AB0689 The importance of the sun. Vitamin D and spondyloarthritis: our experience in a third level hospital

[EN] Vitamin D plays an important role in the pathogenesis of autoimmune diseases, so that it has been shown that an adequate level is associated with a lower risk of developing this group of entities as well as a lower severity of them. Specifically, in spondyloarthritis (SpA) the deficiency has been associated with greater aggressiveness and greater radiological progression.S

Blended transdiagnostic group CBT for emotional disorders: A feasibility trial protocol

Introduction: Emotional disorders (anxiety and depressive disorders) are a relevant public health concern associated with high prevalence, high costs, and important disability. Therefore, research priorities include designing and testing cost-effective interventions to reach everyone in need. Internet-delivered interventions for emotional disorders are effective and can help to disseminate and implement evidence-based treatments. However, although these treatments are generally effective, not all patients benefit from this treatment format equally. Blended treatments are a new form of intervention that combines the strengths of face-to-face and Internet approaches. Nevertheless, research on blended interventions has focused primarily on individual therapy, and less attention has been paid to the potential of using this format in group psychotherapy. This study aims to analyze the feasibility of blended transdiagnostic group CBT for emotional disorders. The current article describes the study protocol for this trial. Method and analysis: A one-armed pilot trial will be conducted. Participants will be 30 adults suffering from DSM-5 anxiety and/or depressive disorders. The treatment consists of a blended transdiagnostic group intervention delivered during a period of 24 weeks. Groups of 6 to 10 patients will attend a total of eight 2-hour, face-to-face sessions, alternated with the use of an online platform where they will find the contents of the treatment protocol. The intervention has four core components: present-focused awareness, cognitive flexibility, identification and modification of behavioral and cognitive patterns of emotional avoidance, and interoceptive and situational exposure. These components are delivered in 16 modules. Assessments will be performed at baseline, during the treatment, at post-treatment, and at 3-month follow-up. Clinical and treatment acceptability outcomes will be included. Quantitative and qualitative data (participants’ views about blended group psychotherapy) will be analyzed. Ethics and dissemination: The trial has received ethical approval from the Ethics Committee of Universitat Jaume I (September 2019) and will be conducted in accordance with the study protocol, the Declaration of Helsinki, and good clinical practice. The results of this study will be disseminated by presentation at conferences and will be submitted for publication in a peer-reviewed journal. Trial registration: ClinicalTrials.gov Identifier: NCT04008576. Registered 05 July 2019, https://clinicaltrials.gov/ct2/show/NCT0400857

Proyecto eMadrid: metodologías educativas, ludificación y calidad

Esta comunicación presenta un conjunto de trabajos de investigación sobre metodologías docentes, ludificación y calidad realizados en el seno del proyecto eMadrid, de la Comunidad Autónoma de Madrid. En primer lugar se resumen los trabajos realizados en los dos primeros años del proyecto. Posteriormente se presentan las líneas de trabajo previstas para los dos años restantesEstos trabajos se han financiado parcialmente por el proyecto eMadrid (S2013/ICE-2715) de la Comunidad de Madrid, los proyectos FLEXOR (TIN2014-52129-R), RESET (TIN2014-53199-C3-1-R) e iProg (TIN2015-66731-C2-1-R) del Ministerio de Economía y Competitividad, y el proyecto “Adaptación de la metodología PhyMEL a la formación clínica mediante el uso de simuladores” financiado por la empresa Medical Simulato

Information Management within the LHC Hardware Commissioning Project

The core task of the commissioning of the LHC technical systems was the individual test of the 1572 superconducting circuits of the collider, the powering tests. The two objectives of these tests were the validation of the different sub-systems making each superconducting circuit as well as the validation of the superconducting elements of the circuits in their final configuration in the tunnel. A wide set of software applications were developed by the team in charge of coordinating the powering activities (Hardware Commissioning Coordination) in order to manage the amount of information required for the preparation, execution and traceability of the tests. In all the cases special care was taken in order to keep the tools consistent with the LHC quality assurance policy, avoid redundancies between applications, ensure integrity and coherence of the test results and optimise their usability within an accelerator operation environment. This paper describes the main characteristics of these tools; it details their positive impact on the completion on time of the LHC Hardware Commissioning Project and presents usage being envisaged during the coming years of operation of the LHC

Electrophoretic mobility of supercoiled, catenated and knotted DNA molecules.

