Accelerating the Configuration Tuning of Big Data Analytics with Similarity-aware Multitask Bayesian Optimization

One of the key challenges for data analytics deployment is configuration tuning. The existing approaches for configuration tuning are expensive and overlook the dynamic characteristics of the analytics environment (i.e. frequent changes in workload due to receiving evolving input sizes or change in the underlying cluster environment). Such workload/environment changes can cause significant performance degradation, with retuning the configuration to accommodate those changes can yield up to 85\% potential execution time saving. We propose SimTune, an approach that accommodates such changes through efficient configuration tuning. SimTune combines workload characterization and Multitask Bayesian optimization to identify similarity across workloads and accelerate finding near-optimal configurations. Our experimental results show that SimTune reduces the search time for finding close-to-optimal configurations by 56-73\% (at the median) when compared to existing state-of-the-art techniques. This means that the amortization of the tuning cost happens significantly faster, enabling practical tuning in the rapidly changing environment of distributed analytics.Google Cloud, Amazon AW

To Tune or Not to Tune?: In Search of Optimal Configurations for Data Analytics

This experimental study presents several overlooked issues that pose a challenge for data analytics configuration tuning and deployment. These issues include: 1) the assumption of static workload/environment ignoring the dynamic characteristics of the analytics environment (e.g. the frequent need for workload retuning). 2) the speed of tuning cost amortization and how this influences the tuning decision. 3) the need for a comprehensive incremental tuning for a diverse set of workloads. To prove our point, we present Tuneful, an efficient configuration tuning framework for data analytics. We show how it is designed to overcome the above issues and illustrate its applicability by experimenting with it on two cloud service providers

Documenting the Recovery of Vascular Services in European Centres Following the Initial COVID-19 Pandemic Peak: Results from a Multicentre Collaborative Study

Objective: To document the recovery of vascular services in Europe following the first COVID-19 pandemic peak. Methods: An online structured vascular service survey with repeated data entry between 23 March and 9 August 2020 was carried out. Unit level data were collected using repeated questionnaires addressing modifications to vascular services during the first peak (March – May 2020, “period 1”), and then again between May and June (“period 2”) and June and July 2020 (“period 3”). The duration of each period was similar. From 2 June, as reductions in cases began to be reported, centres were first asked if they were in a region still affected by rising cases, or if they had passed the peak of the first wave. These centres were asked additional questions about adaptations made to their standard pathways to permit elective surgery to resume. Results: The impact of the pandemic continued to be felt well after countries’ first peak was thought to have passed in 2020. Aneurysm screening had not returned to normal in 21.7% of centres. Carotid surgery was still offered on a case by case basis in 33.8% of centres, and only 52.9% of centres had returned to their normal aneurysm threshold for surgery. Half of centres (49.4%) believed their management of lower limb ischaemia continued to be negatively affected by the pandemic. Reduced operating theatre capacity continued in 45.5% of centres. Twenty per cent of responding centres documented a backlog of at least 20 aortic repairs. At least one negative swab and 14 days of isolation were the most common strategies used for permitting safe elective surgery to recommence. Conclusion: Centres reported a broad return of services approaching pre-pandemic “normal” by July 2020. Many introduced protocols to manage peri-operative COVID-19 risk. Backlogs in cases were reported for all major vascular surgeries

Effects of Mycorrhizal Colonization on Transcriptional Expression of the Responsive Factor JERF3 and Stress-Responsive Genes in Banana Plantlets in Response to Combined Biotic and Abiotic Stresses

Banana plants (Musa acuminata L.) are exposed to various biotic and abiotic stresses that affect their production worldwide. Banana plants respond to these stresses, but their responses to combined stresses are unique and differ from those to various individual stresses. This study reported the effects of the mycorrhizal colonization of banana roots and/or infection with root rot on the transcriptional expression of the responsive factor JERF3 and stress-responsive genes (POD, PR1, CHI, and GLU) under different salinity levels. Different transcriptional levels were recorded in response to the individual, dual, or triple treatments. All the applied biotic and abiotic stresses triggered the transcriptional expression of the tested genes when individually applied, but they showed different influences varying from synergistic to antagonistic when applied in combinations. The salinity stress had the strongest effect when applied in combination with the biotic stress and/or mycorrhizal colonization, especially at high concentrations. Moreover, the salinity level differentially affects the banana responses under combined stresses and/or mycorrhizal colonization in addition, the mycorrhizal colonization of banana plantlets improved their growth, photosynthesis, and nutrient uptake, as well as greatly alleviated the detrimental effects of salt and infection stresses. In general, the obtained results indicated that the responses of banana plantlets under the combined stresses are more complicated and differed from those under the individual stresses depending on the crosstalks between the signaling pathways.</jats:p

Renal Protective Effect of Ginkgo biloba and L-carnitine Extracts against Pentylenetetrazol Induced Toxicity, Oxidative Stress, Injury and Proliferation Alternation in Epileptic Rats

Objectives: Ginkgo biloba leaf extract (GBLE) and L-carnitine extract are a commercial product used as a nutraceutic herbal widely. They have antioxidant and reactive oxygen species (ROS) scavenger. This study hypothesized that GB and L-carnitine may have protective effects against pentylenetetrazol (PTZ) induced oxidative damage in kidney in male albino rats.&#x0D; Materials and Methods: A total of 80 male albino rats were equally divided into eight groups (G1, control; G2, GBLE; G3, L-carnitine; G4, Pentylenetetrazole; G5&amp;G6, pre and post treated PTZ with L-carnitine groups respectively; G7&amp;G8, pre and post treated PTZ with GBLE respectively). Results: Serum urea, creatinine, uric acid and cystatin c were significantly increased in PTZ group when compared with control. Also; kidney homogenate MDA and DNA fragmentation were increased when compared with control while, significant decrease in CAT, SOD, GST and TAC in PTZ when compared with control. On other hand pre and post-treatment with L-carnitine and GBLE improved these parameters.&#x0D; Conclusions: The results revealed that; the treatment with L-carnitine improved these parameters more than GBLE and the results of post treatment were better than pre-treatment.</jats:p

Studies on Dry Sliding Wear and Solid Particle Erosive Wear Behaviours of Natural Fibre Composite Developed from Water Hyacinth Aquatic Plant for Automotive Application

In this research, an attempt is made to investigate the abrasive and erosion wear resistance of aquatic waste plant water hyacinth converted fibre-reinforced polymer composites. From a novel approach, the new fibre extraction machine is designed to extract the hyacinth fibre from the parent plant and reinforce it to the epoxy matrix material to produce a natural fibre composite for frictional applications. The extracted fibre is dried in the open sunlight area for 22 to 35 days to remove moisture and external dust particles. Then, different weight percentages (15, 20, 25, 30, and 35) of composite samples are produced with the help of the hot press compression moulding technique. Improved hyacinth composite tribology properties are tested by utilizing the pin on the disk machine. This setup included various processing parameters like load (10, 20, and 30 N), velocities (1, 2, and 3 m/s), speed (160, 320, and 479 rpm), and constant sliding distance condition, and the erosion setup also influences the essential parameters like impact angle (30, 45, and 60°), erodent velocity (1, 2.5, and 3.3 m/s), and discharge rate (28, 41, and 72 g/m). The factorial techniques are used to identify the important design factors. The final results represent the weight loss, volume loss, and erosion rate of hyacinth fibre composite. By utilizing the SEM (scanning electron microscope), the worn surface morphology of different weight percentages of hyacinth fibre samples are analysed. To upgrade the usage of hyacinth reinforced composites for different industrial applications, wear and erosion studies are conducted with different parameter conditions