Phonological disorders in children? Design and user experience evaluation of a mobile serious game approach

This paper presents the concept and the user evaluation study of the first Super-Fon’s prototype, which is a mobile health app with a serious game approach for Android Tablets. It was developed with the main goal of working as a complement to the therapeutic intervention in phonological disorders in children between 3 and 8 years old. The app comprises a range of activities, grouped into levels, presenting a therapeutic intervention that follows the Metaphon methodology. The serious game dimension was added to better engage children in its use. The paper presents a user study conducted with two groups of children, without and with the phonological disorders. The first one worked as a control group to better help finding out if the prototype is well designed and provides a positive user experience to be well received by the children, engaging them, despite their condition. The results of the study were very positive and promising.info:eu-repo/semantics/publishedVersio

Protective effect of antigen delivery using monoolein-based liposomes in experimental hematogenously disseminated candidiasis

We evaluated the potential of a liposomal antigen delivery system (ADS) containing Candida albicans cell wall surface proteins (CWSP) in mediating protection against systemic candidiasis. Treatment of bonemarrow- derived dendritic cells with CWSP-loaded dioctadecyldimethylammonium bromide:monoolein (DODAB:MO) liposomes enhanced and prolonged their activation comparatively to free antigen, indicating that liposome-entrapped CWSP were released more sustainable. Therefore, we immunized mice with CWSP either in a free form or loaded into two different DODAB:MO liposome formulations, respectively designated as ADS1 and ADS2, prior to intravenous C. albicans infection. Immunization with ADS1, but not with ADS2, conferred significant protection to infected mice, comparatively to immunization with CWSP or empty liposomes as control. ADS1-immunized mice presented significantly higher serum levels of C. albicans-specific antibodies that enhanced phagocytosis of this fungus. In these mice, a mixed cytokine production profile was observed encompassing IFN-c, IL-4, IL-17A and IL-10. Nevertheless, only production of IL-4, IL-17 and IL-10 was higher than in controls. In this study we demonstrated that DODAB:MO liposomes enhance the immunogenicity of C. albicans antigens and host protection in a murine model of systemic candidiasis. Therefore, this liposomal adjuvant could be a promising candidate to assess in vaccination against this pathogenic fungus.This work was supported by the strategic programme UID/BIA/04050/2013 (POCI-01-0145-FEDER-007569) funded by national funds through the FCT I.P. and by the ERDF through the COMPETE2020 – Programa Operacional Competitividade e Internacionalização (POCI). Catarina Carneiro holds scholarship SFRH/BD/69068/2010. We acknowledge NanoDelivery-I&D em Bionanotecnologia, Lda for access to their equipment

As relações de poder em Michel Foucault: reflexões teóricas

Este artigo baseia-se em reflexões acerca das relações de poder em obras de Michel Foucault. Procurou-se percorrer o contexto de sua vida de forma introdutória e os diferentes modos de poder, perpassando pelas formas de força e disciplina. O procedimento metodológico foi a pesquisa bibliográfica dos acontecimentos considerados pelo autor em seu tempo, história e espaço. Diante do triângulo de Foucault (poder - direito - verdade) e das passagens em que ele se refere ao aparelho de Estado, este artigo compara o tripé da sociedade (Estado - mercado - sociedade civil) com o triângulo de Foucault. Constata-se que o poder está por toda parte e provoca ações ora no campo do direito, ora no da verdade. Deve ser entendido como uma relação flutuante, não estando em uma instituição nem em ninguém, enquanto o saber está numa relação de formas e conteúdos