42 research outputs found
ΠΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡΡ ΠΏΠ΅ΡΠ΅Π±ΡΠ³Ρ ΠΎΠΊΠΈΡΠ½ΡΠ²Π°Π»ΡΠ½ΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠ² Ρ ΡΡΡΡΠ², ΡΡΠ°ΠΆΠ΅Π½ΠΈΡ ΡΠ΅ΡΡΠ°Ρ Π»ΠΎΡΠΎΠΌΠ΅ΡΠ°Π½ΠΎΠΌ Π½Π° ΡΠ»Ρ ΡΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΡΡ ΠΊΠ°ΡΠ±ΠΎΡΠΎΡΠΎΠΌ
Topicality. The chemical pollution of environment and its impact on the human body is one of the problems not fully studied. It is a question of priority. Carbon and tetrachloride malathion are the most dangerous contaminative elementsconsidered to be the risk factors for many environmentally dependent diseases. Therefore, it is actual to study the characteristics and mechanisms of the aforementioned xenobiotics combined action on the body.Aim. To investigate the free radical processes activity and the endogenous markers of intoxication at the conditions of effect on the rats organism by tetrachloride bbeing affected by malathion.Materials and methods. Experiments conducted on white rats being under carbon tetrachloride intoxication influence (4th, 7th days of the affection) on the basis of thirtieth days malathion affection . Rats were taken out of the experimentby the thiopental anesthesia.Results and discussion. The experimental data proved the malathion and carbon tetrachloride toxic effect, which increases by the conditions of their combined using.Conclusions. It was established, that the maximum activation of free radical processes and deepening endogenous intoxication observed on the seventh day affection by the carbon tetrachloride on on the basis of thirtieth days malathion intoxication.Β ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. ΠΡΠΎΠ±Π»Π΅ΠΌΠ° Π²Π»ΠΈΡΠ½ΠΈΡ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π·Π°Π³ΡΡΠ·Π½Π΅Π½ΠΈΡ ΠΎΠΊΡΡΠΆΠ°ΡΡΠ΅ΠΉ ΡΡΠ΅Π΄Ρ Π½Π° ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΠ΄Π½ΠΎΠΉ ΠΈΠ· ΠΏΡΠΈΠΎΡΠΈΡΠ΅ΡΠ½ΡΡ
ΠΈ Π΄ΠΎ ΠΊΠΎΠ½ΡΠ° Π½Π΅ ΠΈΠ·ΡΡΠ΅Π½Π½ΡΡ
. Π‘ΡΠ΅Π΄ΠΈ Π·Π°Π³ΡΡΠ·Π½ΠΈΡΠ΅Π»Π΅ΠΉ Π±ΠΎΠ»ΡΡΡΡ ΡΠ³ΡΠΎΠ·Ρ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡ ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΌΠ΅ΡΠ°Π½ ΠΈ ΠΊΠ°ΡΠ±ΠΎΡΠΎΡ β ΡΠ°ΠΊΡΠΎΡΡ ΡΠΈΡΠΊΠ° ΠΌΠ½ΠΎΠ³ΠΈΡ
ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π·Π°Π²ΠΈΡΠΈΠΌΡΡ
Π±ΠΎΠ»Π΅Π·Π½Π΅ΠΉ. ΠΠΎΡΡΠΎΠΌΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΠΈ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π²Π»ΠΈΡΠ½ΠΈΡ Π²ΡΡΠ΅ΡΠΏΠΎΠΌΡΠ½ΡΡΡΡ
