Effect of dried leaves of Leucaena leucocephala on rumen fermentation, rumen microbial population, and enteric methane production in crossbred heifers

The effects of dietary inclusion of dried Leucaena leucocephala leaves (DLL) on nutrient digestibility, fermentation parameters, microbial rumen population, and production of enteric methane (CH4) in crossbred heifers were evaluated. Four heifers were used in a 4 × 4 Latin square design consisting of four periods and four levels of inclusion of DLL: 0%, 12%, 24%, and 36% of dry matter (DM) intake. Results showed that DM intake (DMI), organic matter intake, and gross energy intake (GEI) were similar (p > 0.05) among treatments. Apparent digestibility of organic matter, neutral detergent fiber, and energy decreased with increasing levels of DLL in the ration (p 0.05) rumen pH and total volatile fatty acids. Rumen microbial community was not affected (p > 0.05) by treatment. There was a linear reduction (p < 0.05) in CH4 emissions as the levels of DLL in the ration were increased. Results of this study suggest that an inclusion of 12% DM of ration as DLL enhances digestible CP and reduces daily production of enteric CH4 without adversely affecting DMI, rumen microbial population, and fermentation parameters

Principal Component Analysis Applied to Digital Pulse Shape Analysis for Isotope Discrimination

Digital pulse shape analysis (DPSA) techniques are becoming increasingly important for the study of nuclear reactions since the development of fast digitizers. These techniques allow us to obtain the (A, Z) values of the reaction products impinging on the new generation solid-state detectors. In this paper, we present a computationally efficient method to discriminate isotopes with similar energy levels, with the aim of enabling the edge-computing paradigm in future field-programmable gate-array-based acquisition systems. The discrimination of isotope pairs with analogous energy levels has been a topic of interest in the literature, leading to various solutions based on statistical features or convolutional neural networks. Leveraging a valuable dataset obtained from experiments conducted by researchers in the FAZIA Collaboration at the CIME cyclotron in GANIL laboratories, we aim to establish a comparative analysis regarding selectivity and computational efficiency, as this dataset has been employed in several prior publications. Specifically, this work presents an approach to discriminate between pairs of isotopes with similar energies, namely, 12,13C, 36,40Ar, and 80,84Kr, using principal component analysis (PCA) for data preprocessing. Consequently, a linear and cubic machine learning (ML) support vector machine (SVM) classification model was trained and tested, achieving a high identification capability, especially in the cubic one. These results offer improved computational efficiency compared to the previously reported methodologies.Grant TED2021-131075B-I00 funded byMCIN/AEI/10.13039/501100011033. Grant PID2021-127711NB-I00 funded by MCIN/AEI/10.13039/501100011033

Current Aspects in Trichinellosis

Currently, it is estimated that more than 11 million humans in the world are infected by helminth parasites of Trichinella species, mainly by Trichinella spiralis (T. spiralis), responsible for causing Trichinellosis disease in both animals and humans. Trichinellosis is a cosmopolitan parasitic zoonotic disease, which has direct relevance to human and animal health, because it presents a constant and important challenge to the host’s immune system, especially through the intestinal tract. Currently, there is an intense investigation of new strategies in pharmacotherapy and immunotherapy against infection by Trichinella spiralis. In this chapter, we will present the most current aspects of biology, epidemiology, immunology, clinicopathology, pharmacotherapy and immunotherapy in Trichinellosis

Acceso cliente de forma segura a los servicios de un PCMAAA a través de la tecnología inalámbrica

El tiempo es un recurso crítico en el ámbito militar, por ello es importante que un usuario que se encuentra en un Puesto de Mando acceda a los sistemas de información de forma rápida y segura sin necesidad de esperar a que se realicen complejas instalaciones de cableado. Esta necesidad se incrementa debido a la gran cantidad de sistemas de información y usuarios desplegados en un Puesto de Mando de Defensa Antiaérea, que comprende sistemas clasificados y sin clasificar El hecho de poder acceder de forma inalámbrica a los servicios del Puesto de Mando (proporcionando así una mayor rapidez en el acceso a los sistemas) supone un gran avance de cara a un aumento en la flexibilidad de la maniobra, disminuyendo la cantidad de material físico a instalar o recoger y , por ende, reduciéndose el tiempo total necesario para poner en marcha una red o realizar modificaciones de su distribución. El objetivo de este Trabajo de Fin de Grado es realizar un estudio detallado del hardware y software necesarios para crear una red inalámbrica entre los clientes y los servidores de un Puesto de Mando de Artillería Antiaérea y establecer los criterios de seguridad adecuados para la transmisión de datos clasificados y no clasificados por dicha red. Se pretende que la red inalámbrica tenga el nivel de seguridad necesario para aprobar las evaluaciones que dan acceso a la obtención de certificaciones de seguridad expedidas por el Centro Criptológico Nacional. Dichas certificaciones dan luz verde a su implantación.<br /

Efficacy and safety of preoperative preparation with Lugol's iodine solution in euthyroid patients with Graves’ disease (LIGRADIS Trial): Study protocol for a multicenter randomized trial

