We review the optical properties of the FMO complex as found by spectroscopic studies of the Qy band over the last two decades. This article emphasizes the different methods used, both experimental and theoretical, to elucidate the excitonic structure and dynamics of this pigment–protein complex
Background: Following addition of a biosimilar filgrastim product to the formulary, sites in the authors’ provincial health authority transitioned from using the originator filgrastim to the biosimilar for autologous stem cell mobilization.
Objective: To assess the effect on patient outcomes of a universal change to use of the biosimilar filgrastim in stem cell mobilization.
Methods: This retrospective pre–post study included patients undergoing autologous stem cell mobilization at 2 cancer hospitals in Alberta, Canada, between July 1, 2018, and November 30, 2019. Clinical outcomes were investigated for patients treated with a granulocyte colony-stimulating factor (biosimilar or originator product) for mobilization before stem cell transplant, approximately 6 months before and after the defined date of product change.
Results: In total, 102 patients were treated with the originator product and 101 patients with the biosimilar. Effectiveness was similar between the originator and biosimilar products, with 98% successful harvest of stem cells in all patients treated. Independent t tests showed no statistically significant differences between patients receiving the originator and those receiving the biosimilar in terms of time from mobilization to collection (difference of means –0.9 days, 95% confidence interval [CI] –2.12 to 0.32), time for neutrophil engraftment (difference of means 0 days, 95% CI –0.36 to 0.36), time for platelet engraftment (difference of means 1 day, 95% CI –0.55 to 2.55), average length of stay (difference of means –0.7 day, 95% CI –2.71 to 1.31), and CD34+ value (difference of means –1 × 106/kg body weight, 95% CI –2.11 to 0.11). A 98% rate of conversion to use of the biosimilar filgrastim was achieved, with an estimated annual drug-cost saving of 67500.Conclusions:Inthispre–poststudy,changingtothebiosimilarproductfromtheoriginatormaintainedclinicaleffectivenessoutcomeswhiledecreasingoveralldrugexpenditures.Awell−plannedchangetothebiosimilarproduct,executedinconjunctionwithclinicianconsultationandmonitoringofeffectivenessoutcomes,canensureappropriatepatienttherapywhilesignificantlyimprovingtheuptakeofbiosimilarsanddecreasingexpendituresforbiologicdrugs.REˊSUMEˊContexte:Aˋlasuitedel’ajoutd’unproduitfilgrastimbiosimilaireaˋlalistedesmeˊdicaments,lessitesrelevantdel’autoriteˊsanitaireprovincialedesauteurssontpasseˊsdel’utilisationdufilgrastimprincepsaˋlaversiongeˊneˊriquepourlamobilisationdescellulessouchesautologues.Objectif:Eˊvaluerl’effetsurlesreˊsultatsdespatientsd’unchangementgeˊneˊraliseˊvisantaˋutiliserlefilgrastimgeˊneˊriquepourlamobilisationdescellulessouches.Meˊthodes:Cetteeˊtudereˊtrospectivepreˊ−postcomprenaitdespatientssoumisaˋunemobilisationdescellulessouchesautologuesdansdeuxho^pitauxdecanceˊrologieenAlberta(Canada)entrele1erjuillet2018etle30novembre2019.L’examendesreˊsultatscliniquesdespatientstraiteˊsaˋl’aided’unfacteurstimulantlescoloniesdegranulocytes(G−CSF)(geˊneˊriqueouprinceps)pourunemobilisationavantlagreffedecellulessouchesaeulieuenvironsixmoisavantetapreˋsladateduchangementdeproduit.Reˊsultats:Autotal,102patientsonteˊteˊtraiteˊsaˋl’aideduproduitprincepset101patientsaˋl’aidedugeˊneˊrique.Lesdeuxproduitspreˊsentaientuneefficaciteˊsimilaire,et98.
Conclusions : Dans cette étude pré-post, le passage du produit princeps au générique a préservé l’efficacité des résultats cliniques, tout en diminuant les dépenses générales liées au médicament. Un changement bien programmé pour passer au produit générique, mené conjointement avec la consultation d’un clinicien et un contrôle des résultats d’efficacité, peut assurer une thérapie du patient appropriée tout en améliorant grandement la prise de produits génériques et en diminuant les dépenses associées aux médicaments biologiques.