ΠΊΡΠ΅Π½ΠΎΠ±ΠΈΠΎΡΠΈΠΊΠΎΠ² Π½Π° ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ ΡΠ²Π»ΡΠ΅ΡΡΡ Π°ΠΊΡΡΠ°Π»ΡΠ½ΡΠΌ.Π¦Π΅Π»ΡΡ ΡΠ°Π±ΠΎΡΡ Π±ΡΠ»ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΠΎΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΠΉ ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΏΡΠΈ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠΈ Π½Π° ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ ΠΊΡΡΡ ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΌΠ΅ΡΠ°Π½Π° ΠΈ ΠΊΠ°ΡΠ±ΠΎΡΠΎΡΠ°.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Ρ Π½Π° Π±Π΅Π»ΡΡ
ΠΊΡΡΡΠ°Ρ
, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΠΎΠ΄Π²Π΅ΡΠ³Π°Π»ΠΈΡΡ ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΌΠ΅ΡΠ°Π½ΠΎΠΌ (4-ΡΠ΅, 7-Π΅ ΡΡΡΠΊΠΈ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ) Π½Π° ΡΠΎΠ½Π΅ ΡΡΠΈΠ΄ΡΠ°ΡΠΈΠ΄Π½Π΅Π²Π½ΠΎΠ³ΠΎ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ ΠΊΠ°ΡΠ±ΠΎΡΠΎΡΠΎΠΌ. ΠΡΡΡ Π²ΡΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΈΠ· ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ° ΠΏΠΎΠ΄ ΡΠΈΠΎΠΏΠ΅Π½ΡΠ°Π»ΠΎΠ²ΡΠΌ Π½Π°ΡΠΊΠΎΠ·ΠΎΠΌ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΈΡ
ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈe. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠ΄ΠΈΠ»ΠΈ ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΊΠ°ΡΠ±ΠΎΡΠΎΡΠ° ΠΈ ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΌΠ΅ΡΠ°Π½Π°, ΠΊΠΎΡΠΎΡΠΎΠ΅ ΡΡΠΈΠ»ΠΈΠ²Π°Π΅ΡΡΡ ΠΏΡΠΈ ΡΡΠ»ΠΎΠ²ΠΈΠΈ ΠΈΡ
ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ. ΠΡΠΎ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π°Π΅ΡΡΡΠ°ΠΊΡΠΈΠ²Π°ΡΠΈΠ΅ΠΉ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΠΎΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΈ ΡΠ³Π»ΡΠ±Π»Π΅Π½ΠΈΠ΅ΠΌ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΠΉ ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ, ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ΅ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΠΊΠΎΡΠΎΡΠΎΠΉ Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΎΡΡ Π½Π° ΡΠ΅Π΄ΡΠΌΡΠ΅ ΡΡΡΠΊΠΈ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΌΠ΅ΡΠ°Π½ΠΎΠΌ Π½Π° ΡΠΎΠ½Π΅ ΡΡΠΈΠ΄ΡΠ°ΡΠΈΠ΄Π½Π΅Π²Π½ΠΎΠΉ ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΊΠ°ΡΠ±ΠΎΡΠΎΡΠΎΠΌ.ΠΡΠ²ΠΎΠ΄Ρ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½Π°Ρ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΠΎΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΈ ΡΠ³Π»ΡΠ±Π»Π΅Π½ΠΈΠ΅ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΠΉ ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΈΡΡ Π½Π° ΡΠ΅Π΄ΡΠΌΡΠ΅ ΡΡΡΠΊΠΈ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΌΠ΅ΡΠ°Π½ΠΎΠΌ Π½Π° ΡΠΎΠ½Π΅ ΡΡΠΈΠ΄ΡΠ°ΡΠΈΠ΄Π½Π΅Π²Π½ΠΎΠΉ ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΊΠ°ΡΠ±ΠΎΡΠΎΡΠΎΠΌ.ΠΠΊΡΡΠ°Π»ΡΠ½ΡΡΡΡ. ΠΡΠΎΠ±Π»Π΅ΠΌΠ° Π²ΠΏΠ»ΠΈΠ²Ρ Ρ
