Validation of Non-Traditional Approaches to Annual Average Daily Traffic (AADT) Volume Estimation

For this validation study, NREL compiled traffic volume data from permanent traffic counters at over 500 locations across the U.S. These data were used to validate annual average daily traffic (AADT) estimates developed by Streetlight Data using passive data sources. The analysis revealed a strong correlation between estimates derived from passive sources and the permanent counters. However, statistical differences were observed, and deviations from ground truth may be unacceptable for some applications. Toll locations were particularly prone to high errors, possibly due to complex geometry. While the validation sheds light on the utility of AADT estimation from passive sources, its findings were limited by a lack of permanent counter data. It is possible that an analysis using a larger sample size could result in more robust findings

Reading Graphic Novels in School: texts, contexts and the interpretive work of critical reading

This paper uses the example of an extra-curricular Graphic Novel Reading Group in order to explore the institutional critical reading practices that take place in English classrooms in the senior years of secondary school. Drawing on Stanley Fish's theory of interpretive communities, it questions the restrictive interpretive strategies applied to literary texts in curriculum English. By looking closely at the interpretive strategies pupils apply to a different kind of text (graphic novels) in an alternative context (an extra-curricular space) the paper suggests that there may be other ways of engaging with text that pupils find less alienating, more pleasurable and less reminiscent of 'work'

Characterisation of the muon beams for the Muon Ionisation Cooling Experiment

A novel single-particle technique to measure emittance has been developed and used to characterise seventeen different muon beams for the Muon Ionisation Cooling Experiment (MICE). The muon beams, whose mean momenta vary from 171 to 281 MeV/c, have emittances of approximately 1.2–2.3 π mm-rad horizontally and 0.6–1.0 π mm-rad vertically, a horizontal dispersion of 90–190 mm and momentum spreads of about 25 MeV/c. There is reasonable agreement between the measured parameters of the beams and the results of simulations. The beams are found to meet the requirements of MICE

Anthrax Toxin Receptor Drives Protective Antigen Oligomerization and Stabilizes the Heptameric and Octameric Oligomer by a Similar Mechanism

Anthrax toxin is comprised of protective antigen (PA), lethal factor (LF), and edema factor (EF). These proteins are individually nontoxic; however, when PA assembles with LF and EF, it produces lethal toxin and edema toxin, respectively. Assembly occurs either on cell surfaces or in plasma. In each milieu, PA assembles into a mixture of heptameric and octameric complexes that bind LF and EF. While octameric PA is the predominant form identified in plasma under physiological conditions (pH 7.4, 37°C), heptameric PA is more prevalent on cell surfaces. The difference between these two environments is that the anthrax toxin receptor (ANTXR) binds to PA on cell surfaces. It is known that the extracellular ANTXR domain serves to stabilize toxin complexes containing the PA heptamer by preventing premature PA channel formation--a process that inactivates the toxin. The role of ANTXR in PA oligomerization and in the stabilization of toxin complexes containing octameric PA are not understood.Using a fluorescence assembly assay, we show that the extracellular ANTXR domain drives PA oligomerization. Moreover, a dimeric ANTXR construct increases the extent of and accelerates the rate of PA assembly relative to a monomeric ANTXR construct. Mass spectrometry analysis shows that heptameric and octameric PA oligomers bind a full stoichiometric complement of ANTXR domains. Electron microscopy and circular dichroism studies reveal that the two different PA oligomers are equally stabilized by ANTXR interactions.We propose that PA oligomerization is driven by dimeric ANTXR complexes on cell surfaces. Through their interaction with the ANTXR, toxin complexes containing heptameric and octameric PA oligomers are similarly stabilized. Considering both the relative instability of the PA heptamer and extracellular assembly pathway identified in plasma, we propose a means to regulate the development of toxin gradients around sites of infection during anthrax pathogenesis

Sexual dimorphism in cancer.

The incidence of many types of cancer arising in organs with non-reproductive functions is significantly higher in male populations than in female populations, with associated differences in survival. Occupational and/or behavioural factors are well-known underlying determinants. However, cellular and molecular differences between the two sexes are also likely to be important. In this Opinion article, we focus on the complex interplay that sex hormones and sex chromosomes can have in intrinsic control of cancer-initiating cell populations, the tumour microenvironment and systemic determinants of cancer development, such as the immune system and metabolism. A better appreciation of these differences between the two sexes could be of substantial value for cancer prevention as well as treatment

Think Again : Contrarian Reflections on Life, Culture, Politics, Religion, Law, and Education

From 1995 to 2013, Stanley Fish\u27s provocative New York Times columns consistently generated passionate discussion and debate. In Think Again, he has assembled almost one hundred of his best columns into a thematically arranged collection with a substantial new introduction that explains his intention in writing these pieces and offers an analysis of why they provoked so much reaction. Some readers reported being frustrated when they couldn\u27t figure out where Fish, one of America\u27s most influential thinkers, stood on the controversies he addressed in the essays--from atheism and affirmative action to plagiarism and postmodernism. But, as Fish says, that is the point. Opinions are cheap; you can get them anywhere. Instead of offering just another set of them, Fish analyzes and dissects the arguments put forth by different sides--in debates over free speech, identity politics, the gun lobby, and other hot-button topics--in order to explain how their arguments work or don\u27t work. In short, these are essays that teach you not what to think but how to think more clearly. Brief and accessible yet challenging, these essays provide all the hard-edged intellectual, cultural, and political analysis one expects from Fish. At the same time, the collection includes a number of revealing and even poignant autobiographical essays in which, as Fish says, readers will learn about my anxieties, my aspirations, my eccentricities, my foibles, my father, and my obsessions--Frank Sinatra, Ted Williams, basketball, and Jews. Reflecting the wide-ranging interests of one of today\u27s leading critics, this is Fish\u27s broadest and most engaging book to date.https://ecollections.law.fiu.edu/faculty_books/1019/thumbnail.jp

Assessing the Value of Brief Automated Biographies

New systems have been introduced that support the visualisation and sharing of personal digital data, but relatively little work has been done to establish how such systems support reminiscence and personal reflection. In this paper, we explore Intel’s Museum of Me, a tool that collates and presents Facebook data in the form of a virtual museum, by asking how such an automated biography might support personal reflection and a process of life review. We supported users in their creation of personal virtual museums and interviewed them about their experiences, using a theoretical framework that highlighted the importance of personal narratives and life review in identity formation and psychological well-being. Our participants enjoyed the experience and welcomed the opportunity for reminiscence, but considered their resulting videos to be rather shallow representations of self, reflective of some of the more trivial exchanges and relationships that can come to dominate social media. We argue that social media in its current form is not well suited to support a meaningful life-review process