De neguinha do Bará a Exú : a psicologia entrou para roda

O presente trabalho busca a partir da metodologia da roda investigar os conceitos encontrados ao longo da graduação da autora e refletir como eles auxiliaram a encontrar sentido na psicologia. O trabalho busca responder a pergunta: qual psicologia se produz ao colocarmos em roda os conceitos que eu encontrei ao longo do meu percurso acadêmico? Deste modo, é revisitado teorias como desenvolvimento humano, psicologia social, psicologia afro referenciada, acompanhamento terapêutico e psicologia africana. As discussões são disparadas por escrevivências em forma de memória, desenhos, música e escritas. Ao colocar as teorias em roda, nota-se muitos encontros entre elas e que as suas respostas para cada fenômeno podem ser diferentes e necessárias no mesmo contexto. Logo, a roda dos conceitos encontrados ao longo do percurso acadêmico da autora constituiu uma psicologia das encruzilhadas.The present work seeks, from the methodology of the circle, to investigate the concepts found throughout the author's graduation and reflect on how they helped to find meaning in psychology. The work seeks to answer the question: what psychology is produced when we put together the concepts that I found throughout my academic career? In this way, theories such as human development, social psychology, Afro-referenced psychology, therapeutic accompaniment and African psychology are revisited. Discussions are triggered by escrevivências in the form of memory, drawings, music and writing. When putting theories in a circle, it is noticed many encounters between them and that their answers to each phenomenon may be different and necessary in the same context. Therefore, the circle of concepts found throughout the author's academic career constituted a psychology of encruzilhadas

Optimization of gold core-mesoporous silica shell functionalization with TPGS and PEI for cancer therapy

Photothermal therapy (PTT) has captured the attention of different researchers around the world, since the application of NIR light responsive-nanomaterials has shown promising results in cancer therapy. Gold-core mesoporous silica shell (Au-MSS) nanoparticles allow the combination of gold mediated PTT with the drug delivery in order to improve their therapeutic potential. In this study, two different methodologies, electrostatic or chemical linkage, were explored to functionalize Au-MSS nanorods with TPGS and PEI. For that purpose, the TPGS and PEI were chemically coupled to each other or modified with 3-(triethoxysilyl)propyl isocyanate. The produced Au-MSS nanorods display a uniform morphology and a well-defined gold nucleus and silica shell. Further, the particles surface charge was dependent on the synthesis methodology. The particles modified by electrostatic interactions (Au-MSS/TPGS-PEI) were slightly negative (−16.9 and −5.1 mV) whereas the formulations produced by chemical linkage (Au-MSS/TPGS/PEI) resulted in positively charged nanoparticles (30.9 and 6.8 mV). The successful incorporation of the polymers was confirmed by Fourier Transformed Infrared spectroscopy and thermogravimetric analysis. Moreover, the Au-MSS functionalization did not affect the particles PTT capacity. However, the Au-MSS/TPGS/PEI nanorods displayed a decreased drug encapsulation efficiency. In vitro assays demonstrated the cytocompatibility of Au-MSS up to concentrations of 200 μg/mL, however the positively charged formulations only remained biocompatible until 100 and 125 μg/mL. Overall, the attained data confirm the successful modification of Au-MSS nanorods with TPGS and PEI as well as their applicability as PTT and drug delivery agents.info:eu-repo/semantics/publishedVersio

Technology and special educational needs: let's play “Doing Good Deeds!”

“Doing Good Deeds!” is a game directed to children with special needs, in pre and elementary school age that aims to promote the development of social skills in diferente contexts. Structurally, this game has available a set of Avatars that players can choose to represent them. To adapt the game to each child, an administration module was developed, corresponding to the back office of the game, which allows the educator to create or change contexts, difficulty levels and sequences. This module includes also the visualization of the user performance, in particular the duration of each game, the number of attempts with and without success, allowing the educator to analyze the progress of each player.The authors would like to express their acknowledgments to COMPETE: POCI-01-0145-FEDER-007043 and FCT – Fundação para a Ciência e Tecnologia within the Project Scope: UID/CEC/00319/2013 for the support. The authors are also grateful to the Portuguese Foundation for the Science and Technology (FCT) through the financial support, Pest-OE/CED/UI1661/2014 projects, FEDER funds through the Competitivity Factors Operational Program – COMPETE.info:eu-repo/semantics/publishedVersio

