Spatial distribution of shore-based fishers in the greater Perth Metropolitan area over summer 2010/2011

Aerial surveys are a useful technique for estimating numbers of recreational fishers. Following the success of a pilot study to examine the spatial patterns of recreational shore-based fishing activity in the Perth Metropolitan area from April – June 2010, another survey was conducted from December 2010 – February 2011 between Lancelin – Bunbury. More than 7,000 shorebased fishers were counted during 36 aerial flights, with significantly more recorded on morning and afternoon flights, when compared to those conducted at midday. Flights on weekends/public holidays also recorded more fishers than weekdays. The spatial distribution of fishers was variable along the coast, with sandy beaches at the northern and southern sections of the study area having high counts of fishers, along with groynes in the central section. Comparisons with the previous (autumn) study revealed that the northern beaches generally had higher numbers of shore-based fishers in summer, while those in the south had more during autumn. Data from this study assists with understanding the patterns of shore-based recreational fishing occurring along the greater Perth Metropolitan coast. Such information can be used to assist in the design of future on-ground surveys, compliance and education activities

The International Union for Health Promotion and Education (IUHPE) Student and Early Career Network (ISECN): A Case Illustrating Three Strategies for Maximizing Synergy in Professional Collaboration

The International Union for Health Promotion and Education (IUHPE) Student and Early Career Network (ISECN) was constructed upon a foundation of research, using the Bergen Model of Collaborative Functioning (BMCF) as a blueprint to inform its leadership, communication, structure, and culture. The BMCF consists of inputs (partners, mission, and financial resources), throughputs (operational processes), and outputs (synergy and antagony). In this commentary, we use the BMCF to describe the ISECN work, highlighting opportunities, successes, and challenges. We also put forward three strategies derived from the BMCF that have been purposefully employed by ISECN to maximize its production of synergy from the voluntary contributions of its members

An Investigation into the Scallop Parasite Outbreak on the Mid-Atlantic Shelf: Transmission Pathways, Spatio-Temporal Variation of Infection and Consequences to Marketability : Final Report

A disease epizootic has developed that threatens one of the most valuable fisheries in the US. The U.S. sea scallop (Placopecten magellanicus) fishery landed $512 million worth of scallop meats in 2017 (NMFS, 2018). This fishery is based on landings of scallop adductor muscles only, with the remainder of the scallop discarded at sea (NEFSC, 2018). During the spring of 2015 both industry and scientific assessment crews noted unprecedented numbers of a parasitic nematode in the adductor muscle of captured scallops (Figure 1). The presence of the parasite in the adductor muscle is expressed through macroscopic lesions, or cysts. These lesions are rust-brown to orange/brown in color with a typically elongated shape, ranging from 2 -12 mm in length and 1 - 4 mm in width. Nearly all lesions were observed along the exterior edge of the adductor muscle between the mantle velar folds of both valves opposite the catch muscle (sweet-meat). This location on the adductor muscle is anatomically adjacent to the kidney-adductor muscle attachment site and opposite of scallop intestine and anus. Infected scallops were observed in the southern portion of the stock and corresponded with the re-opening of three spatial management areas in this region. The wide distribution of the observed parasite is of concern from a product marketability standpoint and may represent the early stages of an expansion of parasite prevalence and intensity. Preliminary investigations suggest that the nematode observed is Sulcasaris sulcata (Rudders and Roman, 2018a)

Reviews

Tolkien, Race and Cultural History: From Fairies to Hobbits. Dimitra Fimi. Reviewed by Jason Fisher. Charles Williams and his Contemporaries. Suzanne Bray and Richard Sturch, eds. Reviewed by Joe R. Christopher. In the Land of Invented Languages: Esperanto Rock Stars, Klingon Poets, Loglan Lovers, and the Mad Dreamers who Tried to Build a Perfect Language. Arika Okrent. Reviewed by Harley J. Sims. Millennial Mythmaking: Essays on the Power of Science Fiction and Fantasy Literature, Films and Games. John Perlich & David Whitt, eds. Reviewed by Priscilla Hobbs Middle-earth Minstrel: Essays on Music in Tolkien. Bradford Lee Eden, ed. Reviewed by Emily A. Moniz. Harry Potter & Imagination: The Way Between Two Worlds. Travis Prinzi. Reviewed by David D. Oberhelman. Fastitocalon: Studies in Fantasticism Ancient to Modern: Immortals and the Undead. Eds. Thomas Honneger and Fanfan Chen. Reviewed by Janet Brennan Croft. Theodor Seuss Geisel [sic]. Donald E. Pease. Reviewed by Joe R. Christopher

RCT Testing Bystander Effectiveness to Reduce Violence

Introduction: Bystander-based programs have shown promise to reduce interpersonal violence at colleges, yet limited rigorous evaluations have addressed bystander intervention effectiveness in high schools. This study evaluated the Green Dot bystander intervention to reduce sexual violence and related forms of interpersonal violence in 26 high schools over 5 years. Design: A cluster RCT was conducted. Setting/participants: Kentucky high schools were randomized to intervention or control (wait list) conditions. Intervention: Green Dot−trained educators conducted schoolwide presentations and recruited student popular opinion leaders to receive bystander training in intervention schools beginning in Year 1. Main outcome measures: The primary outcome was sexual violence perpetration, and related forms of interpersonal violence victimization and perpetration were also measured using anonymous student surveys collected at baseline and annually from 2010 to 2014. Because the school was the unit of analysis, violence measures were aggregated by school and year and school-level counts were provided. Results: A total of 89,707 students completed surveys. The primary, as randomized, analyses conducted in 2014–2016 included linear mixed models and generalized estimating equations to examine the condition−time interaction on violence outcomes. Slopes of school-level totals of sexual violence perpetration (condition−time, p \u3c 0.001) and victimization (condition−time, p \u3c 0.001) were different over time. During Years 3–4, when Green Dot was fully implemented, the mean number of sexual violent events prevented by the intervention was 120 in Intervention Year 3 and 88 in Year 4. For Year 3, prevalence rate ratios for sexual violence perpetration in the intervention relative to control schools were 0.83 (95% CI=0.70, 0.99) in Year 3 and 0.79 (95% CI=0.67, 0.94) in Year 4. Similar patterns were observed for sexual violence victimization, sexual harassment, stalking, and dating violence perpetration and victimization. Conclusions: Implementation of Green Dot in Kentucky high schools significantly decreased not only sexual violence perpetration but also other forms of interpersonal violence perpetration and victimization

Lymphovascular and perineural invasion as selection criteria for adjuvant therapy in intrahepatic cholangiocarcinoma: a multi-institution analysis

AbstractObjectivesCriteria for the selection of patients for adjuvant chemotherapy in intrahepatic cholangiocarcinoma (IHCC) are lacking. Some authors advocate treating patients with lymph node (LN) involvement; however, nodal assessment is often inadequate or not performed. This study aimed to identify surrogate criteria based on characteristics of the primary tumour.MethodsA total of 58 patients who underwent resection for IHCC between January 2000 and January 2010 at any of three institutions were identified. Primary outcome was overall survival (OS).ResultsMedian OS was 23.0months. Median tumour size was 6.5cm and the median number of lesions was one. Overall, 16% of patients had positive margins, 38% had perineural invasion (PNI), 40% had lymphovascular invasion (LVI) and 22% had LN involvement. A median of two LNs were removed and a median of zero were positive. Lymph nodes were not sampled in 34% of patients. Lymphovascular and perineural invasion were associated with reduced OS [9.6months vs. 32.7months (P= 0.020) and 10.7months vs. 32.7months (P= 0.008), respectively]. Lymph node involvement indicated a trend towards reduced OS (10.7months vs. 30.0months; P= 0.063). The presence of either LVI or PNI in node-negative patients was associated with a reduction in OS similar to that in node-positive patients (12.1months vs. 10.7months; P= 0.541). After accounting for adverse tumour factors, only LVI and PNI remained associated with decreased OS on multivariate analysis (hazard ratio4.07, 95% confidence interval 1.60–10.40; P= 0.003).ConclusionsLymphovascular and perineural invasion are separately associated with a reduction in OS similar to that in patients with LN-positive disease. As nodal dissection is often not performed and the number of nodes retrieved is frequently inadequate, these tumour-specific factors should be considered as criteria for selection for adjuvant chemotherapy