ΡΠΌΡΡΠ½ΠΎΠ³ΠΎ Π·Π°Π±ΡΡΠ΄Π½Π΅Π½Π½Ρ Π½Π°Π²ΠΊΠΎΠ»ΠΈΡΠ½ΡΠΎΠ³ΠΎ cΠ΅ΡΠ΅Π΄ΠΎΠ²ΠΈΡΠ° Π½Π° ΠΎΡΠ³Π°Π½ΡΠ·ΠΌ Π»ΡΠ΄ΠΈΠ½ΠΈ Ρ ΠΎΠ΄Π½ΡΡΡ Π· ΠΏΡΡΠΎΡΠΈΡΠ΅ΡΠ½ΠΈΡ
ΡΠ° Π½Π΅ Π΄ΠΎ ΠΊΡΠ½ΡΡ Π²ΠΈΠ²ΡΠ΅Π½ΠΈΡ
. Π‘Π΅ΡΠ΅Π΄ Π·Π°Π±ΡΡΠ΄Π½ΡΠ²Π°ΡΡΠ² Π·Π½Π°ΡΠ½Ρ Π·Π°Π³ΡΠΎΠ·Ρ ΡΡΠ°Π½ΠΎΠ²Π»ΡΡΡ ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΎΠΌΠ΅ΡΠ°Π½ ΡΠ° ΠΊΠ°ΡΠ±ΠΎΡΠΎΡ - ΡΠ°ΠΊΡΠΎΡΠΈ ΡΠΈΠ·ΠΈΠΊΡ Π²ΠΈΠ½ΠΈΠΊΠ½Π΅Π½Π½Ρ Π±Π°Π³Π°ΡΡΠΎΡ
Π΅ΠΊΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎ Π·Π°Π»Π΅ΠΆΠ½ΠΈΡ
Ρ
Π²ΠΎΡΠΎΠ±. Π’ΠΎΠΌΡ Π²ΠΈΠ²ΡΠ΅Π½Π½Ρ ΠΎΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡΠ΅ΠΉ ΡΠ° ΠΌΠ΅Ρ
Π°Π½ΡΠ·ΠΌΡΠ² ΠΊΠΎΠΌΠ±ΡΠ½ΠΎΠ²Π°Π½ΠΎΡ Π΄ΡΡ Π²ΠΈΡΠ΅Π²ΠΊΠ°Π·Π°Π½ΠΈΡ
ΠΊΡΠ΅Π½ΠΎΠ±ΡΠΎΡΠΈΠΊΡΠ² Π½Π° ΠΎΡΠ³Π°Π½ΡΠ·ΠΌ Ρ Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΈΠΌ. ΠΠ΅ΡΠΎΡ ΡΠΎΠ±ΠΎΡΠΈ Π±ΡΠ»ΠΎ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π²ΡΠ»ΡΠ½ΠΎΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ² ΡΠ° ΠΌΠ°ΡΠΊΠ΅ΡΡΠ² Π΅Π½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΡ ΡΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΡΡ Π·Π° ΡΠΌΠΎΠ² Π²ΠΏΠ»ΠΈΠ²Ρ Π½Π° ΠΎΡΠ³Π°Π½ΡΠ·ΠΌ ΡΡΡΡΠ² ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΎΠΌΠ΅ΡΠ°Π½Ρ Π½Π° ΡΠ»Ρ ΡΡΠ°ΠΆΠ΅Π½Π½Ρ ΠΊΠ°ΡΠ±ΠΎΡΠΎΡΠΎΠΌ.ΠΠ°ΡΠ΅ΡΡΠ°Π»ΠΈ ΡΠ° ΠΌΠ΅ΡΠΎΠ΄ΠΈ. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Ρ Π½Π° Π±ΡΠ»ΠΈΡ
ΡΡΡΠ°Ρ
, ΡΠΊΡ ΠΏΡΠ΄Π΄Π°Π²Π°Π»ΠΈΡΡ ΡΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΡΡ ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΎΠΌΠ΅ΡΠ°Π½ΠΎΠΌ (4-ΡΠ°, 7-Π° Π΄ΠΎΠ±Π° ΡΡΠ°ΠΆΠ΅Π½Π½Ρ) Π½Π° ΡΠ»Ρ ΡΡΠΈΠ΄ΡΡΡΠΈΠ΄Π΅Π½Π½ΠΎΠ³ΠΎ ΡΡΠ°ΠΆΠ΅Π½Π½Ρ ΠΊΠ°ΡΠ±ΠΎΡΠΎΡΠΎΠΌ. Π©ΡΡΡΠ² Π²ΠΈΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π· Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΡ ΠΏΡΠ΄ ΡΡΠΎΠΏΠ΅Π½ΡΠ°Π»ΠΎΠ²ΠΈΠΌ Π½Π°ΡΠΊΠΎΠ·ΠΎΠΌ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ ΡΠ° ΡΡ
ΠΎΠ±Π³ΠΎΠ²ΠΎΡΠ΅Π½Π½Ρ. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½Ρ Π΄Π°Π½Ρ ΠΏΡΠ΄ΡΠ²Π΅ΡΠ΄ΠΈΠ»ΠΈ ΡΠΎΠΊΡΠΈΡΠ½ΠΈΠΉ Π²ΠΏΠ»ΠΈΠ² ΠΊΠ°ΡΠ±ΠΎΡΠΎΡΡ ΡΠ° ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΎΠΌΠ΅ΡΠ°Π½Ρ, ΡΠΊΠΈΠΉ ΠΏΡΠ΄Π²ΠΈΡΡΡΡΡΡΡ Π·Π° ΡΠΌΠΎΠ² ΡΡ
