Mercado interno de Uluses Árticos de Sakha (Yakutia) en el Área Macro del Distrito Federal del Lejano Oriente

This study reviews and compares the market potential of two macro-areas in the Republic of Sakha (Yakutia) in the AZRF (Arctic zone of the Russian Federation) and the FEFD (Far Eastern Federal District. Moreover, this work shows that a significant part of supply and demand in municipalities' domestic markets is concentrated in the FEFD. Until recently, the AZRF and the FEFD were not considered by the State as a single government body. Transferred powers to the Ministry of the Russian Federation for the development of the Far East and the Arctic has allowed the territory of the Arctic uluses of the Republic of Sakha (Yakutia) to be included in the social and economic development of the FEFD.Este estudio revisa y compara el potencial de mercado de dos macro áreas en la República de Sakha (Yakutia) en la AZRF (zona ártica de la Federación de Rusia) y el FEFD (Distrito Federal del Lejano Oriente. Además, este trabajo muestra que una parte significativa de la oferta y la demanda en los mercados internos de los municipios se concentra en el FEFD. Hasta hace poco, el Estado no consideraba al AZRF y al FEFD como un solo organismo gubernamental. Se transfirieron competencias al Ministerio de la Federación de Rusia para el desarrollo de la El Lejano Oriente y el Ártico han permitido que el territorio de los uluses árticos de la República de Sakha (Yakutia) se incluya en el desarrollo social y económico del FEFD

Mercado interno de Uluses Árticos de Sakha (Yakutia) en el Área Macro del Distrito Federal del Lejano Oriente

Este estudio revisa y compara el potencial de mercado de dos macro áreas en la República de Sakha (Yakutia) en la AZRF (zona ártica de la Federación de Rusia) y el FEFD (Distrito Federal del Lejano Oriente. Además, este trabajo muestra que una parte significativa de la oferta y la demanda en los mercados internos de los municipios seconcentra en el FEFD. Hasta hace poco, el Estado no consideraba al AZRF y al FEFD como un solo organismo gubernamental. Se transfirieron competencias al Ministerio de la Federación de Rusia para el desarrollo de la El Lejano Oriente y el Ártico han permitido que el territorio de los uluses árticos de la República de Sakha (Yakutia) se incluya en el desarrollo social y económico del FEF

Spin-Photovoltaic Effect in Quantum Wires Due to Intersubband Transitions

We consider the current induced in a quantum wire by external electromagnetic radiation. The photocurrent is caused by the interplay of spin-orbit interaction (Rashba and Dresselhaus terms) and an external in-plane magnetic field. We calculate this current using a Wigner functions approach, taking into account radiation-induced transitions between transverse subbands. The magnitude and the direction of the current depends on the Dresselhaus and Rashba constants, strength of magnetic field, radiation frequency, and intensity. The current can be controlled by changing some of these parameters

Skew scattering in dilute ferromagnetic alloys

The challenging problem of skew scattering for Hall effects in dilute ferromagnetic alloys, with intertwined effects of spin-orbit coupling, magnetism and impurity scattering, is studied here from first principles. Our main aim is to identify chemical trends and work out simple rules for large skew scattering in terms of the impurity and host states at the Fermi surface, with particular emphasis on the interplay of the spin and anomalous Hall effects in one and the same system. The predicted trends are benchmarked by referring to three different \emph{ab initio} methods based on different approximations with respect to the electronic structure and transport properties.Comment: 5 pages, 4 figure

Functional Profiling Reveals Critical Role for miRNA in Differentiation of Human Mesenchymal Stem Cells

BACKGROUND:Mesenchymal stem (MS) cells are excellent candidates for cell-based therapeutic strategies to regenerate injured tissue. Although human MS cells can be isolated from bone marrow and directed to differentiate by means of an osteogenic pathway, the regulation of cell-fate determination is not well understood. Recent reports identify critical roles for microRNAs (miRNAs), regulators of gene expression either by inhibiting the translation or by stimulating the degradation of target mRNAs. METHODOLOGY/PRINCIPAL FINDINGS:In this study, we employed a library of miRNA inhibitors to evaluate the role of miRNAs in early osteogenic differentiation of human MS cells. We discovered that miR-148b, -27a and -489 are essential for the regulation of osteogenesis: miR-27a and miR-489 down-regulate while miR-148b up-regulates differentiation. Modulation of these miRNAs induced osteogenesis in the absence of other external differentiation cues and restored osteogenic potential in high passage number human MS cells. CONCLUSIONS/SIGNIFICANCE:Overall, we have demonstrated the utility of the functional profiling strategy for unraveling complex miRNA pathways. Our findings indicate that miRNAs regulate early osteogenic differentiation in human MS cells: miR-148b, -27a, and -489 were found to play a critical role in osteogenesis

Aurintricarboxylic Acid is a Canonical Disruptor of the TAZ-TEAD Transcriptional Complex