Verifiable self-certifying autonomous systems

Autonomous systems are increasingly being used in safety-and mission-critical domains, including aviation, manufacturing, healthcare and the automotive industry. Systems for such domains are often verified with respect to essential requirements set by a regulator, as part of a process called certification. In principle, autonomous systems can be deployed if they can be certified for use. However, certification is especially challenging as the condition of both the system and its environment will surely change, limiting the effective use of the system. In this paper we discuss the technological and regulatory background for such systems, and introduce an architectural framework that supports verifiably-correct dynamic self-certification by the system, potentially allowing deployed systems to operate more safely and effectively

Flavin Mononucleotide as a Biomarker of Organ Quality-A Pilot Study.

BACKGROUND: Flavin mononucleotide (FMN), released from damaged mitochondrial complex I during hypothermic liver perfusion, has been shown to be predictive of 90-day graft loss. Normothermic machine perfusion (NMP) and normothermic regional perfusion (NRP) are used for organ reconditioning and quality assessment before transplantation. This pilot study aimed to investigate the changes of FMN levels during normothermic reperfusion of kidneys, livers, and lungs and examine whether FMN could serve as a biomarker to predict posttransplant allograft quality. METHODS: FMN concentrations, in perfusates collected during NMP of kidneys, abdominal NRP, and ex vivo lung perfusion, were measured using fluorescence spectrometry and correlated to the available perfusion parameters and clinical outcomes. RESULTS: Among 7 transplanted kidneys out of the 11 kidneys that underwent NMP, FMN levels at 60 minutes of NMP were significantly higher in the allografts that developed delayed graft function and primary nonfunction (P = 0.02). Fifteen livers from 23 circulatory death donors that underwent NRP were deemed suitable for transplantation. Their FMN levels at 30 minutes of NRP were significantly lower than those not procured for transplantation (P = 0.004). In contrast, little FMN was released during the 8 lung perfusions. CONCLUSIONS: This proof of concept study suggested that FMN in the perfusates of kidney NMP has the potential to predict posttransplant renal function, whereas FMN at 30 minutes of NRP predicts whether a liver would be accepted for transplantation. More work is required to validate the role of FMN as a putative biomarker to facilitate safe and reliable decision-making before embarking on transplantation.NIHR BTR

Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination

Developmental axon remodeling is characterized by the selective removal of branches from axon arbors. The mechanisms that underlie such branch loss are largely unknown. Additionally, how neuronal resources are specifically assigned to the branches of remodeling arbors is not understood. Here we show that axon branch loss at the developing mouse neuromuscular junction is mediated by branch-specific microtubule severing, which results in local disassembly of the microtubule cytoskeleton and loss of axonal transport in branches that will subsequently dismantle. Accordingly, pharmacological microtubule stabilization delays neuromuscular synapse elimination. This branch-specific disassembly of the cytoskeleton appears to be mediated by the microtubule-severing enzyme spastin, which is dysfunctional in some forms of upper motor neuron disease. Our results demonstrate a physiological role for a neurodegeneration-associated modulator of the cytoskeleton, reveal unexpected cell biology of branch-specific axon plasticity and underscore the mechanistic similarities of axon loss in development and disease

Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2

Polycomb proteins maintain cell identity by repressing the expression of developmental regulators specific for other cell types. Polycomb repressive complex-2 (PRC2) catalyzes trimethylation of histone H3 lysine-27 (H3K27me3). Although repressed, PRC2 targets are generally associated with the transcriptional initiation marker H3K4me3, but the significance of this remains unclear. Here, we identify a class of short RNAs, ~50–200 nucleotides in length, transcribed from the 5′ end of polycomb target genes in primary T cells and embryonic stem cells. Short RNA transcription is associated with RNA polymerase II and H3K4me3, occurs in the absence of mRNA transcription, and is independent of polycomb activity. Short RNAs form stem-loop structures resembling PRC2 binding sites in Xist, interact with PRC2 through SUZ12, cause gene repression in cis, and are depleted from polycomb target genes activated during cell differentiation. We propose that short RNAs play a role in the association of PRC2 with its target genes.National Institutes of Health (U.S.) (Grant HG002668)National Institutes of Health (U.S.) (Grant NS055923