482 research outputs found
Sequential Combination Therapy Leading to Sustained Remission in a Patient with SAPHO Syndrome
The SAPHO syndrome represents a variety of clinically similar disorders with the key features of hyperostotic bone lesions in combination with chronic pustular skin disease. The respective pathophysiology of bone and joint manifestations in SAPHO syndrome is still a matter of discussion. For example it does not appear to represent reactive arthritis and HLA B27 antigen, with the latter being typically present in patients with spondyloarthopathies. Treatment of SAPHO syndrome is also not well established and consists of various antiinflammatory and antirheumatic drugs. Here, we report a female patient with active SAPHO syndrome suffering from sternal swelling of unknown origin that had been known for 10 years and a 4-year-history of severe lower back pain. Remarkable were also a typical pustulous palmar erythema associated with swelling and decreased motility of both MCP-I joints. Inflammation parameters were high with an ESR 68 mm/1st hour and a CRP of 19.6 mg/l. She was initially treated with rofecoxib and doxycycline, followed by sulfasalazine with only partial clinical response. Thereafter, both articular symptoms as well as cutaneous lesions responded well to a combination therapy with methotrexate and sulfasalazine. Thus, the case illustrates nicely that methotrexate in combination with another DMARD can be successfully applied to patients with long-term active SAPHO syndrome
Moments of the spin structure functions g(1)(p) and g(1)(d) for 0.05 \u3c Q(2) \u3c 3.0 GeV2
The spin structure functions g, for the proton and the deuteron have been measured over a wide kinematic range in x and Q(2) using 1.6 and 5.7 GeV longitudinally polarized electrons incident upon polarized NH3 and ND3 targets at Jefferson Lab. Scattered electrons were detected in the CEBAF Large Acceptance Spectrometer, for 0.05 \u3c Q(2) \u3c 5 GeV2 and W \u3c 3 GeV. The first moments of g(1) for the proton and deuteron are presented - both have a negative slope at low Q(2), as predicted by the extended Gerasimov-Drell-Hearn sum rule. The first extraction of the generalized forward spin polarizability of the proton gamma(p)(0) is also reported. This quantity shows strong Q(2) dependence at low Q(2). Our analysis of the Q(2) evolution of the first moment of g, shows agreement in leading order with Heavy Baryon Chiral Perturbation Theory. However, a significant discrepancy is observed between the gamma(p)(0) data and Chiral Perturbation calculations for gamma(p)(0), even at the lowest Q(2). (C) 2009 Elsevier B.V. All rights reserved
Measurement of the 12C(e,e'p)11B Two-Body Breakup Reaction at High Missing Momentum Values
The five-fold differential cross section for the 12C(e,e'p)11B reaction was
determined over a missing momentum range of 200-400 MeV/c, in a kinematics
regime with Bjorken x > 1 and Q2 = 2.0 (GeV/c)2. A comparison of the results
and theoretical models and previous lower missing momentum data is shown. The
theoretical calculations agree well with the data up to a missing momentum
value of 325 MeV/c and then diverge for larger missing momenta. The extracted
distorted momentum distribution is shown to be consistent with previous data
and extends the range of available data up to 400 MeV/c.Comment: 12 pages, 1 table and 3 figures for submission to Journal Physics
Deeply Virtual Compton Scattering off the neutron
The present experiment exploits the interference between the Deeply Virtual
Compton Scattering (DVCS) and the Bethe-Heitler processes to extract the
imaginary part of DVCS amplitudes on the neutron and on the deuteron from the
helicity-dependent D cross section measured at =1.9
GeV and =0.36. We extract a linear combination of generalized parton
distributions (GPDs) particularly sensitive to , the least constrained
GPD. A model dependent constraint on the contribution of the up and down quarks
to the nucleon spin is deduced.Comment: Published in Phys. Rev. Let
The E00-110 experiment in Jefferson Lab's Hall A: Deeply Virtual Compton Scattering off the Proton at 6 GeV
We present final results on the photon electroproduction
() cross section in the deeply virtual Compton
scattering (DVCS) regime and the valence quark region from Jefferson Lab
experiment E00-110. Results from an analysis of a subset of these data were
published before, but the analysis has been improved which is described here at
length, together with details on the experimental setup. Furthermore,
additional data have been analyzed resulting in photon electroproduction cross
sections at new kinematic settings, for a total of 588 experimental bins.
