Climate Change Risk for Irish Timber Power Pole Networks

The latest IPCC report states that warming of the climate system is unequivocal, and this warming may lead to increased risk of breakdown of infrastructure networks due to extreme weather. Before appropriate action can be taken for power infrastructure in this regard, we must first understand existing risk, and then try to predict potential climate related changes in risk. The work described in this paper examines both existing vulnerability, and potential future vulnerability, for a notional network of Irish timber power poles. These power pole networks represent important critical infrastructure assets, both nationally, and internationally. There are currently approximately two million timber power poles in service in Ireland, five million timber power poles in service in Australia, worth over $10 billion, and approximately 200 million treated power poles in service in the United States. The impacts of climate change on Irish power poles will be examined herein using a Monte-Carlo event-based sequential model, which incorporates structural reliability, deterioration, climatic effects and network maintenance. The hazards of interest are storm winds and timber decay - both of which may worsen due to a changing climate.The authors would like to acknowledge the financial support of the Irish Environmental Protection Agency who funded this research. The authors would also like to acknowledge Fergus Sweeney and Kevin OConnor, of the Irish Electricity Supply Board, for their invaluable expertise and support in developing appropriate model parameters

Perivascular spaces in the brain:anatomy, physiology and pathology

Perivascular spaces include a variety of passageways around arterioles, capillaries and venules in the brain, along which a range of substances can move. Although perivascular spaces were first identified over 150 years ago, they have come to prominence recently owing to advances in knowledge of their roles in clearance of interstitial fluid and waste from the brain, particularly during sleep, and in the pathogenesis of small vessel disease, Alzheimer disease and other neurodegenerative and inflammatory disorders. Experimental advances have facilitated in vivo studies of perivascular space function in intact rodent models during wakefulness and sleep, and MRI in humans has enabled perivascular space morphology to be related to cognitive function, vascular risk factors, vascular and neurodegenerative brain lesions, sleep patterns and cerebral haemodynamics. Many questions about perivascular spaces remain, but what is now clear is that normal perivascular space function is important for maintaining brain health. Here, we review perivascular space anatomy, physiology and pathology, particularly as seen with MRI in humans, and consider translation from models to humans to highlight knowns, unknowns, controversies and clinical relevance

Improving public health by improving clinical trial guidelines and their application.

Evidence generated from randomized controlled trials forms the foundation of cardiovascular therapeutics and has led to the adoption of numerous drugs and devices that prolong survival and reduce morbidity, as well as the avoidance of interventions that have been shown to be ineffective or even unsafe. Many aspects of cardiovascular research have evolved considerably since the first randomized trials in cardiology were conducted. In order to be large enough to provide reliable evidence about effects on major outcomes, cardiovascular trials may now involve thousands of patients recruited from hundreds of clinical sites in many different countries. Costly infrastructure has developed to meet the increasingly complex organizational and operational requirements of these clinical trials. Concerns have been raised that this approach is unsustainable, inhibiting the reliable evaluation of new and existing treatments, to the detriment of patient care. These issues were considered by patients, regulators, funders, and trialists at a meeting of the European Society of Cardiology Cardiovascular Roundtable in October 2015. This paper summarizes the key insights and discussions from the workshop, highlights subsequent progress, and identifies next steps to produce meaningful change in the conduct of cardiovascular clinical research

Parent–Adolescent Relationship Quality as an Intervening Variable on Adolescent Outcomes among Families at Risk: Dyadic Analyses

The purpose of this study was to examine mother and adolescent reports of relationship quality over time and to test whether mother–adolescent relationship quality intervened with the known association between maternal depressive symptoms and higher levels of adolescent externalizing and internalizing problem behaviors using actor‐partner interdependence modeling. Data were from the Longitudinal Studies of Child Abuse and Neglect and included a sample of 278 mother–adolescent dyads at risk for child maltreatment. Results revealed that mothers and adolescents reported high‐quality relationships at ages 12 and 14. Mother and adolescent reports of relationship quality were also interdependent such that one\u27s perception of relationship quality significantly influenced the other\u27s report of relationship quality. Importantly, mother–adolescent relationship quality significantly intervened in the association between maternal depressive symptoms and adolescent externalizing and internalizing problem behaviors. These findings have implications for family interventions with mothers and adolescents to strengthen relationship quality