Paroxysmal nocturnal hemoglobinuria: a case report in a pandemic environment

Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal, rare, complement-mediated hemolytic anemia. PNH can be associated with marrow failure and thrombophilia. We present a clinical report of splenic vein thrombosis in a patient with classic PNH. A 41-year-old male with classic PNH, naïve to complement inhibitor therapy, developed splenic vein thrombosis as a major adverse effect after vaccination protocol to prevent meningococcal disease. We also report anticoagulant and eculizumab treatment outcomes. In PNH patients, vaccination should be monitored to prevent major outcome events, like vaccine-induced thrombosis. Eculizumab proves effective for treating intravascular hemolysis and preventing more thrombotic events. The potential protective role of eculizumab on controlling complement activity and consequent inflammation may help the patient to not experience breakthrough hemolysis when infected with SARS-CoV-2. Extravascular hemolysis remains present, but new molecules are being studied to inhibit proximal complement and there is a good health prospective for PNH patients.info:eu-repo/semantics/publishedVersio

Imagens em trânsito, poderes e arquivos

This article intends at a critique of the images and power spaces in which they circulate, based on the notion of visibility developed by the Algerian philosopher Marie-José Mondzain. The author highlights the vocation for transit and relations with power as fundamental characteristics of images. The consequences of this, which include controlling the visibilities, will be taken into consideration for the analysis of the object of our research: the archive, including a personal archive of family photographs, on the one hand, and digital image archives made by a cellphone, on the other hand.Este artículo pretende elaborar una crítica a las imágenes y a los espacios de poder en que circulan, basándose en la noción de visibilidad elaborada por la filósofa argelina Marie-José Mondzain. La autora destaca la vocación para el tránsito y las relaciones con el poder como características fundamentales de aquellas. Las consecuencias de eso, que incluyen el control de visibilidades, serán tomadas en cuenta para el análisis del objeto de nuestras investigaciones: el archivo, incluido un archivo personal de fotografías familiares, por un lado, y archivos de imágenes digitales tomadas con el teléfono celular de otro.Este artigo visa à elaboração de uma crítica às imagens e aos espaços de poder em que circulam, apoiando-se na noção de visibilidade elaborado pela filósofa argelina Marie-José Mondzain. A autora destaca a vocação para o trânsito e as relações com o poder como características fundamentais das imagens. As consequências disso, que incluem o controle de visibilidades, serão levadas em consideração para a análise do objeto de nossas pesquisas: o arquivo, incluindo um arquivo pessoal de fotografias de família, por um lado, e arquivos de imagens digitais feitas com celular de outro

Tratamento térmico em sementes de cenoura

This study aimed at erradicating seed-borne fungi on carrot, Daucus carota L., seeds, cv. Brasília, by thermotherapy (dry heat) without any damage to its viability. The study was carried out in 1994/95, at Faculdade de Agronomia Eliseu Maciel, Federal University of Pelotas, RS, Brazil. Four seed lots, two harvested in 1993/94 and two harvested in 1994/95, were heated at 70°C for periods of: 0, 3, 6, 9, 12 and 15 days. The following parameters were used to evaluate the seeds: seed health test (blotter-test), standard germination test and vigor tests (cold test and accelerated aging test). The results showed that: dry heat at 70°C for 15 days eliminated seed-borne fungi of high quality carrot seeds, without reducing germination and vigor; high quality carrot seeds can be dehydrated to 1% moisture content without damage to it; and the seed quality or age affects its performance in heat treatments.O objetivo do presente estudo foi desenvolver um método para erradicar fungos de sementes de cenoura, Daucus carota L., da cultivar Brasília, por termoterapia (calor seco), sem prejuízo da viabilidade. O trabalho foi desenvolvido em 1994 e 1995, no Campus da Faculdade de Agronomia Eliseu Maciel, da Universidade Federal de Pelotas, RS. Quatro lotes de sementes de cenoura, dois da safra 93/94 e dois da safra 94/95 foram submetidos a diferentes tempos de exposição ao calor: 0, 3, 6, 9, 12 e 15 dias, em estufa com circulação de ar a 70°C. Os parâmetros utilizados para avaliação foram: teste de sanidade (blotter-test), teste de germinação padrão e testes de vigor (teste de frio e teste de envelhecimento acelerado). Os resultados obtidos indicam que a exposição ao calor seco, com temperatura de 70°C, durante 15 dias controla todos os fungos presentes em sementes de cenoura de alta qualidade fisiológica, sem prejuízo da germinação e do vigor; que sementes de cenoura com alta qualidade fisiológica podem ter seu grau de umidade reduzido a níveis próximos a 1,0% sem prejuízo da germinação e do vigor; e que a qualidade fisiológica e/ou idade das sementes influencia seu desempenho na termoterapia

