3,326 research outputs found
Hepatocyte growth factor stimulates neutrophil degranulation but not respiratory burst
Neutrophil function is regulated in part by cytokines with growth factor activities for different cell types. Hepatocyte growth factor (HGF) is a cytokine produced during injury to the liver and other organs. Neutrophils are numerous in such tissue injury sites and may be influenced by HGF. In the present study the effect of HGF on neutrophils was investigated. The data show that HGF at 1–10 ng/ml increased lysosomal enzyme release from both specific and azurophilic granules of cytochalasin-B treated neutrophils. The release of specific granule contents in response to N-formyl-methionyl-leucylphenylalanine was also increased by HGF. In contrast there were no significant effects of HGF on neutrophil respiratory burst, adherence or locomotion. It is concluded that HGF modulates neutrophil granule exocytosis
Tracking the connection between disorder and energy landscape in glasses using geologically hyperaged amber
Fossil amber offers the unique opportunity of investigating an amorphous
material which has been exploring its energy landscape for more than 110 Myears
of natural aging. By applying different x-ray scattering methods to amber
before and after annealing the sample to erase its thermal history, we identify
a link between the potential energy landscape and the structural and
vibrational properties of glasses. We find that hyperaging induces a depletion
of the vibrational density of states in the THz region, also ruling the sound
dispersion and attenuation properties of the corresponding acoustic waves.
Critically, this is accompanied by a densification with structural implications
different in nature from that caused by hydrostatic compression. Our results,
rationalized within the framework of fluctuating elasticity theory, reveal how
upon approaching the bottom of the potential energy landscape (9% decrease in
the fictive temperature ) the elastic matrix becomes increasingly less
disordered (6%) and longer-range correlated (22%).Comment: 9 pages, 10 figure
An estimate of attributable cases of alzheimer disease and vascular dementia due to modifiable risk factors. the impact of primary prevention in europe and in italy
Background:
Up to 53.7% of all cases of dementia are assumed to be due to Alzheimer disease (AD), while 15.8% are considered to be due to vascular dementia (VaD). In Europe, about 3 million cases of AD could be due to 7 potentially modifiable risk factors: diabetes, midlife hypertension and/or obesity, physical inactivity, depression, smoking, and low educational level.
Aims:
To estimate the number of VaD cases in Europe and the number of AD and VaD cases in Italy attributable to these 7 potentially modifiable risk factors.
Methods:
Assuming the nonindependence of the 7 risk factors, the adjusted combined population attributable risk (PAR) was estimated for AD and VaD.
Results:
In Europe, adjusted combined PAR was 31.4% for AD and 37.8% for VaD. The total number of attributable cases was 3,033,000 for AD and 873,000 for VaD. In Italy, assuming a 20% reduction of the prevalence of each risk factor, adjusted combined PAR decreased from 45.2 to 38.9% for AD and from 53.1 to 46.6% for VaD, implying a 6.4 and 6.5% reduction in the prevalence of AD and VaD, respectively.
Conclusion:
A relevant reduction of AD and VaD cases in Europe and Italy could be obtained through primary prevention
New results on pushdown module checking with imperfect information
Model checking of open pushdown systems (OPD) w.r.t. standard branching
temporal logics (pushdown module checking or PMC) has been recently
investigated in the literature, both in the context of environments with
perfect and imperfect information about the system (in the last case, the
environment has only a partial view of the system's control states and stack
content). For standard CTL, PMC with imperfect information is known to be
undecidable. If the stack content is assumed to be visible, then the problem is
decidable and 2EXPTIME-complete (matching the complexity of PMC with perfect
information against CTL). The decidability status of PMC with imperfect
information against CTL restricted to the case where the depth of the stack
content is visible is open. In this paper, we show that with this restriction,
PMC with imperfect information against CTL remains undecidable. On the other
hand, we individuate an interesting subclass of OPDS with visible stack content
depth such that PMC with imperfect information against the existential fragment
of CTL is decidable and in 2EXPTIME. Moreover, we show that the program
complexity of PMC with imperfect information and visible stack content against
CTL is 2EXPTIME-complete (hence, exponentially harder than the program
complexity of PMC with perfect information, which is known to be
EXPTIME-complete).Comment: In Proceedings GandALF 2011, arXiv:1106.081
Molecular anatomy of the human glucose 6-phosphate dehydrogenase core promoter
The gene encoding glucose 6-phosphate dehydrogenase (G6PD), which plays a pivotal role in cell defense against oxidative stress, is ubiquitously expressed at widely different levels in various tissues; moreover, G6PD expression is regulated by a number of stimuli. In this study we have analyzed the molecular anatomy of the G6PD core promoter. Our results indicate that the G6PD promoter is more complex than previously assumed; G6PD expression is under the control of several elements that are all required for correct promoter functioning and, furthermore, a still unidentified mammalian specific factor is needed. Copyright (C) 1998 Federation of European Biochemical Societies
On the Feasibility of Malware Authorship Attribution
There are many occasions in which the security community is interested to
discover the authorship of malware binaries, either for digital forensics
analysis of malware corpora or for thwarting live threats of malware invasion.