Biodegradation and metabolic pathway of the neonicotinoid insecticide thiamethoxam by Labrys portucalensis F11

Thiamethoxam (TMX) is an effective neonicotinoid insecticide. However, its widespread use is detrimental to non-targeted organisms and water systems. This study investigates the biodegradation of this insecticide by Labrys portucalensis F11. After 30 days of incubation in mineral salt medium, L. portucalensis F11 was able to remove 41%, 35% and 100% of a supplied amount of TMX (10.8 mg L−1) provided as the sole carbon and nitrogen source, the sole carbon and sulfur source and as the sole carbon source, respectively. Periodic feeding with sodium acetate as the supplementary carbon source resulted in faster degradation of TMX (10.8 mg L−1); more than 90% was removed in 3 days. The detection and identification of biodegradation intermediates was performed by UPLC-QTOF/MS/MS. The chemical structure of 12 metabolites is proposed. Nitro reduction, oxadiazine ring cleavage and dechlorination are the main degradation pathways proposed. After biodegradation, toxicity was removed as indicated using Aliivibrio fischeri and by assessing the synthesis of an inducible β-galactosidase by an E. coli mutant (Toxi-Chromo test). L. portucalensis F11 was able to degrade TMX under different conditions and could be effective in bioremediation strategies.info:eu-repo/semantics/publishedVersio

Aspectos sociais, econômicos e ambientais de comunidades pesqueiras de uma reserva extrativista marinha na Amazônia paraense

In the Amazon, among the several population groups dedicated to extractivism, those related to artisanal fishing stand out and are representative of the population who lives in line with the rivers and the sea. The objective of this study was to analyze and trace the socio-environmental profile of artisanal fishermen living in three fishing communities in the municipality of Bragança, northeastern Pará state, in the Caeté-Taperaçu Marine Extractive Reserve. To this end, interviews were carried out through questionnaires to 251 families of artisanal fishermen, between men and women, 85 (33.86%) from Vila dos Pescadores, 96 (38.25%) from Vila do Castelo and 70 (27.89 %) from Vila do Taperuçu. The results indicate the age of respondents between 18 and 55 years old, found low schooling, most have their own house, and annual income ranging from R$3,905.85 to R$ 5,506.56. Access to water is through the distribution network and the provision of urban cleaning services serves almost 50% of communities. The results obtained allowed us to trace a social, economic, and environmental profile of artisanal fishermen from fishing communities in the extractive reserve, which could serve as a basis for the generation of subsidies that involve the implementation of public policies that are directed to artisanal fishermen in the conservation unit in question.En la Amazonía, entre los diversos grupos poblacionales dedicados al extractivismo, se destacan los relacionados con la pesca artesanal y son representativos de la población que vive en la ribera de los ríos y el mar. El estudio tiene como objetivo analizar y rastrear el perfil socioambiental de los pescadores artesanales que residen en tres comunidades pesqueras en el municipio de Bragança, al noreste del estado de Pará, en la Reserva de Extracción Marina Caeté-Taperaçu. Para ello, se realizaron entrevistas a través de cuestionarios a 251 familias de pescadores artesanales, entre hombres y mujeres, siendo 85 (33,86%) de Vila dos Pescadores, 96 (38,25%) de Vila do Castelo y 70 (27,89%) de Vila hacer Taperuçu. Los resultados indican que la edad de los encuestados entre 18 y 55 años, encontró baja escolaridad, la mayoría tiene casa propia e ingresos anuales que oscilan entre R$3.905,85 y R$ 5.506,56. El acceso al agua es a través de la red de distribución y la prestación de los servicios de limpieza urbana atienden a casi el 50% de las comunidades. Los resultados obtenidos permitieron trazar un perfil social, económico y ambiental de los pescadores artesanales de las comunidades pesqueras de la reserva extractiva, que podría servir de base para la generación de subsidios que impliquen la implementación de políticas públicas que estén dirigidas a los pescadores artesanales en la unidad de conservación en cuestión.Na Amazônia, entre os vários grupos populacionais que se dedicam ao extrativismo, destacam-se os que estão relacionados à pesca praticada de forma artesanal e são representativos da população que habita em consonância aos rios e o mar. O estudo objetiva a caracterização social, econômica e ambiental em três comunidades pertencentes a Reserva Extrativista Marinha Caeté- Taperuçu e, para assim, contribuir para traçar o perfil de pescadores que residem em três comunidades pesqueiras do município de Bragança, nordeste do estado do Pará, na Reserva Extrativista Marinha Caeté-Taperaçu. Foi realizada entrevista através de questionários a 251 famílias de pescadores artesanais entre homens e mulheres, sendo 85 (33,86%) da Vila dos Pescadores, 96 (38,25%) da Vila do Castelo e 70 (27,89%) da Vila do Taperuçu. Os resultados indicam a idade dos entrevistados entre 18 e 55 anos, constatou baixa escolaridade, a maioria possui casa própria e renda anual variando de R$3.905,85 a R$5.506,56. O acesso à água se dá pela rede de distribuição e a disponibilização dos serviços de limpeza urbana atendem quase 50% das comunidades. Os resultados obtidos permitiram obter um perfil social, econômico e ambiental dos pescadores artesanais de comunidades pesqueiras na reserva extrativista, podendo contribuir como base para a geração de subsídios que envolvam a implementação de políticas públicas que esteja direcionada a pescadores artesanais na unidade de conservação em questão

