2,622 research outputs found

    Os moinhos da Abelheira: contributo para a valorização arquitetónica e patrimonial

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    Dissertação apresentada à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Arquitetura e UrbanismoA presente dissertação constitui-se como sendo um trabalho elaborado sobre um conjunto de moinhos situado na freguesia de Marinhas, concelho de Esposende. Estes moinhos, denominados de moinhos da Abelheira, encontram-se hoje classificados como património municipal. Marinhas é uma freguesia inserida num meio rural e é detentora de inúmeros elementos de Arquitetura Popular, os quais constituem um património local notável, mas que, infelizmente se tem vindo a perder ou descaracterizar por intervenções menos apropriadas ou seu abandono. Neste sentido pretende-se identificar o valor patrimonial dos Moinhos da Abelheira, e analisar estratégias de intervenção no património, que ajudem a definir um modelo concetual que esteja na base de uma posterior intervenção nos Moinhos da Abelheira, no qual os monumentos se inserem enquanto potencial arquitetónico, turístico e/ou sociocultural e económico, dada a sua reconhecida qualidade enquanto, testemunho histórico-arqueológico. O método de investigação a utilizar é o estudo multicasos. É composto no total por 4 casos de estudo que correspondem a intervenções com valor patrimonial, analisados através de fichas técnicas comparando o estado anterior e o atual. No tratamento da informação realizar-se-á uma análise de dados qualitativa, da qual se obterão os princípios e critérios de intervenção para a definição de uma proposta de intervenção. Este estudo contribuiu para aprofundar o conhecimento do objeto de estudo, usando-o enquanto alavanca para o desenvolvimento do seu entendimento e demais questões de partida. Assim sendo, para além do inventário da estrutura molinológica e análise do sistema construtivo, pretende-se ainda com este trabalho de investigação demonstrar a possibilidade de valorização da arquitetura popular presente nos moinhos e mostrar a importância de uma intervenção naqueles que são o símbolo de uma freguesia.This work is constituted as a work done on a number of mills situated in the Marinhas parish, Esposende municipality. These mills, called the Abelheira mills, are now classified as municipal heritage. Marinhas is inserted in a rural parish and holds numerous vernacular architectural elements, which constitute a remarkable local heritage, but that unfortunately has been lost or misread by less appropriate interventions or its abandonment. In this sense it is intended to identify the asset values Abelheira mills, and analyze intervention strategies that help to define a conceptual model on which to base a subsequent intervention in Abelheira mills, in which the monuments are inserted as a potential architectural, tourist and / or socio-cultural and economic, given its recognized quality while, historical and archaeological evidence. The research method used is the multicases study. It comprises a total of 4 case studies that relate to action in heritage analyzed by fact sheets comparing the previous and the current status. In information processing will be carried out a qualitative data analysis, from which it will obtain the principles and intervention criteria for the definition of an intervention proposal. This study contributed to deepen the knowledge of the subject matter, using it as leverage to develop its understanding and other starting issues. Therefore, in addition to the inventory of molinologic structure and analysis of the construction system, it is intended to further this research work demonstrated the possibility of appreciation of popular architecture present in mills and show the need for intervention in those who are the symbol of a parish

    Keratinocyte growth factor, interleukins (1 beta, 6, 8, 10, 12), and tumor necrosis factor alpha in culture medium of dermal fibroblast of burned patients

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    PURPOSE:To evaluate the level of cytokines and keratinocyte growth factor (KGF) or Fibroblast Growth Factor 7 (FGF-7) in the culture medium of cultured human dermal fibroblasts from patients with large burn in comparison to small burn.METHODS:Fibroblasts of 10 patients (four large burns, four small burns and two controls) were initiated by the enzymatic method using collagenase. Cytokines and KGF in the supernatant of the culture medium was measured by, respectively, flow cytometry using Cytometric Bead Array Human Inflammation kit (CBA, BD Biosciences, USA) and the enzyme immunoassay method using the Quantikine (r) Human KGF. The experiments were performed in triplicate.RESULTS:The expression of IL-12 protein in patients with large burns showed a tendency to increase. IL- 6, IL- 10, and IL- 1beta were observed no difference. For IL - 8, TNF - alpha and KGF was observed a significant difference between the expression in large and small burned patient.CONCLUSION:That IL-8, TNF-alpha and KGF showed higher expression in cultured fibroblasts of large burned patients.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)UNIFESP-EPM Department of SurgeryUNIFESP-EPMUNIFESP-EPM Department of GynecologyUniversidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Department of SurgeryUNIFESP, EPM, Department of SurgeryUNIFESP-EPMUNIFESP, EPM Department of GynecologyUNIFESP, EPM, Department of SurgeryFAPESP: 2011/12945-4FAPESP: 2011/23.985-7SciEL

