Coexistence of predators in time: Effects of season and prey availability on species activity within a Mediterranean carnivore guild

The degree of coexistence among predators can determine the structure of ecological communities. Niche partitioning is a common strategy applied by species to enhance their coexistence. Diet, habitat, or time use can be responsible for segregation among carnivore species, the latter factor being the least studied in Mediterranean ecosystems. Terrestrial medium‐sized carnivores (i.e., mesocarnivores) carry out important functions in ecosystems, and identifying their interactions is essential for their conservation. In this study, we explore the activity of a terrestrial mesocarnivore guild in order to determine seasonal differences in daily activity patterns of competitors and prey. We also investigate how the abundance of a common mesocarnivore prey in the region, small mammals, influences the activity of predators. During a year, camera trap devices (n = 18) were installed in Montseny Natural Park (Catalan Pre‐Coastal Range, North‐East Iberian Peninsula), a region that hosts five mesocarnivore species. Camera trapping detections were used to estimate their daily activity patterns and corresponding overlaps. We also surveyed small mammal plots (n = 5) in order to calculate prey abundance and test its effect on the relative activity of each carnivore species. Despite all target mesocarnivores are mainly nocturnal, the activity overlap among them varies according to species particularities and season. Red fox (Vulpes vulpes) appears as a generalist species in terms of time use, whereas stone marten (Martes foina) and genet (Genetta genetta) show the most similar activity patterns and both of them seem to be positively influenced by small mammal abundance. Overall, the diversity found in the way mesocarnivore species use time could facilitate their coexistence. Despite activity pattern similarities among carnivore species should not be directly translated to negative interactions, they can have a strong influence in habitat and resource‐limited ecosystems. Therefore, activity overlaps should be taken into account when discussing wildlife management actions

Secular changes in length of day: Effect of the mass redistribution

In this paper the secular change in the length of day due to mass redistribution effects is revisited using the Hamiltonian formalism of the Earth rotation theories. The framework is a two-layer deformable Earth model including dissipative effects at the core–mantle boundary, which are described through a coupling torque formulated by means of generalized forces. The theoretical development leads to the introduction of an effective time-averaged polar inertia moment, which allows us to quantify the level of core–mantle coupling throughout the secular evolution of the Earth. Taking advantage of the canonical procedure, we obtain a closed analytical formula for the secular deceleration of the rotation rate, numerical evaluation of which is performed using frequency-dependent Love numbers corresponding to solid and oceanic tides. With this Earth modeling, under the widespread assumption of totally coupled core and mantle layers in the long term response, a secular angular acceleration of − 1328.6′′ cy−2 is obtained, which is equivalent to an increase of 2.418 ms cy−1 in the length of day. The ocean tides and the semidiurnal band of the mass-redistribution-perturbing potential, mostly induced by the Moon, constitute the main part of this deceleration. This estimate is shown to be in very good agreement with recent observational values, and with other theoretical predictions including comparable modeling features

Redundant regulation of meristem identity and plant architecture by FRUITFULL, APETALA1 and CAULIFLOWER

The transition from vegetative to reproductive phases during Arabidopsis development is the result of a complex interaction of environmental and endogenous factors. One of the key regulators of this transition is LEAFY (LFY), whose threshold levels of activity are proposed to mediate the initiation of flowers. The closely related APETALA1 (AP1) and CAULIFLOWER (CAL) meristem identity genes are also important for flower initiation, in part because of their roles in upregulating LFY expression. We have found that mutations in the FRUITFULL (FUL) MADS-box gene, when combined with mutations in AP1 and GAL, lead to a dramatic non-flowering phenotype in which plants continuously elaborate leafy shoots in place of flowers. We demonstrate that this phenotype is caused both by the lack of LFY upregulation and by the ectopic expression of the TERMINAL FLOWER1 (TFL1) gene. Our results suggest that the FUL, AP1 and CAL genes act redundantly to control inflorescence architecture by affecting the domains of LFY and TFL1 expression as well as the relative levels of their activities

Value-Based Differential Pricing: Efficient Prices for Drugs in a Global Context

This paper analyzes pharmaceutical pricing between and within countries to achieve second-best static and dynamic efficiency. We distinguish countries with and without universal insurance, because insurance undermines patients\u27 price sensitivity, potentially leading to prices above second-best efficient levels. In countries with universal insurance, if each payer unilaterally sets an incremental cost-effectiveness ratio (ICER) threshold based on its citizens\u27 willingness-to-pay for health; manufacturers price to that ICER threshold; and payers limit reimbursement to patients for whom a drug is cost-effective at that price and ICER, then the resulting price levels and use within each country and price differentials across countries are roughly consistent with second-best static and dynamic efficiency. These value-based prices are expected to differ cross-nationally with per capita income and be broadly consistent with Ramsey optimal prices. Countries without comprehensive insurance avoid its distorting effects on prices but also lack financial protection and affordability for the poor. Improving pricing efficiency in these self-pay countries includes improving regulation and consumer information about product quality and enabling firms to price discriminate within and between countries