ΠΊΠΎΠΌΠ±ΡΠ½ΠΎΠ²Π°Π½ΠΎΠ³ΠΎ Π·Π°ΡΡΠΎΡΡΠ²Π°Π½Π½Ρ.ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. ΠΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΠΎ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½Π° Π°ΠΊΡΠΈΠ²Π°ΡΡΡ Π²ΡΠ»ΡΠ½ΠΎΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ² ΡΠ° ΠΏΠΎΠ³Π»ΠΈΠ±Π»Π΅Π½Π½Ρ Π΅Π½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΡ ΡΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΡΡ ΡΠΏΠΎΡΡΠ΅ΡΡΠ³Π°ΡΡΡΡΡ Π½Π° ΡΡΠΎΠΌΡ Π΄ΠΎΠ±Ρ ΡΡΠ°ΠΆΠ΅Π½Π½Ρ ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΎΠΌΠ΅ΡΠ°Π½ΠΎΠΌ Π½Π° ΡΠ»Ρ ΡΡΠΈΠ΄ΡΡΡΠΈΠ΄Π΅Π½Π½ΠΎΡ ΡΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΡΡ ΠΊΠ°ΡΠ±ΠΎΡΠΎΡΠΎΠΌ
ΠΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡΡ ΠΏΠ΅ΡΠ΅Π±ΡΠ³Ρ ΠΎΠΊΠΈΡΠ½ΡΠ²Π°Π»ΡΠ½ΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠ² Ρ ΡΡΡΡΠ², ΡΡΠ°ΠΆΠ΅Π½ΠΈΡ ΡΠ΅ΡΡΠ°Ρ Π»ΠΎΡΠΎΠΌΠ΅ΡΠ°Π½ΠΎΠΌ Π½Π° ΡΠ»Ρ ΡΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΡΡ ΠΊΠ°ΡΠ±ΠΎΡΠΎΡΠΎΠΌ
Topicality. The problem of the environment chemical pollution impact on the human body is one of the priority and not fully studied. Among the pollutants carbon tetrachloride malathion poses a significant reat β it is a factor of risk for many environmentally dependent diseases. There fore, it is important to study the characteristics and mechanisms of a mentioned xenobiotics combined action on the body .Aim. To investigate the activity of free radical processes and the markers of endogenous intoxication at the conditions of effect on the rats organism by tetrachloride on the background of malathion.Materials and methods. While carrying out an experiment white rats were intoxicated by carbon tetrachloride intoxication (4th, 7th days of the affection) in a period of thirty days malathion affection. Rats were taken out of the experiment by the thiopental anesthesia.Results and discussion. The experimental data proved the malathion and carbontetrachloride toxic effect, which increases the conditions of their combined using. Conclusions. It was established, that the maximum activation of free radical processes and deepening endogenous intoxication observed on the seventh day affection by carbontetrachloride in a period of thirty days malathion intoxication.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. ΠΡΠΎΠ±Π»Π΅ΠΌΠ° Π²Π»ΠΈΡΠ½ΠΈΡ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π·Π°Π³ΡΡΠ·Π½Π΅Π½ΠΈΡ ΠΎΠΊΡΡΠΆΠ°ΡΡΠ΅ΠΉ ΡΡΠ΅Π΄Ρ Π½Π° ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΎΠ΄Π½ΠΎΠΉ ΠΈΠ· ΠΏΡΠΈΠΎΡΠΈΡΠ΅ΡΠ½ΡΡ
ΠΈ Π΄ΠΎ ΠΊΠΎΠ½ΡΠ° Π½Π΅ ΠΈΠ·ΡΡΠ΅Π½Π½ΡΡ
. Π‘ΡΠ΅Π΄ΠΈ Π·Π°Π³ΡΡΠ·Π½ΠΈΡΠ΅Π»Π΅ΠΉ Π±ΠΎΠ»ΡΡΡΡ ΡΠ³ΡΠΎΠ·Ρ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡ ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΌΠ΅ΡΠ°Π½ ΠΈ ΠΊΠ°ΡΠ±ΠΎΡΠΎΡ β ΡΠ°ΠΊΡΠΎΡΡ ΡΠΈΡΠΊΠ° ΠΌΠ½ΠΎΠ³ΠΈΡ
ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π·Π°Π²ΠΈΡΠΈΠΌΡΡ
Π±ΠΎΠ»Π΅Π·Π½Π΅ΠΉ. ΠΠΎΡΡΠΎΠΌΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΠΈ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π²Π»ΠΈΡΠ½ΠΈΡ Π²ΡΡΠ΅ΡΠΏΠΎΠΌΡΠ½ΡΡΡΡ
ΠΊΡΠ΅Π½ΠΎΠ±ΠΈΠΎΡΠΈΠΊΠΎΠ² Π½Π° ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ Π΅ΡΡΡ Π°ΠΊΡΡΠ°Π»ΡΠ½ΡΠΌ. Π¦Π΅Π»ΡΡ ΡΠ°Π±ΠΎΡΡ Π±ΡΠ»ΠΎ ΠΈΠ·ΡΡΠΈΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΠΎΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΡ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΠΉ ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΏΡΠΈ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠΈ Π½Π° ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ ΠΊΡΡΡ ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΌΠ΅ΡΠ°Π½Π° ΠΈ ΠΊΠ°ΡΠ±ΠΎΡΠΎΡΠ°. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Ρ Π½Π° Π±Π΅Π»ΡΡ
ΠΊΡΡΡΠ°Ρ
, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΠΎΠ΄Π²Π΅ΡΠ³Π°Π»ΠΈΡΡ ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΌΠ΅ΡΠ°Π½ΠΎΠΌ (4-ΡΠ΅, 7-Π΅ ΡΡΡΠΊΠΈ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ) Π½Π° ΡΠΎΠ½Π΅ ΡΡΠΈΠ΄ΡΠ°ΡΠΈΠ΄Π½Π΅Π²Π½ΠΎΠ³ΠΎ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ ΠΊΠ°ΡΠ±ΠΎΡΠΎΡΠΎΠΌ. ΠΡΡΡ Π²ΡΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΈΠ· ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ° ΠΏΠΎΠ΄ ΡΠΈΠΎΠΏΠ΅Π½ΡΠ°Π»ΠΎΠ²ΡΠΌ Π½Π°ΡΠΊΠΎΠ·ΠΎΠΌ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΈΡ
ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠ΄ΠΈΠ»ΠΈ ΡΠΎΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΊΠ°ΡΠ±ΠΎΡΠΎΡΠ° ΠΈ ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΌΠ΅ΡΠ°Π½Π°, ΠΊΠΎΡΠΎΡΠΎΠ΅ ΡΡΠΈΠ»ΠΈΠ²Π°Π΅ΡΡΡ ΠΏΡΠΈ ΡΡΠ»ΠΎΠ²ΠΈΠΈ ΠΈΡ
ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ. ΠΡΠΎ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π°Π΅ΡΡΡ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠ΅ΠΉ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΠΎΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΈ ΡΠ³Π»ΡΠ±Π»Π΅Π½ΠΈΠ΅ΠΌ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΠΉ ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ, ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ΅ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΠΊΠΎΡΠΎΡΠΎΠΉ Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΎΡΡ Π½Π° ΡΠ΅Π΄ΡΠΌΡΠ΅ ΡΡΡΠΊΠΈ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΌΠ΅ΡΠ°Π½ΠΎΠΌ Π½Π° ΡΠΎΠ½Π΅ ΡΡΠΈΠ΄ΡΠ°ΡΠΈΠ΄Π½Π΅Π²Π½ΠΎΠΉ ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΊΠ°ΡΠ±ΠΎΡΠΎΡΠΎΠΌ.