On multicurve models for the term structure

In the context of multi-curve modeling we consider a two-curve setup, with one curve for discounting (OIS swap curve) and one for generating future cash flows (LIBOR for a give tenor). Within this context we present an approach for the clean-valuation pricing of FRAs and CAPs (linear and nonlinear derivatives) with one of the main goals being also that of exhibiting an "adjustment factor" when passing from the one-curve to the two-curve setting. The model itself corresponds to short rate modeling where the short rate and a short rate spread are driven by affine factors; this allows for correlation between short rate and short rate spread as well as to exploit the convenient affine structure methodology. We briefly comment also on the calibration of the model parameters, including the correlation factor.Comment: 16 page

The ATLAS-SPT Radio Survey of Cluster Galaxies

Using a high-performance computing cluster to mosaic 4,787 pointings, we have imaged the 100 sq. deg. South Pole Telescope (SPT) deep-field at 2.1 GHz using the Australian Telescope Compact Array to an rms of 80 $\mu$Jy and a resolution of 8". Our goal is to generate an independent sample of radio-selected galaxy clusters to study how the radio properties compare with cluster properties at other wavelengths, over a wide range of redshifts in order to construct a timeline of their evolution out to $z \sim 1.3$. A preliminary analysis of the source catalogue suggests there is no spatial correlation between the clusters identified in the SPT-SZ catalogue and our wide-angle tail galaxies.Comment: 9 pages, 4 figures. Submitted to Proceedings of Science for "The many facets of extragalactic radio surveys: towards new scientific challenges", Bologna, Italy 20-23 October 2015 (EXTRA-RADSUR2015

HFPK 334: An unusual Supernova Remnant in the Small Magellanic Cloud

We present new Australia Telescope Compact Array (ATCA) radio-continuum and XMM-Newton/Chandra X-ray Observatory (CXO) observations of the unusual supernova remnant HFPK 334 in the Small Magellanic Cloud (SMC). The remnant follows a shell type morphology in the radio-continuum and has a size of $\sim$20~pc at the SMC distance. The X-ray morphology is similar, however, we detect a prominent point source close to the center of the SNR exhibiting a spectrum with a best fit powerlaw with a photon index of $\Gamma = 2.7 \pm 0.5$. This central point source is most likely a background object and cannot be directly associated with the remnant. The high temperature, nonequilibrium conditions in the diffuse region suggest that this gas has been recently shocked and point toward a younger SNR with an age of $\lesssim 1800$ years. With an average radio spectral index of $\alpha=-0.59\pm0.09$ we find that an equipartition magnetic field for the remnant is $\sim$90~$\mu$G, a value typical of younger SNRs in low-density environments. Also, we report detection of scattered radio polarisation across the remnant at 20~cm, with a peak fractional polarisation level of 25$\pm$5\%.Comment: 19 pages, 6-figures, submitted to A

XMMU J0541.8-6659, a new supernova remnant in the Large Magellanic Cloud

The high sensitivity of the XMM-Newton instrumentation offers the opportunity to study faint and extended sources in the Milky Way and nearby galaxies such as the Large Magellanic Cloud (LMC) in detail. The ROSAT PSPC survey of the LMC has revealed more than 700 X-ray sources, among which there are 46 supernova remnants (SNRs) and candidates. We have observed the field around one of the most promising SNR candidates in the ROSAT PSPC catalogue, labelled [HP99] 456 with XMM-Newton, to determine its nature. We investigated the XMM-Newton data along with new radio-continuum, near infrared and optical data. In particular, spectral and morphological studies of the X-ray and radio data were performed. The X-ray images obtained in different energy bands reveal two different structures. Below 1.0 keV the X-ray emission shows the shell-like morphology of an SNR with a diameter of ~73 pc, one of the largest known in the LMC. For its thermal spectrum we estimate an electron temperature of (0.49 +/- 0.12)keV assuming non-equilibrium ionisation. The X-ray images above 1.0 keV reveal a less extended source within the SNR emission, located ~1' west of the centre of the SNR and coincident with bright point sources detected in radio-continuum. This hard component has an extent of 0.9' (i.e. ~13 pc at a distance of ~50 kpc) and a non-thermal spectrum. The hard source coincides in position with the ROSAT source [HP99] 456 and shows an indication for substructure. We firmly identify a new SNR in the LMC with a shell-like morphology and a thermal spectrum. Assuming the SNR to be in the Sedov phase yields an age of ~23 kyr. We explore possible associations of the hard non-thermal emitting component with a pulsar wind nebula (PWN) or background active galactic nuclei (AGN).Comment: 8 pages, 7 figures, accepted for publication in Astronomy and Astrophysic

Polarographic Investigations of Some Metal Monocarboxylato Complexes . I. Monocarboxylato Complexes of Lead

