Fish Out of Water

Panel: Sense of Plac

Woman in the Mirror: Reflections

In A Room of One’s Own (1929) Virginia Woolf asserts: “Women have served all these centuries as looking-glasses possessing the magic and delicious power of reflecting the figure of man at twice its natural size”. (34) The use of the mirror is key to Woolf’s arguments about the position of women in general and in particular that of women writers. Complicating Woolf’s view less than a century later, I examine how black women function as looking-glasses in a dual way: as blacks, we shared the past (and now share the current) fate of black people reflecting the “darker” side of white people, as many whites projected onto blacks the unacknowledgeable traits of their own nature. The mirror is also key then to the way in which racial oppression has been analysed in literature. My paper offers an account, by way of selected examples from the history of our literature, of indicating how the mirror has been essential to how black British women are viewed and reflected back. I suggest that the misshapen image in the looking glass created by white people and also black men, allows them to see an inflated reflection of themselves, to assume false feelings of superiority, and to perpetuate oppression against us. I focus on Mary Prince, Mary Seacole, Una Marson, Joan Riley and Helen Oeyemi–authors whose work either anticipates or relates to Woolf’s notion of mirroring, by seeking ways to addressor overcome the situation in which we are placed. The texts explored not only trace the development of the tradition of our writing - the shift from being represented to representing ourselves– but also present a range of cultural and political views and identify three recurring themes: firstly, the denigration in our portrayal; secondly, the assumed superiority white people and black men adopt over us; and thirdly our resistance in remonstrating against such treatment and exposure

Linking tumour susceptibility ESCRT proteins and epithelial cell polarity

The ESCRT machinery has a well established role within the endocytic pathway. Studies conducted in Drosophila have identified ESCRT proteins as important regulators of epithelial cell polarity and growth. Consequently ESCRTs have been classified as potential tumour suppressors. Alterations in the expression of various ESCRT components have been observed in human cancers. However, the possible link between ESCRT proteins, mammalian epithelial cell polarity and tumourigenesis has not been investigated. This thesis demonstrates for the first time that the ESCRT-I protein, Tsg101, is required for maintenance of mammalian epithelial cell organisation and polarity. siRNA knockdown of Tsg101 in the human Caco-2 cell line results in the formation of a multilayered epithelium with compromised apicobasal polarity. In addition, Tsg101 depletion impairs differentiation of the epithelial sheet and formation of polarised 3D Caco-2 cysts. Depletion of Tsg101 also results in intracellular accumulation of the tight junction protein, claudin-1. This is shown to be constitutively endocytosed and recycled in Caco-2 epithelial monolayers, suggesting that ESCRT-I is required for claudin-1 recycling to tight junctions. Tsg101 knockdown also impairs epithelial barrier formation and enhances Caco-2 migratory ability. This suggests that tight junction integrity is impaired and may contribute to the loss of Caco-2 cell organisation and polarity observed upon Tsg101 depletion. Finally, Tsg101 depleted Caco-2 cells appear to overproliferate, forming multilayered regions of the epithelial sheet. However, multilayered cells are eventually eliminated via apoptosis. Preliminary results suggest that inhibition of this apoptotic response enhances the aberrant epithelial phenotype, suggesting that the ability to evade apoptosis may be an important factor in determining the tumourigenic potential of ESCRT-I depletion. Therefore, results presented in this thesis suggest that the role of ESCRT-I as a tumour suppressor is conserved from Drosophila to mammals.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Associations of relationship experiences dating violence, sexual harassment, and assault with alcohol use among sexual and gender minority adolescents

Sexual and gender minority (SGM) adolescents report higher rates of dating violence victimization compared with their heterosexual and cisgender peers. Research on dating violence often neglects diversity in sexual and gender identities and is limited to experiences in relationships. Further, given that dating violence and alcohol use are comorbid, research on experiences of dating violence could provide insights into alcohol use disparities among SGM adolescents. We aimed to map patterns of relationship experiences, sexual and physical dating violence, and sexual and physical assault and explored differences in these experiences among SGM adolescents. Further, we examined how these patterns explained alcohol use. We used a U.S. non-probability national web-based survey administered to 13–17-year-old SGM adolescents (N = 12,534). Using latent class analyses, four patterns were identified: low relationship experience, dating violence and harassment and assault (72.0%), intermediate dating experiences, sexual harassment, and assault and low levels of dating violence (13.1%), high dating experiences, dating violence, and sexual assault (8.6%), and high dating experiences, dating violence, and sexual harassment and assault (6.3%). Compared to lesbian and gay adolescents, bisexual adolescents reported more experiences with dating, dating violence, and sexual assault, whereas heterosexual adolescents reported fewer experiences with dating, dating violence, and sexual harassment and assault. Compared to cisgender boys, cisgender girls, transgender boys, and non-binary/assigned male at birth adolescents were more likely to experience dating violence inside and outside of relationship contexts. Experiences of dating, dating violence, and sexual harassment and assault were associated with both drinking frequency and heavy episodic drinking. Together, the findings emphasize the relevance of relationship experiences when studying dating violence and how dating violence and sexual harassment and assault might explain disparities in alcohol use

