426 research outputs found
Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy
Background: Progressive multifocal leukoencephalopathy (PML) was reported to have developed in three patients treated with natalizumab. We conducted an evaluation to determine whether PML had developed in any other treated patients.
Methods: We invited patients who had participated in clinical trials in which they received recent or long-term treatment with natalizumab for multiple sclerosis, Crohn's disease, or rheumatoid arthritis to participate. The clinical history, physical examination, brain magnetic resonance imaging (MRI), and testing of cerebrospinal fluid for JC virus DNA were used by an expert panel to evaluate patients for PML. We estimated the risk of PML in patients who completed at least a clinical examination for PML or had an MRI.
Results: Of 3417 patients who had recently received natalizumab while participating in clinical trials, 3116 (91 percent) who were exposed to a mean of 17.9 monthly doses underwent evaluation for PML. Of these, 44 patients were referred to the expert panel because of clinical findings of possible PML, abnormalities on MRI, or a high plasma viral load of JC virus. No patient had detectable JC virus DNA in the cerebrospinal fluid. PML was ruled out in 43 of the 44 patients, but it could not be ruled out in one patient who had multiple sclerosis and progression of neurologic disease because data on cerebrospinal fluid testing and follow-up MRI were not available. Only the three previously reported cases of PML were confirmed (1.0 per 1000 treated patients; 95 percent confidence interval, 0.2 to 2.8 per 1000).
Conclusions: A detailed review of possible cases of PML in patients exposed to natalizumab found no new cases and suggested a risk of PML of roughly 1 in 1000 patients treated with natalizumab for a mean of 17.9 months. The risk associated with longer treatment is not known
Infrared exponents and the strong-coupling limit in lattice Landau gauge
We study the gluon and ghost propagators of lattice Landau gauge in the
strong-coupling limit beta=0 in pure SU(2) lattice gauge theory to find
evidence of the conformal infrared behavior of these propagators as predicted
by a variety of functional continuum methods for asymptotically small momenta
. In the strong-coupling limit, this same
behavior is obtained for the larger values of a^2q^2 (in units of the lattice
spacing a), where it is otherwise swamped by the gauge field dynamics.
Deviations for a^2q^2 < 1 are well parameterized by a transverse gluon mass
. Perhaps unexpectedly, these deviations are thus no finite-volume
effect but persist in the infinite-volume limit. They furthermore depend on the
definition of gauge fields on the lattice, while the asymptotic conformal
behavior does not. We also comment on a misinterpretation of our results by
Cucchieri and Mendes in Phys. Rev. D81 (2010) 016005.Comment: 17 pages, 12 figures. Revised version (mainly sections I and II);
references and comments on subsequent work on the subject added
Infrared Features of the Landau Gauge QCD
The infrared features of Landau gauge QCD are studied by the lattice
simulation of and . We
adopt two definitions of the gauge field; 1) linear 2) and
measured the gluon propagator and ghost propagator. Infrared singularity of the
gluon propagator is less than that of tree level result but the gluon
propagator at 0 momentum remains finite. The infrared singularity of ghost
propagator is stronger than the tree level. The QCD running coupling measured
by using the gluon propagator and the ghost propagator has a maximum
at around and decreases as approaches 0.
The data are analyzed in use of formula of the principle of minimal
sensitivity(PMS), the effective charge method and the contour-improved
perturbation method, which suggest necessity of the resummation of perturbation
series in the infrared region together with existence of the infrared fixed
point. Kugo-Ojima parameter saturates at about -0.8 in contrast to the
theoretically expected value -1.Comment: RevTex4, 9 pages, 10 eps figures, Typos corrected. To be published in
Phys. Rev. D(2004
Strong-coupling study of the Gribov ambiguity in lattice Landau gauge
We study the strong-coupling limit beta=0 of lattice SU(2) Landau gauge
Yang-Mills theory. In this limit the lattice spacing is infinite, and thus all
momenta in physical units are infinitesimally small. Hence, the infrared
behavior can be assessed at sufficiently large lattice momenta. Our results
show that at the lattice volumes used here, the Gribov ambiguity has an
enormous effect on the ghost propagator in all dimensions. This underlines the
severity of the Gribov problem and calls for refined studies also at finite
beta. In turn, the gluon propagator only mildly depends on the Gribov
ambiguity.Comment: 14 pages, 22 figures; minor changes, matches version to appear in
Eur. Phys. J.
Laser ablation loading of a radiofrequency ion trap
The production of ions via laser ablation for the loading of radiofrequency
(RF) ion traps is investigated using a nitrogen laser with a maximum pulse
energy of 0.17 mJ and a peak intensity of about 250 MW/cm^2. A time-of-flight
mass spectrometer is used to measure the ion yield and the distribution of the
charge states. Singly charged ions of elements that are presently considered
for the use in optical clocks or quantum logic applications could be produced
from metallic samples at a rate of the order of magnitude 10^5 ions per pulse.
A linear Paul trap was loaded with Th+ ions produced by laser ablation. An
overall ion production and trapping efficiency of 10^-7 to 10^-6 was attained.
