Facilitating independence: The benefits of a post-diagnostic support project for people with dementia.

Providing support in the form of information, advice and access to services or social events is promoted as beneficial for people newly diagnosed with dementia and their families. This paper reports on key findings from an evaluation of a post-diagnostic support pilot project in Scotland addressing local service gaps, namely information provision, emotional and practical support and maintaining community links. Twenty-seven participants (14 people newly diagnosed with dementia and 13 family carers) were interviewed at two time points: T1 shortly after joining the pilot project and T2 approximately six months later, to ascertain their views on existing services and the support offered by the pilot project. A comparative thematic analysis revealed that the project facilitated increased independence (associated with increased motivation and self-confidence) of people with dementia. The project illustrates what can be achieved if resources are targeted at providing individualised post-diagnostic support, particularly where there are service delivery gaps

A test of the model that RNA polymerase III transcription is regulated by selective induction of the 110 kDa subunit of TFIIIC

TFIIIC is a RNA polymerase (pol) III-specific DNA-binding factor that is required for transcription of tRNA and 5S rRNA genes. Active human TFIIIC consists of five subunits. However, an inactive form has also been isolated that lacks one of the five subunits, called TFIIIC110. A model was proposed in which pol III transcription might be regulated by the specific induction of TFIIIC110, allowing formation of active TFIIIC from the inactive form. We have tested this model by transient transfection of HeLa and HEK293 cells with a vector expressing TFIIIC110. We have also made stably transfected HeLa cell lines that carry a doxycycline-inducible version of the cDNA for TFIIIC110. We show that the induced TFIIIC110 enters the nucleus, binds other TFIIIC subunits and is recruited to tRNA and 5S rRNA genes in vivo. However, little or no effect is seen on the expression of pol III transcripts. The data argue against the model that pol III transcription can be effectively modulated through the specific induction of TFIIIC110

Evaluation of the Indiana Child Care Financing Initiative

A research report evaluating the results of the Indiana Child Care Financing Initiative, a statewide effort to improve child care in Indiana. The report summarizes results in the areas of improving capacity, quality, and community awareness of child care issues, as well as the role of 69 local projects in initiating or expanding local partnerships focused on child care

Abusive Interactions: Research in Locked Wards for People with dementia

This paper reports on a study in which unique access to 3 locked psycho-geriatric wards of a hospital allowed ethnographic exploration into everyday social worlds of fourteen people with dementia. Findings indicate abusive practice in the wards and show that participants in receipt of such practice responded with self-defence and resistance, but ultimately were defeated. In a development of Sabat’s (2001) Selfs 1-3 framework, I identify how abusive practice arose due to staffs’ inability to recognise different aspects of patients’ self. Recommendations for practice include integrating a developed Selfs 1-3 framework into staff training and evaluating its impact on practice

‘Facing dementia Together’: Post diagnostic support pilot for people with dementia and their families in Renfrewshire and East Renfrewshire - Final Project Evaluation Report

This document reports on the evaluation, conducted between January 2010 and April 2011, of a post diagnostic support project for people with dementia and their family carers living in Renfrewshire and East Renfrewshire. Ethical approval was obtained for the evaluation. A comparative design was adopted whereby fourteen people with dementia and twelve carers were interviewed and completed structured questionnaires at two points in time. In addition twenty-two local professionals and frontline workers were interviewed at the beginning and towards the end of the evaluation period to identify their views of post-diagnostic support in the area. Data were analysed quantitatively and qualitatively to allow for comparison in reported experiences over time

“Mosaicking”: cross construction, sense-making and methods of police investigation

Purpose This article explores how homicide detectives make sense of and manipulate multiple physical, digital and informational artefacts when assembling case narratives. The authors introduce the concept of mosaicking to illuminate how different modes of information, deriving from different investigative methods, are used in concert at key moments of the investigative process – defining what type of crime has occurred; the incrimination and elimination of suspects; and decisions to charge key suspects. Design/methodology/approach The data qualitatively analysed include several hundred case papers, interview transcripts (n = 144) and detailed ethnographic fieldnotes relating to 44 homicide investigations across four police services. These were collected during a four-year ethnographic study of the use of forensic sciences and technologies (FSTs) in British homicide investigations. Findings Mosaicking describes how investigators blend and combine information, intelligence and evidence generated via different techniques and methods, to make sense of “who did what to whom and why?” Through processes of convergent and divergent mosaicking, detectives are able to “lean” on different kinds of material to reinforce or connect key points of evidence or intelligence. Originality/value The findings fill a gap in knowledge about how investigators blend and composite diverse sources of information in the construction of case narratives. The findings present a more complex and nuanced understanding of the epistemological and interpretative work conducted by contemporary detectives, given the array of investigative technologies they increasingly have at their disposal

Dichotomising dementia: is there another way?

