8,558 research outputs found
CONDOR: A Hybrid IDS to Offer Improved Intrusion Detection
Intrusion Detection Systems are an accepted and very
useful option to monitor, and detect malicious activities.
However, Intrusion Detection Systems have inherent limitations which lead to false positives and false negatives; we propose that combining signature and anomaly based IDSs should be examined. This paper contrasts signature and anomaly-based IDSs, and critiques some proposals about hybrid IDSs with signature and heuristic capabilities, before considering some of their contributions in order to include them as main features of a new hybrid IDS named CONDOR (COmbined Network intrusion Detection ORientate), which is designed to offer superior pattern analysis and anomaly detection by reducing false positive rates and administrator intervention
AIP and MEN1 mutations and AIP immunohistochemistry in pituitary adenomas in a tertiary referral center.
Background: Pituitary adenomas have a high disease burden due to tumor growth/
invasion and disordered hormonal secretion. Germline mutations in genes such as MEN1
and AIP are associated with early onset of aggressive pituitary adenomas that can be
resistant to medical therapy.
Aims: We performed a retrospective screening study using published risk criteria to
assess the frequency of AIP and MEN1 mutations in pituitary adenoma patients in a
tertiary referral center.
Methods: Pituitary adenoma patients with pediatric/adolescent onset, macroadenomas
occurring ≤30 years of age, familial isolated pituitary adenoma (FIPA) kindreds and
acromegaly or prolactinoma cases that were uncontrolled by medical therapy were
studied genetically. We also assessed whether immunohistochemical staining for
AIP (AIP-IHC) in somatotropinomas was associated with somatostatin analogs (SSA)
response.
Results: Fifty-five patients met the study criteria and underwent genetic screening for
AIP/MEN1 mutations. No mutations were identified and large deletions/duplications were
ruled out using MLPA. In a cohort of sporadic somatotropinomas, low AIP-IHC tumors
were significantly larger (P = 0.002) and were more frequently sparsely granulated
(P = 0.046) than high AIP-IHC tumors. No significant relationship between AIP-IHC and
SSA responses was seen.
Conclusions: Germline mutations in AIP/MEN1 in pituitary adenoma patients are rare and
the use of general risk criteria did not identify cases in a large tertiary-referral setting.
In acromegaly, low AIP-IHC was related to larger tumor size and more frequent sparsely
granulated subtype but no relationship with SSA responsiveness was seen. The genetics
of pituitary adenomas remains largely unexplained and AIP screening criteria could be
significantly refined to focus on large, aggressive tumors in young patients
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Sceloporus jalapae
Number of Pages: 5Integrative BiologyGeological Science
Oceanic terranes of S-Central America - 200 Million years of accretion history recorded on the W-edge of the Caribbean Plate
Breaking a Chaotic Cryptographic Scheme Based on Composition Maps
Recently, a chaotic cryptographic scheme based on composition maps was
proposed. This paper studies the security of the scheme and reports the
following findings: 1) the scheme can be broken by a differential attack with
chosen-plaintext, where is the size of
plaintext and is the number of different elements in plain-text; 2) the
scheme is not sensitive to the changes of plaintext; 3) the two composition
maps do not work well as a secure and efficient random number source.Comment: 9 pages, 7 figure
Loss of pancreas upon activated Wnt signaling is concomitant with emergence of gastrointestinal identity
Organ formation is achieved through the complex interplay between signaling pathways
and transcriptional cascades. The canonical Wnt signaling pathway plays multiple roles
during embryonic development including patterning, proliferation and differentiation in distinct
tissues. Previous studies have established the importance of this pathway at multiple
stages of pancreas formation as well as in postnatal organ function and homeostasis. In
mice, gain-of-function experiments have demonstrated that activation of the canonical Wnt
pathway results in pancreatic hypoplasia, a phenomenon whose underlying mechanisms
remains to be elucidated. Here, we show that ectopic activation of epithelial canonical Wnt
signaling causes aberrant induction of gastric and intestinal markers both in the pancreatic
epithelium and mesenchyme, leading to the development of gut-like features. Furthermore,
we provide evidence that β -catenin-induced impairment of pancreas formation depends on
Hedgehog signaling. Together, our data emphasize the developmental plasticity of pancreatic
progenitors and further underscore the key role of precise regulation of signaling pathways