Capitalizing on the Teachable Moment: Improving Self-Help Smoking Cessation Interventions

The Teachable Moment (TM) model suggests that there are certain times when an individual is especially ready to change behavior and thus, especially open to receiving messages about behavior change. According to the TM model, experiences that jointly 1) increase risk perceptions, 2) prompt concordant emotional responses, and 3) impact self-concept may offer a powerful motivational context for promoting behavior change. Further, tailoring smoking cessation interventions on TM components may increase the salience of health messages. The TM model was used to examine desire to quit smoking among family members of lung cancer patients. Further, the relationship between desire to quit and engagement with and reactions to self-help smoking cessation materials was examined. Participants were family members of lung cancer patients recruited for a randomized controlled trial testing a counseling intervention for smoking cessation. Study results indicate that components of the TM model were related to desire to quit in family members of lung cancer patients. Specifically, increased perceived risk, negative self image, and high subjective norm for quitting were related to high desire to quit. Nonwhites were more likely to have a high desire to quit than whites. There was a significant interaction between worry and gender, such that women with low worry were less likely to have a high desire to quit than were men and women with high worry. Findings on engagement with and reactions to materials were mixed. Engagement with materials was not related to baseline desire to quit, but was related to positive reactions to the materials. Those with a higher desire to quit were more likely to report that the information in the tailored booklet applied to them, and was new to them, interesting, trustworthy, and moving. Finally, family members with a higher desire to quit were more likely to say that the information in the booklet make them want to quit smoking. Evidence from this initial study indicates that the TM model provides a strong conceptual framework for 1) identifying specific determinants of desire to quit among family members of lung cancer patients; and 2) developing effective tailored self-help materials for this population

Diferenças entre os sexos na percepção de asma e sintomas respiratórios em uma amostra populacional em quatro cidades brasileiras

OBJECTIVE: To evaluate the impact of asthma, by gender, in a population sample of asthma patients in Brazil. METHODS: We conducted face-to-face interviews with 400 subjects (> 12 years of age) included in a national probability telephone sample of asthma patients in the Brazilian state capitals of São Paulo, Rio de Janeiro, Curitiba, and Salvador. Each of those 400 subjects completed a 53-item questionnaire that addressed five asthma domains: symptoms; impact of asthma on quality of life; perception of asthma control; exacerbations; and treatment/medication. RESULTS: Of the 400 patients interviewed, 272 (68%) were female. In relation to respiratory symptoms, the proportion of women reporting extremely bothersome symptoms (cough with sputum, tightness in the chest, cough/shortness of breath/tightness in the chest during exercise, nocturnal shortness of breath, and nocturnal cough) was greater than was that of men. Daytime symptoms, such as cough, shortness of breath, wheezing, and tightness in the chest, were more common among women than among men. Women also more often reported that their asthma interfered with normal physical exertion, social activities, sleep, and life in general. Regarding the impact of asthma on quality of life, the proportion of subjects who reported that asthma caused them to feel that they had no control over their lives and affected the way that they felt about themselves was also greater among women than among men. CONCLUSIONS: Among women, asthma tends to be more symptomatic, as well as having a more pronounced effect on activities of daily living and on quality of life.OBJETIVO: Avaliar o impacto da asma em relação ao sexo em uma amostra populacional de pacientes asmáticos no Brasil. MÉTODOS: Foram entrevistados pessoalmente 400 pacientes asmáticos com idade > 12 anos de uma amostra probabilística nacional por contato telefônico nas cidades de São Paulo, Rio de Janeiro, Curitiba e Salvador. Os indivíduos responderam um questionário de 53 questões relacionadas com cinco domínios da asma: sintomas; impacto da asma na vida; percepção do controle da asma; exacerbações; tratamento e medicação. RESULTADOS: Dos 400 pacientes entrevistados, 272 (68%) eram do sexo feminino. Em relação aos sintomas respiratórios, uma maior proporção de mulheres relatou se sentir extremamente incomodada com seus sintomas (tosse com secreção, sensação de aperto no peito, tosse/falta de ar/sensação de aperto no peito durante exercícios, falta de ar noturna e tosse noturna) do que os homens. Sintomas diurnos, como tosse, falta de ar, chiado e sensação de aperto no peito, foram mais comuns nas mulheres que nos homens. Além disso, a asma interferiu mais frequentemente nos esforços físicos normais, atividades sociais, durante o sono e na vida em geral nas mulheres. Sobre o impacto da asma na qualidade de vida, as mulheres relataram mais frequentemente que os homens que a asma causava uma sensação de falta de controle sobre a própria vida e que eram afetadas na forma como se sentiam em relação a si mesmas. CONCLUSÕES: As mulheres asmáticas apresentam mais sintomas e são mais afetadas em suas atividades diárias e qualidade de vida.Federal University of São Paulo Paulista School of MedicineUniversity of Puerto Rico School of Public HealthMerck Sharp & Dohme Corp.UNIFESP, EPMSciEL

