Managing occupational safety and health in culturally diverse small businesses: a commentary

International audienceIt is estimated that over 175 million people, or 3 per cent of the world's population, live outside their country of origin. While this diaspora has a significant impact on workforce demographics, there is still a lack of documented evidence on managing occupational health and safety in culturally diverse small businesses. In response to this lack of evidence, an international, collaborative research group was formed in 2009 to investigate the health and safety of culturally diverse workforces and resolve the inherent methodological issues. The research group has begun to undertake a number of exploratory studies located in different countries and within different jurisdictions, focusing primarily on small businesses. Informed by discussions at two recent colloquia on the topic, this commentary provides an overview of the themes and key debates in the extant literature and suggests ways forward. It concludes with an appeal that new approaches to researching and managing culturally diverse small businesses are needed

Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study

Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 x 10(-8) to P = 2.7 x 10(-24)). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining similar to 25% of the familial risk in this disease, have now been identified

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (