619 research outputs found
Barriers and facilitators to public bicycle scheme use: A qualitative approach
The purpose of this study was to explore barriers and facilitators to using CityCycle, a public bicycle share scheme in Brisbane, Australia. Focus groups were conducted with participants belonging to one of three categories. Group one consisted of infrequent and noncyclists (no bicycle riding over the past month), group two were regular bicycle riders (ridden a bicycle at least once in the past month) and group three was composed of CityCycle members. A thematic analytic method was used to analyse the data. Three main themes were found: Accessibility/spontaneity, safety and weather/topography. The lengthy sign-up process was thought to stifle the spontaneity typically thought to attract people to public bike share. Mandatory helmet legislation was thought to reduce spontaneous use. Safety was a major concern for all groups and this included a perceived lack of suitable bicycle infrastructure, as well as regular riders describing a negative attitude of some car drivers. Interestingly, CityCycle riders unanimously perceived car driver attitudes to improve when on CityCycle bicycles relative to riding on personal bicycles. Conclusions: In order to increase the popularity of the CityCycle scheme, the results of this study suggest that a more accessible, spontaneous sign-up process is required, 24/7 opening hours, and greater incentives to sign up new members and casual users, as seeing people using CityCycle appears critical to further take up
Investigating prostate cancer tumour-stroma interactions - clinical and biological insights from an evolutionary game
BACKGROUND: Tumours are made up of a mixed population of different types of cells that include normal structures as well as ones associated with the malignancy, and there are multiple interactions between the malignant cells and the local microenvironment. These intercellular interactions, modulated by the microenvironment, effect tumour progression and represent a largely under appreciated therapeutic target. We use observations of primary tumor biology from prostate cancer to extrapolate a mathematical model: specifically; it has been observed that in prostate cancer three disparate cellular outcomes predominate: (i) the tumour remains well differentiated and clinically indolent - in this case the local stromal cells may act to restrain the growth of the cancer; (ii) early in its genesis the tumour acquires a highly malignant phenotype, growing rapidly and displacing the original stromal population (often referred to as small cell prostate cancer) - these less common aggressive tumours are relatively independent of the local microenvironment; and, (iii) the tumour co-opts the local stroma - taking on a classic stromagenic phenotype where interactions with the local microenvironment are critical to the cancer growth. METHODS: We present an evolutionary game theoretical construct that models the influence of tumour-stroma interactions in driving these outcomes. We consider three characteristic and distinct cellular populations: stromal cells, tumour cells that are self-reliant in terms of microenvironmental factors and tumour cells that depend on the environment for resources but can also co-opt stroma. 
RESULTS: Using evolutionary game theory we explore a number of different scenarios that elucidate the impact of tumour-stromal interactions on the dynamics of prostate cancer growth and progression and how different treatments in the metastatic setting can affect different types of tumors.
CONCLUSIONS: The tumour microenvironment plays a crucial role selecting the traits of the tumour cells that will determine prostate cancer progression. Equally important, treatments like hormone therapy affect the selection of these cancer phenotypes making it very important to understand how they impact prostate cancer’s somatic evolution
Dimer Decimation and Intricately Nested Localized-Ballistic Phases of Kicked Harper
Dimer decimation scheme is introduced in order to study the kicked quantum
systems exhibiting localization transition. The tight-binding representation of
the model is mapped to a vectorized dimer where an asymptotic dissociation of
the dimer is shown to correspond to the vanishing of the transmission
coefficient thru the system. The method unveils an intricate nesting of
extended and localized phases in two-dimensional parameter space. In addition
to computing transport characteristics with extremely high precision, the
renormalization tools also provide a new method to compute quasienergy
spectrum.Comment: There are five postscript figures. Only half of the figure (3) is
shown to reduce file size. However, missing part is the mirror image of the
part show
The re-birth of the "beat": A hyperlocal online newsgathering model
This is an Author's Accepted Manuscript of an article published in Journalism Practice, 6(5-6), 754 - 765, 2012, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/17512786.2012.667279.Scholars have long lamented the death of the 'beat' in news journalism. Today's journalists generate more copy than they used to, a deluge of PR releases often keeping them in the office, and away from their communities. Consolidation in industry has dislodged some journalists from their local sources. Yet hyperlocal online activity is thriving if journalists have the time and inclination to engage with it. This paper proposes an exploratory, normative schema intended to help local journalists systematically map and monitor their own hyperlocal online communities and contacts, with the aim of re-establishing local news beats online as networks. This model is, in part, technologically-independent. It encompasses proactive and reactive news-gathering and forward planning approaches. A schema is proposed, developed upon suggested news-gathering frameworks from the literature. These experiences were distilled into an iterative, replicable schema for local journalism. This model was then used to map out two real-world 'beats' for local news-gathering. Journalists working within these local beats were invited to trial the models created. It is hoped that this research will empower journalists by improving their information auditing, and could help re-define journalists' relationship with their online audiences
Chaotic systems in complex phase space
This paper examines numerically the complex classical trajectories of the
kicked rotor and the double pendulum. Both of these systems exhibit a
transition to chaos, and this feature is studied in complex phase space.