The FRUITFULL MADS-box gene mediates cell differentiation during Arabidopsis fruit development

Fruit morphogenesis is a process unique to flowering plants, and yet little is known about its developmental control, Following fertilization, fruits typically undergo a dramatic enlargement that is accompanied by differentiation of numerous distinct cell types. We have identified a mutation in Arabidopsis called fruitfull (ful-1), which abolishes elongation of the silique after fertilization. The ful-1 mutation is caused by the insertion of a DsE transposable enhancer trap element into the 5' untranslated leader of the AGL8 MADS-box gene. beta-glucuronidase (GUS) reporter gene expression in the enhancer trap line is observed specifically in all cell layers of the valve tissue, but not in the replum, the septum or the seeds, and faithfully mimics RNA in situ hybridization data reported previously, The lack of coordinated growth of the fruit tissues leads to crowded seeds, a failure of dehiscence and, frequently, the premature rupture of the carpel valves, The primary defect of ful-1 fruits is within the valves, whose cells fail to elongate and differentiate. Stomata, which are frequent along the epidermis of wild-type valves, are completely eliminated in the ful mutant valves. In addition to the effect on fruit development, ful cauline leaves are broader than those of wild type and show a reduction in the number of internal cell layers. These data suggest that AGL8/FUL regulates the transcription of genes required for cellular differentiation during fruit and leaf development

Teaching operations management to lawyers

[EN] This paper deals with a problem present in most Master in Business Administration (MBA) classrooms. This problem is the heterogeneity of students and their backgrounds. Different backgrounds pose a challenge to teachers that require the use of quantitative techniques such as optimization within an Operations Management subject. Engineers and other students with mathematical training probably get bored if the level is too low. On the contrary, Lawyers and other students without technical background usually find contents cumbersome. This paper aims to find a compromise between the heterogeneity of backgrounds and the fulfilment of learning objectives for students of Operations Management in an MBA. To this end, we propose a methodology to support the selection of teaching methods from a multiobjective perspective. The results derived from this methodology enable professors to consider their particular preferences and to integrate important decision-making principles by selecting the appropriate distance function to an ideal point that acts as a reference.Salas-Molina, F.; Vercher-Ferrandiz, M.; Pla Santamaría, D.; Garcia-Bernabeu, A. (2022). Teaching operations management to lawyers. IATED. 9293-9299. https://doi.org/10.21125/edulearn.2022.22399293929

Development and characterization of bioactive alginate microcapsules with cedarwood essential oil

In this work, sodium alginate microcapsules containing cedarwood essential oil (CWO) for uses in anti-acne tonic were prepared by ionic gelification of alginate with calcium chloride (CaCl2) and subsequent addition of glutaraldehyde to improve the crosslinking degree. Alginate microcapsules with cedarwood essential oil were obtained in an encapsulator with a 600 μm nozzle using different alginate concentrations (1, 3 and 4% w/v) , and different compositions of the coagulation solution with CaCl2 concentrations of 0.1, 0.25 and 0.5 M, and addition of glutaraldehyde at two concentrations: 12.5% and 50% (0.1 g L−1 and 10 g L−1, respectively). The effect of alginate concentration was followed by viscosimetry and the influence of the CaCl2 concentration and presence of glutaraldehyde on the microcapsules' shape as well as the total content on encapsulated cedarwood essential oil were evaluated by means of stereoscopic magnifying glass, scanning electron microscopy (SEM) and UV vis spectrophotometry. Results show that proper shape formation is obtained for an alginate concentration of 3% w/v. With regard to the total encapsulated cedarwood oil, as the CaCl2 concentration in the gelifying-coagulating solution increases the efficiency of the encapsulated oil. Best results in terms of micro-bead shape and total amount of encapsulated oil were obtained for a CaCl2 concentration of 0.5 M without glutaraldehyde with a maximum encapsulation of 177.2 mg per gram of microcapsule.Ferrandiz, M.; Lopez, A.; Franco, E.; Garcia-Garcia, D.; Fenollar, D.; Balart, R. (2017). Development and characterization of bioactive alginate microcapsules with cedarwood essential oil. Flavour and Fragrance Journal. 32(3):184-190. doi:10.1002/ffj.3373S18419032

