1,436 research outputs found
Cross modal perception of body size in domestic dogs (Canis familiaris)
While the perception of size-related acoustic variation in animal vocalisations is well documented, little attention has been given to how this information might be integrated with corresponding visual information. Using a cross-modal design, we tested the ability of domestic dogs to match growls resynthesised to be typical of either a large or a small dog to size- matched models. Subjects looked at the size-matched model significantly more often and for a significantly longer duration than at the incorrect model, showing that they have the ability to relate information about body size from the acoustic domain to the appropriate visual category. Our study suggests that the perceptual and cognitive mechanisms at the basis of size assessment in mammals have a multisensory nature, and calls for further investigations of the multimodal processing of size information across animal species
Effective growth of matter density fluctuations in the running LCDM and LXCDM models
We investigate the matter density fluctuations \delta\rho/\rho for two dark
energy (DE) models in the literature in which the cosmological term \Lambda is
a running parameter. In the first model, the running LCDM model, matter and DE
exchange energy, whereas in the second model, the LXCDM model, the total DE and
matter components are conserved separately. The LXCDM model was proposed as an
interesting solution to the cosmic coincidence problem. It includes an extra
dynamical component, the "cosmon" X, which interacts with the running \Lambda,
but not with matter. In our analysis we make use of the current value of the
linear bias parameter, b^2(0)= P_{GG}/P_{MM}, where P_{MM} ~
(\delta\rho/\rho)^2 is the present matter power spectrum and P_{GG} is the
galaxy fluctuation power spectrum. The former can be computed within a given
model, and the latter is found from the observed LSS data (at small z) obtained
by the 2dF galaxy redshift survey. It is found that b^2(0)=1 within a 10%
accuracy for the standard LCDM model. Adopting this limit for any DE model and
using a method based on the effective equation of state for the DE, we can set
a limit on the growth of matter density perturbations for the running LCDM
model, the solution of which is known. This provides a good test of the
procedure, which we then apply to the LXCDM model in order to determine the
physical region of parameter space, compatible with the LSS data. In this
region, the LXCDM model is consistent with known observations and provides at
the same time a viable solution to the cosmic coincidence problem.Comment: LaTeX, 38 pages, 8 figures. Version accepted in JCA
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Spring School on Language, Music, and Cognition: Organizing Events in Time
The interdisciplinary spring school “Language, music, and cognition: Organizing events in time” was held from February 26 to March 2, 2018 at the Institute of Musicology of the University of Cologne. Language, speech, and music as events in time were explored from different perspectives including evolutionary biology, social cognition, developmental psychology, cognitive neuroscience of speech, language, and communication, as well as computational and biological approaches to language and music. There were 10 lectures, 4 workshops, and 1 student poster session.
Overall, the spring school investigated language and music as neurocognitive systems and focused on a mechanistic approach exploring the neural substrates underlying musical, linguistic, social, and emotional processes and behaviors. In particular, researchers approached questions concerning cognitive processes, computational procedures, and neural mechanisms underlying the temporal organization of language and music, mainly from two perspectives: one was concerned with syntax or structural representations of language and music as neurocognitive systems (i.e., an intrapersonal perspective), while the other emphasized social interaction and emotions in their communicative function (i.e., an interpersonal perspective). The spring school not only acted as a platform for knowledge transfer and exchange but also generated a number of important research questions as challenges for future investigations
Cosmological Constant Problems and Renormalization Group
The Cosmological Constant Problem emerges when Quantum Field Theory is
applied to the gravitational theory, due to the enormous magnitude of the
induced energy of the vacuum. The unique known solution of this problem
involves an extremely precise fine-tuning of the vacuum counterpart. We review
a few of the existing approaches to this problem based on the account of the
quantum (loop) effects and pay special attention to the ones involving the
renormalization group.Comment: 12 pages, LaTeX, based on the on the talk at IRGAC-2006 (Barcelona,
July 11-15, 2006), misprints corrected, comment on anthropic approach
modified, some references added, accepted in Journal of Physics
Urinary bicarbonate and metabolic alkalosis during exacerbations in cystic fibrosis
The aetiology of increased serum bicarbonate and metabolic alkalosis in CF is complex and appears to be driven, at least in part, by renal tubular CFTR dysfunction https://bit.ly/3NFPkU
The UK's Global Health Respiratory Network: Improving respiratory health of the world's poorest through research collaborations.
Respiratory disorders are responsible for considerable morbidity, health care utilisation, societal costs and approximately one in five deaths worldwide [1-4]. Yet, despite this substantial health and societal burden – which particularly affects the world’s poorest populations and as such is a major contributor to global health inequalities – respiratory disorders have historically not received the
policy priority they warrant. For example, despite causing an estimated 1000 deaths per day, less than half of the world’s countries collect data on asthma prevalence (http://www.globalasthmareport.org/). This
is true for both communicable and non-communicable respiratory disorders, many of which are either amenable to treatment or preventable
Risk factors for delayed presentation and referral of symptomatic cancer: Evidence for common cancers
Background:It has been suggested that the known poorer survival from cancer in the United Kingdom, compared with other European countries, can be attributed to more advanced cancer stage at presentation. There is, therefore, a need to understand the diagnostic process, and to ascertain the risk factors for increased time to presentation.Methods:We report the results from two worldwide systematic reviews of the literature on patient-mediated and practitioner-mediated delays, identifying the factors that may influence these.Results:Across cancer sites, non-recognition of symptom seriousness is the main patient-mediated factor resulting in increased time to presentation. There is strong evidence of an association between older age and patient delay for breast cancer, between lower socio-economic status and delay for upper gastrointestinal and urological cancers and between lower education level and delay for breast and colorectal cancers. Fear of cancer is a contributor to delayed presentation, while sanctioning of help seeking by others can be a powerful mediator of reduced time to presentation. For practitioner delay, ‘misdiagnosis’ occurring either through treating patients symptomatically or relating symptoms to a health problem other than cancer, was an important theme across cancer sites. For some cancers, this could also be linked to inadequate patient examination, use of inappropriate tests or failing to follow-up negative or inconclusive test results.Conclusion:Having sought help for potential cancer symptoms, it is therefore important that practitioners recognise these symptoms, and examine, investigate and refer appropriately. © 2009 Cancer Research UK All rights reserved
Ipl1/aurora kinase suppresses S-CDK-driven spindle formation during prophase I to ensure chromosome integrity during meiosis
Cells coordinate spindle formation with DNA repair and morphological modifications to chromosomes prior to their segregation to prevent cell division with damaged chromosomes. Here we uncover a novel and unexpected role for Aurora kinase in preventing the formation of spindles by Clb5-CDK (S-CDK) during meiotic prophase I and when the DDR is active in budding yeast. This is critical since S-CDK is essential for replication during premeiotic S-phase as well as double-strand break induction that facilitates meiotic recombination and, ultimately, chromosome segregation. Furthermore, we find that depletion of Cdc5 polo kinase activity delays spindle formation in DDR-arrested cells and that ectopic expression of Cdc5 in prophase I enhances spindle formation, when Ipl1 is depleted. Our findings establish a new paradigm for Aurora kinase function in both negative and positive regulation of spindle dynamics
Genetic heterogeneity within an electrophoretic phenotype of phosphoglucose isomerase in a Japanese population
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65884/1/j.1469-1809.1979.tb00662.x.pd
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