Clean H2 production by lignin-assisted electrolysis in a polymer electrolyte membrane flow reactor

Biomass-derived products, such as lignin, are interesting resources for energetic purposes. Lignin is a natural polymer that, when added to the anode of an alkaline exchange membrane water electrolyser, enhances H2 production rates and efficiencies due to the substitution of the oxygen evolution reaction. Higher efficiencies are reported when different catalytic materials are employed for constructing the lignin anolyte, demonstrating that lower catalytic loadings for the anode improves the H2 production when compared to higher loadings. Furthermore, when a potential of −1.8 V is applied, higher gains are obtained than when −2.3 V is applied. An increase of 200% of H2 flow rates with respect to water electrolysis is reported when commercial lignin is used coupled with Pt-Ru at 0.09 mg cm−2 and E = −1.8 V is applied at the cathode. This article provides deep information about the oxidation process, as well as an optimisation of the method of the lignin electro-oxidation in a flow-reactor as a pre-step for an industrial implementationThis work was supported by the Madrid Regional Research Council (CAM) and ERDF (European Regional Development Fund), grant no. P2018/EMT-4344 BIOTRES-CM. We thank the Spanish Ministry of Economy, PID 2020-116712RBC21 funded by MCIN/AEI/10.13039/501100011033 is acknowledge

Up-scaling Mate Marote: a university-industry interaction experience

The new digital era opens up great possiblilities in education. Mate Marote is a platform including activities and educational games for massive scale interventions. Recent creation of Fundación Sadosky, has favored the collaboration between industry and academia in projects involving novel methods and ideas with big scale software platforms which require experience in architecture and high-end software development. The collaboration established showed exceptional conditions for the mutual benefit: the incorporation of academic research in educational neuroscience in the industry and the transference of well-established methodology and software development experience in the academic environment.Sociedad Argentina de Informática e Investigación Operativa (SADIO

Up-scaling Mate Marote: a university-industry interaction experience

The new digital era opens up great possiblilities in education. Mate Marote is a platform including activities and educational games for massive scale interventions. Recent creation of Fundación Sadosky, has favored the collaboration between industry and academia in projects involving novel methods and ideas with big scale software platforms which require experience in architecture and high-end software development. The collaboration established showed exceptional conditions for the mutual benefit: the incorporation of academic research in educational neuroscience in the industry and the transference of well-established methodology and software development experience in the academic environment.Sociedad Argentina de Informática e Investigación Operativa (SADIO

Up-scaling Mate Marote: a university-industry interaction experience

The new digital era opens up great possiblilities in education. Mate Marote is a platform including activities and educational games for massive scale interventions. Recent creation of Fundación Sadosky, has favored the collaboration between industry and academia in projects involving novel methods and ideas with big scale software platforms which require experience in architecture and high-end software development. The collaboration established showed exceptional conditions for the mutual benefit: the incorporation of academic research in educational neuroscience in the industry and the transference of well-established methodology and software development experience in the academic environment.Sociedad Argentina de Informática e Investigación Operativa (SADIO

Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas

Transcription factor NRF2 orchestrates a cellular defense against oxidative stress and, so far, has been involved in tumor progression by providing a metabolic adaptation to tumorigenic demands and resistance to chemotherapeutics. In this study, we discover that NRF2 also propels tumorigenesis in gliomas and glioblastomas by inducing the expression of the transcriptional co-activator TAZ, a protein of the Hippo signaling pathway that promotes tumor growth. The expression of the genes encoding NRF2 (NFE2L2) and TAZ (WWTR1) showed a positive correlation in 721 gliomas from The Cancer Genome Atlas database. Moreover, NRF2 and TAZ protein levels also correlated in immunohistochemical tissue arrays of glioblastomas. Genetic knock-down of NRF2 decreased, while NRF2 overexpression or chemical activation with sulforaphane, increased TAZ transcript and protein levels. Mechanistically, we identified several NRF2-regulated functional enhancers in the regulatory region of WWTR1. The relevance of the new NRF2/TAZ axis in tumorigenesis was demonstrated in subcutaneous and intracranial grafts. Thus, intracranial inoculation of NRF2-depleted glioma stem cells did not develop tumors as determined by magnetic resonance imaging. Forced TAZ overexpression partly rescued both stem cell growth in neurospheres and tumorigenicity. Hence, NRF2 not only enables tumor cells to be competent to proliferate but it also propels tumorigenesis by activating the TAZ-mediated Hippo transcriptional program.This study was funded by the Spanish Ministry of Economy and Competitiveness (MINECO) under the grant SAF2016-76520-R. ME is recipient of a postdoctoral contract Juan de la Cierva; DL and NRA of a FPU contract of MINECO; MP and RFG of a FPI contracts of Autonomous University of Madrid. RG has been funded by the AECC Scientific Foundation