Precession of the non-rigid Earth: Effect of the mass redistribution

This research is focused on determining the contribution to the precession of the Earth’s equator due to the mass redistribution stemming from the gravitational action of the Moon and the Sun on a rotating solid Earth. In the IAU2006 precession theory, this effect is taken into account through a contribution of −0.960 mas cy−1 for the precession in longitude (with the unspecific name of non-linear effect). In this work, the revised value of that second-order contribution reaches −37.847 mas cy−1 when using the Love numbers values given in IERS Conventions, and −43.945 mas cy−1 if those values are supplemented with the contributions of the oceanic tides. Such variations impose a change of the first-order precession value that induces relative changes of the Earth’s dynamical ellipticity of about 7.3 and 8.5 ppm, respectively. The corresponding values for the obliquity rate are 0.0751 and 0.9341 mas cy−1, respectively, in contrast to 0.340 mas cy−1 considered in IAU2006. The fundamentals of the modeling have been revisited by giving a clear construction of the redistribution potential of the Earth through the corresponding changes in the Earth tensor of inertia. The dynamical problem is tackled within the Hamiltonian framework of a two-layer Earth model, introduced and developed by Getino and Ferrándiz. This approach allows for the achievement of closed-analytical formulae for the precession in longitude and obliquity. It makes it possible to obtain numerical values for different Earth models once a set of associated Love numbers is selected. The research is completed with a discussion on the permanent tide and the related estimation of the variation of the second degree zonal Stokes parameter, J2, and also the indirect effects on nutations arising from the relative change of the Earth’s dynamical ellipticity.This work has been partially supported by the Spanish project AYA2016-79775-P (AEI/FEDER, UE)

Forecasting pharmaceutical expenditure in Europe : adjusting for the impact of rebates and discounts

European healthcare systems are under constant pressure to contain healthcare expenditure. Understanding future drug expenditure is an important consideration for payers when formulating policies. QuintileIMS publishes European forecasts that are underpinned by its audited volume data and publicly available list prices. With increasing price pressures, list to net price divergence is growing, although some of this information is commercially sensitive and thus not publicly available. The objective of this study was to further develop an established forecast to account for this divergence and explore its impact

The impact of information given to patients’ families: Breast cancer risk notification

ABSTRACT: A family history of breast cancer is a clear risk for developing the disease. Therefore, when a woman is diagnosed with breast cancer all her female first degree relatives become population at risk. This involve a number of important aspects to be taken into account by psychooncology professionals. (a) First, in addition to the stress associated with the diagnosis and treatment of breast cancer in a close relative, first degree relatives of breast cancer patients have the added stress of learning that they are at risk of this disease. (b) Second, these women become the main target of secondary breast cancer prevention strategies. However, various reports show that a considerable percentage of these women do not follow the recommended screening methods. For this reason, it is necesary to study the possible contribution of psychosocial factors, specially health beliefs, in the practice of preventive behavior aimed at preventing breast cancer in this population, and to design strategies to promote preventive practices. (c) Most of the research on health beliefs among women at risk for breat cancer has focused on risk perception. This research as found that some women with a family history of breast cancer have significantly overestimated their risk, while others have underestimated their risk. The need to provide risk counselling schemes for these women is therefore proposed, in order to estimate and advise them of their real risk. (d) Finally, these women may request genetic testing to determine whether they carry genetic mutations (BRCA1, BRCA2, or others) that cause some types of breast cancer. However, it must be remembered that, although many first degree relatives will have heard of and seek «the cancer gene test», currently testing is appropiate and available only for rare individuals. All these issues are reviewed in the present paper.ABSTRACT: Uma história familiar de cancro da mama é um factor de risco para o desenvolvimento da doença. Assim, quando é diagnosticado um cancro da mama a uma mulher, todas as mulheres suas familiares em primeiro grau são uma população em risco. Isto implica aspectos importantes que devem ser tidos em conta pelos profissionais de psico-oncologia. (a) Juntamente com o stress associado ao diagnóstico e tratamento do cancro numa familiar próxima, estas mulheres experimentam também o stress de saberem que também têm risco de desenvolverem a doença. (b) Estas mulheres tornam- -se, portanto, um grupo-alvo de estratégias de prevenção secundária do cancro da mama. Por esta razão, é necessário estudar a influência de factores psicossociais, especialmente das crenças de saúde, na prática de comportamentos especificamente direccionados para a prevenção do cancro da mama nessa população e, ao mesmo tempo, também é necessário delinear estratégias que promovam práticas preventivas. (c) A maior parte da investigação sobre as crenças de saúde de mulheres em risco de desenvolverem cancro da mama tem-se centrado na percepção de risco. Este estudo mostra que algumas mulheres com história familiar de cancro da mama sobrestimam significativamente o seu risco, enquanto outras o subestimam. Faz-se uma proposta de aconselhamento de risco, com a finalidade de avaliá-lo e aconselhar essas mulheres sobre o seu risco real. (d) Finalmente, estas mulheres podem necessitar de realizar testes genéticos para averiguar se são portadoras de marcadores relacionados com certos tipos de cancro da mama. Contudo, deve ser lembrado que, embora várias familiares em primeiro grau já tenham ouvido falar e solicitem fazer «o teste do gene do cancro », a sua realização só está indicada para algumas. Todos estes aspectos são revistos neste artigo.info:eu-repo/semantics/publishedVersio