Late-life depression accelerates cognitive decline in a tauopathy mouse model

Background: Clinical studies suggest that depressive symptoms could be considered an important risk factor for the future development of cognitive impairment and even Alzheimer's disease (AD). In fact, there is a strong association between depression in later life and AD. The age of onset of AD has been shown to be accelerated in patients with mild cognitive impairment (MCI) with a history of depression, and women appear to be particularly more vulnerable to this condition. In addition, individuals with MCI who present depressive symptoms have an elevated burden of amyloid-beta, one of the featured toxic proteins associated with Alzheimer's pathology, and a higher risk of developing AD compared to non-depressed MCI patients. Although it has been described that some transgenic models of AD can develop signs similar to depression in advanced stages, it is unknown whether late-life depression can accelerate tau-associated pathology and, therefore, acting as a risk factor for AD. Method: In this study, we induced chronic unpredictable mild stress (CUMS) in P301S tau transgenic mice to determine whether depression is a cause, rather than a consequence, of the development of AD. Result: The results of our study indicate that the induction of CUMS in transgenic animals induces phenotypic changes related to a depressive state. Conclusion: The findings obtained after inducing late-life depression-like in P301S mice indicate that depression could be considered a risk factor for AD, by accelerating tau aggregation and worsening clinical signs.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Virtual Environment for the Training of the Hands in Minimally Invasive Thoracic Surgery

The hand and eye coordination of the surgeon is one of the most important factor minimally invasive thoracic surgery. Virtual Simulation is a powerful training tool in surgery. At present, the main problems of the learning process are to reduce the learning time and to improve specific skills by the simulation. There are different options to perform tests: working with animals, with artificial tissues to simulate the pressure, and even simulators through joystick. The main disadvantage is the high cost of this systems and the complexity to replicate the situation during a real operations. In this paper, a virtual reality system is presented. This system allows to reduce the learning time and to improve the hand and eye coodination of the surgeon. Moreover, it is a low cost, portable and easy-to-use solution for future surgeons

Design rules for antenna placement on MIMO systems

In recent works, it is demonstrated that, depending on the different spatial distributions and distance between elements, there exists a different true polarization diversity (TPD) configuration that provides a high improvement in terms of capacity. This means that it is necessary to choose the appropriate TPD configuration to maximize the multiple-input-multiple-output (MIMO) capacity. In this work, a genetic algorithm is used to optimize the element positions for four new different configurations in combination with the TPD technique. It is shown that, for some configurations, the same polarization option is always found to reach the maximum capacity. Based on this, some novel design rules are provided to maximize MIMO capacity when the area for placing the antennas is very small. This is the case for most of the wireless devices, where the antenna design and location is one of the latest design constraints to be taken into consideration in the device design

Gain-Reconfigurable Hybrid Metal-Graphene Printed Yagi Antenna for Energy Harvesting Applications

This paper presents a hybrid metal-graphene printed Yagi antenna with reconfigurable gain that operates in the 5.5-GHz band. The balun and the driven elements are made of copper, while the directors are made of graphene. The graphene acts as a tunable material in the design. By switching the conductivity of the graphene, it is achieved a similar effect to adding or subtracting directors in the antenna. Hence the gain of the printed Yagi can be easily controlled. This could be of special interest in RF energy harvesting in the design of reconfigurable harvesting elements.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Cognitive impairment acceleration after late-life depression in a model of Alzheimer´s disease

Background: Clinical studies suggest that depressive symptoms could be considered an important risk factor for the future development of cognitive impairment and even Alzheimer's disease (AD). In fact, there is a strong association between depression in later life and AD. The age of onset of AD has been shown to be accelerated in patients with mild cognitive impairment (MCI) with a history of depression, and women appear to be particularly more vulnerable to this condition. In addition, individuals with MCI who present with depressive symptoms have an elevated burden of amyloid-beta (Aβ), the main toxic protein associated with Alzheimer's pathology, and a higher risk of developing AD compared to non-depressed MCI patients. However, it is unknown whether depression can be considered a risk factor for the development of AD. Although it has been described that some transgenic models of AD can develop signs similar to depression in advanced stages, the induction of Alzheimer's pathology due to a depressive process has not been studied under experimental conditions to emulate late-life depression as a risk factor for AD. Method: In this study, we induced chronic unpredictable mild stress (CUMS) in P301S tau transgenic mice to determine whether depression is a cause, rather than a consequence, of the development of AD. Result: The results of our study indicate that the induction of CUMS in transgenic animals of the disease give rise to changes in depressive state of the animals. Conclusion: The findings generated in this project could provide evidence of depression as a risk factor for AD, its mechanisms of action, use as early biomarkers, as well as the discovery of new therapies for AD.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. Ministerio de Ciencia e Innovación Brain and Behavior Research Foundation Fondos FEDER y Universidad de Málag

Broadband electronically tunable reflectionbased phase shifter for active-steering microwave reflectarray systems in Ku-band

This document provides the design of an electronically reconfigurable microwave phase shifter for reflectarray systems. The phase shifter is based on a hybrid coupler with reflective circuits in three ports. Each reflective circuit introduces a phase variation that can be modified due to the variable capacity value of a varactor inserted in it. The phase shifting process includes three different stages of phase shifting for the incoming signal in its way through the phase shifter: the signal is conducted through the device towards the reflective circuits in four different ways. The input port of the device is also the output one, providing the desired reflective phase shifting effect. This device is of great interest in reflectarray applications in order to provide more than 360° of controllable phase shifting at each array element. The document includes the complete design of the phase shifter along with its design parameters and circuital behaviour