By the polarographic method of DeFord and Hume the stability constants of plumbous monocarboxylato co mplexes have been determined, in water solutions of a constant ionic s trength 2 and a con stant concentration of 2 M of monocarboxylic acid. The examinations were carried out in the monocarboxyla te concent r a t ion range up to 2 M. The following values of stability const a nts were obtained: formiato complexes /31= 13, /32 = 50, /33 = 30; acetato complexes /31 = 150 , /32 = 900, fJ3 = 3000; propionato complexes fJ 1 = 170, /J2 = 2200, /J3 = 5800 ; butyrato complexes /J 1 = 120 , /32 = 2000 , /3 3 = = 5800. It i s evident that with the increase of b ase strength and the size of the monoc arboxylate ion the complex stability increas es in the m\u27ljority of cases

AGN behind the SMC selected from radio and X-ray surveys

The XMM-Newton survey of the Small Magellanic Cloud (SMC) revealed 3053 X-ray sources with the majority expected to be active galactic nuclei (AGN) behind the SMC. However, the high stellar density in this field often does not allow assigning unique optical counterparts and hinders source classification. On the other hand, the association of X-ray point sources with radio emission can be used to select background AGN with high confidence, and to constrain other object classes like pulsar wind nebula. To classify X-ray and radio sources, we use clear correlations of X-ray sources found in the XMM-Newton survey with radio-continuum sources detected with ATCA and MOST. Deep radio-continuum images were searched for correlations with X-ray sources of the XMM-Newton SMC-survey point-source catalogue as well as galaxy clusters seen with extended X-ray emission. Eighty eight discrete radio sources were found in common with the X-ray point-source catalogue in addition to six correlations with extended X-ray sources. One source is identified as a Galactic star and eight as galaxies. Eight radio sources likely originate in AGN that are associated with clusters of galaxies seen in X-rays. One source is a PWN candidate. We obtain 43 new candidates for background sources located behind the SMC. A total of 24 X-ray sources show jet-like radio structures.Comment: 9 pages, 6 figures, accepted for publication in A&

Multi-frequency study of a new Fe-rich supernova remnant in the Large Magellanic Cloud, MCSNR J0508-6902

We present a detailed radio, X-ray and optical study of a newly discovered Large Magellanic Cloud (LMC) supernova remnant (SNR) which we denote MCSNR J0508-6902. Observations from the Australian Telescope Compact Array (ATCA) and the $\textit{XMM-Newton}$ X-ray observatory are complemented by deep H$\alpha$ images and Anglo Australian Telescope AAOmega spectroscopic data to study the SNR shell and its shock-ionisation. Archival data at other wavelengths are also examined. The remnant follows a filled-in shell type morphology in the radio-continuum and has a size of $\sim$74 pc $\times$ 57 pc at the LMC distance. The X-ray emission exhibits a faint soft shell morphology with Fe-rich gas in its interior $-$ indicative of a Type Ia origin. The remnant appears to be mostly dissipated at higher radio-continuum frequencies leaving only the south-eastern limb fully detectable while in the optical it is the western side of the SNR shell that is clearly detected. The best-fit temperature to the shell X-ray emission ($kT = 0.41^{+0.05}_{-0.06}$ keV) is consistent with other large LMC SNRs. We determined an O/Fe ratio of $<21$ and an Fe mass of 0.5-1.8$~M_{\odot}$ in the interior of the remnant, both of which are consistent with the Type Ia scenario. We find an equipartition magnetic field for the remnant of $\sim$28 $\mu$G, a value typical of older SNRs and consistent with other analyses which also infer an older remnant

Inhibition of γ-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells

γ-Secretase activity is vital for the transmembrane cleavage of Notch receptors and the subsequent migration of their intracellular domains to the nucleus. Notch overexpression has been associated with breast, colon, cervical and prostate cancers. We tested the effect of three different γ-secretase inhibitors (GSIs) in breast cancer cells. One inhibitor (GSI1) was lethal to breast cancer cell lines at concentrations of 2 μM and above but had a minimal effect on the non-malignant breast lines. GSI1 was also cytotoxic for a wide variety of cancer cell lines in the NCI60 cell screen. GSI1 treatment resulted in a marked decrease in γ-secretase activity and downregulation of the Notch signalling pathway with no effects on expression of the γ-secretase components or ligands. Flow cytometric and western blot analyses indicated that GSI1 induces a G2/M arrest leading to apoptosis, through downregulation of Bcl-2, Bax and Bcl-XL. GSI1 also inhibited proteasome activity. Thus, the γ-secretase inhibitor GSI1 has a complex mode of action to inhibit breast cancer cell survival and may represent a novel therapy in breast cancer