1,218 research outputs found

    Strong fuzzy subsethood measures and strong equalities via implication functions

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    In this work we present the definition of strong fuzzy subsethood measure as a unifiying concept for the different notions of fuzzy subsethood that can be found in the literature. We analyze the relations of our new concept with the definitions by Kitainik ( [20]), Young ( [26]) and Sinha and Dougherty ( [23]) and we prove that the most relevant properties of the latter are preserved. We show also several construction methods. © 2014 Old City Publishing, Inc

    Marcadores moleculares aplicados a la identificación genética animal

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    La fibrosis congénita hepática ha sido descrita en la raza de caballos Franches Montagnes como una enfermedad letal en los primeros estadios de vida y de herencia monogénica autosómica recesiva. La fibrosis congénita hepática en caballos se ha asociado con el gen PKHD1, cuyas variantes causan fibrosis congénita hepática y renal en la especie humana (ARPKD). En el Departamento de Patología Animal de la Universidad de Zaragoza se ha diagnosticado recientemente el primer caso de fibrosis congénita hepática en un potro Pura Raza Español. El objetivo de este proyecto fue el estudio del gen PKHD1 y su asociación con la fibrosis congénita hepática, para ello se analizaron dos polimorfismos asociados fuertemente con la enfermedad en la raza de caballos Franches-Montagnes, g.49,597,760A>T y g.49,630,834G>A. Estos polimorfismos causan cambios en la proteína fibrocistina, codificada por el gen PKHD1, en una región conservada en varias especies, siendo la pérdida de función de dicha proteína una posible causa de la enfermedad. Se llevó a cabo el análisis de estos SNPs en el potro afectado y en sus parientes cercanos. También se hizo un estudio de la frecuencia de los polimorfismos en animales no emparentados de Pura Raza Español. Se han detectado cuatro nuevos SNPs en los fragmentos analizados correspondientes al gen PKHD1. Los resultados obtenidos permiten afirmar que no existe una asociación entre los polimorfismos analizados con la fibrosis hepática congénita en la raza Pura Raza Española a diferencia de lo descrito en la raza Franches-Montagnes

    A proposal for pellet production from residual woody biomass in the island of Majorca (Spain)

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    The use of residual biomass for energy purposes is of great interest in isolated areas like Majorca for waste reduction, energy sufficiency and renewable energies development. In addition, densification processes lead to easy-to-automate solid biofuels which additionally have higher energy density. The present study aims at (i) the estimation of the potential of residual biomass from woody crops as well as from agri-food and wood industries in Majorca, and (ii) the analysis of the optimal location of potential pellet plants by means of a GIS approach (location-allocation analysis) and a cost evaluation of the pellets production chain. The residual biomass potential from woody crops in Majorca Island was estimated at 35,874 metric tons dry matter (t DM) per year, while the wood and agri-food industries produced annually 21,494 t DM and 2717 t DM, respectively. Thus, there would be enough resource available for the installation of 10 pellet plants of 6400 t·year−1 capacity. These plants were optimally located throughout the island of Mallorca with a maximum threshold distance of 28 km for biomass transport from the production points. Values found for the biomass cost at the pellet plant ranged between 57.1 €·t−1 and 63.4 €·t−1 for biomass transport distance of 10 and 28 km. The cost of pelleting amounted to 56.7 €·t−1; adding the concepts of business fee, pellet transport and profit margin (15%), the total cost of pelleting was estimated at 116.6 €·t−1. The present study provides a proposal for pellet production from residual woody biomass that would supply up to 2.8% of the primary energy consumed by the domestic and services sector in the Balearic Islands

    Effects of resisted vs. conventional sprint training on physical fitness in young elite tennis players

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    This study aimed to compare the effects of 6-week resisted sprint (RST) versus conventional (unresisted) sprint training (CG) on sprint time, change of direction (COD) speed, repeated sprint ability (RSA) and jump performance (countermovement jump (CMJ) and standing long jump (SLJ)) in male young tennis players. Twenty players (age: 16.5 +/- 0.3 years; body mass: 72.2 +/- 5.5 kg; body height: 180.6 +/- 4.6 cm) were randomly assigned to one of the two groups: RST (n = 10) and CG (n = 10). The training program was similar for both groups consisting of acceleration and deceleration exercises at short distances (3-4 m), and speed and agility drills. The RST group used weighted vests or elastic cords during the exercises. After 6 weeks of intervention, both training regimes resulted in small-to-moderate improvements in acceleration and sprint ability (5, 10, 20 m), SLJ and CMJ performances, COD pivoting on both, the non-dominant (moderate effect) and the dominant (small effect) foot, and the percentage of decrement (small effects) during a RSA test. Between-group comparisons showed that the SLJ (Delta = 2.0%) and 5 m sprint time (Delta = 1.1%) improved more in the RST group compared with the CG group. This study showed that 6 weeks of RST or unresisted training are time-efficient training regimes for physical improvements in young male tennis players

