A quest for the lost types of Lophiotoma (Gastropoda: Conoidea: Turridae): integrative taxonomy in a nomenclatural mess

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Formal symplectic groupoid of a deformation quantization

We give a self-contained algebraic description of a formal symplectic groupoid over a Poisson manifold M. To each natural star product on M we then associate a canonical formal symplectic groupoid over M. Finally, we construct a unique formal symplectic groupoid `with separation of variables' over an arbitrary Kaehler-Poisson manifold.Comment: 41 page, Lemma 13, several typos and notations correcte

O sistema de tecnologias profissional-educacionais no sistema de formação de especialistas no perfil social

The paper studies the problem of the use of modern educational technologies for training specialists in the social profile. The quality of university professional training is an integrity of several educational technologies, each of which separately has a fairly independent character, but only together can provide a new quality of breeding professionals in the field of social work. The results of the introduction of modern educational technologies in the teaching and education process of the university social system show: the increase of graduates competing in the labor market, in addition to the development and growth of their social, professional and research competence. Therefore, the quality of university professional training of experts in the social sphere is caused by the synergistic integrity of several educational technologies that together provide a new quality of education in the field of social work.El artículo estudia el problema del uso de tecnologías educativas modernas para los especialistas en capacitación en el perfil social. La calidad de la formación profesional universitaria es una integridad de varias tecnologías educativas, cada una de las cuales por separado tiene un carácter bastante independiente, pero solo juntas pueden proporcionar una nueva calidad de profesionales de la cría en el campo del trabajo social. Los resultados de la introducción de tecnologías educativas modernas en el proceso de enseñanza y educación del sistema social universitario muestran: el aumento de los graduados que compiten en el mercado laboral, ademas del desarrollo y crecimiento de su competencia social, profesional y de investigación. Por lo tanto, la calidad de la formación profesional universitaria de los expertos de la esfera social está causada por la integridad sinérgica de varias tecnologías educativas que juntas proporcionan una nueva calidad de educación en el campo del trabajo social.O artigo estuda o problema do uso de tecnologias educacionais modernas para formação de especialistas no perfil social. A qualidade da formação profissional universitária é uma integridade de várias tecnologias educacionais, cada uma das quais separadamente tem um caráter bastante independente, mas apenas em conjunto pode fornecer uma nova qualidade de profissionais de criação no campo do trabalho social. Os resultados da introdução de modernas tecnologias educacionais no processo de ensino e educação do sistema social universitário mostram: o aumento de graduados competindo no mercado de trabalho, além do desenvolvimento e crescimento de sua competência social, profissional e de pesquisa. Portanto, a qualidade da formação profissional universitária de especialistas na esfera social é causada pela integridade sinérgica de várias tecnologias educacionais que, juntas, proporcionam uma nova qualidade de educação no campo do trabalho social

Infinitesimal deformations of a formal symplectic groupoid

Given a formal symplectic groupoid $G$ over a Poisson manifold $(M, \pi_0)$, we define a new object, an infinitesimal deformation of $G$, which can be thought of as a formal symplectic groupoid over the manifold $M$ equipped with an infinitesimal deformation $\pi_0 + \epsilon \pi_1$ of the Poisson bivector field $\pi_0$. The source and target mappings of a deformation of $G$ are deformations of the source and target mappings of $G$. To any pair of natural star products $(\ast, \tilde\ast)$ having the same formal symplectic groupoid $G$ we relate an infinitesimal deformation of $G$. We call it the deformation groupoid of the pair $(\ast, \tilde\ast)$. We give explicit formulas for the source and target mappings of the deformation groupoid of a pair of star products with separation of variables on a Kaehler- Poisson manifold. Finally, we give an algorithm for calculating the principal symbols of the components of the logarithm of a formal Berezin transform of a star product with separation of variables. This algorithm is based upon some deformation groupoid.Comment: 22 pages, the paper is reworked, new proofs are adde

On Gammelgaard's formula for a star product with separation of variables

We show that Gammelgaard's formula expressing a star product with separation of variables on a pseudo-Kaehler manifold in terms of directed graphs without cycles is equivalent to an inversion formula for an operator on a formal Fock space. We prove this inversion formula directly and thus offer an alternative approach to Gammelgaard's formula which gives more insight into the question why the directed graphs in his formula have no cycles.Comment: 29 pages, changes made in the last two section

Music improves the therapeutic effects of bevacizumab in rats with glioblastoma: Modulation of drug distribution to the brain

Background: The development of new methods for modulation of drug distribution across to the brain is a crucial step in the effective therapies for glioblastoma (GBM). In our previous work, we discovered the phenomenon of music-induced opening of the blood-brain barrier (OBBB) in healthy rodents. In this pilot study on rats, we clearly demonstrate that music-induced BBB opening improves the therapeutic effects of bevacizumab (BZM) in rats with GBM via increasing BZM distribution to the brain along the cerebral vessels. Methods: The experiments were performed on Wistar male rats (200-250 g, n=161) using transfected C6-TagRFP cell line and the loud rock music for OBBB. The OBBB was assessed by spectrofluorometric assay of Evans Blue (EB) extravasation and confocal imaging of fluorescent BZM (fBZM) delivery into the brain. Additionally, distribution of fBZM and Omniscan in the brain was studied using fluorescent and magnetic resonance imaging (MRI), respectively. To analyze the therapeutic effects of BZM on the GBM growth in rats without and with OBBB, the GBM volume (MRI scans), as well as immunohistochemistry assay of proliferation (Ki67 marker) and apoptosis (Bax marker) in the GBM cells were studied. The Mann-Whitney-Wilcoxon test was used for all analysis, the significance level was p < 0.05, n=7 in each group. Results: Our finding clearly demonstrates that music-induced OBBB increases the delivery of EB into the brain tissues and the extravasation of BZM into the brain around the cerebral vessels of rats with GBM. Music significantly increases distribution of tracers (fBZM and Omniscan) in the rat brain through the pathways of brain drainage system (perivascular and lymphatic), which are an important route of drug delivery into the brain. The music-induced OBBB improves the suppressive effects of BZM on the GBM volume and the cellular mechanisms of tumor progression that was accompanied by higher survival among rats in the GBM+BZM+Music group vs. other groups. Conclusion: We hypothesized that music improves the therapeutic effects of BZM via OBBB in the normal cerebral vessels and lymphatic drainage of the brain tissues. This contributes better distribution of BZM in the brain fluids and among the normal cerebral vessels, which are used by GBM for invasion and co-opt existing vessels as a satellite tumor form. These results open the new perspectives for an improvement of therapeutic effects of BZM via the music-induced OBBB for BZM in the normal cerebral vessels, which are used by GBM for migration and progression