The CLIMALERT project: Climate alert smart system for sustainable water and agriculture

The vulnerability of sensitive European regions to hydro-meteorological extremes has increased dramatically over the past few decades. Extreme weather and climate events are increasingly happening worldwide due to ongoing climate change. As a consequence, hydro- meteorological disaster events are affecting the European economy, environment and society, with impacts on food production, food distribution infrastructure, livelihood assets and human health, in both rural and urban areas. Meanwhile, climate services have started to be developed to further anticipate the impacts of climate variability and to apply climate forecasts in different sectors, such as agriculture and water management. However, connections between climate information users and providers are still weak. The CLIMALERT project emerges to provide climate information in a format that prospective users find it easy to understand and/or incorporate into decision-making. The project main goals are: i) strengthen the link between climate research, water resources and the agriculture sector to assist the management of natural resources, enhance agricultural livelihoods and reduce underlying causes of vulnerability, ii) improve the techniques and tools currently used to incorporate weather and climate information into risk assessment and decision making in agriculture and water sectors, and, iii) contribute to assist decision- makers in the implementation of adaptation and mitigation strategies. In this talk, we will present the project framework, the study areas, the engagement with stakeholders, the selection of climate and hydrological indicators, and the development of an alert system platform that aims to contribute to reduce the risks and vulnerabilities for the agriculture and water management sectors, providing economically valuable services and long-term benefits to farmers and societyERA4CS/0004/2016 - CLIMALER

Livestock-ranching, forest regeneration and restoration: experiences from the Chaco forest

La ganadería extensiva en bosques como el Chaco Seco, es un importante uso de la tierra practicado por comunidades locales. Esta actividad ha sido estudiada en décadas pasadas y recientemente, siendo necesario resumir lo conocido hasta la fecha. Aquí, sintetizamos nuestra evidencia sobre la relación ganadería-regeneración y experiencias de restauración en dos áreas del Chaco Seco argentino: Parque Nacional Copo (Santiago del Estero) y Finca El Paraíso (Salta). La relación ganado-regeneración dependió de la presión ganadera. En zonas alejadas de puestos del Parque Nacional Copo, no detectamos diferencias con y sin ganadería, mientras que en los peladares (alta presión) fue claro el efecto negativo del ganado. En El Paraíso, la alta presión ganadera disminuyó la regeneración. En sitios con menor presión y 10 años de exclusión del Parque Nacional Copo, las clausuras aumentaron la biomasa de gramíneas, la cobertura del suelo y la altura de renovales de Schinopsis lorentzii. Para restaurar peladares, recomendamos excluir el ganado y reintroducir el banco de semillas en suelos escarificados utilizando nodrizas o sombra artificial. Además describimos los procedimientos para propagar arbustos nodrizas y crear micrositios de regeneración. Esta síntesis ayudará a planificar futuras experiencias de restauración de sitios sobrepastoreados del Chaco Seco.Extensive cattle ranching in forests such as the dry Chaco is an important land use practiced by local communities. This activity has been studied in past decades and recently, and it is necessary to summarize what is known to date. Here, we synthesize evidence on the relationship between livestock and regeneration and restoration experiences in two areas of the Argentinean dry Chaco: Copo National Park (Santiago del Estero province) and finca El Paraíso (Salta province). The relationship between livestock and regeneration depended on livestock pressure. In lands that were far from human settlements in Copo National Park, regeneration on sites with and with our livestock was similar, while on heavy degraded lands, the negative effect of livestock was clear. Recent exclosures in heavy degraded lands in Copo National Park have not shown conclusive results yet. In Paraíso, high livestock pressure decreased regeneration. In sites with less pressure and 10 years of exclusion from Copo National Park, exclosures increased grass biomass and soil cover, and favored sapling growth of Schinopsis lorentzii. Restoring heavily degraded lands requires excluding livestock and reintroducing the seed bank in scarified soils under nurse plants or artificial shade. Furthermore, we describe how to propagate nurse shrubs to create regeneration microsites. This synthesis will help to plan future restoration experiences on overgrazed sites in dry Chaco.Fil: Tálamo, Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Bio y Geociencias del NOA. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Museo de Ciencias Naturales. Instituto de Bio y Geociencias del NOA; ArgentinaFil: Martínez Gálvez, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Bio y Geociencias del NOA. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Museo de Ciencias Naturales. Instituto de Bio y Geociencias del NOA; ArgentinaFil: Trigo, Carolina Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Bio y Geociencias del NOA. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Museo de Ciencias Naturales. Instituto de Bio y Geociencias del NOA; ArgentinaFil: Pérez Viscarra, Susana. Universidad Nacional de Salta. Facultad de Ciencias Naturales; ArgentinaFil: Alauie, Alejandro Emiliano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Salta. Facultad de Ciencias Naturales; ArgentinaFil: Núñez Regueiro Mauricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Bio y Geociencias del NOA. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Museo de Ciencias Naturales. Instituto de Bio y Geociencias del NOA; Argentina. Universidad Católica de Salta; Argentin

[beta Thalassemia Major And Pregnancy During Adolescence: Report Of Two Cases].

