Sketchplore

| openaire: EC/H2020/637991/EU//COMPUTEDThis paper studies a novel concept for integrating real-time design optimisation to a sketching tool. Although optimisation methods can attack very complex design problems, their insistence on precise objectives and a point optimum is a poor fit with sketching practices. Sketchplorer is a multitouch sketching tool that uses a real-time layout optimiser. It automatically infers the designer's task to search for both local improvements to the current design and global (radical) alternatives. Using predictive models of sensorimotor performance and perception, these suggestions steer the designer toward more usable and aesthetic layouts without overriding the designer or demanding extensive input.Peer reviewe

Intracardiac leiomyomatosis: Diagnosis and treatment

Intracardiac leiomyomatosis is the presence of a benign smooth muscle tumor within a cardiac chamber reaching the heart by direct intravenous extension from an extracardiac source. After a case report and a review of the 13 previously reported cases, the clinical features, diagnostic considerations, differential diagnosis and treatment modalities of intracardiac leiomyomatosis are discussed

γ-heregulin is the product of a chromosomal translocation fusing the DOC4 and HGL/NRG1 genes in the MDA-MB-175 breast cancer cell line

International audiencegamma-heregulin is a recently described novel isoform of the heregulin/neuregulin class of EGF-like ligands that bind to and activate receptors of the ErbB family. Deregulated signaling through the heregulin-ErbB pathway is thought to be implicated in the development of a subset of human breast cancers. gamma-heregulin has been found to be expressed in the culture supernatant of MDA-MB-175, a breast carcinoma cell line. gamma-heregulin is characterized by the presence of a large N-terminal peptide extension that is not found in other heregulin isoforms. Here we report that this unique N-terminal extension of gamma-heregulin is identical to the N-terminus of DOC4, a product of a recently identified CHOP-dependent stress-induced gene. Human DOC4 and the heregulin-encoding genes map to different chromosomes and the MDA-MB-175 cell line contains a chromosomal translocation that leads to the fusion of DOC4 and HGL, on chromosomes 11 and 8, respectively. Thus, gamma-heregulin is a product of a mutant fusion gene and not a bona fide normal isoform. We speculate that the mutation may be selected for by virtue of its ability to activate ErbB signaling through the production of an autocrine ligand