Aplicación, cenizas de conchas de abanico para estabilización nivel sub subrasante en el camino vecinal Nuevo Tambo Real Chimbote – 2022

El trabajo de investigación titula “Aplicación, cenizas de conchas de abanico para estabilización nivel sub subrasante en el camino vecinal Nuevo Tambo Real Chimbote – 2022”, de acuerdo a lo planteado nace la pregunta ¿De qué manera la aplicación de cenizas de conchas de abanico mejorara la estabilización del suelo a nivel de subrasante en el camino vecinal Nuevo Tambo Real, Chimbote – 2022? La metodología empleada fue experimental, porque no se manipularon las variables, siendo del tipo aplicado, donde se concluyó que para las propiedades físicas del material se determinó una clasificación del tipo SP-SM, SP-SM, SP,SP, mientras para las propiedades del material se determinó una capacidad portante del suelo se determinó para C1= 16.2%, C2=15.0%, C3=17.2% y para C4=16.3%, así mismo respecto a las propiedades mecánicas del suelo al añadir la adición del 5 % de cenizas de conchas de abanicos se obtuvo una densidad máxima seca de 2.166 gr/cm3 y un OCH de 6.09 % y un CBR del 17.2 %, para la propuesta de diseño del paquete estructural fue 15 cm para la Subbase , por ultimo para la prueba de hipótesis se determinó que demuestra que en resumen se rechaza la hipótesis nula debido que el grado de significancia fue menor a 0.05, demostrando que las cenizas de conchas de abanico mejora las propiedades mecánicas del suelo, para estabilización de la Subrasante

Propuesta de una metodología para la gestión económica de la obra en marcha. Aplicación práctica al proyecto de una infraestructura civil

[EN] Civil Engineers possess sufficient technical information related to construction and engineering, despite this, they do not have enough information or preparation to understand the economic performance of a work. This is because construction projects do not have standardized methods or procedures and each work that is executed is different. This proposal deals with the economic management of works, work will be done by simulating the execution of a work site in Pedralabes, Valencia; In this simulation, two scenarios of economic management are presented, depending on the low offered by the contractor. The purpose of this work is to start theoretically in the concepts used to manage a work and start in the practical to develop the ability to analyze the moment in which a work is managed. We tried to make the simulation as real as possible in order to cover a greater number of variables and uncertainty, we can see that the proposed method is not only limited to the economic management of the items, but can also be used for personnel control , machinery and tools if desired. The economic management of a work is one of the most important aspects of the construction sector after all a project is managed by a company whose purpose is to generate income to make a profit.[CA] Els enginyers civils posseeixen suficient informació tècnica relacionada amb la construcció però a enginyeria, malgrat tot, no compten amb la suficient informació o preparació per entendre el funcionament econòmic d'una obra. Això és degut a que els projectes de construcció no tenen mètodes ni procediments estandarditzats i cada obra que es du a terme és diferent. En aquesta proposta es tracta la gestió econòmica d'obres i es treballarà fent una simulació de l'execució d'una obra vial a Pedralba, València; en aquesta simulació es presenten dos escenaris de gestió econòmica depenent de la baixa ofertada pel contractista. La finalitat d' aquest treball és la iniciació de manera teòrica als conceptes utilitzats per la gestió d'una obra i la iniciació en lo pràctica per desenvolupar la capacitat d'anàlisi en el moment en el que es gestiona una obra. S'ha intentat fer la simulació de la manera més real possible per a així poder incloure un major número de variables i d'incertesa. Es podrà veure que el mètode proposat no només es limita a la gestió econòmica de les partides, ja que pot utilitzar-se també per el control de personal, maquinària y eines si així es desitja. La gestió econòmica d'una obra es un dels aspectes més importants del sector de la construcció, perquè al cap i a la fi, un projecte és gestionat per una empresa que té com objectiu generar ingressos per poder obtenir beneficis.[ES] Los Ingenieros Civiles poseen suficiente información técnica relacionada con construcción y a ingeniería, a pesar de esto, no cuentan con la suficiente información o preparación para entender el funcionamiento económico de una obra. Esto debido a que los proyectos de construcción no tienen métodos ni procedimientos estandarizados y cada obra que se ejecuta es diferente. En esta propuesta se trata la gestión de económica de obras, se trabajará haciendo una simulación de la ejecución de una obra víal en Pedralabes, Valencia; en dicha simulación se presentan dos escenarios de gestión económica dependiendo de la baja ofertada por el contratista. La finalidad de este trabajo es iniciarse de manera teórica en los conceptos utilizados para gestión de una obra e iniciarse en lo práctico para desarrollar la capacidad de análisis al momento en que se gestiona una obra. Se intentó hacer la simulación de la manera más real posible para asi poder abarcar un mayor número de variables e incertidumbre, se podrá ver que el método propuesto no solo se límita a la gestión económica de las partidas, pudiendo también utilizarse para el control de personal, máquinaria y herramientas si así se desea. La gestión económica de una obra es uno de los aspectos más importante del sector construcción al fin y al cabo un proyecto es gestionado por una empresa que tiene como fin generar ingresos para obtener ganancias.Cruz Reyes, MFDL. (2019). Propuesta de una metodología para la gestión económica de la obra en marcha. Aplicación práctica al proyecto de una infraestructura civil. http://hdl.handle.net/10251/123186Archivo delegad

