Multiparameter ergodic Cesàro-α averages

Let (X,F,ν) be a σ-finite measure space. Associated with k Lamperti operators on Lp(ν), T1,…,Tk, nˉ=(n1,…,nk)∈Nk and αˉ=(α1,…,αk) with 0<αj≤1, we define the ergodic Cesàro-αˉ averages Rnˉ,αˉf=1∏kj=1Aαjnj∑ik=0nk⋯∑i1=0n1∏j=1kAαj−1nj−ijTikk⋯Ti11f. For these averages we prove the almost everywhere convergence on X and the convergence in the Lp(ν) norm, when n1,…,nk→∞ independently, for all f∈Lp(dν) with p>1/α∗ where α∗=min1≤j≤kαj. In the limit case p=1/α∗, we prove that the averages Rnˉ,αˉf converge almost everywhere on X for all f in the Orlicz–Lorentz space Λ(1/α∗,φm−1) with φm(t)=t(1+log+t)m. To obtain the result in the limit case we need to study inequalities for the composition of operators Ti that are of restricted weak type (pi,pi). As another application of these inequalities we also study the strong Cesàro-αˉ continuity of functions.Fil: Bernardis, Ana Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Matemática Aplicada del Litoral. Universidad Nacional del Litoral. Instituto de Matemática Aplicada del Litoral; ArgentinaFil: Crescimbeni, Raquel Liliana. Universidad Nacional del Comahue; ArgentinaFil: Ferrari Freire, Cecilia. Universidad Nacional del Comahue; Argentin

Qui a mis le roi en prison ?

Souvenirs d’un théâtre populaire Le théâtre des plus humbles : une politique culturelle Nous proposons dans cet article quelques réflexions sur le « théâtre populaire » d’après-guerre en France. Il semble qu’aujourd’hui nous donnons une connotation idéalisée, à la fois séduisante et floue, à la notion de et à l’expression « théâtre populaire ». Cette idée évoque en nous de nombreuses images que ce ..

Targeting pituitary adenylate cyclase-activating polypeptide (PACAP) with monoclonal antibodies in migraine prevention: a brief review

Introduction Interest is growing in the role of pituitary adenylate cyclase-activating polypeptide (PACAP) and its specific PAC1 receptor in migraine and in their antagonism as a strategy for migraine prevention. Areas covered We discuss and critically evaluate (i) the evidence of the role of PACAP in migraine pathophysiology and (ii) the first clinical trials in migraine prophylaxis with monoclonal antibodies AMG 301 and ALD1910 which act against PAC1 and PACAP38 respectively. We examined PubMed, Scopus, and ClinicalTrials.gov electronic databases to examine the relevant material. Expert opinion There is much proof of the ability of PACAP to cause migraine, but there is limited evidence that blocking PACAP or PAC1 receptor can prevent migraine. However, the potential of anti-PACAP antibodies in migraine prophylaxis is high. Theoretically, if these antibodies block the activation of the trigeminovascular system, they will prevent the onset of migraine attacks. There are still knowledge gaps in the role of PACAP in migraine and the risk/benefit ratio of anti-PACAP antibodies must be carefully studied

Effect of extreme temperature on egg development, larval and adult survival of Chordodes nobilii Camerano, 1901 (Gordiida, Nematomorpha)

On the basis of experimental studies we analyzed the effect of extreme temperatures on the aquatic free-living phases of the life cycle of Chordodes nobilii (Gordiida, Nematomorpha). Bioassays were performed with eggs, larvae, and adults. Eggs and larvae were exposed to 3°C below zero and 40.5°C; adults were exposed to 3°C below zero and to 38.5°C and 40.5°C. The results showed that egg development was inhibited in both tests. Exposed larvae showed a decrease in their infective capacity, which resulted almost null at 40.5°C. Adults exposed to 38.5°C showed mortality ≤10%, at 40.5°C the mortality was 100% and the adult's mortality at 3°C below zero was 89%. Results indicate that free living stages of Chordodes nobilii are susceptible to extreme temperatures.Facultad de Ciencias Naturales y Muse

Supervivencia de las laptops XO : ¿las características sociodemográficas de los alumnos inciden en la igualdad de acceso?