We systematically varied conditions of two-dimensional (2D) agarose gel electrophoresis to optimize separation of DNA topoisomers that differ either by the extent of knotting, the extent of catenation or the extent of supercoiling. To this aim we compared electrophoretic behavior of three different families of DNA topoisomers: (i) supercoiled DNA molecules, where supercoiling covered the range extending from covalently closed relaxed up to naturally supercoiled DNA molecules; (ii) postreplicative catenanes with catenation number increasing from 1 to ∼15, where both catenated rings were nicked; (iii) knotted but nicked DNA molecules with a naturally arising spectrum of knots. For better comparison, we studied topoisomer families where each member had the same total molecular mass. For knotted and supercoiled molecules, we analyzed dimeric plasmids whereas catenanes were composed of monomeric forms of the same plasmid. We observed that catenated, knotted and supercoiled families of topoisomers showed different reactions to changes of agarose concentration and voltage during electrophoresis. These differences permitted us to optimize conditions for their separation and shed light on physical characteristics of these different types of DNA topoisomers during electrophoresis

Negative and positive affect regulation in a transdiagnostic internet-based protocol for emotional disorders: Randomized controlled trial

Background: Emotional disorders (EDs) are among the most prevalent mental disorders. Existing evidence-based psychological treatments are not sufficient to reduce the disease burden of mental disorders. It is therefore essential to implement innovative solutions to achieve a successful dissemination of psychological treatment protocols, and in this regard, the use of information and communication technologies such as the internet can be very useful. Furthermore, the literature suggests that not everyone with an ED receives the appropriate treatment. This situation has led to the development of new intervention proposals based on the transdiagnostic perspective, which attempts to address the underlying processes common to EDs. Most of these transdiagnostic interventions focus primarily on downregulating negative affectivity (NA), and less attention has been paid to strengths and the upregulation of positive affectivity, despite its importance for well-being and mental health. Objective: This study aims to evaluate the efficacy of a transdiagnostic internet-based treatment for EDs in a community sample. Methods: A 3-armed randomized controlled trial was conducted. A total of 216 participants were randomly assigned to a transdiagnostic internet-based protocol (TIBP), a TIBP+ positive affect (PA) component, or a waiting list (WL) control group. The treatment protocol contained core components mainly addressed to downregulate NA (ie, present-focused emotional awareness and acceptance, cognitive flexibility, behavioral and emotional avoidance patterns, and interoceptive and situational exposure) as well as a PA regulation component to promote psychological strengths and enhance well-being. Data on depression, anxiety, quality of life, neuroticism and extraversion, and PA/NA before and after treatment were analyzed. Expectations and opinions of treatment were also analyzed. Results: Within-group comparisons indicated significant pre-post reductions in the two experimental conditions. In the TIBP+PA condition, the effect sizes were large for all primary outcomes (d=1.42, Beck Depression Inventory [BDI-II]; d=0.91, Beck Anxiety Inventory [BAI]; d=1.27, Positive and Negative Affect Schedule-Positive [PANAS-P]; d=1.26, Positive and Negative Affect Schedule-Negative [PANAS-N]), whereas the TIBP condition yielded large effect sizes for BDI-II (d=1.19) and PANAS-N (d=1.28) and medium effect sizes for BAI (d=0.63) and PANAS-P (d=0.69). Between-group comparisons revealed that participants who received one of the two active treatments scored better at posttreatment than WL participants. Although there were no statistically significant differences between the two intervention groups on the PA measure, effect sizes were consistently larger in the TIBP+PA condition than in the standard transdiagnostic protocol. Conclusions: Overall, the findings indicate that EDs can be effectively treated with a transdiagnostic intervention via the internet, as significant improvements in depression, anxiety, and quality of life measures were observed. Regarding PA measures, promising effects were found, but more research is needed to study the role of PA as a therapeutic component

Optimization of the powering tests of the LHC superconducting circuits

The Large Hadron Collider has (LHC) 1572 superconducting circuits which are distributed along the eight 3.5 km LHC sectors [1]. Time and resources during the commissioning of the LHC technical systems were mostly consumed by the powering tests of each circuit. The tests consisted in carrying out several powering cycles at different current levels for each superconducting circuit. The Hardware Commissioning Coordination was in charge of planning, following up and piloting the execution of the test program. The first powering test campaign was carried out in summer 2007 for sector 7-8 with an expected duration of 12 weeks. The experience gained during these tests was used by the commissioning team for minimising the duration of the following powering campaigns to comply with the stringent LHC project deadlines. Improvements concerned several areas: strategy, procedures, control tools, automatization, and resource allocation led to an average daily test rate increase from 25 to 200 tests per day. This paper describes these improvements and details their impact on the operation during the last months of LHC Hardware Commissioning

