192 research outputs found
Assessment of Rights-Related Personal Outcomes in Young People with Intellectual Disability and Autism Spectrum Disorder
Despite the great importance of the quality of life concept in the intellectual disability (ID) field, literature about its application to youth with autism spectrum disorder (ASD) is scarce, especially for the rights domain, an area that has become particularly important after the ratification of the Convention on the Rights of Persons with Disabilities. This study focuses on assessing the rights of youth with ASD and ID and comparing their results obtained by people with ID and other associated conditions: Down syndrome and cerebral palsy. The Rights subscale from the field-test version of the KidsLife Scale was administered in a sample composed of 153 participants with ID aged from 4 to 21 years old (ASD = 51; Down syndrome = 51; cerebral palsy = 51). The variables gender, type of schooling, level of ID and level of support needs were significant for the group with ASD. The three groups showed positive outcomes, though youth with Down syndrome obtained statistically significant higher scores than participants with ASD.Aun teniendo gran relevancia el concepto de calidad de vida en el ámbito de la discapacidad intelectual (DI), existe escasa investigación acerca de su aplicación en jóvenes con trastorno del espectro del autismo (TEA), especialmente acerca de la dimensión derechos, área que ha cobrado especial importancia en los últimos años con la ratificación de la Convención de los Derechos de las Personas con Discapacidad de Naciones Unidas. Este estudio se centra en la evaluación de derechos en jóvenes con TEA y DI, comparando sus resultados con dos grupos de jóvenes que presentan DI y otra condición comórbida: síndrome de Down y parálisis cerebral. Para ello, se utilizó la subescala derechos de la versión piloto de la Escala KidsLife en una muestra de 153 participantes con DI entre 4 y 21 años (TEA = 51; síndrome de Down = 51; parálisis cerebral = 51). En el grupo con TEA, el género, el tipo de escolarización, el nivel de DI y de necesidades de apoyo dieron lugar a diferencias significativas. Los tres grupos obtuvieron resultados positivos, aunque los jóvenes con síndrome de Down obtienen resultados significativamente superiores a los obtenidos por jóvenes con TEA
Antiferromagnetic 4-d O(4) Model
We study the phase diagram of the four dimensional O(4) model with first
(beta1) and second (beta2) neighbor couplings, specially in the beta2 < 0
region, where we find a line of transitions which seems to be second order. We
also compute the critical exponents on this line at the point beta1 =0 (F4
lattice) by Finite Size Scaling techniques up to a lattice size of 24, being
these exponents different from the Mean Field ones.Comment: 26 pages LaTeX2e, 7 figures. The possibility of logarithmic
corrections has been considered, new figures and tables added. Accepted for
publication in Physical Review
SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150
SPROUTY-2 (SPRY2) is a modulator of tyrosine kinase receptor signaling with
receptor- and cell type-dependent inhibitory or enhancing effects. Studies on the action
of SPRY2 in major cancers are conflicting and its role remains unclear. Here we have
dissected SPRY2 action in human colon cancer. Global transcriptomic analyses show
that SPRY2 downregulates genes encoding tight junction proteins such as claudin-7 and
occludin and other cell-to-cell and cell-to-matrix adhesion molecules in human SW480-
ADH colon carcinoma cells. Moreover, SPRY2 represses LLGLL2/HUGL2,
PATJ1/INADL and ST14, main regulators of the polarized epithelial phenotype, and
ESRP1, an epithelial-to-mesenchymal transition (EMT) inhibitor. A key action of
SPRY2 is the upregulation of the major EMT inducer ZEB1, as these effects are
reversed by ZEB1 knock-down by means of RNA interference. Consistently, we found
an inverse correlation between the expression level of claudin-7 and those of SPRY2
and ZEB1 in human colon tumors. Mechanistically, ZEB1 upregulation by SPRY2
results from the combined induction of ETS1 transcription factor and the repression of
microRNAs (miR-200 family, miR-150) that target ZEB1 RNA. Moreover, SPRY2
increased AKT activation by epidermal growth factor (EGF) whereas AKT and also Src
inhibition reduced the induction of ZEB1. Altogether, these data suggest that AKT and
Src are implicated in SPRY2 action. Collectively, these results show a tumorigenic role
of SPRY2 in colon cancer that is based on the dysregulation of tight junction and
epithelial polarity master genes via upregulation of ZEB1. The dissection of the
mechanism of action of SPRY2 in colon cancer cells is important to understand the
upregulation of this gene in a subset of patients with this neoplasia that have poor
prognosis.This study was supported by the Ministerio de
Economía y Competitividad of Spain and Fondo Europeo de Desarrollo Regional
(FEDER) (grant SAF2013-43468-R to A.M., SAF2011-29530 to F.X.R.); FEDERInstituto
de Salud Carlos III (RD12/0036/0021 to A.M. and J.M.R., RD12/0036/0034 to
F.X.R., RD12/0036/0016 to M.S., RD12/0036/0012 to H.G.P., RD06/0020/0003,
PS09/00562 and PI13/00703 to J.M.R.); Comunidad de Madrid (S2010/BMD-2344
Colomics2 to A.M.); Fundación Científica de la Asociación Española contra el Cáncer
(to J.M.R.); U.S. Department of Defense (CA093471 and CA110602 to E.H.); National
Institutes of Health/National Cancer Institute (1R01CA155234-01 to E.H.); National
Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin
Diseases (1R21AR062239-01 to E.H.); and the Melanoma Research Alliance (to E. H.)