For ions injected individually, a dependence of the capture probability on the
phase of the RF field has been predicted. In the experiment this was not
observed, presumably because of collective effects within the ablation plume.Comment: submitted to Appl. Phys. B., special issue on ion trappin
Neutral weak currents in pion electroproduction on the nucleon
Parity violating asymmetry in inclusive scattering of longitudinally
polarized electrons by unpolarized protons with or meson
production, is calculated as a function of the momentum transfer squared
and the total energy of the -system. This asymmetry, which is
induced by the interference of the one-photon exchange amplitude with the
parity-odd part of the -exchange amplitude, is calculated for the
processes ( is a virtual photon and
a virtual Z-boson) considering the -contribution in the channel,
the standard Born contributions and vector meson ( and )
exchanges in the channel. Taking into account the known isotopic properties
of the hadron electromagnetic and neutral currents, we show that the P-odd term
is the sum of two contributions. The main term is model independent and it can
be calculated exactly in terms of fundamental constants. It is found to be
linear in . The second term is a relatively small correction which is
determined by the isoscalar component of the electromagnetic current. Near
threshold and in the -region, this isoscalar part is much smaller (in
absolute value) than the isovector one: its contribution to the asymmetry
depend on the polarization state (longitudinal or transverse) of the virtual
photon.Comment: 30 pages 9 figure
Analytic properties of the Landau gauge gluon and quark propagators
We explore the analytic structure of the gluon and quark propagators of
Landau gauge QCD from numerical solutions of the coupled system of renormalized
Dyson--Schwinger equations and from fits to lattice data. We find sizable
negative norm contributions in the transverse gluon propagator indicating the
absence of the transverse gluon from the physical spectrum. A simple analytic
structure for the gluon propagator is proposed. For the quark propagator we
find evidence for a mass-like singularity on the real timelike momentum axis,
with a mass of 350 to 500 MeV. Within the employed Green's functions approach
we identify a crucial term in the quark-gluon vertex that leads to a positive
definite Schwinger function for the quark propagator.Comment: 42 pages, 16 figures, revtex; version to be published in Phys Rev
TEM-EELS study of low-friction superlattice TiAlN/VN coating: the wear mechanisms
A 20-50 nm thick tribofilm was generated on the worn surface of a multilayer coating TiAlN/VN after dry sliding test against an alumina counterpart. The tribofilm was characterized by applying analytical transmission electron microscopy techniques with emphasis on detailed electron energy loss spectrometry and energy loss near edge structure analysis. Pronounced oxygen in the tribofilm indicated a predominant tribo-oxidation wear. Structural changes in the inner-shell ionization edges of N, Ti and V suggested decomposition of nitride fragments
Vagal nerve stimulation started just prior to reperfusion limits infarct size and no-reflow
Vagal nerve stimulation (VNS) started prior to, or during, ischemia has been shown to reduce infarct size. Here, we investigated the effect of VNS when started just prior to, and continued during early, reperfusion on infarct size and no-reflow and studied the underlying mechanisms. For this purpose, swine (13 VNS, 10 sham) underwent 45 min mid-LAD occlusion followed by 120 min of reperfusion. VNS was started 5 min prior to reperfusion and continued until 15 min of reperfusion. Area at risk, area of no-reflow (% of infarct area) and infarct size (% of area at risk), circulating cytokines, and regional myocardial leukocyte influx were assessed after 120 min of reperfusion. VNS significantly reduced infarct size from 67 ± 2 % in sham to 54 ± 5 % and area of no-reflow from 54 ± 6 % in sham to 32 ± 6 %. These effects were accompanied by reductions in neutrophil (~40 %) and macrophage (~60 %) infiltration in the infarct area (all p < 0.05), whereas systemic circulating plasma levels of TNFα and IL6 were not affected. The degree of cardioprotection could not be explained by the VNS-induced bradycardia or the VNS-induced decrease in the double product of heart rate and left ventricular systolic pressure. In the presence of NO-synthase inhibitor LNNA, VNS no longer attenuated infarct size and area of no-reflow, which was paralleled by similarly unaffected regional leukocyte infiltration. In conclusion, VNS is a promising novel adjunctive therapy that limits reperfusion injury in a large animal model of acute myocardial infarction
Masses of ground and excited-state hadrons
We present the first Dyson-Schwinger equation calculation of the light hadron
spectrum that simultaneously correlates the masses of meson and baryon ground-
and excited-states within a single framework. At the core of our analysis is a
symmetry-preserving treatment of a vector-vector contact interaction. In
comparison with relevant quantities the
root-mean-square-relative-error/degree-of freedom is 13%. Notable amongst our
results is agreement between the computed baryon masses and the bare masses
employed in modern dynamical coupled-channels models of pion-nucleon reactions.
Our analysis provides insight into numerous aspects of baryon structure; e.g.,
relationships between the nucleon and Delta masses and those of the
dressed-quark and diquark correlations they contain.Comment: 25 pages, 7 figures, 4 table
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