Synthesis of polyamides from diamines of the fluorene series

Aromatic polyamides were prepared by polycondensation of isophthaloyl chloride and 2,7-diaminofluorene, 2,7-dimainofluorenone, or 2,5-diaminofluorenone in AcNMe2 or N-methyl-2-pyrrolidinone at 20 deg - 30 deg for 1.5-2 hr. Isophthaloyl chloride-2,5-diaminofluorenone copolymer 39609-29-51 was sol. in AcNMe2, N-methyl-2-pyrrolidinone, DMF, and hexamethylphosphoramide, whereas isophthaloyl chloride-2,7-diamino-fluorene copolymer 39609-30-3 and isophthaloyl chloride-2,7-diamino-fluorenone copolymer 39609-31-0 were not sol. in the solvents cited. The aromatic polyamides revealed thixotropic properties in 0.5% solutions in H2SO4

Organic chemistry. History and mutual relations of universities of Russia

© 2017, Pleiades Publishing, Ltd. The review describes the history of development of organic chemistry in higher schools of Russia over a period of 170 years, since the emergence of organic chemistry in our country till now

Modern Trends of Organic Chemistry in Russian Universities

© 2018, Pleiades Publishing, Ltd. This review is devoted to the scientific achievements of the departments of organic chemistry in higher schools of Russia within the past decade

Анализ заболеваемости инвазией Opisthorchis felineus и злокачественными новообразованиями гепатобилиарной системы в Российской Федерации

The purpose of this paper is to perform the pilot review of the official medical statistics on reported Opisthorchis felineus (O. felineus) infection and liver and intrahepatic bile duct cancer in Russian Federation, covering the period 2011–2013.Materials and methods. Statistical data collected from 81 regions of Russia, reflecting the incidence of opisthorchiasis over a period from the 1st of January 2011 to the 31st of December 2013 was analyzed. The analysis of official health statistics of malignant hepatic lesions and intrahepatic bile duct was conducted in 82 regions of Russia over the same period. The data was obtained from the annual reports of the Russian center of information technologies and epidemiological studies in the field of oncology.Results. The average annual incidence of O. felineus was 24,7 ± 9,0 cases per 100,000 population. The highest incidence was observed in Khanty-Mansiysk Autonomous Okrug, Yamalo-Nenets Autonomous Okrug, Tyumen Oblast, Tomsk Oblast, Omsk Oblast and Novosibirsk Oblast. We did not observe any significant change in O. felineus infection rates within last 20 years. However, we found that infection incidence had increased in some geographical units of Western Siberia. The incidence of liver and intrahepatic bile duct cancers was 4,8 ± 0,2 cases per 100,000 population; the highest rate was reported in Far East regions, Siberia and Volgograd Oblast. This study documents the importance of opisthorchiasis in certain endemic areas and presents the best available data on associations between O. felineus infection and liver/intrahepatic bile duct cancers in endemic areas of Russian Federation.Цель. Исследовать взаимосвязь заболеваемости инвазией Opisthorchis felineus (O. felineus) и злокачественными новообразованиями гепатобилиарной системы у населения Российской Федерации на основании анализа данных официальной медицинской отчетности за период 2011–2013 гг.Материал и методы. Проанализированы статистические данные 81 региона России, отражающие заболеваемость описторхозом за период с 1 января 2011 г. по 31 декабря 2013 г. Проведен анализ официальных медицинских статистических данных злокачественного поражения печени и внутрипеченочных желчных протоков в 82 регионах России за аналогичный период, полученный из годовых отчетов Российского центра информационных технологий и эпидемиологических исследований в области онкологии.Результаты. Заболеваемость инвазией O. felineus составила 24,7 ± 9,0 на 100 000 населения. К гиперэндемичным по описторхозу регионам (уровень заболеваемости > 100 на 100 000 населения) относятся Ханты-Мансийский автономный округ, Ямало-Ненецкий автономный округ, а также Тюменская, Томская, Омская и Новосибирская области (Западная Сибирь). Средний показатель заболеваемости инвазией O. felineus в динамике за последние 20 лет относительно стабилен, однако отмечается распространение инвазии на новые территории. Заболеваемость раком печени и внутрипеченочных желчных протоков составила 4,8 ± 0,2 случаев на 100 000 населения, при этом наиболее высокие показатели регистрируются на Дальнем Востоке, в Сибири и Волгоградской области. Получены пилотные данные о взаимосвязи заболеваемости инвазией O. felineus и онкологическими заболеваниями гепатобилиарной системы у населения эндемичных регионов Российской Федерации

Using global team science to identify genetic parkinson's disease worldwide.

No abstract available

Embracing monogenic Parkinson's disease: the MJFF Global Genetic PD Cohort

© 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Background: As gene-targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction of the estimated number of subjects with monogenic PD worldwide are currently represented in the literature and availability of clinical data and clinical trial-ready cohorts is limited. Objective: The objectives are to (1) establish an international cohort of affected and unaffected individuals with PD-linked variants; (2) provide harmonized and quality-controlled clinical characterization data for each included individual; and (3) further promote collaboration of researchers in the field of monogenic PD. Methods: We conducted a worldwide, systematic online survey to collect individual-level data on individuals with PD-linked variants in SNCA, LRRK2, VPS35, PRKN, PINK1, DJ-1, as well as selected pathogenic and risk variants in GBA and corresponding demographic, clinical, and genetic data. All registered cases underwent thorough quality checks, and pathogenicity scoring of the variants and genotype-phenotype relationships were analyzed. Results: We collected 3888 variant carriers for our analyses, reported by 92 centers (42 countries) worldwide. Of the included individuals, 3185 had a diagnosis of PD (ie, 1306 LRRK2, 115 SNCA, 23 VPS35, 429 PRKN, 75 PINK1, 13 DJ-1, and 1224 GBA) and 703 were unaffected (ie, 328 LRRK2, 32 SNCA, 3 VPS35, 1 PRKN, 1 PINK1, and 338 GBA). In total, we identified 269 different pathogenic variants; 1322 individuals in our cohort (34%) were indicated as not previously published. Conclusions: Within the MJFF Global Genetic PD Study Group, we (1) established the largest international cohort of affected and unaffected individuals carrying PD-linked variants; (2) provide harmonized and quality-controlled clinical and genetic data for each included individual; (3) promote collaboration in the field of genetic PD with a view toward clinical and genetic stratification of patients for gene-targeted clinical trials. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Michael J. Fox Foundation for Parkinson's Research. Grant Number: ID 15015.02. NIHR Cambridge Biomedical Research Centre. Grant Number: BRC-1215-20014info:eu-repo/semantics/publishedVersio

Structure and magnetic properties of Co/Pd multilayers prepared on porous nanotubular TiO2 substrate

We used porous nanotubular templates of TiO2 for fabrication of Co/Pd antidot arrays with strong perpendicular magnetic anisotropy. The morphology of porous multilayers followed the features of the initial template demonstrating a pronounced relief consisting of the cells with periodic pores with small inclination. We confirmed the formation of Co0.4Pd0.6 alloy at the Co/Pd interface. We observed the conservation of perpendicular magnetic anisotropy in the Co/Pd porous film with coercive field HC = 2.7 kOe, enhanced with respect to the continuous film due to the pinning of magnetic moments on the nanopore edges. From angular dependence of the coercive field HC we deduced the change of the magnetization reversal mechanism from domain wall motion in the continuous film to the predominantly coherent rotation mechanism in the porous film