What drives change? A framework to observe and understand broad-­‐ scale change in river basins

Development in river basins is strongly influenced by a range of non-­‐random factors, called global drivers. These can present a bewildering array of effects that confound concerted action. This report summarizes these effects with the CPWF’s six basins and presents a method of visualizing them together within a process of scenario visualization

First observations of volcanic eruption clouds from the L1 Earth-Sun Lagrange point by DSCOVR/EPIC

Volcanic sulfur dioxide (SO2) emissions have been measured by ultraviolet sensors on polar‐orbiting satellites for several decades but with limited temporal resolution. This precludes studies of key processes believed to occur in young (~1–3 hr old) volcanic clouds. In 2015, the launch of the Earth Polychromatic Imaging Camera (EPIC) aboard the Deep Space Climate Observatory (DSCOVR) provided an opportunity for novel observations of volcanic eruption clouds from the first Earth‐Sun Lagrange point (L1). The L1 vantage point provides continuous observations of the sunlit Earth, offering up to eight or nine observations of volcanic SO2 clouds in the DSCOVR/EPIC field of view at ~1‐hr intervals. Here we demonstrate DSCOVR/EPIC\u27s sensitivity to volcanic SO2 using several volcanic eruptions from the tropics to midlatitudes. The hourly cadence of DSCOVR/EPIC observations permits more timely measurements of volcanic SO2 emissions, improved trajectory modeling, and novel analyses of the temporal evolution of volcanic clouds

Evolution of the most recent common ancestor of a population with no selection

We consider the evolution of a population of fixed size with no selection. The number of generations $G$ to reach the first common ancestor evolves in time. This evolution can be described by a simple Markov process which allows one to calculate several characteristics of the time dependence of $G$. We also study how $G$ is correlated to the genetic diversity.Comment: 21 pages, 10 figures, uses RevTex4 and feynmf.sty Corrections : introduction and conclusion rewritten, references adde

Iron supplementation to treat anaemia in adult critical care patients: a systematic review and meta-analysis

Anaemia affects 60-80 % of patients admitted to intensive care units (ICUs). Allogeneic red blood cell (RBC) transfusions remain the mainstay of treatment for anaemia but are associated with risks and are costly. Our objective was to assess the efficacy and safety of iron supplementation by any route, in anaemic patients in adult ICUs.Electronic databases (CENTRAL, MEDLINE, EMBASE) were searched through March 2016 for randomized controlled trials (RCT)s comparing iron by any route with placebo/no iron. Primary outcomes were red blood cell transfusions and mean haemoglobin concentration. Secondary outcomes included mortality, infection, ICU and hospital length of stay, mean difference (MD) in iron biomarkers, health-related quality of life and adverse events.Five RCTs recruiting 665 patients met the inclusion criteria; intravenous iron was tested in four of the RCTs. There was no difference in allogeneic RBC transfusion requirements (relative risk 0.87, 95 % confidence interval (CI) 0.70 to 1.07, p = 0.18, five trials) or mean number of RBC units transfused (MD -0.45, 95 % CI -1.34 to 0.43, p = 0.32, two trials) in patients receiving or not receiving iron. Similarly, there was no difference between groups in haemoglobin at short-term (up to 10 days) (MD -0.25, 95 % CI -0.79 to 0.28, p = 0.35, three trials) or mid-term follow up (last measured time point in hospital or end of trial) (MD 0.21, 95 % CI -0.13 to 0.55, p = 0.23, three trials). There was no difference in secondary outcomes of mortality, in-hospital infection, or length of stay. Risk of bias was generally low although three trials had high risk of attrition bias; only one trial had low risk of bias across all domains.Iron supplementation does not reduce RBC transfusion requirements in critically ill adults, but there is considerable heterogeneity between trials in study design, nature of interventions, and outcomes. Well-designed trials are needed to investigate the optimal iron dosing regimens and strategies to identify which patients are most likely to benefit from iron, together with patient-focused outcomes.PROSPERO International prospective register of systematic reviews CRD42015016627 . Registered 2 March 2015

Non-Universal Quasi-Long Range Order in the Glassy Phase of Impure Superconductors

The structural correlation functions of a weakly disordered Abrikosov lattice are calculated for the first time in a systematic RG-expansion in d=4-\epsilon dimensions. It is shown, that in the asymptotic limit the Abrikosov lattice exhibits still quasi long range translational order described by a non-universal exponent \bar\eta_{\bf G} which depends on the ratio of the renormalized elastic constants \kappa =\tilde c_{66}/\tilde c_{11} of the flux line (FL) lattice. Our calculations show clearly three distinct scaling regimes corresponding to the Larkin, the manifold and the asymptotic Bragg glass regime. On a wide range of intermediate length scales the FL displacement correlation function increases as a power law with twice of the manifold roughness exponent \zeta_{rm}(\kappa), which is also non-universal. Our results, in particular the \kappa-dependence of the exponents, are in variance with those of the variational treatment with replica symmetry breaking which allows in principle an experimental discrimination between the two approaches.Comment: 4 pages, 3 figure

Cerebellar developmental deficits underlie neurodegenerative disorder spinocerebellar ataxia type 23

Contains fulltext : 231334.pdf (Publisher’s version ) (Open Access

Test of Replica Theory: Thermodynamics of 2D Model Systems with Quenched Disorder

We study the statistics of thermodynamic quantities in two related systems with quenched disorder: A (1+1)-dimensional planar lattice of elastic lines in a random potential and the 2-dimensional random bond dimer model. The first system is examined by a replica-symmetric Bethe ansatz (RBA) while the latter is studied numerically by a polynomial algorithm which circumvents slow glassy dynamics. We establish a mapping of the two models which allows for a detailed comparison of RBA predictions and simulations. Over a wide range of disorder strength, the effective lattice stiffness and cumulants of various thermodynamic quantities in both approaches are found to agree excellently. Our comparison provides, for the first time, a detailed quantitative confirmation of the replica approach and renders the planar line lattice a unique testing ground for concepts in random systems.Comment: 16 pages, 14 figure

Association of Demographic Factors and Comorbid Diagnoses with Crime Typein an Arrest Cohort with Schizophrenia and/or Related Psychosis

The implications of the interface between the criminal justice system and individuals with schizophrenia persist despite decades of research on criminalization and risk of arrest. Research exploring the broader construct of criminality has predominantly focused on individuals with severe mental illness as a collective. This study diverges from others by examining diagnoses comorbid with schizophrenia and related psychoses and their relationships with risk of arrest across a spectrum of criminal categories ranging in severity