentary formations. A geomorphological study of Lolodorf-Mvengué region which is a portion of the movable area Eburnean owned by the Nyong comlex of Paleoproterozoic age in Cameroon showing that it equally presents potential risks for the population living near rivers and equally for their goods.Keywords: structural geomorphology, natural hazard, Lolodorf-Mvengué, Nyong complex, SW Cameroon

Immunolocalization of AQP5 in resting and stimulated normal labial glands and in Sjogren's syndrome.

OBJECTIVE: In our current work in vivo examination of AQP5 distribution in labial salivary glands following stimulation of secretion has been done in normal individuals and in Sjogren's syndrome patients. SUBJECTS AND METHODS: For this study, we selected 5 patients with primary Sjogren's syndrome (mean age 62,4 + 10,6 SD years) diagnosed in accordance with the European Cooperative Community classification criteria. There were 5 patients (mean age 27 + 2,5 SD years) in the control group. The subcellular distribution of AQP5 in human labial gland biopsies was determined with light and immunoelectron microscopy before and 30 min after administration of oral pilocarpine. RESULTS: In unstimulated control and Sjogren's labial glands AQP5 is about 90% localized in the apical plasma membrane, with only rarely associated gold particles with intracellular membrane structures. We have found no evidence of pilocarpine-induced changes in localization of AQP5 in either healthy individuals or Sjogren's patients. CONCLUSIONS: Our studies indicate that neither Sjogren's syndrome itself, nor muscarinic cholinergic stimulation in vivo caused any significant changes in the distribution of AQP5 in the labial salivary gland cells. This article is protected by copyright. All rights reserved