MEDICINA DE ESTILO DE VIDA Y RIESGO DE DESARROLLAR DIABETES MELLITUS EN PERSONAL DE LA CLÍNICA GOOD HOPE, LIMA – PERÚ, 2017.: LIFESTYLE MEDICINE AND DIABETES RISK IN STAFF OF GOOD HOPE CLINIC, LIMA-PERU 2017

Abstract   Diabetes is a chronic disease that occurs when the pancreas does not produce enough insulin or when the body does not use efficiently the insulin it produces. According to the ENDES 2013, it has found a prevalence of overweight of 33.8% and obesity of 18.3%. Objective: Determine the results of the risk test for diabetes mellitus type 2 of the American Diabetes Society in the care and administrative personnel of a particular clinic. Methods: Observational, cross-sectional, analytical study that evaluates the probability of workers suffering from diabetes mellitus. The population of the study will be made up of workers, both clinical and administrative staff of the institution. Results: 34% of the population had normal BMI, 49% were overweight and 18.3% were obese. 15% of the studied population is at risk of developing diabetes mellitus type 2 according to the risk test for diabetes mellitus type 2 of the American Diabetes Society. The factors significantly associated with the risk of developing diabetes were older than 40 years OR: 10,14 IC95% 4,29, 23,98, p: 0.000; male sex OR: 2,35 % 1,06-5,21, p: 0.03; family history of diabetes OR: 6,330 IC95% 2,76-14,51, p: 0.000; BMI greater than 25 OR: 19,706 IC95% 2,62-147,96, p: 0.000 and physical activity OR: 28,95 IC95% 3,86-217,18; as well as the diagnosis of arterial hypertension OR: 13.500 IC95% 4.87-37.38. Conclusion: The risk found to develop diabetes was 15%, being higher in the administrative group than in the healthcare group. The factors associated with the risk of developing diabetes are directly linked to lifestyle medicine. Key words: Diabetes Mellitus; Risk Factors; Massive Screening. (source: MeSH NLM) DOI: https://doi.org/10.25176/RFMH.v18.n1.126

The Neurovascular Unit Dysfunction in Alzheimer's Disease

Funding: This work was supported by Fondo Nacional de Ciencia y Tecnologia (FONDOCyT) from the Ministry of Higher Education, Science and Technology, Dominican Republic (2015-3A2-127 to M.P.-H.) and (2018-2019-2A3-208 to J.L.-M. and M.P.-H.). Acknowledgments: The authors want to express their gratitude to the Mexican families who have donated the brain of their loved ones affected by Alzheimer’s disease and made our research possible. We also want to express our gratitude to the Union Medical University Clinic, Dominican Republic, for their support and collaboration in developing of this research project. This work is dedicated to the memory of José Raúl Mena López †.Peer reviewedPublisher PD

Insoluble Vascular Amyloid Deposits Trigger Disruption of the Neurovascular Unit in Alzheimer’s Disease Brains

Funding: This work was supported by Fondo Nacional de Ciencia y Tecnologia, FONDOCyT, from the Ministry of Higher Education, Science and Technology, Dominican Republic (2015-3A2-127 to MP-H) and (2018-2019-2A3-208 to J.L.-M. and M.P.-H). Acknowledgments: The authors want to express their gratitude to the following: P. Davies†(Albert Einstein College of Medicine, Bronx, NY, USA) and Lester I. Binder† (North Western, Chicago, IL, USA) for the generous gift of mAbs TG-3 and Alz-50, and Tau-1, Tau-5, and Tau-7, respectively; Tec. Amparo Viramontes Pintos for the handling of the brain tissue; support in the confocal microscopy unit of CIIDIR Durango, Instituto Politécnico Nacional; Union Medica University Clinic, Dominican Republic, for their support and collaboration in the development of this research project. We also want to express our gratitude to the Mexican families who have donated the brain of their loved ones affected by Alzheimer’s disease and made our research possible. This work is dedicated to the memory of José Raúl Mena López† . †Deceased.Peer reviewedPublisher PD

