Evaluatuation of the competitiveness of the product offered by the dairy company

The milk market provides prosperity only to those companies that are able to satisfy customer requirements with a competitive product. The need to increase competitiveness is driven mainly by the increased customer requirements to the product of the milk - to its quality, price and service. In the dairy products industry the product itself is crucial and it should be considered a priority. Without this element the milk companies have nothing to distribute, advertise or sell. It must be competitive. The paper focuses on the evaluation of the competitiveness of the dairy companies in Greece. The major research methods used in this paper are questionnaire survey, interview, method of comparison, method of analysis and synthesis

A new neutron study of the short range order inversion in Fe1−x_{1-x}Crx_x

We have performed new neutron diffuse scattering measurements in Fe$_{1-x}$Cr$_x$ solid solutions, in a concentration range 0$<$x$<$0.15, where the atomic distribution shows an inversion of the short range order. By optimizing the signal-background ratio, we obtain an accurate determination of the concentration of inversion x$_0$ =0.110(5). We determine the near neighbor atomic short range order parameters and pair potentials, which change sign at x$_0$. The experimental results are compared with previous first principle calculations and atomistic simulations.Comment: 6 pages; 6 figure

Evaluatuation of the competitiveness of the product offered by the dairy company

The milk market provides prosperity only to those companies that are able to satisfy customer requirements with a competitive product. The need to increase competitiveness is driven mainly by the increased customer requirements to the product of the milk - to its quality, price and service. In the dairy products industry the product itself is crucial and it should be considered a priority. Without this element the milk companies have nothing to distribute, advertise or sell. It must be competitive. The paper focuses on the evaluation of the competitiveness of the dairy companies in Greece. The major research methods used in this paper are questionnaire survey, interview, method of comparison, method of analysis and synthesis

Shell-Model Effective Operators for Muon Capture in ^{20}Ne

It has been proposed that the discrepancy between the partially-conserved axial-current prediction and the nuclear shell-model calculations of the ratio $C_P/C_A$ in the muon-capture reactions can be solved in the case of ^{28}Si by introducing effective transition operators. Recently there has been experimental interest in measuring the needed angular correlations also in ^{20}Ne. Inspired by this, we have performed a shell-model analysis employing effective transition operators in the shell-model formalism for the transition $^{20}Ne(0^+_{g.s.})+\mu^- \to ^{20}F(1^+; 1.057 MeV) + \nu_\mu$. Comparison of the calculated capture rates with existing data supports the use of effective transition operators. Based on our calculations, as soon as the experimental anisotropy data becomes available, the limits for the ratio $C_P/ C_A$ can be extracted.Comment: 9 pages, 3 figures include

Technical innovations for combating alcohol intoxication on the roads

The article discusses technical innovations aimed at combating driving under the influence of alcohol. The main focus is on ignition lock (IID) breathalyzers, which are already successfully used in some countries, and systems for recognizing signs of alcohol intoxication, which are under development. Legal and ethical issues related to the use of these technologies are also discussed, including issues of liability, data protection and privacy of drivers. Despite the potential effectiveness of these technologies, their implementation faces a number of problems that require further discussion and solution. The article also examines the situation in the Republic of Sakha (Yakutia), where there are currently no plans to introduce systems that prevent driving under the influence of alcohol

Modern approaches to organizational structure in transport logistics

The article emphasizes the importance of the organizational structure for the effective functioning of any industrial or trade organization. The organizational structure determines the speed, reliability and cost of transportation, and as a result, the competitiveness of the company as a whole. The authors present an overview of the main types of organizational structures used in transport logistics, including functional, product (or divisional), matrix, project and hybrid structures. Each type of structure is considered in the context of its advantages and disadvantages, as well as the possibilities of application in various conditions. The article also provides examples of organizational structures of large international transport and logistics companies, such as DHL, FedEx, Maersk, UPS and C. H. Robinson. These examples allow us to demonstrate a variety of approaches to organizing work in transport logistics and identify the most effective practices. Special attention is paid in the article to the analysis of the organizational structure of the SLTC and the possibilities of its optimization. The authors propose several alternative approaches that can help improve the efficiency and flexibility of the company. In particular, the possibilities of switching to a matrix or hybrid structure, using the project structure to process unique projects or tasks, as well as improving internal communication and coordination are being considered. In conclusion, the article emphasizes that the choice of the optimal organizational structure requires a comprehensive analysis and must take into account many factors, including the current business strategy, customer requirements, internal resources and capabilities, as well as trends and opportunities in the field of transport logistics. The authors emphasize that any changes in the organizational structure should be accompanied by adequate changes in the corporate culture and management system, as well as support and training of employees. In general, the article is a valuable source of information for specialists in the field of transport logistics, as well as for managers and business owners who want to improve the efficiency of their operations and increase the competitiveness of their companies