    Predicting Subclinical Atherosclerosis in Low-Risk Individuals Ideal Cardiovascular Health Score and Fuster-BEWAT Score

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    BACKGROUND The ideal cardiovascular health score (ICHS) is recommended for use in primary prevention. Simpler tools not requiring laboratory tests, such as the Fuster-BEWAT (blood pressure [B], exercise [E], weight [W], alimentation [A], and tobacco [T]) score (FBS), are also available. OBJECTIVES The purpose of this study was to compare the effectiveness of ICHS and FBS in predicting the presence and extent of subclinical atherosclerosis. METHODS A total of 3,983 participants 40 to 54 years of age were enrolled in the PESA (Progression of Early Subclinical Atherosclerosis) cohort. Subclinical atherosclerosis was measured in right and left carotids, abdominal aorta, right and left iliofemoral arteries, and coronary arteries. Subjects were classified as having poor, intermediate, or ideal cardiovascular health based on the number of favorable ICHS or FBS. RESULTS With poor ICHS and FBS as references, individuals with ideal ICHS and FBS showed lower adjusted odds of having atherosclerotic plaques (ICHS odds ratio [OR]: 0.41; 95\% confidence interval [CI]: 0.31 to 0.55 vs. FBS OR: 0.49; 95\% CI: 0.36 to 0.66), coronary artery calcium (CACS) >= 1 (CACS OR: 0.41; 95\% CI: 0.28 to 0.60 vs. CACS OR: 0.53; 95\% CI: 0.38 to 0.74), higher number of affected territories (OR: 0.32; 95\% CI: 0.26 to 0.41 vs. OR: 0.39; 95\% CI: 0.31 to 0.50), and higher CACS level (OR: 0.40; 95\% CI: 0.28 to 0.58 vs. OR: 0.52; 95\% CI: 0.38 to 0.72). Similar levels of significantly discriminating accuracy were found for ICHS and FBS with respect to the presence of plaques (C-statistic: 0.694; 95\% CI: 0.678 to 0.711 vs. 0.692; 95\% CI: 0.676 to 0.709, respectively) and for CACS >= 1 (C-statistic: 0.782; 95\% CI: 0.765 to 0.800 vs. 0.780; 95\% CI: 0.762 to 0.798, respectively). CONCLUSIONS Both scores predict the presence and extent of subclinical atherosclerosis with similar accuracy, highlighting the value of the FBS as a simpler and more affordable score for evaluating the risk of subclinical disease. (C) 2017 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.The PESA study was co-funded by Fundacion Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) and Banco Santander. Funding was also provided by Institute of Health Carlos III (PI15/02019) and European Regional Development Fund. CNIC is supported by the Ministry of Economy, Industry and Competitiveness and Pro CNIC Foundation; and is a Severo Ochoa Center of Excellence (SEV-2015-0505). This work is part of a project that received funding from the European Union Horizon 2020 research and innovation program under Marie Sklodowska-Curie grant 707642 and American Heart Association grant 14SFRN20490315. Dr. Bueno has received research funding from Instituto de Salud Carlos III (PIE16/00021), AstraZeneca, Bristol-Myers Squibb, Janssen, and Novartis; is a consultant for Abbott, AstraZeneca, Bayer, Bristol-Myers Squibb-Pfizer, and Novartis; and has received speakers fees and travel and attendance support from AstraZeneca, Bayer, Bristol-Myers Squibb-Pfizer, Ferrer, Novartis, Servier, and Medscape. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Matthew Budoff, MD, served as Guest Editor for this paper.S

    Impact of an excise tax on the consumption of sugar-sweetened beverages in young people living in poorer neighbourhoods of Catalonia, Spain: a difference in differences study

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    BACKGROUND: Sugar-sweetened beverage consumption is contributing to the obesity epidemic. On 28 March 2017, Catalonia enacted a law levying an excise tax on sugar-sweetened beverages for public health reasons. The purpose of this study is to assess the impact of the tax on the consumption of sugar-sweetened beverages in Catalonia (Spain). METHODS: Before-and-after study to assess changes in the prevalence of consumption of sugar-sweetened beverages among 1929 persons aged 12 to 40 years residing in low-income neighbourhoods of Barcelona (intervention) and Madrid (control). Beverage consumption frequency was ascertained via a validated questionnaire administered during the month prior to the tax's introduction (May 2017) and again at 1 year after it had come into force. The effect of the tax was obtained using Poisson regression models with robust variance weighted using propensity scores. RESULTS: While the prevalence of regular consumers of taxed beverages fell by 39% in Barcelona as compared to Madrid, the prevalence of consumers of untaxed beverages remained stable. The main reason cited by more than two-thirds of those surveyed for reducing their consumption of sugar-sweetened beverages was the increase in price, followed by a heightened awareness of their health effects. CONCLUSIONS: The introduction of the Catalonian excise tax on sugar-sweetened beverages was followed by a reduction in the prevalence of regular consumers of taxed beverages.This study was supported by the Spanish Health Research Fund (Fondo deInvestigación Sanitaria - FIS) of the Carlos III Institute of Health (Project ENPY120/18) and the Spanish Consumers’Organisation (Organización deConsumidores y Usuarios - OCU). The funders had no role in the design of thestudy, in collection, analysis, and interpretation of data, or in writing themanuscriptS

