Calculation of conventional and prompt lepton fluxes at very high energy

An efficient method for calculating inclusive conventional and prompt atmospheric leptons fluxes is presented. The coupled cascade equations are solved numerically by formulating them as matrix equation. The presented approach is very flexible and allows the use of different hadronic interaction models, realistic parametrizations of the primary cosmic-ray flux and the Earth's atmosphere, and a detailed treatment of particle interactions and decays. The power of the developed method is illustrated by calculating lepton flux predictions for a number of different scenarios.Comment: 8 pages, 10 figures, for Proceedings of the International Symposium for Very-High Energy Cosmic-Ray Interactions (ISVHECRI 2014

Sibyll★^\bigstar: ad-hoc modifications for an improved description of muon data in extensive air showers

Current simulations of air showers produced by ultra-high energy cosmic rays (UHECRs) do not satisfactorily describe recent experimental data, particularly when looking at the muonic shower component relative to the electromagnetic one. Discrepancies can be seen in both average values and on an individual shower-by-shower basis. It is thought that the muonic part of the air showers isn't accurately represented in simulations, despite various attempts to boost the number of muons within standard hadronic interaction physics. In this study, we investigate whether modifying the final state of events created with Sibyll~2.3d in air shower simulations can achieve a more consistent description of the muon content observed in experimental data. We create several scenarios where we separately increase the production of baryons, $\rho^0$, and strange particles to examine their impact on realistic air shower simulations. Our results suggest that these ad-hoc modifications can improve the simulations, providing a closer match to the observed muon content in air showers. One side-effect of the increased muon production in the considered model versions is a smaller difference in the predicted total muon numbers for proton and iron showers. However, more research is needed to find out whether any of these adjustments offers a realistic solution to the mismatches seen in data, and to identify the precise physical process causing these changes in the model. We hope that these modified model versions will also help to develop improved machine-learning analyses of air shower data and to estimate sys.{} uncertainties related to shortcomings of hadronic interaction models

The hadronic interaction model SIBYLL 2.3c and Feynman scaling

The Monte Carlo model Sibyll has been designed for efficient simulation of hadronic multiparticle production up to the highest energies as needed for interpreting cosmic ray measurements. For more than 15 years, version 2.1 of Sibyll has been one of the standard models for air shower simulation. Motivated by data of LHC and fixed-target experiments and a better understanding of the phenomenology of hadronic interactions, we have developed an improved version of this model, version 2.3, which has been released in 2016. In this contribution we present a revised version of this model, called Sibyll 2.3c, that is further improved by adjusting particle production spectra to match the expectation of Feynman scaling in the fragmentation region. After a brief introduction to the changes implemented in Sibyll 2.3 and 2.3c with respect to Sibyll 2.1, the current predictions of the model for the depth of shower maximum, the number of muons at ground, and the energy spectrum of muons in extensive air showers are presented.Comment: 35th International Cosmic Ray Conferenc

Folding and unfolding of a triple-branch DNA molecule with four conformational states

Single-molecule experiments provide new insights into biological processes hitherto not accessible by measurements performed on bulk systems. We report on a study of the kinetics of a triple-branch DNA molecule with four conformational states by pulling experiments with optical tweezers and theoretical modelling. Three distinct force rips associated with different transitions between the conformational states are observed in the folding and unfolding trajectories. By applying transition rate theory to a free energy model of the molecule, probability distributions for the first rupture forces of the different transitions are calculated. Good agreement of the theoretical predictions with the experimental findings is achieved. Furthermore, due to our specific design of the molecule, we found a useful method to identify permanently frayed molecules by estimating the number of opened basepairs from the measured force jump values.Comment: 17 pages, 12 figure

The multiple signaling modalities of adhesion G protein-coupled receptor GPR126 in development

The G protein-coupled receptor (GPCR) superfamily is the largest known receptor family in the human genome. Although the family of adhesion GPCRs comprises the second largest sub-family, their function is poorly understood. Here, we review the current knowledge about the adhesion GPCR family member GPR126. GPR126 possesses a signal peptide, a 7TM domain homologous to secretin-like GPCRs, a GPS motif and an extended N-terminus containing a CUB (Complement, Uegf, Bmp1) domain, a PTX (Pentraxin) domain, a hormone binding domain and 27 putative N-glycosylation sites. Knockdown and knockout experiments in zebrafish and mice have demonstrated that Gpr126 plays an essential role in neural, cardiac and ear development. In addition, genome-wide association studies have implicated variations at the GPR126 locus in obstructive pulmonary dysfunction, in scoliosis and as a determinant of trunk length and body height. Gpr126 appears to exert its function depending on the organ system via G protein- and/or N-terminus-dependent signaling. Here, we review the current knowledge about Gpr126, which, due to the variety of its functions and its multiple signaling modalities, provides a model adhesion GPCR to understand general functional concepts utilized by adhesion GPCRs

The multiple signaling modalities of adhesion G protein-coupled receptor GPR126 in development

The G protein-coupled receptor (GPCR) superfamily is the largest known receptor family in the human genome. Although the family of adhesion GPCRs comprises the second largest sub-family, their function is poorly understood. Here, we review the current knowledge about the adhesion GPCR family member GPR126. GPR126 possesses a signal peptide, a 7TM domain homologous to secretin-like GPCRs, a GPS motif and an extended N-terminus containing a CUB (Complement, Uegf, Bmp1) domain, a PTX (Pentraxin) domain, a hormone binding domain and 27 putative N-glycosylation sites. Knockdown and knockout experiments in zebrafish and mice have demonstrated that Gpr126 plays an essential role in neural, cardiac and ear development. In addition, genome-wide association studies have implicated variations at the GPR126 locus in obstructive pulmonary dysfunction, in scoliosis and as a determinant of trunk length and body height. Gpr126 appears to exert its function depending on the organ system via G-protein- and/or N-terminus-dependent signaling. Here, we review the current knowledge about Gpr126, which, due to the variety of its functions and its multiple signaling modalities, provides a model adhesion GPCR to understand general functional concepts utilized by adhesion GPCRs

The Threat of Capital Drain: A Rationale for Public Banks?

This paper yields a rationale for why subsidized public banks may be desirable from a regional perspective in a financially integrated economy. We present a model with credit rationing and heterogeneous regions in which public banks prevent a capital drain from poorer to richer regions by subsidizing local depositors, for example, through a public guarantee. Under some conditions, cooperative banks can perform the same function without any subsidization; however, they may be crowded out by public banks. We also discuss the impact of the political structure on the emergence of public banks in a political-economy setting and the role of interregional mobility

Optical inter-site spin transfer probed by energy and spin-resolved transient absorption spectroscopy

Optically driven spin transport is the fastest and most efficient process to manipulate macroscopic magnetization as it does not rely on secondary mechanisms to dissipate angular momentum. In the present work, we show that such an optical inter-site spin transfer (OISTR) from Pt to Co emerges as a dominant mechanism governing the ultrafast magnetization dynamics of a CoPt alloy. To demonstrate this, we perform a joint theoretical and experimental investigation to determine the transient changes of the helicity dependent absorption in the extreme ultraviolet spectral range. We show that the helicity dependent absorption is directly related to changes of the transient spin-split density of states, allowing us to link the origin of OISTR to the available minority states above the Fermi level. This makes OISTR a general phenomenon in optical manipulation of multi-component magnetic systems. Optically driven spin transfer is the fastest process to manipulate magnetism. Here, the authors show that this process emerges as the dominant mechanism in femtosecond spin dynamics enabling to the engineering of functional magnetic systems for future all optical technologies