PHONO-PRAGMATIQUE ET ATTÉNUATION DANS LA COMMUNICATION ESPAGNOL/FRANÇAIS

Dans cette recherche, une seconde approche est réalisée quant à l’étude des traits phono-pragmatiques (Hidalgo, 2009) de la communication en langue française d’étudiants en langue du nord-est mexicain. Il s’agit d’examiner les stratégies d’atténuation sous l’angle de l’incidence du genre et de la culture du locuteur, qui génèrent des variations de sens au sein de ce système de langue. Nous nous intéresserons également aux implications de l’enseignement de ces influences durant l’apprentissage de la langue français

Warehouse management model integrating BPM-Lean Warehousing to increase order fulfillment in SME distribution companies

In many cases, warehouse logistics in the distribution SMEs usually do not have a standardization, structure, and methodology for the reception, storage, and dispatch. Most of the flows within the warehouse tend to occur over time, but there is no feedback or a choice of logistics tools to make it more efficient. This lack of tools causes problems such as a non-existent flow of information, a lack of warehouse organization, inventory control, and a non-existent work protocol. These problems cause the customer satisfaction index to shallow since mishaps usually occur during order delivery. The general objective of this research is to increase the indicator of complete orders, so the root causes of the problem are identified and quantified. After that, a model based on implementing Lean Warehousing tools such as multi-criteria ABC, 5S, Kardex and work standardization, and BPM methodology was also applied. Subsequently, the model's reliability was guaranteed using a simulation through Arena software and a pilot test. Finally, the model increased the indicator of orders entirely delivered by 12%. Likewise, as a secondary consequence, other indicators were increased: inventory record accuracy, location registration accuracy, coverage, cycle time, and productivity by 16%, 32%, 57%, 3%, and 24%, respectively

Two-Swim Operators in the Modified Bacterial Foraging Algorithm for the Optimal Synthesis of Four-Bar Mechanisms

This paper presents two-swim operators to be added to the chemotaxis process of the modified bacterial foraging optimization algorithm to solve three instances of the synthesis of four-bar planar mechanisms. One swim favors exploration while the second one promotes fine movements in the neighborhood of each bacterium. The combined effect of the new operators looks to increase the production of better solutions during the search. As a consequence, the ability of the algorithm to escape from local optimum solutions is enhanced. The algorithm is tested through four experiments and its results are compared against two BFOA-based algorithms and also against a differential evolution algorithm designed for mechanical design problems. The overall results indicate that the proposed algorithm outperforms other BFOA-based approaches and finds highly competitive mechanisms, with a single set of parameter values and with less evaluations in the first synthesis problem, with respect to those mechanisms obtained by the differential evolution algorithm, which needed a parameter fine-tuning process for each optimization problem

Morphological and molecular evidence of Oslerus osleri (Nematoda: Filaroididae) in the Andean fox (Lycalopex culpaeus)

Oslerus osleri is a cosmopolitan filaroid nematode that parasitizes the respiratory system of domestic and wild canids. Natural infection by O. osleri is reported in the Andean fox (Lycalopex culpaeus) in this study. Nematodes, enclosed in small and compact fibrous nodules of 1 to 5 mm in diameter, were found on the surface of the trachea near the bronchial bifurcation on four Andean foxes during necropsy (one from Cuzco, Peru and three from Northwestern Patagonia in Argentina). The nematodes were identified as O. osleri by morphological and molecular methods. Ribosomal and mitochondrial DNA analyses were performed amplifying the second internal transcribed spacer region (ITS-2), the partial cytochrome c oxidase 1 (cox1), and the large subunit of nuclear ribosomal RNA (LSU rRNA) genes. Sequences of the ITS-2 and LSU rRNA had a genetic variation of 1.5% and 1.0%, respectively, with previous sequences of O. osleri registered in Genbank. This is the first amplification of the cox1 gene of O. osleri and demonstrated an identity of 92% to Perostrongylus falciformis (KY365437), and 90% to Angiostrongylus cantonensis (KY779735) and Angiostrongylus costaricensis (AP017675).Fil: Gomez Puerta, Luis A.. Universidad Nacional Mayor de San Marcos; PerúFil: Flores, Verónica Roxana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche. Departamento de Zoología. Laboratorio de Parasitología; ArgentinaFil: Vega, Rocío Marisol. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche. Departamento de Zoología. Laboratorio de Parasitología; ArgentinaFil: Brugni, Norma Leonor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche. Departamento de Zoología. Laboratorio de Parasitología; ArgentinaFil: Viozzi, Gustavo Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche. Departamento de Zoología. Laboratorio de Parasitología; ArgentinaFil: Lopez Urbina, Maria T.. Universidad Nacional Mayor de San Marcos; PerúFil: Gonzalez, Armando E.. Universidad Nacional Mayor de San Marcos; Per