ΠΡΠ²ΠΎΠ΄Ρ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½Π°Ρ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΠΎΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΈ ΡΠ³Π»ΡΠ±Π»Π΅Π½ΠΈΠ΅ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΠΉ ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΈΡΡ Π½Π° ΡΠ΅Π΄ΡΠΌΡΠ΅ ΡΡΡΠΊΠΈ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΌΠ΅ΡΠ°Π½ΠΎΠΌ Π½Π° ΡΠΎΠ½Π΅ ΡΡΠΈΠ΄ΡΠ°ΡΠΈΠ΄Π½Π΅Π²Π½ΠΎΠΉ ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΊΠ°ΡΠ±ΠΎΡΠΎΡΠΎΠΌ.Β ΠΠΊΡΡΠ°Π»ΡΠ½ΡΡΡΡ. ΠΡΠΎΠ±Π»Π΅ΠΌΠ° Π²ΠΏΠ»ΠΈΠ²Ρ Ρ
ΡΠΌΡΡΠ½ΠΎΠ³ΠΎ Π·Π°Π±ΡΡΠ΄Π½Π΅Π½Π½Ρ Π½Π°Π²ΠΊΠΎΠ»ΠΈΡΠ½ΡΠΎΠ³ΠΎ cΠ΅ΡΠ΅Π΄ΠΎΠ²ΠΈΡΠ° Π½Π° ΠΎΡΠ³Π°Π½ΡΠ·ΠΌ Π»ΡΠ΄ΠΈΠ½ΠΈ Ρ ΠΎΠ΄Π½ΡΡΡ Π· ΠΏΡΡΠΎΡΠΈΡΠ΅ΡΠ½ΠΈΡ
ΡΠ° Π½Π΅ Π΄ΠΎ ΠΊΡΠ½ΡΡ Π²ΠΈΠ²ΡΠ΅Π½ΠΈΡ
. Π‘Π΅ΡΠ΅Π΄ Π·Π°Π±ΡΡΠ΄Π½ΡΠ²Π°ΡΡΠ² Π·Π½Π°ΡΠ½Ρ Π·Π°Π³ΡΠΎΠ·Ρ ΡΡΠ°Π½ΠΎΠ²Π»ΡΡΡ ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΎΠΌΠ΅ΡΠ°Π½ ΡΠ° ΠΊΠ°ΡΠ±ΠΎΡΠΎΡ β ΡΠ°ΠΊΡΠΎΡΠΈ ΡΠΈΠ·ΠΈΠΊΡ Π±Π°Π³Π°ΡΡΠΎΡ
Π΅ΠΊΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΠ·Π°Π»Π΅ΠΆΠ½ΠΈΡ
Ρ
Π²ΠΎΡΠΎΠ±. Π’ΠΎΠΌΡ Π²ΠΈΠ²ΡΠ΅Π½Π½Ρ ΠΎΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡΠ΅ΠΉ ΡΠ° ΠΌΠ΅Ρ
Π°Π½ΡΠ·ΠΌΡΠ² ΠΊΠΎΠΌΠ±ΡΠ½ΠΎΠ²Π°Π½ΠΎΡ Π΄ΡΡ Π²ΠΈΡΠ΅Π²ΠΊΠ°Π·Π°Π½ΠΈΡ
ΠΊΡΠ΅Π½ΠΎΠ±ΡΠΎΡΠΈΠΊΡΠ² Π½Π° ΠΎΡΠ³Π°Π½ΡΠ·ΠΌ Ρ Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΈΠΌ.ΠΠ΅ΡΠΎΡ ΡΠΎΠ±ΠΎΡΠΈ Π±ΡΠ»ΠΎ Π΄ΠΎΡΠ»ΡΠ΄ΠΈΡΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ Π²ΡΠ»ΡΠ½ΠΎΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ² ΡΠ° ΠΌΠ°ΡΠΊΠ΅ΡΠΈ Π΅Π½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΡ ΡΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΡΡ Π·Π° ΡΠΌΠΎΠ² Π²ΠΏΠ»ΠΈΠ²Ρ Π½Π° ΠΎΡΠ³Π°Π½ΡΠ·ΠΌ ΡΡΡΡΠ² ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΎΠΌΠ΅ΡΠ°Π½Ρ Π½Π° ΡΠ»Ρ ΡΡΠ°ΠΆΠ΅Π½Π½Ρ ΠΊΠ°ΡΠ±ΠΎΡΠΎΡΠΎΠΌ.ΠΠ°ΡΠ΅ΡΡΠ°Π»ΠΈ ΡΠ° ΠΌΠ΅ΡΠΎΠ΄ΠΈ. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Ρ Π½Π° Π±ΡΠ»ΠΈΡ
ΡΡΡΠ°Ρ
, ΡΠΊΡ ΠΏΡΠ΄Π΄Π°Π²Π°Π»ΠΈΡΡ ΡΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΡΡ ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΎΠΌΠ΅ΡΠ°Π½ΠΎΠΌ (4-ΡΠ°, 7-Π° Π΄ΠΎΠ±Π° ΡΡΠ°ΠΆΠ΅Π½Π½Ρ) Π½Π° ΡΠ»Ρ ΡΡΠΈΠ΄ΡΡΡΠΈΠ΄Π΅Π½Π½ΠΎΠ³ΠΎ ΡΡΠ°ΠΆΠ΅Π½Π½Ρ ΠΊΠ°ΡΠ±ΠΎΡΠΎΡΠΎΠΌ. Π©ΡΡΡΠ² Π²ΠΈΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π· Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΡ ΠΏΡΠ΄ ΡΡΠΎΠΏΠ΅Π½ΡΠ°Π»ΠΎΠ²ΠΈΠΌ Π½Π°ΡΠΊΠΎΠ·ΠΎΠΌ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ ΡΠ° ΡΡ
ΠΎΠ±Π³ΠΎΠ²ΠΎΡΠ΅Π½Π½Ρ. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½Ρ Π΄Π°Π½Ρ ΠΏΡΠ΄ΡΠ²Π΅ΡΠ΄ΠΈΠ»ΠΈ ΡΠΎΠΊΡΠΈΡΠ½ΠΈΠΉ Π²ΠΏΠ»ΠΈΠ² ΠΊΠ°ΡΠ±ΠΎΡΠΎΡΡ ΡΠ° ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΎΠΌΠ΅ΡΠ°Π½Ρ, ΡΠΊΠΈΠΉ ΠΏΡΠ΄Π²ΠΈΡΡΡΡΡΡΡ Π·Π° ΡΠΌΠΎΠ² ΡΡ