Beta thalassemia major is a rare hereditary blood disease in which impaired synthesis of beta globin chains causes severe anemia. Medical treatment consists of chronic blood transfusions and iron chelation. We describe two cases of adolescents with beta thalassemia major with unplanned pregnancies and late onset of prenatal care. One had worsening of anemia with increased transfusional requirement, fetal growth restriction, and placental senescence. The other was also diagnosed with hypothyroidism and low maternal weight, and was admitted twice during pregnancy due to dengue shock syndrome and influenza H1N1-associated respiratory infection. She also developed fetal growth restriction and underwent vaginal delivery at term complicated by uterine hypotonia. Both patients required blood transfusions after birth and chose medroxyprogesterone as a contraceptive method afterwards. This report highlights the importance of medical advice on contraceptive methods for these women and the role of a specialized prenatal follow-up in association with a hematologist.37291-29

Calidad pericial: el estudio y estandarización de los procesos en un laboratorio de informática forense

La implantación de sistemas de calidad en laboratorios forenses es cada vez más demandada, y constituye una estrategia para la búsqueda continua de la calidad de los resultados, tratando de minimizar los márgenes de error. Se requiere de Sistemas de Gestión de Calidad en laboratorios forenses sólo en el campo de la medicina, y para casos puntuales. Dentro de la órbita de los poderes judiciales existentes en el país, no se han establecido ningún tipo de exigencias respecto a la instalación o funcionamiento de los mismos. Tampoco se dispone de normas o sistemas de gestión de calidad que certifiquen su funcionamiento en el ámbito de esta disciplina, debido a que se trata de una temática relativamente nueva, aunque cada vez más requerida y relevante. El objetivo del presente trabajo es mostrar las herramientas de calidad utilizadas en la aplicación del enfoque a procesos para el estudio y estandarización de los procesos del laboratorio de informática forense de la ciudad de Mar del Plata, las propuestas de mejora, los resultados parciales obtenidos y las ventajas y dificultades durante el desarrollo del proyecto. En primer lugar, se determinaron los procesos críticos del laboratorio y sus interacciones, utilizando una herramienta de mapeo. Luego se trabajó en la importancia de la información documentada, analizando problemas y propuestas de mejora. El proceso de implementación de una nueva información documentada se planificó para ser llevada a cabo de manera gradual, según el tipo de cambio y complejidad de la mejora.Sociedad Argentina de Informática e Investigación Operativ

Psychological morbidity as a moderator of intention to quit smoking : a study of smokers and former smokers

Objective: To analyze psychological morbidity as a moderator of the relationship between smoking representations and quality of life in smokers and former smokers, as well as to determine which psychological variables discriminate between smokers with and without the intention to quit smoking. Methods: This was a quantitative, correlational cross-sectional study involving a convenience sample of 224 smokers and 169 former smokers. Results: In smokers and former smokers, psychological morbidity had a moderating effect on the relationship between mental/physical quality of life and smoking representations (cognitive representations, emotional representations, and comprehensibility). Smokers with the intention to quit smoking more often presented with low comprehensibility, threatening emotional representations, behavioral beliefs, and perceived behavioral control, as well as with normative/control beliefs, than did those without the intention to quit. Conclusions: The results of this study underscore the importance of the moderating effect exerted by psychological morbidity, as well as that of sociocognitive variables, among smokers who have the intention to quit smoking.ResumoObjetivo: Analisar a morbidade psicológica como um moderador na relação entre as representações do tabaco e a qualidade de vida em fumantes e ex-fumantes, assim como conhecer as variáveis psicológicas que discriminam os fumantes com e sem intenção para deixar de fumar. Métodos: Estudo quantitativo, correlacional e transversal com uma amostra de conveniência constituída por 224 fumantes e 169 ex-fumantes. Resultados: Verificou-se um efeito moderador da morbidade psicológica na relação entre a qualidade de vida (física e mental) e as representações do tabaco (representações cognitivas e emocionais e compreensão) nos fumantes e nos ex-fumantes. Os fumantes com intenção para deixar de fumar apresentavam menor compreensão, representações emocionais mais ameaçadoras, mais crenças de comportamento, maior controle comportamental percebido e mais crenças normativas/controle do que aqueles sem essa intenção. Conclusões: Os resultados deste estudo enfatizam a importância da morbidade psicológica como moderadora, bem como das variáveis sociocognitivas, junto dos fumantes que querem deixar de fumar