    Active learning and social commitment projects as a teaching-learning intervention in engineering degrees

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    [EN] The purpose of universities, apart from produce qualified professionals with problem-solving capabilities and soft-skills, should be to develop the social responsibility sense on their students. In this context, our proposal combines project based learning (PBL) and service based learning (SBL) along with gamming and the use of open-source machines, with the aim to increase student’s motivation and their social commitment with an affordable budget. The strategy, from now on named OS-PBL-SR (Open-Source-based PBL projects with Social Responsibility), mainly includes three important aspects: (i) assignment with projects orientated towards a social benefit; (ii) development of the projects using open-source Do It Yourself desktop machines (DIY-DkM); and (iii) include gamming in the evaluation method. The strategy was applied in the subject Manufacturing Technology but it might be easily exportable to other technical subjects. The results from the last academic year are presented. Also, a new OS-PBL-SR proposal aimed to the design and fabrication of autonomy-oriented products for people in a dependency situation is presented. The results showed the beneficial impact on undergraduate students by keeping high levels of motivation reflected on excellent success rates and scores. In addition, essential advantages in the use of DIY-DkM were found regarding the implementation of this kind of PBL strategy.The authors would like to acknowledge the financial support received from the University of La Rioja through the programs ‘Proyectos de Innovación Docente 2018/2019’. The authors also want to express their gratitude to the Instituto de Estudios Riojanos (IER). One of the authors, A.S.G., would also like to acknowledge the financial support from the Academy of Finland No. 273689.Pernía-Espinoza, A.; Sanz-Garcia, A.; Martinez-De-Pison-Ascacibar, FJ.; Peciña-Marqueta, S.; Blanco-Fernandez, J. (2019). Active learning and social commitment projects as a teaching-learning intervention in engineering degrees. En HEAD'19. 5th International Conference on Higher Education Advances. Editorial Universitat Politècnica de València. 281-288. https://doi.org/10.4995/HEAD19.2019.9605OCS28128

    Does Socioeconomic Status Influence the Risk of Subclinical Atherosclerosis?: A Mediation Model

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    BACKGROUND: Socioeconomic status (SES)-education, income level, and occupation-is associated with cardiovascular risk. OBJECTIVES: This study aimed to investigate the association between SES and subclinical atherosclerosis and the potential mechanisms involved. METHODS: SES, lifestyle habits (smoking, dietary patterns, physical activity, and hours of sleep), traditional risk factors, and subclinical atherosclerosis extent were prospectively assessed in 4,025 individuals aged 40 to 54 years without known cardiovascular disease enrolled in the PESA (Progression of Early Subclinical Atherosclerosis) study. After factors associated with atherosclerosis were identified, a multiple mediation model was created to quantify the effect of SES on subclinical atherosclerosis as explained by lifestyle behaviors. RESULTS: Although education level was significantly associated with the presence of atherosclerosis, no differences were found according to income level in this population. Participants with lower education presented with a higher risk of generalized atherosclerosis than those with higher education (odds ratio: 1.46; 95% confidence interval: 1.15 to 1.85; p = 0.002). Lifestyle behaviors associated with both education level and atherosclerosis extent were: smoking status, number of cigarettes/day, and dietary pattern, which explained 70.5% of the effect of SES on atherosclerosis. Of these, tobacco habit (smoking status 35% and number of cigarettes/day 32%) accounted for most of the explained differences between groups, whereas dietary pattern did not remain a significant mediator in the multiple mediation model. CONCLUSIONS: Despite the relative economic homogeneity of the cohort, lower education level is associated with increased subclinical atherosclerosis, mainly mediated by the higher and more frequent tobacco consumption. Smoking cessation programs are still needed, particularly in populations with lower education level.The PESA study is cofunded equally by the Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; and Banco Santander, Madrid, Spain. The study also receives funding from the Institute of Health Carlos III (PI15/02019) and the European Regional Development Fund. The CNIC is supported by the Ministry of Economy, Industry and Competitiveness and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). This work is part of a project that has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No707642; and from the American Heart Association under grantnumber14SFRN20490315. Dr. Bueno has received research funding from the Instituto de Salud Carlos III (PIE16/00021), AstraZeneca, Bristol-Myers Squibb, Janssen, and Novartis; has received consulting fees from Abbott, AstraZeneca, Bayer, Bristol-Myers Squibb-Pfizer, and Novartis; and has received speaking fees or support for attending scientific meetings from AstraZeneca, Bayer, Bristol-Myers Squibb-Pfizer, Ferrer, Novartis, Servier, and MEDSCAPE-the heart.org.S
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