Excited-State OH Masers and Supernova Remnants

The collisionally pumped, ground-state 1720 MHz maser line of OH is widely recognized as a tracer for shocked regions and observed in star-forming regions and supernova remnants. Whereas some lines of excited states of OH have been detected and studied in star-forming regions, the subject of excited-state OH in supernova remnants-where high collision rates are to be expected-is only recently being addressed. Modeling of collisional excitation of OH demonstrates that 1720, 4765, and 6049 MHz masers can occur under similar conditions in regions of shocked gas. In particular, the 6049 and 4765 MHz masers become more significant at increased OH column densities where the 1720 MHz masers begin to be quenched. In supernova remnants, the detection of excited-state OH line maser emission could therefore serve as a probe of regions of higher column densities. Using the Very Large Array, we searched for excited-state OH in the 4.7, 7.8, 8.2, and 23.8 GHz lines in four well-studied supernova remnants with strong 1720 MHz maser emission (Sgr A East, W28, W44 and IC 443). No detections were made, at typical detection limits of around 10 mJy beam-1. The search for the 6 GHz lines were done using Effelsberg since the VLA receivers did not cover those frequencies, and are reported on in an accompanying letter (Fish and coworkers). We also cross-correlated the positions of known supernova remnants with the positions of 1612 MHz maser emission obtained from blind surveys. No probable associations were found, perhaps except in the Sgr A East region. The lack of detections of excited-state OH indicates that the OH column densities suffice for 1720 MHz inversion but not for inversion of excited-state transitions, consistent with the expected results for C-type shocks

Human Milk Omega-3 Fatty Acid Composition is Associated with Infant Temperament

There is growing evidence that omega-3 (n-3) polyunsaturated fatty-acids (PUFAs) are important for the brain development in childhood and are necessary for an optimal health in adults. However, there have been no studies examining how the n-3 PUFA composition of human milk influences infant behavior or temperament. To fill this knowledge gap, 52 breastfeeding mothers provided milk samples at 3 months postpartum and completed the Infant Behavior Questionnaire (IBQ-R), a widely used parent-report measure of infant temperament. Milk was assessed for n-3 PUFAs and omega-6 (n-6) PUFAs using gas-liquid chromatography. The total fat and the ratio of n6/n-3 fatty acids in milk were also examined. Linear regression models revealed that infants whose mothers’ milk was richer in n-3 PUFAs had lower scores on the negative affectivity domain of the IBQ-R, a component of temperament associated with a risk for internalizing disorders later in life. These associations remained statistically significant after considering covariates, including maternal age, marital status, and infant birth weight. The n-6 PUFAs, n-6/n-3 ratio, and total fat of milk were not associated with infant temperament. These results suggest that mothers may have the ability to shape the behavior of their offspring by adjusting the n-3 PUFA composition of their milk

Balancing medical education with service in the workplace

Purpose: Finding a balance between the provision of quality individualized care and the ongoing education of junior doctors had been flagged as a concern at a large NHS teaching hospital in the north of England. In response to this, the organization introduced an intervention designed to improve educational culture by providing support to educators, leaders and clinical staff. Method: This article features themed results from eight in-depth interviews with educators, consultants and junior doctors to describe and evaluate the process and impact. Findings: Factors that contributed to a positive educational environment included: trainees and educators feeling valued, the presence of supportive leaders, and the provision of a safe space for learning. Perceived barriers included time constraints, differing motivation, and the generic format of formal education. Participants reflected on how the Wrap Around project helped improve the workplace educational culture and offered suggestions for further improvement including the provision of ongoing feedback to learners about their performance. Originality: Research aimed at recognising and resolving the perceived tensions between the priorities of education and healthcare delivery has been flagged as a gap in the literature. We argue that developing and enhancing collaborative leadership and educational culture within an organization can reduce these tensions for those working on the front line. Future work should focus on addressing the perceived distinction between the two within services.<br/