to maintain appropriate organ boundaries
Reionization and the abundance of galactic satellites
One of the main challenges facing standard hierarchical structure formation
models is that the predicted abundance of galactic subhalos with circular
velocities of 10-30 km/s is an order of magnitude higher than the number of
satellites actually observed within the Local Group. Using a simple model for
the formation and evolution of dark halos, based on the extended
Press-Schechter formalism and tested against N-body results, we show that the
theoretical predictions can be reconciled with observations if gas accretion in
low-mass halos is suppressed after the epoch of reionization. In this picture,
the observed dwarf satellites correspond to the small fraction of halos that
accreted substantial amounts of gas before reionization. The photoionization
mechanism naturally explains why the discrepancy between predicted halos and
observed satellites sets in at about 30 km/s, and for reasonable choices of the
reionization redshift (z_re = 5-12) the model can reproduce both the amplitude
and shape of the observed velocity function of galactic satellites. If this
explanation is correct, then typical bright galaxy halos contain many low-mass
dark matter subhalos. These might be detectable through their gravitational
lensing effects, through their influence on stellar disks, or as dwarf
satellites with very high mass-to-light ratios. This model also predicts a
diffuse stellar component produced by large numbers of tidally disrupted
dwarfs, perhaps sufficient to account for most of the Milky Way's stellar halo.Comment: 5 pages, 2 figures, Submitted to Ap
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Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection.
The interplay between a highly polymorphic set of MHC-I alleles and molecular chaperones shapes the repertoire of peptide antigens displayed on the cell surface for T cell surveillance. Here, we demonstrate that the molecular chaperone TAP-binding protein related (TAPBPR) associates with a broad range of partially folded MHC-I species inside the cell. Bimolecular fluorescence complementation and deep mutational scanning reveal that TAPBPR recognition is polarized toward the α2 domain of the peptide-binding groove, and depends on the formation of a conserved MHC-I disulfide epitope in the α2 domain. Conversely, thermodynamic measurements of TAPBPR binding for a representative set of properly conformed, peptide-loaded molecules suggest a narrower MHC-I specificity range. Using solution NMR, we find that the extent of dynamics at "hotspot" surfaces confers TAPBPR recognition of a sparsely populated MHC-I state attained through a global conformational change. Consistently, restriction of MHC-I groove plasticity through the introduction of a disulfide bond between the α1/α2 helices abrogates TAPBPR binding, both in solution and on a cellular membrane, while intracellular binding is tolerant of many destabilizing MHC-I substitutions. Our data support parallel TAPBPR functions of 1) chaperoning unstable MHC-I molecules with broad allele-specificity at early stages of their folding process, and 2) editing the peptide cargo of properly conformed MHC-I molecules en route to the surface, which demonstrates a narrower specificity. Our results suggest that TAPBPR exploits localized structural adaptations, both near and distant to the peptide-binding groove, to selectively recognize discrete conformational states sampled by MHC-I alleles, toward editing the repertoire of displayed antigens
Transboundary Political Ecology in the Peru-Brazil Borderlands: Mapping Workshops, Geographic Information, and Socio-Environmental Impacts
Development, resource, and settlement frontiers inspired by national policies and global demand continue to expand into the international boundary lands of Amazonia. National policies promote development and conservation projects on lands already inhabited and managed. Regional governments are increasingly frustrated by the inadequate and outdated geographic information available to solve overlapping claims and improve planning in sensitive border regions. The resulting combination of inappropriate policies, contested resources, and poor geographic information in the borderlands create impacts not only for national, regional, and local landscapes and livelihoods but also foreign relations due to transboundary effects. This article uses a transboundary political ecology framework to contextualize the products, process, and promise of a Ucayali, Peru, Acre, Brazil transboundary mapping workshop funded by the Pan American Institute of Geography and History (PAIGH)
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Sceloporus edwardtaylori
Number of Pages: 4Integrative BiologyGeological Science
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