Results of the - and -dependences of both the helicity-dependent and
helicity-independent cross sections are discussed. The -dependence
illustrates the dominance of the twist-2 handbag amplitude in the kinematics of
the experiment, as previously noted. Thanks to the excellent accuracy of this
high luminosity experiment, it becomes clear that the unpolarized cross section
shows a significant deviation from the Bethe-Heitler process in our kinematics,
compatible with a large contribution from the leading twist-2 DVCS term to
the photon electroproduction cross section. The necessity to include
higher-twist corrections in order to fully reproduce the shape of the data is
also discussed. The DVCS cross sections in this paper represent the final set
of experimental results from E00-110, superseding the previous publication.Comment: 48 pages, 32 figure
Parity-Violating Electron Scattering from 4He and the Strange Electric Form Factor of the Nucleon
We have measured the parity-violating electroweak asymmetry in the elastic
scattering of polarized electrons from ^4He at an average scattering angle
= 5.7 degrees and a four-momentum transfer Q^2 = 0.091 GeV^2. From
these data, for the first time, the strange electric form factor of the nucleon
G^s_E can be isolated. The measured asymmetry of A_PV = (6.72 +/- 0.84 (stat)
+/- 0.21 (syst) parts per million yields a value of G^s_E = -0.038 +/- 0.042
(stat) +/- 0.010 (syst), consistent with zero
Quark-Hadron Duality in Neutron (3He) Spin Structure
We present experimental results of the first high-precision test of
quark-hadron duality in the spin-structure function g_1 of the neutron and
He using a polarized 3He target in the four-momentum-transfer-squared range
from 0.7 to 4.0 (GeV/c)^2. Global duality is observed for the spin-structure
function g_1 down to at least Q^2 = 1.8 (GeV/c)^2 in both targets. We have also
formed the photon-nucleon asymmetry A_1 in the resonance region for 3He and
found no strong Q^2-dependence above 2.2 (GeV/c)^2.Comment: 13 pages, 3 figure
Measurements of the Electric Form Factor of the Neutron up to Q2=3.4 GeV2 using the Reaction He3(e,e'n)pp
The electric form factor of the neutron was determined from studies of the
reaction He3(e,e'n)pp in quasi-elastic kinematics in Hall A at Jefferson Lab.
Longitudinally polarized electrons were scattered off a polarized target in
which the nuclear polarization was oriented perpendicular to the momentum
transfer. The scattered electrons were detected in a magnetic spectrometer in
coincidence with neutrons that were registered in a large-solid-angle detector.
More than doubling the Q2-range over which it is known, we find GEn = 0.0225
+/- 0.0017 (stat) +/- 0.0024 (syst), 0.0200 +/- 0.0023 +/- 0.0018, and 0.0142
+/- 0.0019 +/- 0.0013 for Q2 = 1.72, 2.48, and 3.41 GeV2, respectively.Comment: submitted to PR
Scaling Tests of the Cross Section for Deeply Virtual Compton Scattering
We present the first measurements of the \vec{e}p->epg cross section in the
deeply virtual Compton scattering (DVCS) regime and the valence quark region.
The Q^2 dependence (from 1.5 to 2.3 GeV^2) of the helicity-dependent cross
section indicates the twist-2 dominance of DVCS, proving that generalized
parton distributions (GPDs) are accessible to experiment at moderate Q^2. The
helicity-independent cross section is also measured at Q^2=2.3 GeV^2. We
present the first model-independent measurement of linear combinations of GPDs
and GPD integrals up to the twist-3 approximation.Comment: 5 pages, 4 figures, 2 tables. Text shortened for publication.
References added. One figure remove
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