ΠΊΠΎΠΌΠ±ΡΠ½ΠΎΠ²Π°Π½ΠΎΠ³ΠΎ Π·Π°ΡΡΠΎΡΡΠ²Π°Π½Π½Ρ. ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. ΠΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΠΎ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½Π° Π°ΠΊΡΠΈΠ²Π°ΡΡΡ Π²ΡΠ»ΡΠ½ΠΎΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ² ΡΠ° ΠΏΠΎΠ³Π»ΠΈΠ±Π»Π΅Π½Π½Ρ Π΅Π½Π΄ΠΎΠ³Π΅Π½Π½ΠΎΡ ΡΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΡΡ ΡΠΏΠΎΡΡΠ΅ΡΡΠ³Π°ΡΡΡΡΡ Π½Π° ΡΡΠΎΠΌΡ Π΄ΠΎΠ±Ρ ΡΡΠ°ΠΆΠ΅Π½Π½Ρ ΡΠ΅ΡΡΠ°Ρ
Π»ΠΎΡΠΎΠΌΠ΅ΡΠ°Π½ΠΎΠΌ Π½Π° ΡΠ»Ρ ΡΡΠΈΠ΄ΡΡΡΠΈΠ΄Π΅Π½Π½ΠΎΡ ΡΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΡΡ ΠΊΠ°ΡΠ±ΠΎΡΠΎΡΠΎΠΌ
Radiobiological outcomes, microdosimetric evaluations and monte carlo predictions in eye proton therapy
CATANA (Centro di AdroTerapia ed Applicazioni Nucleari Avanzate) was the first Italian protontherapy facility dedicated to the treatment of ocular neoplastic pathologies. It is in operation at the LNS Laboratories of the Italian Institute for Nuclear Physics (INFN-LNS) and to date, 500 patients have been successfully treated. Even though proton therapy has demonstrated success in clinical settings, there is still a need for more accurate models because they are crucial for the estimation of clinically relevant RBE values. Since RBE can vary depending on several physical and biological parameters, there is a clear need for more experimental data to generate predictions. Establishing a database of cell survival experiments is therefore useful to accurately predict the effects of irradiations on both cancerous and normal tissue. The main aim of this work was to compare RBE values obtained from in-vitro experimental data with predictions made by the LEM II (Local Effect Model), Monte Carlo approaches, and semi-empirical models based on LET experimental measurements. For this purpose, the 92.1 uveal melanoma and ARPE-19 cells derived from normal retinal pigmented epithelium were selected and irradiated in the middle of clinical SOBP of the CATANA proton therapy facility. The remarkable results show the potentiality of using microdosimetric spectrum, Monte Carlo simulations and LEM model to predict not only the RBE but also the survival curves
Measurement of gauge blocks by interferometry
The key comparison EURAMET.L-K1.2011 on gauge blocks was carried out in the framework of a EURAMET project starting in 2012 and ending in 2015. It involved the participation of 24 National Metrology Institutes from Europe and Egypt, respectively.