Eficacia y eficiencia de Leader 11 en Andalucía. Aproximación a un índice-resultado en materia de turismo rural

The evaluation has turned into a strategic element of differentiation, into the measurement into that allows to demonstrate his own beneficiaries, that the application of the public or private resources, it is as suitable as possible. To evaluate is necessary a system of indicators, which answer to five big types of which we will centre on two: efficiency (the effort inverted in terms of plysical, human or financial resources and the obtained results) and effectiveness (the impacts or results of the program with regard to his aims). In this article we try to put of manifest as the evaluation of the measurement B.3 (tourist activities) it allows across the analysis of the efficiency (projects) and the effectiveness (investment) in LEADER 11, one approximation in the construction of a proved index.La evaluación se ha convertido en un elemento estratégico de diferenciación, en la medida en que permite demostrar a sus propios beneficiarios, que la aplicación de los recursos públicos o privados, es la más adecuada posible. Para evaluar los programas de desarrollo rural es necesario un sistema de indicadores, que responden a cinco grandes tipos de los que nos centraremos en dos: eficiencia (el esfuerzo invertido en términos de recursos físicos, humanos o financieros y los resultados obtenidos) y eficacia (los impactos o resultados del programa respecto a sus objetivos). En este articulo tratamos de poner de manifiesto como la evaluación de la medida B.3 (actividades turísticas) permite, a través del análisis de la eficacia (proyectos) y la eficiencia (inversión) en LEADER 11, una primera aproximación en la construcción de un índice resultado

Detección de parásitos gastrointestinales en hurones (Mustela putorius furo) mediante análisis coprológico

The aim of this study was to determine the presence of zoonotic gastrointestinal parasites by coprological examination in ferrets (Mustela putorius furo) reared as pets and the role of sex and age. The faeces of 30 ferrets were analysed, 16 [53.3%] from pet stores and 14 [46.7%] from homes in the city of Santiago and Concepción, Chile. Burrows' coprological technique was used for the diagnosis, which allows detecting eggs of protozoan helminths, cysts and trophozoites Three samples (10%) tested positive for protozoa, one for Entamoeba coli, in a 6 month old male from a pet store, and two for Endolimax nana in a 3-month-old female and a 2-year-old male from private homes. This would be the first record for the two species of protozoa commensals in ferrets in Chile, which were probably acquired by the close contact of mustelids with humans.El objetivo del estudio fue determinar la presencia de parásitos gastrointestinales zoonóticos mediante examen coproparasitológico en hurones (Mustela putorius furo) criados como mascotas y el rol de las variables sexo y edad. Se analizaron las heces de 30 hurones, 16 [53.3%] de tiendas de mascotas y 14 [46.7%] de hogares de la ciudad de Santiago y Concepción, Chile. Para el diagnóstico se utilizó la técnica coproparasitaria de Burrows, que permite detectar huevos de helmintos, quistes y trofozoítos de protozoos. Tres muestras (10%) resultaron positivas a protozoos, una a Entamoeba coli, en un macho de 6 meses de una tienda de mascotas, y dos a Endolimax nana en una hembra de 3 meses y un macho se 2 años, ambos de hogares. Este sería el primer registro para las dos especies de protozoos comensales en hurones en Chile, los que probablemente fueron adquiridos por el estrecho contacto de los mustélidos con los humanos. &nbsp

Criterios geomorfológicos sobre actividad tectónica reciente a lo largo de la Costa Recta, Isla Decepción (Antártida Occidental)

Several active tectonic evidences are observed along Costa Recta, located eastward of Deception Island (western Antarctica): marine terraces and fluvial streams cutting a relict glacier. The height of both landforms decrease southward from Macaroni Point, appointing to a tilt movement across a fault plane. Fault planes were measured at Macaroni Point and Baily Head, with a main NNWSSE orientation, similar to the Costa Recta strike. From several scales o f measure, the orientation of the beach was established in two principal segments: N168QE, and N173QE. On the other hand, the beach and glacier dynamics and sedimentary deposits were studied. According to the morpho-tectonic analysis, we conclude that the Costa Recta beach is a retreat scarp of a submarine fault oriented NNW-SSE and located in the Bransfield Strait, although a geophysical study o f the marine bottom is needed to map the fault trace in an accurate way