PHF-Core Tau as the Potential Initiating Event for Tau Pathology in Alzheimer’s Disease

FUNDING This work was supported by Fondo Nacional de Ciencia, Tecnologia, FONDOCyT, from the Ministry of Higher Education, Science and Technology, Dominican Republic (2015- 3A2-127 to MP-H and 2018-2019-2A3-208 to JL-M and MP-H). ACKNOWLEDGMENTS: We want to express our gratitude to the following: Dr. P. Davies (Albert Einstein College of Medicine, Bronx, NY, United States) and Lester I. Binder† (North Western, Chicago, IL, United States) for the generous gifts of mAbs TG3 and Alz-50, and Tau-1, Tau-5, and Tau-7, respectively; Tec. Amparo Viramontes Pintos for the handling of the brain tissue; Samadhi Moreno-Campuzano for her technical assistance/support in the confocal microscopy unit of CIIDIR Durango, Instituto Politécnico Nacional; Union Medical University Clinic, Dominican Republic, for their support and collaboration in the development of this research project. We also want to express our gratitude to the Mexican families who have donated the brain of their loved ones affected with Alzheimer’s disease and made our research possible. This work is dedicated to the memory of Professor Dr. José Raúl Mena López† .Peer reviewedPublisher PD

Tau Protein Phosphorylated at Threonine-231 Is Expressed Abundantly in the Cerebellum in Prion Encephalopathies

ACKNOWLEDGMENTS: The authors want to express their gratitude to the following: Dr. P. Davies † (Albert Einstein College of Medicine, Bronx, NY, USA) and Lester I. Binder † (North Western, Chicago, IL, USA) for the generous gift of mAbs TG-3 and Alz-50, and Tau-1, Tau-5 and Tau-7, respectively; Tec. Amparo Viramontes Pintos for the handling of the brain tissue; support in the confocal microscopy unit of CIIDIR Durango, Instituto Politécnico Nacional; Union Medica University Clinic, Dominican Republic, for their support and collaboration in the development of this research project. We also want to express our gratitude to the Mexican families who have donated the brain of their loved ones affected with Alzheimer's disease and made our research possible. This work is dedicated to the memory of Professor Dr. José Raúl Mena López †. †Deceased. This work was supported by Fondo Nacional de Ciencia y Tecnologia, FONDOCyT, from the Ministry of Higher Education, Science and Technology, Dominican Republic (2015-3A2-127 to MP-H) and (2018-2019-2A3-208 to JL-M and MP-H).Peer reviewedPublisher PD

Molecular Processing of Tau Protein in Progressive Supranuclear Palsy : Neuronal and Glial Degeneration

ACKNOWLEDGMENTS This work was supported by Fondo Nacional de Ciencia y Tecnologia, FONDOCyT, from the Ministry of Higher Education, Science and Technology, Dominican Republic (2015-3A2-127 to MP-H) and (2018-2019-2A3-208 to JL-M and MP-H). The authors want to express their gratitude to the following: Dr. P. Davies† (Albert Einstein College of Medicine, Bronx, NY, USA) and Lester I. Binder† (North Western, Chicago, IL, USA) for the generous gift of mAbs TG–3 and Alz–50, and Tau–1, Tau–5 and Tau–7, respectively; Tec. Amparo Viramontes Pintos for the handling of the brain tissue; support in the confocal microscopy unit of CIIDIR Durango, Instituto Politecnico Nacional; Union Medica Uni- A. Mart´ınez-Maldonado et al. / Molecular Processing of Tau Protein in Progressive Supranuclear Palsy 1529 versity Clinic, Dominican Republic, for their support and collaboration in the development of this research project. We also want to express our gratitude to the Mexican families who have donated the brain of their loved ones affected with Alzheimer’s disease and made our research possible. This work is dedicated to the memory of Professor Dr. Jose Ra ´ ul Mena L ´ opez ´ †. †Deceased. Authors’ disclosures available online (https:// www.j-alz.com/manuscript-disclosures/20-1139r2).Peer reviewedPublisher PD