    Learning Sustainability with EPS@ISEP – Development of an Insectarium

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    8th International Symposium on Project Approaches in Engineering Education (PAEE)Sustainability plays a key role in EPS@ISEP programme - the European Project Semester programme at the School of Engineering of the Polytechnics of Porto. Not just the environmental, but also economical (marketing) and social (ethics) perspectives are explored by multicultural teams during this one semester capstone/internship programme. In 2015, a team of EPS@ISEP students choose to design and develop an insectarium to grow insects for reptile feeding. The team, after exploiting the topic, contemplated growing insects not only for animal feed, but also for human food. Their motivation resulted from the fact that insects, when compared with traditional sources of protein, are more sustainable, i.e., require considerably less resources per kg of protein. This approach, in the current Earth’s population growth scenario, contributes to minimise the resources required for meeting food needs. The main goal of the proposal was to raise the awareness of the participants regarding sustainable development while creating a functional, cost-effective, ecofriendly and attractive prototype. The team, driven by this multidisciplinary problem, performed: (i) a survey of competing products; (ii) a selection of the insect species to grow based on the study and comparison of the life cycle and habitat requirements of different species of insects; (iii) a marketing plan; (iv) a sustainability and an ethic and deontological analysis of the proposed solution; and (v) the design, assembling and testing of the prototype. Furthermore, the students also developed cross-cultural understanding, teamwork and communication skills. The project provided an excellent opportunity to foster the concept of sustainable development amongst the students

    Covid-19 pandemic impacts on follow-up of child growth and development

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    OBJECTIVE To analyze the impact of the covid-19 pandemic on the use of primary health care services to follow-up the child growth and development in Brazil. METHOD A total of 7.9 million consultations of children (0–2 years old) across Brazil between March 2017 and May 2020 were studied. Differences between medians were analyzed using non-parametric tests, the Global Moran Index (IGM) and the Local Indicators of Spatial Association. RESULTS During the initial period of the pandemic, the median number of consultations was significantly lower than the same period in previous years, reducing more than 50%. The drop in 2020, compared to 2019, ranged from 49% to 62.2% across all regions of the country, except the South. The percentage reduction registered in 2019–2020 showed significant spatial autocorrelation (IGM = 0.20; p = 0.04), with the presence of low-low (states with reduction between 29% and 51%) and high-high (states with reduction between 55% and 69%) spatial clusters. CONCLUSION The covid-19 pandemic impacted the follow-up of child growth and development in primary health care services in Brazil, with a geographically uneven reduction

    Do patients lose weight after total hip arthroplasty?

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    AbstractObjectiveTo investigate the effect of total hip arthroplasty (THA) on body mass index (BMI), from before to after the operation.Methods100 patients who underwent THA were retrospectively analyzed. They were stratified according to BMI, as proposed by the World Health Organization (WHO).ResultsThere were 48 male patients and 52 female patients. Their mean age was 63.8±13.5 years. The mean follow-up was 24.6±0.6 months. The men had a mean preoperative BMI of 28.4±3.6kg/m2 and the women, 27.5±5.0kg/m2. The mean postoperative BMI was 28.9±0.7kg/m2 for the men and 27.8±0.7kg/m2 for the women. There was a general mean increase in BMI of 0.4kg/m2. The BMI increased both in patients with normal weight and in those who were overweight, but it decreased slightly in patients who were obese. BMI remained unchanged in the majority of the patients (73%).ConclusionThe improvement in mobility achieved through THA did not promote any reduction in anthropometric measurements in the majority of the patients

    Occurrence records and metadata for sand flies (Diptera, Psychodidae, Phlebotominae) collected in the lands of indigenous people in the Brazilian Amazon

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    In order to contribute to knowledge of the epidemiology of American cutaneous leishmaniasis (ACL) among indigenous people living in sylvatic regions, we studied the sand fly fauna collected in areas of disease transmission in the Brazilian Amazon. Our two datasets reported here are comprised of occurrence data for sand flies from the Suruwaha Indigenous Land in the state of Amazonas collected between 2012-1013, and the Wajãpi Indigenous Land in the state of Amapá collected between 2013-2014. Sand flies were collected using unbaited CDC-like light traps at various sites within each study area and were identified to species-level by taxonomists with expertise in Amazonian fauna. A total of 4,646 records are reported: 1,428 from the Suruwaha and 3,218 from the Wajãpi. These records will contribute to a better understanding of ACL transmission dynamics, as well as the distribution of insect vectors, in these areas