Perfil profesional por competencias y la empleabilidad en la formación docente de estudiantes universitarios

El estudio se propuso analizar y comprobar la relación existente entre el perfil profesional por competencias, y la empleabilidad con la formación docente, variables gravitantes en los cambios operados en la realidad educativa, la calidad de la formación y sus expectativas en el desarrollo y la economía del país. La muestra, estudiantes del X ciclo de la Facultad de educación de la UNMSM. Se aplicó un diseño, descriptivo, analítico, mediante una encuesta y, 2 cuestionarios y una lista de cotejo. Se procesaron los datos con el Software SPSS. Aporta al conocimiento de esta problemática por la implementación de las competencias al perfil profesional, las posibilidades de empleo desde las demandas del mercado en la formación profesional, en el proceso de implementación del enfoque con una visión integral y contextualización de sus elementos. Conclusiones: Existe relación entre el perfil profesional por competencia y la empleabilidad en la formación docente. Los estudiantes no definen con claridad el perfil profesional por competencias y su relación con el empleo, la calidad de la formación docente es dispersa, pero de tendencia positiva. Tienen claras las funciones en la investigación, gestión y evaluación y las TIC. Lo más definido son las expectativas sobre el título profesional

Immunoresponsive Gene 1 Augments Bactericidal Activity of Macrophage-Lineage Cells by Regulating β-Oxidation-Dependent Mitochondrial ROS Production

SummaryEvidence suggests the bactericidal activity of mitochondria-derived reactive oxygen species (mROS) directly contributes to killing phagocytozed bacteria. Infection-responsive components that regulate this process remain incompletely understood. We describe a role for the mitochondria-localizing enzyme encoded by Immunoresponsive gene 1 (IRG1) during the utilization of fatty acids as a fuel for oxidative phosphorylation (OXPHOS) and associated mROS production. In a zebrafish infection model, infection-responsive expression of zebrafish irg1 is specific to macrophage-lineage cells and is regulated cooperatively by glucocorticoid and JAK/STAT signaling pathways. Irg1-depleted macrophage-lineage cells are impaired in their ability to utilize fatty acids as an energy substrate for OXPHOS-derived mROS production resulting in defective bactericidal activity. Additionally, the requirement for fatty acid β-oxidation during infection-responsive mROS production and bactericidal activity toward intracellular bacteria is conserved in murine macrophages. These results reveal IRG1 as a key component of the immunometabolism axis, connecting infection, cellular metabolism, and macrophage effector function

Antioxidant gene therapy against neuronal cell death

Oxidative stress is a common hallmark of neuronal cell death associated with neurodegenerative disorders such as Alzheimer\u27s disease, Parkinson\u27s disease, as well as brain stroke/ischemia and traumatic brain injury. Increased accumulation of reactive species of both oxygen (ROS) and nitrogen (RNS) has been implicated inmitochondrial dysfunction, energy impairment, alterations in metal homeostasis and accumulation of aggregated proteins observed in neurodegenerative disorders, which lead to the activation/modulation of cell death mechanisms that include apoptotic, necrotic and autophagic pathways. Thus, the design of novel antioxidant strategies to selectively target oxidative stress and redox imbalance might represent important therapeutic approaches against neurological disorders. This work reviews the evidence demonstrating the ability of genetically encoded antioxidant systems to selectively counteract neuronal cell loss in neurodegenerative diseases and ischemic brain damage. Because gene therapy approaches to treat inherited and acquired disorders offer many unique advantages over conventional therapeutic approaches, we discussed basic research/clinical evidence and the potential of virus-mediated gene delivery techniques for antioxidant gene therapy