El presente trabajo tiene por objetivo estudiar la incidencia de las características sociodemográficas de los alumnos de Educación Primaria Pública de Uruguay en la supervivencia de las laptops XO de Plan Ceibal. El estudio sobre la sostenibilidad del acceso a la tecnología en el tiempo resulta de gran interés en tanto determina las condiciones de continuidad en el acceso a la información y a los recursos educativos digitales. La implementación de Plan Ceibal en 2007 ha tenido un fuerte impacto en la disminución de la brecha digital en términos de acceso. Asimismo, ha puesto a disposición de la comunidad educativa un gran número de herramientas educativas digitales que tienen como finalidad apoyar los procesos de aprendizaje y contribuir a la generación de capacidades de los alumnos promoviendo una educación de calidad. La sostenibilidad del parque de laptops y el acceso a las tecnologías de la información y comunicación es una de las tareas fundamentales para que todos los alumnos del sistema educativo público puedan acceder en cualquier momento y lugar a los diferentes recursos. En ese sentido, con la finalidad de promover la equidad e igualdad de oportunidades es que la investigación se propone analizar las funciones de supervivencia de los equipos de los diferentes perfiles sociodemográficos de los alumnos de manera que se puedan tomar acciones en base a evidencia empírica. Con esos fines se utiliza la técnica de Análisis de Historia de Eventos para la obtención de las tasas de riesgo y se estiman las funciones de supervivencia de las laptops de la generación de alumnos que en 2010 ingresaron a Educación Primaria. Apartir de la construcción de las tablas de vida se calculan las esperanzas de vida de las XO para los diferentes perfiles de alumnos. Las estimaciones realizadas reflejan que la vida útil de una XO aproximada por la esperanza de vida al momento de la entrega es de 1.084 días, lo que significa prácticamente 3 años, es decir 1 año antes de la fecha planificada de recambio por parte de Plan Ceibal. Además se observa que el contexto sociocultural, así como el género y el área geográfica de residencia del alumno son variables claves para determinar las tasas de riesgo a la rotura de los equipos. El perfil sociodemográfico del alumnado que presenta mayores tasas de riesgo a la rotura total de la laptop son los varones montevideanos de contextos socioculturales más desfavorables, con eventos de repetición de grado escolar en su trayectoria por Educación Primaria, y con registros previos de reparación en servicio técnico. Asimismo se identificó que la principal causa de rotura total de los equipos XO ha sido el teclad

BI as a service: an attempt to understand the leading adoption factors

The research question of this study attempts to identify which are the leading factors for the adoption of a sourcing Software as a Service model for Business Intelligence applications. The objective is to build a model containing enabling factors for the adoption of BI solutions. We seek to expand on the Benlian et al. model which is based on a theoretical framework including axioms from Transaction Cost Theory, Resource Based View, Theory of Planned Behavior. In order to better understand the phenomenon under investigation, we will use also the Organizational Culture Theory. It is a theoretical research in progress

Angiogenesis in Head and Neck Cancer: A Review of the Literature

Angiogenesis is a necessary process for tumor growth, progression and diffusion. In the last years many efforts have been made to understand the mechanisms necessary to the formation of new vessels in tumor tissue and how to integrate these findings in the treatment of different type of cancer. Thanks to these studies there are today many anti-angiogenic drugs with established activity in cancer and approved in clinical practice. Head and neck cancer is a common tumor worldwide that often has advanced stage at diagnosis and poor prognosis. Angiogenesis has a well recognized role in head and neck cancer progression and resistance to drugs and radiotherapy and many clinical trials has been conducted with antiangiogenic agents in this disease, even if they often showed limited efficacy. In this review we summarize the main trials published about angiogenesis in head and neck cancer with particular attention to factors involved in this process and the available data on the efficacy of treatment with anti-angiogenic agents in this disease

A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials

There is no treatment for the myelin loss in multiple sclerosis, ultimately resulting in the axonal degeneration that leads to the progressive phase of the disease. We established a multi-tiered platform for the sequential screening of drugs that could be repurposed as remyelinating agents. We screened a library of 2,000 compounds (mainly Food and Drug Administration (FDA)-approved compounds and natural products) for cellular metabolic activity on mouse oligodendrocyte precursors (OPC), identifying 42 molecules with significant stimulating effects. We then characterized the effects of these compounds on OPC proliferation and differentiation in mouse glial cultures, and on myelination and remyelination in organotypic cultures. Three molecules, edaravone, 5-methyl-7-methoxyisoflavone and lovastatin, gave positive results in all screening tiers. We validated the results by retesting independent stocks of the compounds, analyzing their purity, and performing dose-response curves. To identify the chemical features that may be modified to enhance the compounds' activity, we tested chemical analogs and identified, for edaravone, the functional groups that may be essential for its activity. Among the selected remyelinating candidates, edaravone appears to be of strong interest, also considering that this drug has been approved as a neuroprotective agent for acute ischemic stroke and amyotrophic lateral sclerosis in Japan