Such a discovery of authorship might be possible due to stylistic features
inherent to software codes written by human programmers. Existing studies of
authorship attribution of general purpose software mainly focus on source code,
which is typically based on the style of programs and environment. However,
those features critically depend on the availability of the program source
code, which is usually not the case when dealing with malware binaries. Such
program binaries often do not retain many semantic or stylistic features due to
the compilation process. Therefore, authorship attribution in the domain of
malware binaries based on features and styles that will survive the compilation
process is challenging. This paper provides the state of the art in this
literature. Further, we analyze the features involved in those techniques. By
using a case study, we identify features that can survive the compilation
process. Finally, we analyze existing works on binary authorship attribution
and study their applicability to real malware binaries.Comment: FPS 201
Displacement power spectrum measurement of a macroscopic optomechanical system at thermal equilibrium
The mirror relative motion of a suspended Fabry-Perot cavity is studied in
the frequency range 3-10 Hz. The experimental measurements presented in this
paper, have been performed at the Low Frequency Facility, a high finesse
optical cavity 1 cm long suspended to a mechanical seismic isolation system
identical to that one used in the VIRGO experiment. The measured relative
displacement power spectrum is compatible with a system at thermal equilibrium
within its environmental. In the frequency region above 3 Hz, where seismic
noise contamination is negligible, the measurement distribution is stationary
and Gaussian, as expected for a system at thermal equilibrium. Through a simple
mechanical model it is shown that: applying the fluctuation dissipation theorem
the measured power spectrum is reproduced below 90 Hz and noise induced by
external sources are below the measurement.Comment: 11 pages, 9 figures, 2 tables, to be submitte
Evaluation of borage extracts as potential biostimulant using a phenomic, agronomic, physiological and biochemical approach
Biostimulants are substances able to improve water and nutrient use efficiency and counteract stress factors by enhancing primary and secondary metabolism. Premise of the work was to exploit raw extracts from leaves (LE) or flowers (FE) of Borago officinalis L., to enhance yield and quality of Lactuca sativa ‘Longifolia,’ and to set up a protocol to assess their effects. To this aim, an integrated study on agronomic, physiological and biochemical aspects, including also a phenomic approach, has been adopted. Extracts were diluted to 1 or 10 mL L–1, sprayed onto lettuce plants at the middle of the growing cycle and 1 day before harvest. Control plants were treated with water. Non-destructive analyses were conducted to assess the effect of extracts on biomass with an innovative imaging technique, and on leaf photosynthetic efficiency (chlorophyll a fluorescence and leaf gas exchanges). At harvest, the levels of ethylene, photosynthetic pigments, nitrate, and primary (sucrose and total sugars) and secondary (total phenols and flavonoids) metabolites, including the activity and levels of phenylalanine ammonia lyase (PAL) were assessed. Moreover, a preliminary study of the effects during postharvest was performed. Borage extracts enhanced the primary metabolism by increasing leaf pigments and photosynthetic activity. Plant fresh weight increased upon treatments with 10 mL L–1 doses, as correctly estimated by multi-view angles images. Chlorophyll a fluorescence data showed that FEs were able to increase the number of active reaction centers per cross section; a similar trend was observed for the performance index. Ethylene was three-fold lower in FEs treatments. Nitrate and sugar levels did not change in response to the different treatments. Total flavonoids and phenols, as well as the total protein levels, the in vitro PAL specific activity, and the levels of PAL-like polypeptides were increased by all borage extracts, with particular regard to FEs. FEs also proved efficient in preventing degradation and inducing an increase in photosynthetic pigments during storage. In conclusion, borage extracts, with particular regard to the flower ones, appear to indeed exert biostimulant effects on lettuce; future work will be required to further investigate on their efficacy in different conditions and/or species
Epidural blood patch in Trendelenburg position pre-medicated with acetazolamide to treat spontaneous intracranial hypotension
Background: Spontaneous intracranial hypotension (SIH) is characterized by orthostatic headache, diffuse pachymeningeal enhancement on brain magnetic resonance imaging (MRI) and low cerebrospinal fluid (CSF) pressure. Treatment ranges from conservative management, such as bed rest, overhydration and caffeine, to invasive procedures, such as the autologous epidural blood patch (EBP), computed tomography (CT)-guided fibrin glue injection at the site of the leak and open surgical intervention. EBP has emerged as the treatment of choice for SIH when initial conservative measures fail to bring relief. Methods: Forty-two patients with SIH were treated with lumbar autologous EBP in Trendelenburg position preceded by pre-medication with acetazolamide. Results: A complete recovery was obtained in all patients after one (90%), two (5%) or three (5%) EBPs. After EBP, two patients (5%) also performed evacuation of bilateral chronic subdural hematoma with mass effect. Conclusions: Spontaneous intracranial hypotension can be effectively cured by lumbar autologous EBP in Trendelenburg position pre-medicated with acetazolamide
Extensive Spectroscopy and Photometry of the Type IIP Supernova 2013ej
We present extensive optical (, , and open CCD) and
near-infrared () photometry for the very nearby Type IIP SN ~2013ej
extending from +1 to +461 days after shock breakout, estimated to be MJD
. Substantial time series ultraviolet and optical spectroscopy
obtained from +8 to +135 days are also presented. Considering well-observed SNe
IIP from the literature, we derive bolometric calibrations from
and unfiltered measurements that potentially reach 2\% precision with a
color-dependent correction. We observe moderately strong Si II
as early as +8 days. The photospheric velocity () is
determined by modeling the spectra in the vicinity of Fe II
whenever observed, and interpolating at photometric epochs based on a
semianalytic method. This gives km s at +50
days. We also observe spectral homogeneity of ultraviolet spectra at +10--12
days for SNe IIP, while variations are evident a week after explosion. Using
the expanding photosphere method, from combined analysis of SN 2013ej and SN
2002ap, we estimate the distance to the host galaxy to be
Mpc, consistent with distance estimates from other methods. Photometric and
spectroscopic analysis during the plateau phase, which we estimated to be
days long, yields an explosion energy of
ergs, a final pre-explosion progenitor mass of ~M and a
radius of ~R. We observe a broken exponential profile beyond
+120 days, with a break point at + days. Measurements beyond this
break time yield a Ni mass of ~M.Comment: 29 pages, 23 figures, 15 tables, Published in The Astrophisical
Journa
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