Experiencias de I+D+i en productos avanzados para el análisis de software

El equipo de LaFHIS es un grupo del Departamento de Computación de FCEyN, UBA especializado análisis de software. Actualmente, miembros del LaFHIS son parte constitutiva del nuevo Centro de Transferencia e Investigación en Ingeniería de Software (CETIS). En este artículo se reportan los pasos iniciales de colaboraciones del CETIS con dos compañías locales que brindan servicios de desarrollo y gestión de aplicaciones: Epidata y Pragma Consultores. Estas colaboraciones tienen como objetivo las construcción de herramientas novedosas de análisis de software.Sociedad Argentina de Informática e Investigación Operativa (SADIO

Experiencias de I+D+i en productos avanzados para el análisis de software

El equipo de LaFHIS es un grupo del Departamento de Computación de FCEyN, UBA especializado análisis de software. Actualmente, miembros del LaFHIS son parte constitutiva del nuevo Centro de Transferencia e Investigación en Ingeniería de Software (CETIS). En este artículo se reportan los pasos iniciales de colaboraciones del CETIS con dos compañías locales que brindan servicios de desarrollo y gestión de aplicaciones: Epidata y Pragma Consultores. Estas colaboraciones tienen como objetivo las construcción de herramientas novedosas de análisis de software.Sociedad Argentina de Informática e Investigación Operativa (SADIO

Experiencias de I+D+i en productos avanzados para el análisis de software

El equipo de LaFHIS es un grupo del Departamento de Computación de FCEyN, UBA especializado análisis de software. Actualmente, miembros del LaFHIS son parte constitutiva del nuevo Centro de Transferencia e Investigación en Ingeniería de Software (CETIS). En este artículo se reportan los pasos iniciales de colaboraciones del CETIS con dos compañías locales que brindan servicios de desarrollo y gestión de aplicaciones: Epidata y Pragma Consultores. Estas colaboraciones tienen como objetivo las construcción de herramientas novedosas de análisis de software.Sociedad Argentina de Informática e Investigación Operativa (SADIO

Pre-operative anxiolysis in children through a combined pharmacological therapy with hydroxyzine and a non-pharmacological distraction technique with a clown (SONRISA): study protocol for randomised double-blind clinical trial.

Background Surgery can generate significant stress and anxiety in up to 70% of the paediatric population. There are several pharmacological and non-pharmacological strategies to reduce pre-operative anxiety in children, however, they have several side effects and the available information about them is contradictory. The role of clowns and hydroxyzine in the management of anxiety is controversial, with some studies supporting and others contraindicating both strategies. Methods We propose a randomised double-blind, controlled clinical trial that will evaluate the effectiveness of both interventions (hydroxyzine and clowns), alone or in combination, to reduce pre-operative anxiety (using the modified Yale scale of preoperative anxiety) in children aged 2–16 years undergoing outpatient surgery (n = 188). Subjects will be randomised into two groups – (1) standard procedure (parental accompaniment) combined with placebo or (2) standard procedure combined with preoperative hydroxyzine. After randomisation, they will be divided by chance into two further groups, depending on the presence of clowns on the patient’s surgery day. Control of pre-operative anxiety will be determined in the four groups by a modified Yale scale of preoperative anxiety and cortisol levels. Compliance of children during induction of anaesthesia, time until anaesthesia recovery, presence of postoperative delirium and use of analgesia until discharge will be also assessed. For additional information, the children, parents and healthcare professionals involved in the study will complete a satisfaction survey. Conclusions This study aims to gather evidence on which of these four therapeutic options achieves the highest reduction of pre-operative anxiety with the best safety profile to allow paediatricians and anaesthesiologists to use the most effective and safe option for their patients.post-print781 K

Evaluation of the Effect of Hydroxyzine on Preoperative Anxiety and Anesthetic Adequacy in Children: Double Blind Randomized Clinical Trial.

Surgical procedures can generate significant preoperative anxiety (POA) in as much as 70% of the paediatric population. The role of hydroxyzine and distractive techniques such as clowns in the management of anxiety is controversial. Our main objective was to evaluate the effect of hydroxyzine on the control of POA. The secondary objective was to assess the potential additive effect of hydroxyzine and distracting techniques. We performed a randomized double-blind, controlled clinical trial in children aged 2–16 years undergoing outpatient surgery (). Subjects were randomized to hydroxyzine (group 1) or placebo (group 2). For the secondary objective, two further groups were made by allocation by chance to hydroxyzine plus accompaniment with clowns (group 3) and placebo plus clowns (group 4). All patients were accompanied by their parents as the standard procedure. POA was determined by a modified Yale scale of POA (m-YPAS). Compliance of children during induction of anesthesia (Induction Compliance Checklist (ICC)) was also assessed. No differences () were found in POA control at the time of induction measured by m-YPAS (group 1: ; group 2: ; group 3: ; group 4: ). No differences were found in the level of ICC between the different treatment arms (group 1: ; group 2: ; group 3: ; group 4: ). The combination of all treatments (group 3) was the only effective strategy to contain the progression of anxiety. In conclusion, hydroxyzine was not effective to control POA in children. The combination of hydroxyzine and clowns avoided the progression of POA in our patients. This trial is registered with ClinicalTrials.gov identifier: NCT03324828 (registered 21 September 2017, subject recruitment started on 12th January 2018).post-print489 K