The Effect of Roadside Elements on Driver Behavior and Run-Off-the-Road Crash Severity

Roadside vegetation provides numerous environmental and psychological benefits to drivers. Previous studies have shown that natural landscapes can effectively lower crash rates and cause less stress and frustration to the driver. However, run-off-the-road crashes resulting in a collision with a tree are twice as likely to result in a fatality, thus reinforcing the need to examine the placement of vegetation within the clear zone. This study explores the relationship between the size of the clear zone and the presence of roadside vegetation on selected driver attributes, including both driver speed and lateral positioning. To evaluate the effect on the driver speed selection process, a static evaluation was employed. Completed by more than 100 drivers, the static evaluation was utilized to gather speed selections on both real and virtual roads containing four combinations of clear zone size and roadside vegetation density. Additionally, field data was collected to validate the findings of the static evaluation and to determine the extent to which roadside vegetation impacts driving attributes. When presented with a large clear zone, drivers positioned the vehicle further from the edge of the road as the vegetation density increased. Furthermore, the speeds observed in the field correlated with the speeds that participants selected when watching a video of the same road. Finally, the UMassSafe Traffic Safety Data Warehouse was utilized to link crash and roadway data, allowing for an in-depth analysis of run-off-the-road (ROR) crash severity. The results of this study further demonstrate the nature of the relationship between clear zone design and driver behavior

Evaluating the Impacts of Driver Behavior in the Speed Selection Process and the Related Outcomes

In the United States, traffic crashes claim the lives of 30,000 people every year and is the leading cause of death for 5-24 year olds. Driver error is the leading factor in over 90 percent of motor vehicle crashes, with the roadway and the vehicle each only accounting for about 2 percent of crashes. In the United States, nearly a third of fatal crashes are due to speeding and therefore, a critical step in improving traffic safety is research aimed to reduce speeding, such as crash data analysis, outreach campaigns, targeted enforcement, and understanding speed selection. In this dissertation, a multi-faceted approach was taken to improve roadway safety by examining the speeding-related crash designation, improving speed limit setting practices, and understanding the causes of speeding. Multiple experiments were conducted under this overarching goal. These experiments included an analysis of speeding-related crashes in Massachusetts, a naturalistic driving study, and a driving simulator study which investigated the causes of speeding. Collectively, the findings from these experiments can expand upon existing speed prediction models, improve crash data influence speed limit setting practices, guide speed management programs such as speed enforcement, and be used in public safety outreach campaigns

'Sexercise': Working out heterosexuality in Jane Fonda’s fitness books

This is an Author's Accepted Manuscript of an article published in Leisure Studies, 30(2), 237 - 255, 2011, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/02614367.2010.523837.This paper explores the connection between the promotion of heterosexual norms in women’s fitness books written by or in the name of Jane Fonda during the 1980s and the commodification of women’s fitness space in both the public and private spheres. The paper is set in the absence of overt discussions of normative heterosexuality in leisure studies and draws on critical heterosexual scholarship as well as the growing body of work theorising geographies of corporeality and heterosexuality. Using the principles of media discourse analysis, the paper identifies three overlapping characteristics of heterosexuality represented in Jane Fonda’s fitness books, and embodied through the exercise regimes: respectable heterosexual desire, monogamous procreation and domesticity. The paper concludes that the promotion and prescription of exercise for women in the Jane Fonda workout books centred on the reproduction and embodiment of heterosexual corporeality. Set within an emerging commercial landscape of women’s fitness in the 1980s, such exercise practices were significant in the legitimation and institutionalisation of heteronormativity