Background: Currently, both the American Thyroid Association and the European Thyroid Association recom mend preoperative preparation with Lugol's Solution (LS) for patients undergoing thyroidectomy for Graves’ Disease (GD), but their recommendations are based on low-quality evidence. The LIGRADIS trial aims to pro vide evidence either to support or refute the systematic use of LS in euthyroid patients undergoing thyroidec tomy for GD. Methods: A multicenter randomized controlled trial will be performed. Patients ≥18 years of age, diagnosed with GD, treated with antithyroid drugs, euthyroid and proposed for total thyroidectomy will be eligible for inclusion. Exclusion criteria will be prior thyroid or parathyroid surgery, hyperparathyroidism that requires associated parathyroidectomy, thyroid cancer that requires adding a lymph node dissection, iodine allergy, consumption of lithium or amiodarone, medically unfit patients (ASA-IV), breastfeeding women, preoperative vocal cord palsy and planned endoscopic, video-assisted or remote access surgery. Between January 2020 and January 2022, 270 patients will be randomized for either receiving or not preoper ative preparation with LS. Researchers will be blinded to treatment assignment. The primary outcome will be the rate of postoperative complications: hypoparathyroidism, recurrent laryngeal nerve injury, hematoma, surgical site infection or death. Secondary outcomes will be intraoperative events (Thyroidectomy Difficulty Scale score, blood loss, recurrent laryngeal nerve neuromonitoring signal loss), operative time, postoperative length of stay, hospital readmissions, permanent complications and adverse events associated to LS. Conclusions: There is no conclusive evidence supporting the benefits of preoperative treatment with LS in this set ting. This trial aims to provide new insights into future Clinical Practice Guidelines recommendations. Trial registration: ClinicalTrials.gov identifier: NCT03980132

Quid: observatorio de medios

El informe está estructurado en seis partes. En la primera, “Transparencia y derecho a la información en Jalisco”, se presenta un artículo que sintetiza cómo fue que en diciembre de 2011, el Congreso y el Gobierno del Jalisco se organizaron para aprobar la “Ley de Información Pública de Jalisco y sus Municipios”, como un intercambio de favores entre estos poderes. En la segunda parte, "Medios de comunicación y periodismo en Jalisco", se presentan trabajos sobre los cambios en la prensa local, los medios de comunicación y los juegos panamericanos, las condiciones laborales de los periodistas en Guadalajara, y la prensa roja. En la tercer parte, "Economía política de los medios de comunicación y las industrias culturales en Jalisco" se incluyen trabajos sobre la industria de la música, la propaganda disfrazada de periodismo, y los medios públicos. En la cuarta parte, "Medios de comunicación y telecomunicaciones", se abordan los temas de la lucha por las telecomunicaciones en México, y la televisión abierta como una herramienta política para construir estrategias gubernamentales. En la quinta parte, "Producción de investigación académica del observatorio de medios", se presenta un análisis de contenido de cinco periódicos mexicanos con respecto al tema del medio ambiente. La sexta parte es una semblanza del periodista Víctor Wario Romo.ITESO, A.C

Reading Encouragement from the School Library: Operating Protocols and Action Strategies

Nuestro proyecto se centró en familiarizar a estudiantes de la Facultad de Ciencias de la Educación (UCO) con uno de los ámbitos esenciales del que será su entorno laboral, las bibliotecas de los Centros de Educación Infantil y Primaria (CEIP) cordobeses. La idea era ponerlos en contacto, e iniciarlos, en sus protocolos de funcionamiento y sus múltiples posibilidades como incentivo de animación a la lectura. Como futuros profesionales de la educación, los estudiantes deben concienciarse de la importancia que posee la lectura en la formación del alumnado, así como reconocer las herramientas y estrategias para acercársela de un modo eficaz. Antes y después de la visita, núcleo de nuestra propuesta, se realizaron actividades complementarias: previamente se introdujo en clase un módulo teórico-práctico destinado a poner en contacto a los estudiantes con los presupuestos teóricos, y ejemplos reales, de proyectos de fomento de la lectura realizados desde las bibliotecas de los CEIP y desde otras instituciones educativas. Tras la visita, realizaron un trabajo en el que reflexionaron sobre la lectura como pilar fundamental básico de la formación académica y dieron sus impresiones y valoraciones sobre los distintos proyectos presentados en el centro visitado.Our project focused on students of the School for Educational Science (UCO). The aim is to get students acquainted with one of the main areas of their future work environment, i.e. the libraries in the Children School Centers and Primary Education Centers (CEIP) in Córdoba. The main objective was to put students in contact and provide initial steps in the CEIP environment, while using these centers as a tool to encourage reading. In their ability as future education professionals, our students must understand the key importance of reading in training processes, and get to know the tools and strategies instrumental to an effective educational approach. Before and after the visits, some supplementary activities were included. Before the visit, a theoretical-practical module was included in the lessons, so that the students would get used to the theoretical assumptions involved. In addition, realistic case studies were discussed, describing reading promotion projects previously organized in CEIP libraries and other educational institutions. Following the visit, the students were invited to write a report dealing with the role of reading as a basic pillar in academic careers, and to comment on the different projects presented in the center hosting the visit

The microRNA landscape of cutaneous squamous cell carcinoma

Cutaneous squamous cell carcinoma (cSCC) is a keratinocyte-derived skin tumor. It is the second-most-common cancer affecting the Caucasian population and is responsible for >20% of all skin-cancer-related deaths. The estimated incidence of non-melanoma skin cancer in the USA is >1000000 cases per year, of which roughly 20-30% are squamous cell carcinoma. To better understand and treat this challenging cancer, current research focuses on development of novel strategies to improve the understanding of tumor biogenesis on an individual basis. microRNAs are becoming important biomarkers in the diagnosis, prognosis and treatment of cSCC. This review describes the current knowledge on miRNA expression in cSCC and its role as a biomarker for personalized medicine

Near barrier scattering of 8He on 208Pb

The exotic nucleus 8He is investigated by means of the measurement of the angular distributions of the elastic channel and the 6He and 4He fragment yields produced in the collision with a 208Pb target at two energies around the Coulomb barrier, 16 and 22 MeV. The experiment was performed at the GANIL-SPIRAL facility, with the aim of extracting information about the structure of 8He and the relevant reaction mechanisms. In this contribution, details of the experimental setup and preliminary data on elastic cross sections are reporte