Electronically reconfigurable reflective phase shifter for circularly polarized reflectarray systems

This letter presents the design of a two-port electronically reconfigurable phase shifter for circularly polarized reflectarray systems at microwave frequencies. The phase shifter is based on 3 dB/90? couplers combined with reflective circuits that introduce sequentially the phase variation. Each reflective circuit, formed by printed elements (L) and tunable varactors, produces the phase variation due to the variable capacity value of the varactor. The phase shifting process includes three different stages of phase shifting for the signal in its way from the input port towards the output port through the phase shifter. Both ports are interchangeable, acting either as input or output ports. This fulfils the reflection requirements of circularly polarized reflectarrays, being especially suitable for this purpose. The complete design, together with its circuital behavior and performance results, are depicted in this document

Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology

Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer’s disease (AD). Microglial response in AD has been principally studied in relation to amyloid-beta pathology but, comparatively, little is known about inflammatory processes associated to tau pathology. In the hippocampus of AD patients, where tau pathology is more prominent than amyloid-beta pathology, a microglial degenerative process has been reported. In this work, we have directly compared the microglial response in two different transgenic tau mouse models: ThyTau22 and P301S. Surprisingly, these two models showed important differences in the microglial profile and tau pathology. Where ThyTau22 hippocampus manifested mild microglial activation, P301S mice exhibited a strong microglial response in parallel with high phospho-tau accumulation. This differential phospho-tau expression could account for the different microglial response in these two tau strains. However, soluble (S1) fractions from ThyTau22 hippocampus presented relatively high content of soluble phospho-tau (AT8-positive) and were highly toxic for microglial cells in vitro, whereas the correspondent S1 fractions from P301S mice displayed low soluble phosphotau levels and were not toxic for microglial cells. Therefore, not only the expression levels but the aggregation of phospho-tau should differ between both models. In fact, most of tau forms in the P301S mice were aggregated and, in consequence, forming insoluble tau species.We conclude that different factors as tau mutations, accumulation, phosphorylation, and/or aggregation could account for the distinct microglial responses observed in these two tau models. For this reason, deciphering the molecular nature of toxic tau species for microglial cells might be a promising therapeutic approach in order to restore the deficient immunological protection observed in AD hippocampus.CIBERNEDJunta de Andalucía. Consejería de Economía, Innovación, Ciencia y Empleo CTS-2035Fundación Tatiana Pérez de Guzmán el BuenoMinisterio de Ciencia, Innovación y UniversidadesInstituto de Salud Carlos III. Fondo de Investigación Sanitaria. PI15/00957 PI15/00796Fondo Europeo de Desarrollo Regional PI15/00957 PI15/0079

Modeling photosynthetically active radiation from satellite-derived estimations over mainland Spain

A model based on the known high correlation between photosynthetically active radiation (PAR) and global horizontal irradiance (GHI) was implemented to estimate PAR from GHI measurements in this present study. The model has been developed using satellite-derived GHI and PAR estimations. Both variables can be estimated using Kato bands, provided by Satellite Application Facility on Climate Monitoring (CM-SAF), and its ratio may be used as the variable of interest in order to obtain the model. The study area, which was located in mainland Spain, has been split by cluster analysis into regions with similar behavior, according to this ratio. In each of these regions, a regression model estimating PAR from GHI has been developed. According to the analysis, two regions are distinguished in the study area. These regions belong to the two climates dominating the territory: an Oceanic climate on the northern edge; and a Mediterranean climate with hot summer in the rest of the study area. The models obtained for each region have been checked against the ground measurements, providing correlograms with determination coefficients higher than 0.99This work was supported by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO) [Project CGL2016-79284-P AEI/FEDER/UE]S

Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients

Neuronal loss is the best neuropathological substrate that correlates with cortical atrophy and dementia in Alzheimer’s disease (AD). Defective GABAergic neuronal functions may lead to cortical network hyperactivity and aberrant neuronal oscilla-tions and in consequence, generate a detrimental alteration in memory processes. In this study, using immunohistochemical and stereological approaches, we report that the two major and non-overlapping groups of inhibitory interneurons (SOM-cells and PV-cells) displayed distinct vulnerability in the perirhinal cortex of APP/PS1 mice and AD patients. SOM-positive neurons were notably sensitive and exhibited a dramatic decrease in the perirhinal cortex of 6-month-old transgenic mice (57% and 61% in areas 36 and 35, respectively) and, most importantly, in AD patients (91% in Braak V–VI cases). In addition, this interneuron degenerative process seems to occur in parallel, and closely related, with the progression of the amyloid pathol-ogy. However, the population expressing PV was unaffected in APP/PS1 mice while in AD brains suffered a pronounced and significant loss (69%). As a key component of cortico-hippocampal networks, the perirhinal cortex plays an important role in memory processes, especially in familiarity-based memory recognition. Therefore, disrupted functional connectivity of this cortical region, as a result of the early SOM and PV neurodegeneration, might contribute to the altered brain rhythms and cognitive failures observed in the initial clinical phase of AD patients. Finally, these findings highlight the failure of amyloidogenic AD models to fully recapitulate the selective neuronal degeneration occurring in humans.Instituto de Salud Carlos III (ISCiii) de España y fondos FEDER de la Unión Europea. PI18/01557 y PI18/01556Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía. Proyecto de Excelencia CTS-2035Universidad de Málaga. PPIT.UMA.B1.2017/2