    PREVALÊNCIA E FATORES DE RISCO PARA A PRÉ-ECLÂMPSIA EM GESTANTES

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    Preeclampsia is a serious disease of pregnancy characterized by hypertension and organ failure in premature women. Prevalence varies depending on known risk factors, including history of preeclampsia, chronic kidney disease, hypertension, obesity, and multiple pregnancies. The exact cause is still unknown, but genetic, immunological and blood disorders are thought to play a role. The placenta plays an important role in the development of preeclampsia. The adverse effects of trophoblastic invasion and vascular remodeling result in a lack of oxygen and nutrients in the placenta, leading to the release of vasoactive and pro-inflammatory substances into the maternal circulation. Furthermore, maternal mortality associated with preeclampsia is accompanied by clinical symptoms such as anemia, proteinuria, hematological disorders, liver disease, kidney damage, and cerebrovascular changes. The diagnosis is based on the presence of hemorrhagic syndrome combined with signs of proteinuria and organ failure after 20 weeks of gestation. Treatment methods are multifaceted and, in mild cases, bed rest, salt restriction and increased fluid intake are recommended. However, in severe cases, anticoagulants such as magnesium sulfate should be used to prevent seizures and reduce the risk of maternal and fetal complications. The diagnosis of pre-eclampsia also depends on the severity of the disease and the time of delivery. Serious complications may occur, including eclampsia, kidney disease, bleeding, and fetal growth restriction. Finally, measures to prevent preeclampsia, such as the use of low-dose aspirin in high-risk pregnant women and early intervention for women with a history of preeclampsia, may reduce risk and improve outcomes. Understanding risk factors, underlying mechanisms, early diagnosis, and treatment options are important for improving maternal and fetal outcomes.A pré-eclâmpsia é uma doença grave da gravidez caracterizada por hipertensão e falência de órgãos em mulheres prematuras. A prevalência varia de acordo com fatores de risco conhecidos, incluindo história de pré-eclâmpsia, doença renal crônica, hipertensão, obesidade e gestações múltiplas. A causa exata ainda é desconhecida, mas acredita-se que doenças genéticas, imunológicas e sanguíneas desempenhem um papel. A placenta desempenha um papel importante no desenvolvimento da pré-eclâmpsia. Os efeitos adversos da invasão trofoblástica e da remodelação vascular resultam na falta de oxigênio e nutrientes na placenta, levando à liberação de substâncias vasoativas e pró-inflamatórias na circulação materna. Além disso, a mortalidade materna associada à pré-eclâmpsia é acompanhada por sintomas clínicos como anemia, proteinúria, distúrbios hematológicos, doenças hepáticas, danos renais e alterações cerebrovasculares. O diagnóstico é baseado na presença de síndrome hemorrágica combinada com sinais de proteinúria e falência de órgãos após 20 semanas de gestação. Os métodos de tratamento são multifacetados e, nos casos leves, recomenda-se repouso no leito, restrição de sal e aumento da ingestão de líquidos. Contudo, em casos graves, devem ser utilizados anticoagulantes como o sulfato de magnésio para prevenir convulsões e reduzir o risco de complicações maternas e fetais. O diagnóstico da pré-eclâmpsia também depende da gravidade da doença e do momento do parto. Podem ocorrer complicações graves, incluindo eclâmpsia, doença renal, sangramento e restrição do crescimento fetal. Finalmente, medidas para prevenir a pré-eclâmpsia, como o uso de aspirina em baixas doses em mulheres grávidas de alto risco e a intervenção precoce para mulheres com histórico de pré-eclâmpsia, podem reduzir o risco e melhorar os resultados. Compreender os fatores de risco, os mecanismos subjacentes, o diagnóstico precoce e as opções de tratamento são importantes para melhorar os resultados maternos e fetais