Comparative bioavailability of a newly developed Irbesartan 300 mg containing preparation

Introduction: Irbesartan (CAS registry: 138402-11-6) is a potent, orally active, selective antagonist of the angiotensin II receptors (type AT1) indicated for the treatment of arterial hypertension and chronic heart failure. Aim: The objective of the present study was to demonstrate the bioequivalence of an oral test preparation (Irbesartan 300 mg film-coated tablets Tchaikapharma High Quality Medicines Inc., Bulgaria) and a reference (Aprovel 300 mg film-coated tablets, Sanofi Clir SNC, France), by comparing the rate and extent of absorption of both products upon a single oral administration of the tablets under fasting conditions in healthy volunteers. Methodology: The study was carried out as a single-center, open-label, randomised, twoperiod, single dose, crossover oral bioequivalence study in 40 healthy male and female subjects under fasting conditions. During each study period blood samples for analysis of irbesartan were taken prior to dosing and at 0.25, 0.5, 0.75, 1, 1.25, 1.5, 1.75, 2, 2.5, 3, 3.5, 4, 5, 6, 8, 12, 24, 36, 48 and 72 hours after dosing. The separated plasma was analyzed in the bioanalytical division of Anapharm Europe with a validated method using reversed phase high performance liquid chromatography coupled to a tandem mass spectrometry detector (RP-LC/MS/MS). Results: The point estimates with 90% confidence intervals of the geometric mean ratios of test and reference (T/R) in the study were found to be 102.39% (95.55% - 109.71%) for Cmax and 98.56 % (92.72 % - 104.76 %) for AUC0-72. Thus, the corresponding ratios of Cmax and AUC0-72 met the predetermined criteria for bioequivalence (90% confidence intervals of the geometric mean ratios of test and reference within the 80.00% - 125.00%). Both products were generally very well tolerated. Conclusions: Irbesartan 300 mg film-coated tablets, Tchaikapharma High Quality Medicines Inc., Bulgaria) and Aprovel 300 mg film-coated tablets (Sanofi Clir SNC, France), are bioequivalent with regard to the rate and extent of absorption

A Heightened Perspective - Regional Assessment of the Policy, Legislative and Institutional Frameworks Implementing the Carpathian Convention

This volume aims at assessing the implementation of the Carpathian Convention in the seven member States, through a detailed analysis of the policy, legislative and administrative frameworks. It compares, article by article, the situation in the different Countries, focusing on best practices and formulating recommendations to improve effective implementation, at a national level and regionally

Technical design and performance of the NEMO3 detector

The development of the NEMO3 detector, which is now running in the Frejus Underground Laboratory (L.S.M. Laboratoire Souterrain de Modane), was begun more than ten years ago. The NEMO3 detector uses a tracking-calorimeter technique in order to investigate double beta decay processes for several isotopes. The technical description of the detector is followed by the presentation of its performance.Comment: Preprint submitted to Nucl. Instrum. Methods A Corresponding author: Corinne Augier ([email protected]

Adaptive Evolution in Zinc Finger Transcription Factors

The majority of human genes are conserved among mammals, but some gene families have undergone extensive expansion in particular lineages. Here, we present an evolutionary analysis of one such gene family, the poly–zinc-finger (poly-ZF) genes. The human genome encodes approximately 700 members of the poly-ZF family of putative transcriptional repressors, many of which have associated KRAB, SCAN, or BTB domains. Analysis of the gene family across the tree of life indicates that the gene family arose from a small ancestral group of eukaryotic zinc-finger transcription factors through many repeated gene duplications accompanied by functional divergence. The ancestral gene family has probably expanded independently in several lineages, including mammals and some fishes. Investigation of adaptive evolution among recent paralogs using dN/dS analysis indicates that a major component of the selective pressure acting on these genes has been positive selection to change their DNA-binding specificity. These results suggest that the poly-ZF genes are a major source of new transcriptional repression activity in humans and other primates