Actions for the confirmation of the continuous improvement plan for the Educational Program in Chemical Engineering at UAEMéx

The strategic plan for continuous improvement, through analysis, informs whichever adjustment that should be carried out in the monitoring and contrast by academic year, integrating and monitoring the performance indicators. In this way, the performance of graduates in society can be identified qualitatively and quantitatively as a function of the performance of different processes that impact the training of the student. Additionally, it guarantees to interested groups that the educational program of the Chemical Engineering Degree, and its curricular committee, add value to their graduated students, whose social responsibility impacts societyThe objective of this work was to reflect on the responsibility that the educational program in Chemical Engineering at UAEMex has in translating its intentions into actions, as well as establishing an organised process for continuous planning and systemic evaluation which is reflected in a continuous improvement plan. This process entails the inclusion of tools that permit the evaluation or self-evaluation of the measurements and forms in which the educational program is improving its actions in achieving the criteria established by the acreditory organisation Consejo de Acreditación de la Enseñanza de la Ingeniería (CACEI) (Accreditation Board for the Teaching of Engineering) in their Marco de Referencia (Frame of Reference) 2018 in the international contex

Pelembagaan Perspektif Masyarakat Sasaq dalam Menjaga Potensi Kelautan di Kawasan Pesisir Teluk Jor Kabupaten Lombok Timur Nusa Tenggara Barat

The existence of mangrove forest ecosystems in coastal areas usually doesnt grows and develops by itself, but there are also other ecosystems, such as desert-seagrass ecosystems, algae and coral reefs, thus forming a vast and very complex ecosystem. The conditions like this are also found on the coast of Teluk Jor, Jerowaru, East Lombok Regency, West Nusa Tenggara. The absence of regulation of resource use is a problem in Teluk Jor which starts from the people's perception of marine and fisheries resources as public property, joint property or individual property. This studies aims to see the extent of the awiq-awiq role and the effectiveness of its implementation in developing the coastal community of Teluk Jor. The research method used is a qualitative method, with a phenomenological perspective. The results of the identification shows that awiq-awiq Teluk Jor is formed from local wisdom and community initiation to conserve  the areas

177Lu-Dendrimer conjugated to folate and bombesin with gold nanoparticles in the dendritic cavity: A potential theranostic radiopharmaceutical

177Lu-labeled nanoparticles conjugated to biomolecules have been proposed as a new class of theranostic radiopharmaceuticals. The aim of this research was to synthesize 177Lu-dendrimer(PAMAM-G4)-folate-bombesin with gold nanoparticles (AuNPs) in the dendritic cavity and to evaluate the radiopharmaceutical potential for targeted radiotherapy and the simultaneous detection of folate receptors (FRs) and gastrin-releasing peptide receptors (GRPRs) overexpressed in breast cancer cells. p-SCN-Benzyl-DOTA was conjugated in aqueous-basic medium to the dendrimer.The carboxylate groups of Lys1Lys3(DOTA)-bombesin and folic acid were activatedwithHATUand also conjugated to the dendrimer.The conjugate was mixed with 1%HAuCl4 followed by the addition of NaBH4 and purified by ultrafiltration. Elemental analysis (EDS), particle size distribution (DLS), TEM analysis, UV-Vis, and infrared and fluorescence spectroscopies were performed. The conjugate was radiolabeled using 177LuCl3 or 68GaCl3 and analyzed by radio-HPLC. Studies confirmed the dendrimer functionalization with high radiochemical purity (>95%). Fluorescence results demonstrated that the presence ofAuNPs in the dendritic cavity confers useful photophysical properties to the radiopharmaceutical for optical imaging. Preliminary binding studies in T47D breast cancer cells showed a specific cell uptake (41.15 ± 2.72%). 177Ludendrimer( AuNP)-folate-bombesin may be useful as an optical and nuclear imaging agent for breast tumors overexpressing GRPR and FRs, as well as for targeted radiotherapy.CONACYT-SEP-CB-2014-01-242443 International Atomic Energy Agency (Grant 18358) LaboratorioNacional de Investigaci´on yDesarrollo de Radiof´armacos, CONACy