    USE OF ATHEROGENIC INDICES AS ASSESSMENT METHODS FOR CLINICAL ATHEROSCLEROTIC DISEASES

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    Accurate assessment of clinical atherosclerotic diseases is essential to guide effective therapeutic interventions, and atherogenic indices have emerged as valuable methods in this setting. The complexity of these pathologies demands approaches that go beyond the simple measurement of total cholesterol, requiring tools that consider the interaction between different lipoproteins and other risk factors. In this context, the use of atherogenic indices appears as a promising approach, providing a more comprehensive and refined assessment of atherosclerotic conditions. Objective: To comprehensively analyze scientific studies published in the last 10 years that investigated the use of atherogenic indices as methods of evaluating clinical atherosclerotic diseases. The review seeks to consolidate the available evidence by examining the effectiveness of these indices in early identification, risk stratification and monitoring the progress of atherosclerotic diseases. Methodology: The systematic review was conducted following the PRISMA guidelines. The PubMed, Scielo and Web of Science databases were consulted to identify relevant studies published in the last 10 years. The descriptors used were "atherogenic indices", "atherosclerotic diseases", "clinical assessment", "lipoproteins" and "cardiovascular risk factors". Inclusion criteria considered original studies that investigated the use of atherogenic indices in clinical populations, while exclusion criteria involved studies with unrepresentative samples and inadequate atherosclerotic assessment methods. Results: The results of the review highlight the diversity of available atherogenic indices and their usefulness in evaluating different aspects of atherosclerotic diseases, including prediction of cardiovascular events, risk stratification and treatment monitoring. The analysis identified indices that proved to be particularly sensitive and specific in different clinical contexts. Conclusion: In summary, the systematic review highlights the relevance of atherogenic indices as valuable tools in the assessment of clinical atherosclerotic diseases. The diversity of these indices and their ability to provide comprehensive information highlights their importance in clinical practice, contributing to a more refined and personalized approach to the management of these conditions.Accurate assessment of clinical atherosclerotic diseases is essential to guide effective therapeutic interventions, and atherogenic indices have emerged as valuable methods in this setting. The complexity of these pathologies demands approaches that go beyond the simple measurement of total cholesterol, requiring tools that consider the interaction between different lipoproteins and other risk factors. In this context, the use of atherogenic indices appears as a promising approach, providing a more comprehensive and refined assessment of atherosclerotic conditions. Objective: To comprehensively analyze scientific studies published in the last 10 years that investigated the use of atherogenic indices as methods of evaluating clinical atherosclerotic diseases. The review seeks to consolidate the available evidence by examining the effectiveness of these indices in early identification, risk stratification and monitoring the progress of atherosclerotic diseases. Methodology: The systematic review was conducted following the PRISMA guidelines. The PubMed, Scielo and Web of Science databases were consulted to identify relevant studies published in the last 10 years. The descriptors used were "atherogenic indices", "atherosclerotic diseases", "clinical assessment", "lipoproteins" and "cardiovascular risk factors". Inclusion criteria considered original studies that investigated the use of atherogenic indices in clinical populations, while exclusion criteria involved studies with unrepresentative samples and inadequate atherosclerotic assessment methods. Results: The results of the review highlight the diversity of available atherogenic indices and their usefulness in evaluating different aspects of atherosclerotic diseases, including prediction of cardiovascular events, risk stratification and treatment monitoring. The analysis identified indices that proved to be particularly sensitive and specific in different clinical contexts. Conclusion: In summary, the systematic review highlights the relevance of atherogenic indices as valuable tools in the assessment of clinical atherosclerotic diseases. The diversity of these indices and their ability to provide comprehensive information highlights their importance in clinical practice, contributing to a more refined and personalized approach to the management of these conditions

    Population Prevalence of Trachoma in Nine Rural Non-Indigenous Evaluation Units of Brazil.

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    Purpose: To assess the contemporary prevalence of trachoma in Brazil's non-indigenous population, surveys of those thought to be at greatest risk of disease were conducted.Methods: Rural census tracts of non-indigenous population from nine mesoregions were selected to compose the survey evaluation units (EUs) by considering previously endemic municipalities at greatest risk of trachoma. In each of the nine EUs, we conducted a population-based prevalence survey. Every resident of selected households aged ≥1 year was examined for trachomatous inflammation - follicular (TF) and trachomatous trichiasis (TT). Additionally, data were collected on household-level access to water, sanitation, hygiene (WASH) and education.Results: A total of 27,962 individuals were examined across nine EUs. The age-adjusted TF prevalence in 1-9-year-olds was 99% of surveyed children.Conclusions: The prevalence of TF was well below the target for elimination as a public health problem in all EUs. Because EUs surveyed were selected to represent the highest-risk non-indigenous areas of the country, TF prevalence is unlikely to be ≥5% in non-indigenous populations elsewhere. In one EU, the prevalence of TT was above the target threshold for elimination. Further investigation and possibly improvement in TT surgical provision are required in that EU
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