Galaxy Bias and non-Linear Structure Formation in General Relativity

Length scales probed by large scale structure surveys are becoming closer to the horizon scale. Further, it has been recently understood that non-Gaussianity in the initial conditions could show up in a scale dependence of the bias of galaxies at the largest distances. It is therefore important to include General Relativistic effects. Here we provide a General Relativistic generalization of the bias, valid both for Gaussian and non-Gaussian initial conditions. The collapse of objects happens on very small scales, while long-wavelength modes are always in the quasi linear regime. Around every collapsing region, it is therefore possible to find a reference frame that is valid for all times and where the space time is almost flat: the Fermi frame. Here the Newtonian approximation is applicable and the equations of motion are the ones of the N-body codes. The effects of long-wavelength modes are encoded in the mapping from the cosmological frame to the local frame. For the linear bias, the effect of the long-wavelength modes on the dynamics is encoded in the local curvature of the Universe, which allows us to define a General Relativistic generalization of the bias in the standard Newtonian setting. We show that the bias due to this effect goes to zero as the squared ratio of the physical wavenumber with the Hubble scale for modes longer than the horizon, as modes longer than the horizon have no dynamical effects. However, the bias due to non-Gaussianities does not need to vanish for modes longer than the Hubble scale, and for non-Gaussianities of the local kind it goes to a constant. As a further application, we show that it is not necessary to perform large N-body simulations to extract information on long-wavelength modes: N-body simulations can be done on small scales and long-wavelength modes are encoded simply by adding curvature to the simulation and rescaling the coordinates.Comment: 48 pages, 4 figures; v2: added references, JCAP published versio

Follow-up of breast cancer in primary care vs specialist care: results of an economic evaluation

A randomized controlled trial (RCT) comparing primary-care-centred follow-up of breast cancer patients with the current standard practice of specialist-centred follow-up showed no increase in delay in diagnosing recurrence, and no increase in anxiety or deterioration in health-related quality of life. An economic evaluation of the two schemes of follow-up was conducted concurrent with the RCT. Because the RCT found no difference in the primary clinical outcomes, a cost minimization analysis was conducted. Process measures of the quality of care such as frequency and length of visits were superior in primary care. Costs to patients and to the health service were lower in primary care. There was no difference in total costs of diagnostic tests, with particular tests being performed more frequently in primary care than in specialist care. Data are provided on the average frequency and length of visits, and frequency of diagnostic testing for breast cancer patients during the follow-up period. © 1999 Cancer Research Campaig

Defining the structural requirements for ribose 5-phosphate-binding and intersubunit cross-talk of the malarial pyridoxal 5-phosphate synthase

Most organisms synthesise the B(6) vitamer pyridoxal 5-phosphate (PLP) via the glutamine amidotransferase PLP synthase, a large enzyme complex of 12 Pdx1 synthase subunits with up to 12 Pdx2 glutaminase subunits attached. Deletion analysis revealed that the C-terminus has four distinct functionalities: assembly of the Pdx1 monomers, binding of the pentose substrate (ribose 5-phosphate), formation of the reaction intermediate I(320), and finally PLP synthesis. Deletions of distinct C-terminal regions distinguish between these individual functions. PLP formation is the only function that is conferred to the enzyme by the C-terminus acting in trans, explaining the cooperative nature of the complex

Strongly Correlated Quantum Fluids: Ultracold Quantum Gases, Quantum Chromodynamic Plasmas, and Holographic Duality

Strongly correlated quantum fluids are phases of matter that are intrinsically quantum mechanical, and that do not have a simple description in terms of weakly interacting quasi-particles. Two systems that have recently attracted a great deal of interest are the quark-gluon plasma, a plasma of strongly interacting quarks and gluons produced in relativistic heavy ion collisions, and ultracold atomic Fermi gases, very dilute clouds of atomic gases confined in optical or magnetic traps. These systems differ by more than 20 orders of magnitude in temperature, but they were shown to exhibit very similar hydrodynamic flow. In particular, both fluids exhibit a robustly low shear viscosity to entropy density ratio which is characteristic of quantum fluids described by holographic duality, a mapping from strongly correlated quantum field theories to weakly curved higher dimensional classical gravity. This review explores the connection between these fields, and it also serves as an introduction to the Focus Issue of New Journal of Physics on Strongly Correlated Quantum Fluids: from Ultracold Quantum Gases to QCD Plasmas. The presentation is made accessible to the general physics reader and includes discussions of the latest research developments in all three areas.Comment: 138 pages, 25 figures, review associated with New Journal of Physics special issue "Focus on Strongly Correlated Quantum Fluids: from Ultracold Quantum Gases to QCD Plasmas" (http://iopscience.iop.org/1367-2630/focus/Focus%20on%20Strongly%20Correlated%20Quantum%20Fluids%20-%20from%20Ultracold%20Quantum%20Gases%20to%20QCD%20Plasmas