38 gauge blocks of steel and ceramic with nominal central lengths between 0.5 mm and 500 mm were circulated. The comparison was conducted in two loops with two sets of artifacts. A statistical technique for linking the reference values was applied. As a consequence the reference value of one loop is influenced by the measurements of the other loop although they did not even see the artifacts of the others. This influence comes solely from three "linking laboratories" which measure both sets of artifacts.
In total there were 44 results were not fully consistent with the reference values. This represents 10% of the full set of 420 results which is a considerable high number. At least 12 of them are clearly outliers where the participants have been informed by the pilot as soon as possible.
The comparison results help to support the calibration and measurement capabilities (CMCs) of the laboratories involved in the CIPM MRA
Changes in social norms during the early stages of the COVID-19 pandemic across 43 countries
The emergence of COVID-19 dramatically changed social behavior across societies and contexts. Here we study whether social norms also changed. Specifically, we study this question for cultural tightness (the degree to which societies generally have strong norms), specific social norms (e.g. stealing, hand washing), and norms about enforcement, using survey data from 30,431 respondents in 43 countries recorded before and in the early stages following the emergence of COVID-19. Using variation in disease intensity, we shed light on the mechanisms predicting changes in social norm measures. We find evidence that, after the emergence of the COVID-19 pandemic, hand washing norms increased while tightness and punishing frequency slightly decreased but observe no evidence for a robust change in most other norms. Thus, at least in the short term, our findings suggest that cultures are largely stable to pandemic threats except in those norms, hand washing in this case, that are perceived to be directly relevant to dealing with the collective threat
Translation and Transcultural Validation of Migraine Screening Questionnaire (MS-Q)
Introduction: Between 30 to 59% of patients with migraine without aura are undiagnosed and improperly treated, because primary care physicians are either too busy or unfamiliar with criteria for diagnosing migraine. Aim: The aim of our study was to translate the Migraine Screen Questionnaire (MS-Q) to BHS (Bosnian/Croatian /Serbian) language and to test reliability and validity of the translation on a sample of primary care patients. Material and Methods: The study was designed as cross-sectional, multi centric, diagnostic accuracy trial of an instrument for screening patients who visit general practitioners, with an aim to reveal migraine without aura. The instrument was the MS-Q, originally written in English and validated in Spanish population, and in this study being translated to BHS language. Results: Translation of the MS-Q to BHS language showed good diagnostic accuracy (sensitivity 80.0% and specificity 87.2%) and reliability (Cohen kappa 0.648) for migraine without aura, with significant screening yield among previously undiagnosed patients of 72.7%. The study also confirmed high percentage of patients with hidden MWA (52.9%) revealed by the MS-Q and ICH criteria that would otherwise remain undiagnosed. Conclusion: The MS-Q translation to BHS language could be considered as valid and reliable clinical instrument for revealing migraine without aura, similar by its performance to original questionnaire. It has considerable screening yield, discovering majority of patients with previously undiagnosed migraine without aura, whose definite diagnosis should later on be confirmed by the attending physicians using the ICH criteria