Effect of dissipative forces on the theory of a single-atom microlaser

We describe a one-atom microlaser involving Poissonian input of atoms with a fixed flight time through an optical resonator. The influence of the cavity reservoir during the interactions of successive individual atoms with the cavity field is included in the analysis. The atomic decay is also considered as it is nonnegligible in the optical regime. During the random intervals of absence of any atom in the cavity, the field evolves under its own dynamics. We discuss the steady-state characteristics of the cavity field. Away from laser threshold, the field can be nonclassical in nature.Comment: 9 pages in LaTex; 3 PS figure

HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA

The microRNA (miRNA)-mediated repression of protein synthesis in mammalian cells is a reversible process. Target mRNAs with regulatory AU-rich elements (AREs) in their 3′-untranslated regions (3′-UTR) can be relieved of miRNA repression under cellular stress in a process involving the embryonic lethal and altered vision family ARE-binding protein HuR. The HuR-mediated derepression occurred even when AREs were positioned at a considerable distance from the miRNA sites raising questions about the mechanism of HuR action. Here, we show that the relief of miRNA-mediated repression involving HuR can be recapitulated in different in vitro systems in the absence of stress, indicating that HuR alone is sufficient to relieve the miRNA repression upon binding to RNA ARE. Using in vitro assays with purified miRISC and recombinant HuR and its mutants, we show that HuR, likely by its property to oligomerize along RNA, leads to the dissociation of miRISC from target RNA even when miRISC and HuR binding sites are positioned at a distance. Further, we demonstrate that HuR association with AREs can also inhibit miRNA-mediated deadenylation of mRNA in the Krebs-2 ascites extract, in a manner likewise depending on the potential of HuR to oligomeriz

Synthesis and Properties of High Tilted Antiferroelectric Esters with Partially Fluorinated Alkoxyalkoxy Terminal Chains

Novel chiral esters with partially fluorinated alkoxyalkoxy terminal chains are described. Their phase transition temperatures, enthalpies, and electrooptical properties are reported. A helical pitch in pure compounds and their mixtures based on selective reflection of light is also characterized

Photon trains and lasing : The periodically pumped quantum dot

We propose to pump semiconductor quantum dots with surface acoustic waves which deliver an alternating periodic sequence of electrons and holes. In combination with a good optical cavity such regular pumping could entail anti-bunching and sub-Poissonian photon statistics. In the bad-cavity limit a train of equally spaced photons would arise.Comment: RevTex, 5 pages, 1 figur

Dynamics, correlations and phases of the micromaser

The micromaser possesses a variety of dynamical phase transitions parametrized by the flux of atoms and the time-of-flight of the atom within the cavity. We discuss how these phases may be revealed to an observer outside the cavity using the long-time correlation length in the atomic beam. Some of the phase transitions are not reflected in the average excitation level of the outgoing atom, which is the commonly used observable. The correlation length is directly related to the leading eigenvalue of the time evolution operator, which we study in order to elucidate the phase structure. We find that as a function of the time-of-flight the transition from the thermal to the maser phase is characterized by a sharp peak in the correlation length. For longer times-of-flight there is a transition to a phase where the correlation length grows exponentially with the flux. We present a detailed numerical and analytical treatment of the different phases and discuss the physics behind them.Comment: 60 pages, 18 figure files, Latex + \special{} for the figures, (some redundant figures are eliminated and others are changed

Squeezing generation and revivals in a cavity-ion system in contact with a reservoir

We consider a system consisting of a single two-level ion in a harmonic trap, which is localized inside a non-ideal optical cavity at zero temperature and subjected to the action of two external lasers. We are able to obtain an analytical solution for the total density operator of the system and show that squeezing in the motion of the ion and in the cavity field is generated. We also show that complete revivals of the states of the motion of the ion and of the cavity field occur periodically.Comment: 9 pages, 3 figure

Enhancing Acceleration Radiation from Ground-State Atoms via Cavity Quantum Electrodynamics

When ground state atoms are accelerated through a high Q microwave cavity, radiation is produced with an intensity which can exceed the intensity of Unruh acceleration radiation in free space by many orders of magnitude. The cavity field at steady state is described by a thermal density matrix under most conditions. However, under some conditions gain is possible, and when the atoms are injected in a regular fashion, the radiation can be produced in a squeezed state

MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice

Hepatic steatosis is a global epidemic that is thought to contribute to the pathogenesis of type 2 diabetes. MicroRNAs (miRs) are regulators that can functionally integrate a range of metabolic and inflammatory pathways in liver. We aimed to investigate the functional role of miR-155 in hepatic steatosis. Male C57BL/6 wild-type (WT) and miR-155−/− mice were fed either normal chow or high fat diet (HFD) for 6 months then lipid levels, metabolic and inflammatory parameters were assessed in livers and serum of the mice. Mice lacking endogenous miR-155 that were fed HFD for 6 months developed increased hepatic steatosis compared to WT controls. This was associated with increased liver weight and serum VLDL/LDL cholesterol and alanine transaminase (ALT) levels, as well as increased hepatic expression of genes involved in glucose regulation (Pck1, Cebpa), fatty acid uptake (Cd36) and lipid metabolism (Fasn, Fabp4, Lpl, Abcd2, Pla2g7). Using miRNA target prediction algorithms and the microarray transcriptomic profile of miR-155−/− livers, we identified and validated that Nr1h3 (LXRα) as a direct miR-155 target gene that is potentially responsible for the liver phenotype of miR-155−/− mice. Together these data indicate that miR-155 plays a pivotal role regulating lipid metabolism in liver and that its deregulation may lead to hepatic steatosis in patients with diabetes