Vestibular signal processing in a subject with somatosensory deafferentation: The case of sitting posture

<p>Abstract</p> <p>Background</p> <p>The vestibular system of the inner ear provides information about head translation/rotation in space and about the orientation of the head with respect to the gravitoinertial vector. It also largely contributes to the control of posture through vestibulospinal pathways. Testing an individual severely deprived of somatosensory information below the nose, we investigated if equilibrium can be maintained while seated on the sole basis of this information.</p> <p>Results</p> <p>Although she was unstable, the deafferented subject (DS) was able to remain seated with the eyes closed in the absence of feet, arm and back supports. However, with the head unconsciously rotated towards the left or right shoulder, the DS's instability markedly increased. Small electrical stimulations of the vestibular apparatus produced large body tilts in the DS contrary to control subjects who did not show clear postural responses to the stimulations.</p> <p>Conclusion</p> <p>The results of the present experiment show that in the lack of vision and somatosensory information, vestibular signal processing allows the maintenance of an active sitting posture (i.e. without back or side rests). When head orientation changes with respect to the trunk, in the absence of vision, the lack of cervical information prevents the transformation of the head-centered vestibular information into a trunk-centered frame of reference of body motion. For the normal subjects, this latter frame of reference enables proper postural adjustments through vestibular signal processing, irrespectively of the orientation of the head with respect to the trunk.</p

Rac1 Dynamics in the Human Opportunistic Fungal Pathogen Candida albicans

The small Rho G-protein Rac1 is highly conserved from fungi to humans, with approximately 65% overall sequence identity in Candida albicans. As observed with human Rac1, we show that C. albicans Rac1 can accumulate in the nucleus, and fluorescence recovery after photobleaching (FRAP) together with fluorescence loss in photobleaching (FLIP) studies indicate that this Rho G-protein undergoes nucleo-cytoplasmic shuttling. Analyses of different chimeras revealed that nuclear accumulation of C. albicans Rac1 requires the NLS-motifs at its carboxyl-terminus, which are blocked by prenylation of the adjacent cysteine residue. Furthermore, we show that C. albicans Rac1 dynamics, both at the plasma membrane and in the nucleus, are dependent on its activation state and in particular that the inactive form accumulates faster in the nucleus. Heterologous expression of human Rac1 in C. albicans also results in nuclear accumulation, yet accumulation is more rapid than that of C. albicans Rac1. Taken together our results indicate that Rac1 nuclear accumulation is an inherent property of this G-protein and suggest that the requirements for its nucleo-cytoplasmic shuttling are conserved from fungi to humans

The importance of imprinting in the human placenta.

As a field of study, genomic imprinting has grown rapidly in the last 20 years, with a growing figure of around 100 imprinted genes known in the mouse and approximately 50 in the human. The imprinted expression of genes may be transient and highly tissue-specific, and there are potentially hundreds of other, as yet undiscovered, imprinted transcripts. The placenta is notable amongst mammalian organs for its high and prolific expression of imprinted genes. This review discusses the development of the human placenta and focuses on the function of imprinting in this organ. Imprinting is potentially a mechanism to balance parental resource allocation and it plays an important role in growth. The placenta, as the interface between mother and fetus, is central to prenatal growth control. The expression of genes subject to parental allelic expression bias has, over the years, been shown to be essential for the normal development and physiology of the placenta. In this review we also discuss the significance of genes that lack conservation of imprinting between mice and humans, genes whose imprinted expression is often placental-specific. Finally, we illustrate the importance of imprinting in the postnatal human in terms of several human imprinting disorders, with consideration of the brain as a key organ for imprinted gene expression after birth