Bacterial strain labrys portucalensis F11 degrades the neonicotinoid insecticide thiamethoxam and removes toxicity

info:eu-repo/semantics/publishedVersio

Combinatorial delivery of doxorubicin and acridine orange by gold core silica shell nanospheres functionalized with poly(ethylene glycol) and 4- methoxybenzamide for cancer targeted therapy

Combinatorial therapies based on the simultaneous administration of multiple drugs can lead to synergistic effects, increasing the efficacy of the cancer therapy. However, it is crucial to develop new delivery systems that can increase the drugs' therapeutic selectivity and efficacy. Gold core silica shell (AuMSS) nanoparticles present physicochemical properties that allow their simultaneous application as drug delivery and imaging agents. Herein, poly(ethylene glycol) was modified with 4-methoxybenzamide and 3- (triethoxysilyl)propyl isocyanate (TPANIS) to create a novel surface functionalization capable of improving the colloidal stability and specificity of AuMSS nanospheres towards cancer cells. Moreover, a dual drug combination based on Doxorubicin (DOX) and Acridine orange (AO) was characterized and administered using the AuMSS-TPANIS nanospheres. The obtained results show that the DOX:AO drug combination can mediate a synergistic therapeutic effect in both HeLa and MCF-7 cells, particularly at the 2:1, 1:1, and 1:2 ratios. Otherwise, the TPANIS functionalization increased the AuMSS nanospheres colloidal stability and selectivity towards MCF-7 cancer cells (overexpressing sigma receptors). Such also resulted in an enhanced cytotoxic effect against MCF-7 cells when administering the DOX:AO drug combination with the AuMSSTPANIS nanospheres. Overall, the obtained results confirm the therapeutic potential of the DOX:AO drug combination as well as the targeting capacity of AuMSS-TPANIS, supporting its application in the cancer targeted combinatorial chemotherapy.info:eu-repo/semantics/acceptedVersio

Promoting reminiscences with virtual reality headsets: A pilot study with people with dementia

This study aimed to explore the feasibility and effects of promoting reminiscences, using virtual reality (VR) headsets for viewing 360° videos with personal relevance, with people with dementia. A study with a mixed methods design was conducted with nine older adults diagnosed with dementia. Interventions consisted of four sessions, in which the participants’ engagement, psychological and behavioral symptoms, and simulation sickness symptoms were evaluated. Neuropsychiatric symptomatology and quality of life were measured pre- and post-intervention. Caregivers were interviewed regarding the effect of the approach. In most cases, participants appeared to enjoy the sessions, actively explored the 360° environment, and shared memories associated with the depicted locations, often spontaneously.info:eu-repo/semantics/publishedVersio