The Costs of Obesity and Implications for Policymakers

Obesity, Direct Costs, Indirect Costs, Policy, Food Consumption/Nutrition/Food Safety, I10, I18,

Demand for Cancer Screening Services: Results From Randomized Controlled Discrete Choice Experiments

Objectives: Low uptake of cancer screening services is a global concern. Our aim was to understand factors that influence the screening decision, including screening and treatment subsidies and a gain-frame message designed to present screening as awin–win. Methods: We analyzed preferences for mammography and Pap smear among women in Singapore by means of discretechoice experiments while randomly exposing half of respondents to a gain-framed public health message promoting thebenefits of screening. Results: Results showed that the message did not influence stated uptake, and given the levels shown, respondents were influenced more by treatment attributes, including effectiveness and out-of-pocket cost should they test positive, than by screening attributes, including the offer of a monetary incentive for screening. Respondents also underestimated the survival chances of screen-detected breast and cervical cancers. Conclusions: Combined, these findings suggest that correcting misconceptions about screen-detected cancer prognosis orproviding greater financial protection for those who test positive could be more effective and more cost-effective thans ubsidizing screening directly in increasing screening uptakes

Goal-conflict detection based on temporal satisfiability checking

Goal-oriented requirements engineering approaches propose capturing how a system should behave through the speci ca- tion of high-level goals, from which requirements can then be systematically derived. Goals may however admit subtle situations that make them diverge, i.e., not be satis able as a whole under speci c circumstances feasible within the domain, called boundary conditions . While previous work al- lows one to identify boundary conditions for con icting goals written in LTL, it does so through a pattern-based approach, that supports a limited set of patterns, and only produces pre-determined formulations of boundary conditions. We present a novel automated approach to compute bound- ary conditions for general classes of con icting goals expressed in LTL, using a tableaux-based LTL satis ability procedure. A tableau for an LTL formula is a nite representation of all its satisfying models, which we process to produce boundary conditions that violate the formula, indicating divergence situations. We show that our technique can automatically produce boundary conditions that are more general than those obtainable through existing previous pattern-based approaches, and can also generate boundary conditions for goals that are not captured by these patterns

The HETDEX Pilot Survey III: The Low Metallicities of High-Redshift Lyman Alpha Galaxies

We present Keck/NIRSPEC spectroscopic observations of three Lyman alpha emitting galaxies (LAEs) at z ~ 2.3 discovered with the HETDEX pilot survey. We detect Halpha, [OIII], and Hbeta emission from two galaxies at z = 2.29 and 2.49, designated HPS194 and HPS256, respectively, representing the first detection of multiple rest-frame optical emission lines in galaxies at high-redshift selected on the basis of their Lyman alpha emission. The redshifts of the Lyman alpha emission from these galaxies are offset redward of the systemic redshifts by Delta_v = 162 +/- 37 (photometric) +/- 42 (systematic) km/s for HPS194, and Delta_v = 36 +/- 35 +/- 18 km/s for HPS256. An interpretation for HPS194 is that a large-scale outflow may be occurring in its interstellar medium. The emission line ratios imply that neither LAE hosts an active galactic nucleus. Using the upper limits on the [NII] emission we place meaningful constraints on the gas-phase metallicities in these two LAEs of Z < 0.17 and < 0.28 Zsol (1 sigma). Measuring the stellar masses of these objects via spectral energy distribution (SED) fitting (~ 10^10 and 6 x 10^8 Msol, respectively), we study the nature of LAEs in a mass-metallicity plane. At least one of these two LAEs appears to be more metal poor than continuum-selected star-forming galaxies at the same redshift and stellar mass, implying that objects exhibiting Lyman alpha emission may be systematically less chemically enriched than the general galaxy population. We use the SEDs of these two galaxies to show that neglecting the emission lines when fitting stellar population models to the observed photometry can result in overestimates of the population age by orders of magnitude, and the stellar mass by a factor of ~ 2. This effect is particularly important at z > 7, where similarly strong emission lines may masquerade in the photometry as a 4000 A break (abridged).Comment: Replaced with the accepted (to ApJ) versio

Experimental analysis of the effect of taxes and subsides on calories purchased in an on-line supermarket

Taxes and subsidies are a public health approach to improving nutrient quality of food purchases. While taxes or subsidies influence purchasing, it is unclear whether they influence total energy or overall diet quality of foods purchased. Using a within subjects design, selected low nutrient dense foods (e.g. sweetened beverages, candy, salty snacks) were taxed, and fruits and vegetables and bottled water were subsidized by 12.5% or 25% in comparison to a usual price condition for 199 female shoppers in an experimental store. Results showed taxes reduced calories purchased of taxed foods (coefficient = -6.61, Cl = -11.94 to -1.28) and subsidies increased calories purchased of subsidized foods (coefficient = 13.74, Cl = 8.51 to 18.97). However, no overall effect was observed on total calories purchased. Both taxes and subsidies were associated with a reduction in calories purchased for grains (taxes: coefficient = -6.58, Cl = -11.91 to -1.24, subsidies: coefficient = -12.86, Cl = -18.08 to -7.63) and subsidies were associated with a reduction in calories purchased for miscellaneous foods (coefficient = -7.40, CI = -12.62 to -2.17) (mostly fats, oils and sugars). Subsidies improved the nutrient quality of foods purchased (coefficient = 0.14, Cl = 0.07 to 0.21). These results suggest that taxes and subsidies can influence energy purchased for products taxed or subsidized, but not total energy purchased. However, the improvement in nutrient quality with subsidies indicates that pricing can shift nutritional quality of foods purchased. Research is needed to evaluate if differential pricing strategies based on nutrient quality are associated with reduction in calories and improvement in nutrient quality of foods purchased

The confluence of stereotactic ablative radiotherapy and tumor

Stereotactic radiation approaches are gaining more popularity for the treatment of intracranial as well as extracranial tumors in organs such as the liver and lung. Technology, rather than biology, is driving the rapid adoption of stereotactic body radiation therapy (SBRT), also known as stereotactic ablative radiotherapy (SABR), in the clinic due to advances in precise positioning and targeting. Dramatic improvements in tumor control have been demonstrated; however, our knowledge of normal tissue biology response mechanisms to large fraction sizes is lacking. Herein, we will discuss how SABR can induce cellular expression of MHC I, adhesion molecules, costimulatory molecules, heat shock proteins, inflammatory mediators, immunomodulatory cytokines, and death receptors to enhance antitumor immune responses

The Confluence of Stereotactic Ablative Radiotherapy and Tumor Immunology

Stereotactic radiation approaches are gaining more popularity for the treatment of intracranial as well as extracranial tumors in organs such as the liver and lung. Technology, rather than biology, is driving the rapid adoption of stereotactic body radiation therapy (SBRT), also known as stereotactic ablative radiotherapy (SABR), in the clinic due to advances in precise positioning and targeting. Dramatic improvements in tumor control have been demonstrated; however, our knowledge of normal tissue biology response mechanisms to large fraction sizes is lacking. Herein, we will discuss how SABR can induce cellular expression of MHC I, adhesion molecules, costimulatory molecules, heat shock proteins, inflammatory mediators, immunomodulatory cytokines, and death receptors to enhance antitumor immune responses