Venom insulins of cone snails diversify rapidly and track prey taxa

A specialized insulin was recently found in the venom of a fish-hunting cone snail, Conus geographus. Here we show that many worm-hunting and snail-hunting cones also express venom insulins, and that this novel gene family has diversified explosively. Cone snails express a highly conserved insulin in their nerve ring; presumably this conventional signaling insulin is finely tuned to the Conus insulin receptor, which also evolves very slowly. By contrast, the venom insulins diverge rapidly, apparently in response to biotic interactions with prey and also possibly the cones’ own predators and competitors. Thus, the inwardly directed signaling insulins appear to experience predominantly purifying sele\ction to target an internal receptor that seldom changes, while the outwardly directed venom insulins frequently experience directional selection to target heterospecific insulin receptors in a changing mix of prey, predators and competitors. Prey insulin receptors may often be constrained in ways that prevent their evolutionary escape from targeted venom insulins, if amino-acid substitutions that result in escape also degrade the receptor’s signaling functions

Venom Diversity and Evolution in the Most Divergent Cone Snail Genus Profundiconus

Profundiconus is the most divergent cone snail genus and its unique phylogenetic position, sister to the rest of the family Conidae, makes it a key taxon for examining venom evolution and diversity. Venom gland and foot transcriptomes of Profundiconus cf. vaubani and Profundiconus neocaledonicus were de novo assembled, annotated, and analyzed for differential expression. One hundred and thirty-seven venom components were identified from P. cf. vaubani and 82 from P. neocaledonicus, with only four shared by both species. The majority of the transcript diversity was composed of putative peptides, including conotoxins, profunditoxins, turripeptides, insulin, and prohormone-4. However, there were also a significant percentage of other putative venom components such as chymotrypsin and L-rhamnose-binding lectin. The large majority of conotoxins appeared to be from new gene superfamilies, three of which are highly different from previously reported venom peptide toxins. Their low conotoxin diversity and the type of insulin found suggested that these species, for which no ecological information are available, have a worm or molluscan diet associated with a narrow dietary breadth. Our results indicate that Profundiconus venom is highly distinct from that of other cone snails, and therefore important for examining venom evolution in the Conidae family

Transcriptomic profiling reveals extraordinary diversity of venom peptides in unexplored predatory gastropods of the genus Clavus

Predatory gastropods of the superfamily Conoidea number over 12,000 living species. The evolutionary success of this lineage can be explained by the ability of conoideans to produce complex venoms for hunting, defense and competitive interactions. Whereas venoms of cone snails (family Conidae) have become increasingly well studied, the venoms of most other conoidean lineages remain largely uncharacterized. In the present study we present the venom gland transcriptomes of two species of the genus Clavus that belong to the family Drilliidae. Venom gland transcriptomes of two specimens of Clavus canalicularis, and two specimens of Cv. davidgilmouri were analyzed, leading to the identification of a total of 1,176 putative venom peptide toxins ( drillipeptides ). Based on the combined evidence of secretion signal sequence identity, entire precursor similarity search (BLAST), and the orthology inference, putative Clavus toxins were assigned to 158 different gene families. The majority of identified transcripts comprise signal, pro-, mature peptide, and post- regions, with a typically short ( \u3c 50 amino acids) and cysteine-rich mature peptide region. Thus drillipeptides are structurally similar to conotoxins. However, convincing homology with known groups of Conus toxins was only detected for very few toxin families. Among these are Clavus counterparts of Conus venom insulins (drillinsulins), porins (drilliporins), highly diversified lectins (drillilectins). The short size of most drillipeptpides and structural similarity to conotoxins was unexpected, given that most related conoidean gastropod families (Terebridae and Turridae) possess longer mature peptide regions. Our findings indicate that, similar to conotoxins, drillipeptides may represent a valuable resource for future pharmacological exploration

Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases

Emerging evidence suggests that an important function of the sleeping brain is the removal of wastes and toxins from the central nervous system (CNS) due to the activation of the brain waste removal system (BWRS). The meningeal lymphatic vessels (MLVs) are an important part of the BWRS. A decrease in MLV function is associated with Alzheimer’s and Parkinson’s diseases, intracranial hemorrhages, brain tumors and trauma. Since the BWRS is activated during sleep, a new idea is now being actively discussed in the scientific community: night stimulation of the BWRS might be an innovative and promising strategy for neurorehabilitation medicine. This review highlights new trends in photobiomodulation of the BWRS/MLVs during deep sleep as a breakthrough technology for the effective removal of wastes and unnecessary compounds from the brain in order to increase the neuroprotection of the CNS as well as to prevent or delay various brain diseases.RF GovernmentalRSFRFBRInnovation Fund of WNLO and Innovation Project of Optics Valley LaboratoryNational Natural Science Foundation of China (NSFC)Peer Reviewe