5,218 research outputs found

    Assessing impacts of participation: stakeholders, gender, and difference

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    De retibus socialibus et legibus momenti

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    Online Social Networks (OSNs) are a cutting edge topic. Almost everybody --users, marketers, brands, companies, and researchers-- is approaching OSNs to better understand them and take advantage of their benefits. Maybe one of the key concepts underlying OSNs is that of influence which is highly related, although not entirely identical, to those of popularity and centrality. Influence is, according to Merriam-Webster, "the capacity of causing an effect in indirect or intangible ways". Hence, in the context of OSNs, it has been proposed to analyze the clicks received by promoted URLs in order to check for any positive correlation between the number of visits and different "influence" scores. Such an evaluation methodology is used in this paper to compare a number of those techniques with a new method firstly described here. That new method is a simple and rather elegant solution which tackles with influence in OSNs by applying a physical metaphor.Comment: Changes made for third revision: Brief description of the dataset employed added to Introduction. Minor changes to the description of preparation of the bit.ly datasets. Minor changes to the captions of Tables 1 and 3. Brief addition in the Conclusions section (future line of work added). Added references 16 and 18. Some typos and grammar polishe

    First report of caprine abortions due to Chlamydia abortus in Argentina.

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    Infectious abortions of goats in Argentina are mainly associated with brucellosis and toxoplasmosis. In this paper, we describe an abortion outbreak in goats caused by Chlamydia abortus. Seventy out of 400 goats aborted. Placental smears stained with modified Ziehl-Neelsen stain showed many chlamydia-like bodies within trophoblasts. One stillborn fetus was necropsied and the placenta was examined. No gross lesions were seen in the fetus, but the inter-cotyledonary areas of the placenta were thickened and covered by fibrino-suppurative exudate. The most consistent microscopic finding was found in the placenta and consisted of fibrinoid necrotic vasculitis, with mixed inflammatory infiltration in the tunica media. Immunohistochemistry of the placenta was positive for Chlamydia spp. The results of polymerase chain reaction targeting 23S rRNA gene performed on placenta were positive for Chlamydia spp. An analysis of 417 amplified nucleotide sequences revealed 99% identity to those of C. abortus pm225 (GenBank AJ005617) and pm112 (GenBank AJ005613) isolates. To the best of our knowledge, this is the first report of abortion associated with C. abortus in Argentina

    Knowledge about and Knowledge with: Contributions from Feminist Research to Knowledge Co-Production for Pastoral Systems

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    Globally, the gender dynamics of rangeland social-ecological systems have received scant attention. Further, research paradigms, methods and methodologies that leave little room for equitable engagement with research participants and genuine action-oriented research-practice partnerships dominate in pastoralist/rangeland studies. Our research is informed by a feminist philosophy of science and based on decolonial and feminist political ecology studies that focus on gendered science and knowledge production. Feminist research calls for reflection on who produces knowledge and how such knowledge is used and shared. Feminist practices such as reciprocity, care, and positionality, cultivate awareness of the power dynamics embedded in the research process and motivate us as researchers to counteract asymmetrical or extractive relationships when we identify them. In this paper we first introduce the principles of our feminist research, and then reflect on our experience as researchers and as activists or participants in the Spanish and Catalan networks of women shepherdesses and livestock operators

    Cell Expansion-Dependent Inflammatory and Metabolic Profile of Human Bone Marrow Mesenchymal Stem Cells

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    Stem cell therapy has emerged as a promising new area in regenerative medicine allowing the recovery of viable tissues. Among the many sources of adult stem cells, bone marrow-derived are easy to expand in culture via plastic adherence and their multipotentiality for differentiation make them ideal for clinical applications. Interestingly, several studies have indicated that MSCs expansion in vitro may be limited mainly due to cell aging related to the number of cell divisions in culture. We have determined that MSCs exhibit a progressive decline across successive passages in the expression of stem cell markers, in plasticity and in the inflammatory response, presenting low immunogenicity. We have exposed human MSCs after several passages to TLRs ligands and analyzed their inflammatory response. These cells responded to pro-inflammatory stimuli (i.e., NOS-2 expression) and to anti-inflammatory cytokines (i.e., HO1 and Arg1) until two expansions, rapidly declining upon subculture. Moreover, in the first passages, MSCs were capable to release IL1β, IL6 and IL8, as well as to produce active MMPs allowing them to migrate. Interestingly enough, after two passages, anaerobic glycolysis was enhanced releasing high levels of lactate to the extracellular medium. All these results may have important implications for the safety and efficacy of MSCs-based cell therapies

    Water and Flamingo Feces Bacterial Communities from High- Altitude Andean Lakes under Selective Antibiotic Pressure Studied by PCR-DGGE Analyses

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    High-altitude Andean lakes are exposed to extreme environmental factors like high salinity, ultraviolet radiation, heavy metals, among others. As it was previously shown, these lakes are not only the habitat of a high diversity of bacteria with multiple resistances; they also support an enormous population of flamingos, which migrate among these wetlands, and they could play a role as disseminators and/or reservoirs of pathogenic bacteria

    Cycloidal Domains in the Magnetization Reversal Process of Ni80Fe20/Nd16Co84/Gd12Co88 Trilayers

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    The magnetization reversal of each individual layer in magnetic trilayers ( permalloy / Nd Co / Gd Co ) is investigated in detail with x-ray microscopy and micromagnetic calculations. Two sequential inversion mechanisms are identified. First, magnetic vortex-antivortex pairs move along the field direction while inverting the magnetization of magnetic stripes until they are pinned by defects. The vortex-antivortex displacements are reversible within a field interval which allows their controlled motion. Second, as the reversed magnetic field increases, cycloidal domains appear in the permalloy layer as a consequence of the dissociation of vortex-antivortex pairs due to pinning. The field range where magnetic vortices and antivortices are effectively guided by the stripe pattern is of the order of tens of mT for the Ni Fe layer, as estimated from the stability of cycloid domains in the sample
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