This article discusses the reduction of the complex experience of dementia to a dichotomised 'tragedy' or 'living well' discourse in contemporary Western society. We explore both discourses, placing them in the context of a successful ageing paradigm, highlighting the complex nature of dementia and the risks associated with the emergence of these arguably competing discourses. Specifically, we explore this dichotomy in the context of societal understandings and responses to dementia. We argue for an acceptance of the fluid nature of the dementia experience, and the importance of an understanding that recognises the multiple realities of dementia necessary for social inclusion to occur. Such an acceptance requires that, rather than defend one position over another, the current discourse on dementia is challenged and problematised so that a more nuanced understanding of dementia may emerge; one that fully accepts the paradoxical nature of this complex condition.sch_nur39pub4531pub

Well-being and expression of self in dementia : interactions in long-term wards and creative sessions

This is a multi-method ethnographic study, grounded in symbolic interactionism and social constructionism, which seeks to explore the social worlds of people with dementia in institutional long-term care. Carried out over six months, it uses non-participant observation, Dementia Care Mapping, video-recording, focused conversations and extensive fieldnotes to document types of interactions that fourteen people with dementia received in everyday ward life and during weekly creative sessions facilitated by occupational therapy (OT) staff. Using Kitwood’s (1997) work on person-centred care and Sabat’s (2001) work on selfhood (Selfs 1-3) it identifies their responses to such interactions in terms of their well or ill-being and expressions of Self. The study shows that everyday staff interactions with participants, while sometimes positive, were more often limited in their potential for maintaining or increasing well-being. Sometimes staff interactions were abusive; causing participant ill-being. Participants expressed Selfs 1-3 verbally and visually, although some of these expressions were subtle, fleeting and fragile. During creative sessions, OT staff engaged in sustained positive interactions, raising participant well-being and facilitating Self-expression; a fragile expression of Self could become a robust expression of Self, a past Self could be reclaimed and a desired Self co-constructed. My findings suggest that, in their interactions during creative sessions, OT staff generally recognised and supported Self of participants, raising well-being. However, ward staff did not fully recognise and therefore could not support Self in their interactions with participants, resulting in participant ill-being. This is a crucial finding, which could partially explain the differences in interaction types I observed, and the corresponding differences in participant well-being and Self-expression. This thesis argues for integrating the selfhood and person-centred approaches into an innovative staff-training programme, in order to bring about transformational change in practice. This might encourage care staff to reach out, recognise and respond to aspects of Self as they carry out care; promoting more positive ways of interacting with their patients, increasing patient well-being and fostering staff satisfaction.EThOS - Electronic Theses Online ServiceNMAHP Research Training (Scotland) : NHS Education for Scotland (NES) : Scottish Executive Health Department : Health FoundationGBUnited Kingdo

Hypoxic stress suppresses RNA polymerase III recruitment and tRNA gene transcription in cardiomyocytes

RNA polymerase (pol) III transcription decreases when primary cultures of rat neonatal cardiomyocytes are exposed to low oxygen tension. Previous studies in fibroblasts have shown that the pol III-specific transcription factor IIIB (TFIIIB) is bound and regulated by the proto-oncogene product c-Myc, the mitogen-activated protein kinase ERK and the retinoblastoma tumour suppressor protein, RB. The principal function of TFIIIB is to recruit pol III to its cognate gene template, an activity that is known to be inhibited by RB and stimulated by ERK. We demonstrate by chromatin immunoprecipitation (ChIP) that c-Myc also stimulates pol III recruitment by TFIIIB. However, hypoxic conditions cause TFIIIB dissociation from c-Myc and ERK, at the same time as increasing its interaction with RB. Consistent with this, ChIP assays indicate that the occupancy of tRNA genes by pol III is significantly reduced, whereas promoter binding by TFIIIB is undiminished. The data suggest that hypoxia can inhibit pol III transcription by altering the interactions between TFIIIB and its regulators and thus compromising its ability to recruit the polymerase. These effects are independent of cell cycle changes