Automated inter-rater reliability assessment and electronic data collection in a multi-center breast cancer study

<p>Abstract</p> <p>Background</p> <p>The choice between paper data collection methods and electronic data collection (EDC) methods has become a key question for clinical researchers. There remains a need to examine potential benefits, efficiencies, and innovations associated with an EDC system in a multi-center medical record review study.</p> <p>Methods</p> <p>A computer-based automated menu-driven system with 658 data fields was developed for a cohort study of women aged 65 years or older, diagnosed with invasive histologically confirmed primary breast cancer (N = 1859), at 6 Cancer Research Network sites. Medical record review with direct data entry into the EDC system was implemented. An inter-rater and intra-rater reliability (IRR) system was developed using a modified version of the EDC.</p> <p>Results</p> <p>Automation of EDC accelerated the flow of study information and resulted in an efficient data collection process. Data collection time was reduced by approximately four months compared to the project schedule and funded time available for manuscript preparation increased by 12 months. In addition, an innovative modified version of the EDC permitted an automated evaluation of inter-rater and intra-rater reliability across six data collection sites.</p> <p>Conclusion</p> <p>Automated EDC is a powerful tool for research efficiency and innovation, especially when multiple data collection sites are involved.</p

Heterogeneous natural selection on oxidative phosphorylation genes among fishes with extreme high and low aerobic performance

Background: Oxidative phosphorylation (OXPHOS) is the primary source of ATP in eukaryotes and serves as a mechanistic link between variation in genotypes and energetic phenotypes. While several physiological and anatomical factors may lead to increased aerobic capacity, variation in OXPHOS proteins may influence OXPHOS efficiency and facilitate adaptation in organisms with varied energy demands. Although there is evidence that natural selection acts on OXPHOS genes, the focus has been on detection of directional (positive) selection on specific phylogenetic branches where traits that increase energetic demands appear to have evolved. We examined patterns of selection in a broader evolutionary context, i.e., on multiple lineages of fishes with extreme high and low aerobic performance. Results: We found that patterns of natural selection on mitochondrial OXPHOS genes are complex among fishes with different swimming performance. Positive selection is not consistently associated with high performance taxa and appears to be strongest on lineages containing low performance taxa. In contrast, within high performance lineages, purifying (negative) selection appears to predominate. Conclusions: We provide evidence that selection on OXPHOS varies in both form and intensity within and among lineages through evolutionary time. These results provide evidence for fluctuating selection on OXPHOS associated with divergence in aerobic performance. However, in contrast to previous studies, positive selection was strongest on low performance taxa suggesting that adaptation of OXPHOS involves many factors beyond enhancing ATP production in high performance taxa. The broader pattern indicates a complex interplay between organismal adaptations, ATP demand, and OXPHOS function.This work was supported by NSF award DEB-0732988 (to REB).Ye

Predicting personal injury crash risk through working conditions, job strain, and risky driving behaviors among taxi drivers

Abstract Introduction Taxis play an important role among public transport modes in China, but there has been very little in-depth research regarding taxi drivers’ crash risk. Thus, this study aimed to develop a quantitative method to predict taxi drivers’ crash risk and identify contributory factors. Methods Nine hundred fourty-eight professional taxi drivers in Xi’an, China completed an anonymous, structured face-to-face questionnaire reporting their demographic information, work-related stress, daily risky driving behaviors, and crash experience within the 3 years prior to the survey. A Negative-Binomial regression model was used to predict the risk of personal injury collisions for taxi drivers. Results Drivers’ 7 risky driving behaviors (e.g., disregarding red lights, speeding, aggressive driving, driving while sleepy or fatigued, etc.) were significantly and positively related to the risk of personal injury collisions, while driver’s parking at will to pick up/drop off passengers was not a significant predictor of such risk for taxi drivers. Furthermore, driver’s sociodemographic characteristics and level of occupational workload were not found to be significantly correlated with the personal injury crash risk. Conclusions Risk traits appear to peak among male taxi drivers who drive more hours per day, pay high management fees, and frequently engage in risky behaviors while driving. These findings provide implications to design potentially useful policy initiatives as well as targeted safety promotion programs to prevent road crashes involving professional taxi drivers

Large third-order optical nonlinearity of non-stoichiometric chalcogenide glasses within Ge-In-S ternary system

International audienc

Understanding key motivations for using a hotel gamified application.

While hospitality has been one of the industries that have been keen to adopt and use various technologies, the proliferation of gamification application is still to materialise. It is therefore very interesting to investigate the potential benefits of gamified applications for both demand and supply in the area of the hospitality industry by identifying the motives of individuals’ when they use a hotel-gamified application. Since fun has become the requirement to ensure continuous demands for many products or services, companies and organizations feel the need to involve fun in their offerings to secure continuity in consumption and use. Hence, this study aims to understand the meaning of fun for individuals when they will use a hotel-gamified application. Visual material was prepared so the interviewees would have an idea of how a hotel-gamified application would look if it were in existence today based on the current definitions of gamification.N/