Single cell molecular alterations reveal target cells and pathways of concussive brain injury.

The complex neuropathology of traumatic brain injury (TBI) is difficult to dissect, given the convoluted cytoarchitecture of affected brain regions such as the hippocampus. Hippocampal dysfunction during TBI results in cognitive decline that may escalate to other neurological disorders, the molecular basis of which is hidden in the genomic programs of individual cells. Using the unbiased single cell sequencing method Drop-seq, we report that concussive TBI affects previously undefined cell populations, in addition to classical hippocampal cell types. TBI also impacts cell type-specific genes and pathways and alters gene co-expression across cell types, suggesting hidden pathogenic mechanisms and therapeutic target pathways. Modulating the thyroid hormone pathway as informed by the T4 transporter transthyretin Ttr mitigates TBI-associated genomic and behavioral abnormalities. Thus, single cell genomics provides unique information about how TBI impacts diverse hippocampal cell types, adding new insights into the pathogenic pathways amenable to therapeutics in TBI and related disorders

MÉTODO GUIMARÃES DUQUE UMA TECNOLOGIA AGRÍCOLA PARA O SEMI-ÁRIDO NORDESTINO

Texto originalmente publicado pela Secretaria de Agricultura de Pernambuco e Ministério da Agricultura – DFA/PE, em comemoração ao Dia Nacional de Conservação do Solo, em abril de 1990. Manteve-se a grafia da época

Nonrenormalization of Flux Superpotentials in String Theory

Recent progress in understanding modulus stabilization in string theory relies on the existence of a non-renormalization theorem for the 4D compactifications of Type IIB supergravity which preserve N=1 supersymmetry. We provide a simple proof of this non-renormalization theorem for a broad class of Type IIB vacua using the known symmetries of these compactifications, thereby putting them on a similar footing as the better-known non-renormalization theorems of heterotic vacua without fluxes. The explicit dependence of the tree-level flux superpotential on the dilaton field makes the proof more subtle than in the absence of fluxes.Comment: 16 pages, no figures. Final version, to appear in JHEP. Arguments for validity of R-symmetry made more explicit. Minor extra comments and references adde

Spectral Ranking in Complex Networks Using Memristor Crossbars

Various centrality measures have been proposed to identify the influence of each node in a complex network. Among the most popular ranking metrics, spectral measures stand out from the crowd. They rely on the computation of the dominant eigenvector of suitable matrices related to the graph: EigenCentrality, PageRank, Hyperlink Induced Topic Search (HITS) and Stochastic Approach for Link-Structure Analysis (SALSA). The simplest algorithm used to solve this linear algebra computation is the Power Method. It consists of multiple Matrix-Vector Multiplications (MVMs) and a normalization step to avoid divergent behaviours. In this work, we present an analog circuit used to accelerate the Power Iteration algorithm including current-mode termination for the memristor crossbars and a normalization circuit. The normalization step together with the feedback loop of the complete circuit ensure stability and convergence of the dominant eigenvector. We implement a transistor level peripheral circuitry around the memristor crossbar and take non-idealities such as wire parasitics, source driver resistance and finite memristor precision into account. We compute the different spectral centralities to demonstrate the performance of the system. We compare our results to the ones coming from the conventional digital computers and observe significant energy savings while maintaining a competitive accuracy

Excitation of vibrational modes in the ionization of water molecule by XUV/X-ray radiation

We present a theoretical study of the vibrationally resolved core photoionization of the water molecule up to high photon energies. In order to understand the role of the coupled electron-nuclear motion in polyatomic molecules, we thus have implemented a new methodology to describe all vibrational modes of a polyatomic molecule. We show our preliminary results on the O(1s) photoionization, with special focus on the vibrationally resolved cross sections in a large range of photon energies, reaching up to 1500 e

Chiral bosonization for non-commutative fields

A model of chiral bosons on a non-commutative field space is constructed and new generalized bosonization (fermionization) rules for these fields are given. The conformal structure of the theory is characterized by a level of the Kac-Moody algebra equal to $(1+ \theta^2)$ where $\theta$ is the non-commutativity parameter and chiral bosons living in a non-commutative fields space are described by a rational conformal field theory with the central charge of the Virasoro algebra equal to 1. The non-commutative chiral bosons are shown to correspond to a free fermion moving with a speed equal to $c^{\prime} = c \sqrt{1+\theta^2}$ where $c$ is the speed of light. Lorentz invariance remains intact if $c$ is rescaled by $c \to c^{\prime}$. The dispersion relation for bosons and fermions, in this case, is given by $\omega = c^{\prime} | k|$.Comment: 16 pages, JHEP style, version published in JHE

Building better research partnerships by understanding how Aboriginal health communities perceive and use data: a semi structured interview study

The aim of this study is to describe the perspectives of ACCHS health staff towards data and to identify potential strategies that can maximise the efficient transfer and usage of data collected through collaborative research with the ACCHS, and enhance the capacity to effectively use research data for healthcare improvement and advocacy.The research reported in this paper is a project of the Australian Primary Health Care Research Institute which is supported by a grant from the Australian Government Department of Health and Ageing under the Primary Health Care Research Evaluation and Development Strategy

Ultrastrong plasmon–phonon coupling via epsilon-near-zero nanocavities

Vibrational ultrastrong coupling, where the light–matter coupling strength is comparable to the vibrational frequency of molecules, presents new opportunities to probe the interactions between molecules and zero-point fluctuations, harness cavity-modified chemical reactions and develop novel devices in the mid-infrared spectral range. Here we use epsilon-near-zero nanocavities filled with a model polar medium (SiO2) to demonstrate ultrastrong coupling between phonons and gap plasmons. We present classical and quantum-mechanical models to quantitatively describe the observed plasmon–phonon ultrastrong coupling phenomena and demonstrate a modal splitting of up to 50% of the resonant frequency (normalized coupling strength η > 0.25). Our wafer-scale nanocavity platform will enable a broad range of vibrational transitions to be harnessed for ultrastrong coupling application