Additionally, it is shown that the short-time and long-time behaviors of these
two PT-symmetric dynamical models in complex phase space exhibit strong
qualitative similarities.Comment: 22 page, 16 figure
'My language, my people': language and ethnic identity among British‐born South Asians
This study explores how a group of second generation Asians (SGA) understood and defined language, focusing upon the role they perceived language to have played in their identity. Twelve SGA were interviewed and the data were subjected to qualitative thematic analysis. Four superordinate themes are reported, entitled 'Mother tongue and self', #A sense of ownership and affiliation', 'Negotiating linguistic identities in social space' and 'The quest for a positive linguistic identity'. Participants generally expressed a desire to maintain continuity of self‐definition as Asian, primarily through the maintenance of the heritage language (HL). An imperfect knowledge of the HL was said to have a negative impact upon psychological well‐being. There were ambivalent responses to the perception of language norms, and various strategies were reported for dealing with dilemmatic situations and identity threat arising from bilingualism. Recommendations are offered for interventions that might aid the ‘management’ of bilingualism among SGA
On the paucity of fast radio bursts at low Galactic latitudes
We examine the effect of Galactic diffractive interstellar scintillation as a means of explaining the reported deficit of fast radio burst (FRB) detections at low Galactic latitude. We model the unknown underlying FRB flux density distribution as a power law with a rate scaling as S−5/2+δν and account for the fact that the FRBs are detected at unknown positions within the telescope beam. We find that the event rate of FRBs located off the Galactic plane may be enhanced by a factor of ~30–300 per cent relative to objects near the Galactic plane without necessarily affecting the slope of the distribution. For FRBs whose flux densities are subject to relatively weak diffractive scintillation, as is typical for events detected at high Galactic latitudes, we demonstrate that an effect associated with Eddington bias is responsible for the enhancement. The magnitude of the enhancement increases with the steepness of the underlying flux density distribution, so that existing limits on the disparity in event rates between high and low Galactic latitudes suggest that the FRB population has a steep differential flux density distribution, scaling as S−3.5ν or steeper. Existing estimates of the event rate in the flux density range probed by the High Time Resolution Universe survey overestimate the true rate by a factor of ~3
Capacitating Community: The Writing Innovation Symposium
The topic of this symposium, capacitating community, invites CLJ readers to consider what makes a community possible. This piece showcases one means, small conferences, via a retrospective on the Writing Innovation Symposium (WIS), a regional event with national scope that has hosted writers and writing educators annually in Milwaukee, WI, since 2018. Through a quilted conversation pieced from hours of small-group discussion, twenty-nine participants across academic and nonacademic ranks, roles, and ranges of experience offer insight into the WIS as well as the nature and value of professional community
Health Care Use and Costs Associated With Use of a Health Club Membership Benefit in Older Adults with Diabetes
OBJECTIVE—The purpose of this study was to determine whether elective use of a health plan–sponsored health club membership had an impact on health care use and costs among older adults with diabetes
"Arabic is the language of the Muslims–that's how it was supposed to be": exploring language and religious identity through reflective accounts from young British-born South Asians
This study explores how a group of young British-born South Asians understood and defined their religious and linguistic identities, focusing upon the role played by heritage languages and liturgical languages and by religious socialisation. Twelve British-born South Asians were interviewed using a semi-structured interview schedule. Interview transcripts were subjected to interpretative phenomenological analysis. Four superordinate themes are reported. These addressed participants' meaning-making regarding "the sanctification of language" and the consequential suitability of "the liturgical language as a symbol of religious community"; the themes of "ethnic pride versus religious identity" and "linguistic Otherness and religious alienation" concerned potential ethno-linguistic barriers to a positive religious identity. Findings are interpreted in terms of concepts drawn from relevant identity theories and tentative recommendations are offered concerning the facilitation of positive religious and ethnic identities
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