Herramientas y recursos de motivación online para actividades en clase
[EN] One essential condition for a good learning process by students is their motivation when
facing the activities proposed by teachers in class. New generations of students, already
formed by digital natives, push us to face changes in this teaching-learning process. We
present a series of online tools that have allowed us to develop different activities such
as interactive presentations or collaborative quizzes, among others, and have been very
positive for motivating our students in the classroom.[ES] Una de las condiciones esenciales para un buen proceso de aprendizaje por parte del alumnado es la motivación del mismo a la hora de afrontar las actividades propuestas por parte del profesor en clase. Las nuevas generaciones de alumnos, formadas ya por nativos digitales, nos empujan a afrontar cambios en este proceso de enseñanza-aprendizaje. Presentamos una serie de herramientas on-line que nos han permitido la realización de diversas actividades tales como presentaciones interactivas o cuestionarios colaborativos, entre otras, que han resultado ser muy positivas a la hora de motivar al alumno en el aula.Este trabajo ha sido realizado en el marco del proyecto docente UV-SFPIE PID-1640839: “Docencia y evaluación
a distancia: uso de herramientas propias de la UV y externas para mejorar la metodología docente en línea e híbrida
en el área de ciencias”Adsuara, JE.; Fernández-Morán, R.; Gómez-Chova, L.; Laparra, V.; Ruescas Orient, AB.; Fernández-Torres, M.; Girbés-Juan, V.... (2022). Herramientas y recursos de motivación online para actividades en clase. Editorial Universitat Politècnica de València. 1055-1065. https://doi.org/10.4995/INRED2022.2022.158851055106
Major role of nutrient supply in the control of picophytoplankton community structure.
abstractThe Margalef´s mandala (1978) is a simplified bottom-up control model that explains how mixing and
nutrient concentration determine the composition of marine phytoplankton communities. Due to the
difficulties of measuring turbulence in the field, previous attempts to verify this model have applied
different proxies for nutrient supply, and very often used interchangeably the terms mixing and
stratification. Moreover, because the mandala was conceived before the discovery of smaller
phytoplankton groups (picoplankton <2 μm), it describes only the succession of vegetative phases of
microplankton. In order to test the applicability of the classical mandala to picoplankton groups, we
used a multidisciplinary approach including specifically designed field observations supported by
remote sensing, database analyses, and modeling and laboratory chemostat experiments.
Simultaneous estimates of nitrate diffusive fluxes, derived from microturbulence observations, and
picoplankton abundance collected in more than 200 stations, spanning widely different hydrographic
regimes, showed that the contribution of eukaryotes to picoautotrophic biomass increases with
nutrient supply, whereas that of picocyanobacteria shows the opposite trend. These findings were
supported by laboratory and modeling chemostat experiments that reproduced the competitive
dynamics between picoeukaryote sand picocyanobacteria as a function of changing nutrient supply.
Our results indicate that nutrient supply controls the distribution of picoplankton functional groups in
the ocean, further supporting the model proposed by Margalef.RADIALES (IEO
Control of tHe structure of marine phytoplAnkton cOmmunities by turbulence and nutrient supply dynamicS (CHAOS)
extended abstract del posterIn order to investigate the role of turbulence mixing on structuring marine phytoplankton communities, the CHAOS project included a multidisciplinary approach involving specifically designed field observations supported by remote sensing, database analyses, and modeling and laboratory chemostat experiments. Field observations carried out in the outer part of Ría de Vigo in summer 2013 showed that, as a result of increased mixing levels, nitrate diffusive input into the euphotic layer was approximately 4-fold higher during spring tides. This nitrate supply could contribute to explain the continuous dominance of large-sized phytoplankton during the upwelling favorable season. Simultaneous estimates of nitrate diffusive fluxes, derived from microturbulence observations, and picoplankton abundance collected in more than 100 stations, spanning widely different hydrographic regimes, showed that the contribution of eukaryotes to picoautotrophic biomass increases with nutrient supply, whereas that of picocyanobacteria shows the opposite trend. These findings were supported by laboratory and modeling chemostat experiments that reproduced the competitive dynamics between picoeukaryote and picocyanobacteria as a function of changing nutrient supply. The results derived from this project confirm that turbulence and mixing control the availability of light and nutrients, which in turn determine the structure of marine phytoplankton communities.RADIALES-20 (IEO), CHAOS (CTM 2012-30680), Malaspina-2010(CSD2008-00077
Nutrient supply does play a role on the structure of marine picophytoplankton communities
Conference communicationThe Margalef´s mandala (1978) is a simplified bottom-up control model that explains how mixing and nutrient concentration determine the composition of marine phytoplankton communities. Due to the difficulties of measuring turbulence in the field, previous attempts to verify this model have applied different proxies for nutrient supply, and very often used interchangeably the terms mixing and stratification. Moreover, because the mandala was conceived before the discovery of smaller phytoplankton groups (picoplankton <2 µm), it describes only the succession of vegetative phases of microplankton. In order to test the applicability of the classical mandala to picoplankton groups, we used a multidisciplinary approach including specifically designed field observations supported by remote sensing, database analyses, and modeling and laboratory chemostat experiments. Simultaneous estimates of nitrate diffusive fluxes, derived from microturbulence observations, and picoplankton abundance collected in more than 200 stations, spanning widely different hydrographic regimes, showed that the contribution of eukaryotes to picoautotrophic biomass increases with nutrient supply, whereas that of picocyanobacteria shows the opposite trend. These findings were supported by laboratory and modeling chemostat experiments that reproduced the competitive dynamics between picoeukaryote sand picocyanobacteria as a function of changing nutrient supply. Our results indicate that nutrient supply controls the distribution of picoplankton functional groups in the ocean, further supporting the model proposed by Margalef.Spanish Governmen
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