Hepatitis E Virus Genotype 3 Diversity, France

We characterized 42 hepatitis E virus (HEV) genotype 3 strains from infected patients in France in 3 parts of the genome and sequenced the full-length HEV genotype 3f genome found in Europe. These strains are closely related to swine strains in Europe, which suggests zoonotic transmission of HEV in France

Hepatitis E Virus Seroprevalence and Chronic Infections in Patients with HIV, Switzerland

We screened 735 HIV-infected patients in Switzerland with unexplained alanine aminotransferase elevation for hepatitis E virus (HEV) immunoglobulin G. Although HEV seroprevalence in this population is low (2.6%), HEV RNA can persist in patients with low CD4 cell counts. Findings suggest chronic HEV infection should be considered as a cause of persistent alanine aminotransferase elevation

Implications thérapeutiques de la variabilité génétique des génotypes 4 et 5 du virus de l'hépatite C

TOULOUSE3-BU Sciences (315552104) / SudocSudocFranceF

Sérodiagnostic de l'hépatite E (évaluation des performances de trois techniques de détection d'immunolglobulines M)

LIMOGES-BU Médecine pharmacie (870852108) / SudocLYON1-BU Santé (693882101) / SudocSudocFranceF

Screening, diagnosis and risks associated with Hepatitis E virus infection

International audienceIntroduction: Hepatitis E virus (HEV) is the main cause of hepatitis worldwide. Our knowledge of this single-strand positive-sense RNA virus, discovered in the 1980s, has improved greatly in recent years. Areas covered: We review the most recent information on diagnostic tools, including serological and molecular assays, the recommended diagnostic algorithm, and the clinical manifestations of HEV infections.Expert opinion: The performance of serological and molecular assays has improved greatly in recent years and the availability of a WHO standard has been invaluable for comparing the performance of molecular assays. The more efficient serological and molecular assays have led to a clearer picture of HEV epidemiology. It is now established that HEV is distributed worldwide. The European Association for the Study of the Liver (EASL) now recommends testing for anti-HEV IgM and HEV RNA. Molecular tests indicate that HEV RNA is very common in asymptomatic blood donors. The description of transfusion-transmitted HEV makes having optimal strategies essential for improving blood safety. Like other hepatitis viruses, HEV infection must be suspected whenever a patient presents with clinical or biochemical features of hepatitis. An HEV infection can also have extra-hepatic manifestations, especially neurological and renal disorders

Hepatitis E Virus Antibodies in Blood Donors, France

Using a validated sensitive assay, we found hepatitis E virus (HEV) IgG in 52.5% of voluntary blood donors in southwestern France. This finding suggests HEV is highly endemic to this region. The high HEV prevalence may reflect local dietary practices, such as eating uncooked pork and game products

Hepatitis E Virus Infection in Solid Organ Transplant Recipients, France.

International audienceThe rate of transfusion-transmitted hepatitis E virus (HEV) in transplant recipients is unknown. We identified 60 HEV-positive solid organ transplant patients and retrospectively assessed their blood transfusions for HEV. Seven of 60 patients received transfusions; 3 received HEV-positive blood products. Transfusion is not the major route of infection in this population