Crack detection in lithium-ion cells using machine learning

It is an open question how the particle microstructure of a lithium-ion electrode influences a potential thermal runaway. In order to investigate this, information on the structural changes, in particular cracked particles, caused by the failure are desirable. For a reliable analysis of these changes a reasonably large amount of data is necessary, which necessitates automatic extraction of particle cracks from tomographic 3D image data. In this paper, a classification model is proposed which is able to decide whether a pair of particles is the result of breakage, of the image segmentation, or neither. The classifier is developed using simulated data based on a 3D stochastic particle model. Its validity is tested by applying the methodology to hand-labelled data from a real electrode. For this dataset, an overall accuracy of 73% is achieved

MISTIC2: Comprehensive server to study coevolution in protein families

Correlated mutations between residue pairs in evolutionarily related proteins arise from constraints needed to maintain a functional and stable protein. Identifying these inter-related positions narrows down the search for structurally or functionally important sites. MISTIC is a server designed to assist users to calculate covariation in protein families and provide them with an interactive tool to visualize the results. Here, we present MISTIC2, an update to the previous server, that allows to calculate four covariation methods (MIp, mfDCA, plmDCA and gaussianDCA). The results visualization framework has been reworked for improved performance, compatibility and user experience. It includes a circos representation of the information contained in the alignment, an interactive covariation network, a 3D structure viewer and a sequence logo. Others components provide additional information such as residue annotations, a roc curve for assessing contact prediction, data tables and different ways of filtering the data and exporting figures. Comparison of different methods is easily done and scores combination is also possible. A newly implemented web service allows users to access MISTIC2 programmatically using an API to calculate covariation and retrieve results. MISTIC2 is available at: https://mistic2.leloir.org.ar.Fil: Colell, Eloy A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Iserte, Javier Alonso. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Simonetti, Franco Lucio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Marino Buslje, Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentin

Characteristics of Sexual Abuse in Childhood and Adolescence Influence Sexual Risk Behavior in Adulthood

Childhood and adolescent sexual abuse has been associated with subsequent (adult) sexual risk behavior, but the effects of force and type of sexual abuse on sexual behavior outcomes have been less well-studied. The present study investigated the associations between sexual abuse characteristics and later sexual risk behavior, and explored whether gender of the child/adolescent moderated these relations. Patients attending an STD clinic completed a computerized survey that assessed history of sexual abuse as well as lifetime and current sexual behavior. Participants were considered sexually abused if they reported a sexual experience (1) before age 13 with someone 5 or more years older, (2) between the ages of 13 and 16 with someone 10 or more years older, or (3) before the age of 17 involving force or coercion. Participants who were sexually abused were further categorized based on two abuse characteristics, namely, use of penetration and force. Analyses included 1177 participants (n=534 women; n=643 men). Those who reported sexual abuse involving penetration and/or force reported more adult sexual risk behavior, including the number of lifetime partners and number of previous STD diagnoses, than those who were not sexually abused and those who were abused without force or penetration. There were no significant differences in sexual risk behavior between nonabused participants and those who reported sexual abuse without force and without penetration. Gender of the child/adolescent moderated the association between sexual abuse characteristics and adult sexual risk behavior; for men, sexual abuse with force and penetration was associated with the greatest number of episodes of sex trading, whereas for women, those who were abused with penetration, regardless of whether the abuse involved force, reported the most episodes of sex trading. These findings indicate that more severe sexual abuse is associated with riskier adult sexual behavior

The translator as cultural mediator

The increased focus on the importance of culture and communicative function in translation has led to a view of translators, not as mere transferrers of words or sentences as units of texts, but as cultural mediators who are responsible for successful cross-cultural communication and for the creation of functionally optimal target texts in target cultures. In order for this to take place translators need sound knowledge of the source text and the target culture, the function that the source text and the target text fulfil in their respective cultures, and the translation strategies available to the translator during the process of cultural transfer. This article aims to investigate this mediating role of the translator and the importance of cultural awareness during the process of translation. The Afrikaans translations Harry Potter en die beker vol vuur (Oosthuysen, 2001) and Harry Potter en die orde van die feniks (Oosthuysen, 2003) of J.K. Rowling's (2000) Harry Potter and the goblet Potter of fire and Harry Potter and the order of the phoenix (2003) are used to illustrate the importance of such awareness within a functional approach to translation, and to emphasise the importance of careful consideration and planning of translation strategies. Copyright © 2006 NISC Pty Ltd.Articl

Trauma, attachment, and family therapy with grandfamilies: A model for treatment

Population estimates indicate that approximately 1.5 million children are in grandparent-headed households without any parents present. This type of grandfamily is often created when biological parents are unable or unwilling to care for their children. Trauma is often experienced as a precursor to, or a consequence of, the biological parents' inability or unwillingness to care for their children. The well-being of both grandparent and grandchild may be affected in grandfamilies. A treatment model is presented that integrates trauma, attachment, and family systems theories and proposes that healing is facilitated through the emerging attachment between the grandparent and grandchild.Grandfamilies Trauma Attachment Family therapy

Zinc finger proteins and the 3D organization of chromosomes

Zinc finger domains are one of the most common structural motifs in eukaryotic cells, which employ the motif in some of their most important proteins (including TFIIIA, CTCF, and ZiF268). These DNA binding proteins contain up to 37 zinc finger domains connected by flexible linker regions. They have been shown to be important organizers of the 3D structure of chromosomes and as such are called the master weaver of the genome. Using NMR and numerical simulations, much progress has been made during the past few decades in understanding their various functions and their ways of binding to the DNA, but a large knowledge gap remains to be filled. One problem of the hitherto existing theoretical models of zinc finger protein DNA binding in this context is that they are aimed at describing specific binding. Furthermore, they exclusively focus on the microscopic details or approach the problem without considering such details at all. We present the Flexible Linker Model, which aims explicitly at describing nonspecific binding. It takes into account the most important effects of flexible linkers and allows a qualitative investigation of the effects of these linkers on the nonspecific binding affinity of zinc finger proteins to DNA. Our results indicate that the binding affinity is increased by the flexible linkers by several orders of magnitude. Moreover, they show that the binding map for proteins with more than one domain presents interesting structures, which have been neither observed nor described before, and can be interpreted to fit very well with existing theories of facilitated target location. The effect of the increased binding affinity is also in agreement with recent experiments that until now have lacked an explanation. We further explore the class of proteins with flexible linkers, which are unstructured until they bind. We have developed a methodology to characterize these flexible proteins. Employing the concept of barcodes, we propose a measure to compare such flexible proteins in terms of a similarity measure. This measure is validated by a comparison between a geometric similarity measure and the topological similarity measure that takes geometry as well as topology into account. \ua9 2013 Elsevier Inc

Umbilical artery catheters: High, low, or no

Peer Reviewe

Marital conflict and adolescent outcomes: A cross-ethnic group comparison of Latino and European American youth

Available research indicates a link between marital conflict and youth outcomes; however, relatively few studies examine these relationships in Latinos, the largest U.S. ethnic group. The present study examines this relationship in both Latino and European American families. Self-report data measuring externalizing and internalizing youth behaviors, along with overt and covert marital conflict, were used in analyses of 788 Latino and 751 European American adolescents. Results support current literature indicating a strong link between marital conflict and youth outcomes, regardless of ethnic group. These associations are similarly related for the differential effects of overt and covert marital conflict on externalizing and internalizing behaviors. However, overt conflict was significantly more predictive of internalizing behaviors than covert conflict. These results yield valuable information for clinical intervention and further research.Marital conflict Latinos Adolescent problem behaviors