Disrupting the formation of the oncogenic YAP/TAZ-TEAD transcriptional complex holds substantial therapeutic potential. However, the three protein interaction interfaces of this complex cannot be easily disrupted using small molecules. Here, we report that the pharmacologically active small molecule aurintricarboxylic acid (ATA) acts as a disruptor of the TAZ-TEAD complex. ATA was identified in a high-throughput screen using a TAZ-TEAD AlphaLISA assay that was tailored to identify disruptors of this transcriptional complex. We further used fluorescence polarization assays both to confirm disruption of the TAZ-TEAD complex and to demonstrate that ATA binds to interface 3. We have previously shown that cell-based models that express the oncogenic TAZ-CAMTA1 (TC) fusion protein display enhanced TEAD transcriptional activity because TC functions as an activated form of TAZ. Utilizing cell-based studies and our TC model system, we performed TC/TEAD reporter, RNA-Seq, and qPCR assays and found that ATA inhibits TC/TEAD transcriptional activity. Further, disruption of TC/TEAD and TAZ/TEAD interaction by ATA abrogated anchorage-independent growth, the phenotype most closely linked to dysregulated TAZ/TEAD activity. Therefore, this study demonstrates that ATA is a novel small molecule that has the ability to disrupt the undruggable TAZ-TEAD interface

Crystallization and Investigation of the Structural and Optical Properties of Ce3+-Doped Y3−xCaxAl5−ySiyO12 Single Crystalline Film Phosphors

This work is devoted to the crystallization and investigation of the optical properties of single crystalline films (SCFs) of Ce3+-doped Y3−xCaxAl5−ySiyO12 garnet, where the content of Ca2+ and Si4+ cations varied in the x = 0.13–0.52 and y = 0.065–0.5 ranges, respectively. The SCF samples were grown using the liquid phase epitaxy technique onto Y3Al5O12 substrates from the melt solution with equimolar Ca and Si content using PbO-B2O3 flux. However, the Ca and Si concentration in Y3−xCax Al5−ySiyO12:Ce SCFs is not equal: the Ca2+ content was systematically larger than that of Si4+, and the Ca2+ excess is compensated for by the Ce4+ ion formation. The absorption, scintillation, and luminescent properties of Y3−xCaxAl5−ySiyO12:Ce SCFs with different Ca/Si concentrations were investigated and compared with the sample of YAG:Ce SCF. Due to the creation of Ce4+ ions, the as-grown Y3−xCaxAl5−ySiyO12:Ce SCFs show relatively low light yield (LY) under α–particle excitation but a fast scintillation response with a decay time in the ns range. After SCF annealing in the reducing (N2 + H2) atmosphere at T > 1000 °C, the recharging of Ce4+→Ce3+ ions occurs. Furthermore, the samples annealed at 1300 °C SCF possess an LY of about 40% in comparison with the reference YAG:Ce SCF and scintillation decay kinetics much closer to that of the SCF counterpart. Due to Ca2+ and Si4+ alloying, the Ce3+ emission spectra in Y3−xCaxAl5−ySiyO12 SCFs are extended to the red range in comparison with the spectra of YAG:Ce SCF. Such an extension is caused by the Ce3+ multicenter formation at the substitutions of both Y3+ and Ca2+ dodecahedral positions in the hosts of these mixed garnets

Scintillating Screens for Micro-Imaging Based on the Ce-Tb Doped LuAP Single Crystal Films

Single Crystal Film (SCF) scintillators are key-components of today's high-resolution 2D X-ray detectors used at synchrotrons for applications such as X-ray Radiography, Computed Tomography (CT), laminography, full-field XANES, and topography. Due to its high density and effective atomic number, LuAlO3 (LuAP) perovskite has a great potential to replace or complement the currently used Eu-doped Gd3Ga5O12 (GGG:Eu) and Tb-doped Lu2SiO5 (LSO:Tb) SCFs. In this article we present the growth of LuAP single crystalline films on undoped YAlO3 (YAP) by the vertical dipping isothermal Liquid Phase Epitaxy (LPE) growth method. For the comparison of the light output of Ce and Tb doped LuAP SCF screens both cathodoluminescence (CL) and X-ray excited luminescence (RL) measurements were used. For investigations of Ce-Tb energy transfer in the afore mentioned oxide hosts, in addition to using traditional spectroscopic methods, we made time-resolved luminescent spectroscopy of Ce-Tb doped LuAP SCFs under excitation by pulsed synchrotron radiation at the Superlumi station (HASYLAB at DESY). Recently we have demonstrated the strong quenching influence of Pb2+ flux related impurity on the Ce3+ emission in the Ce-doped LuAP SCF screens. However our present investigation shows that Tb-doped LuAP SCFs are efficient X-ray scintillators, whose light output can be significantly increased by co-doping with Ce3+ ions. Namely, we demonstrate the efficient Ce→ Tb energy transfer in LuAP:Tb,Ce SCFs. Finally, as-grown LuAP:Tb and LuAP:Tb,Ce films were evaluated for high-resolution X-ray imaging using a spatial resolution target at the European Synchrotron Radiation Facility (ESRF), and displayed promising result

Single Crystalline Films of Ce3+-Doped Y3MgxSiyAl5−x−yO12 Garnets: Crystallization, Optical, and Photocurrent Properties

This research focuses on LPE growth, and the examination of the optical and photovoltaic properties of single crystalline film (SCF) phosphors based on Ce3+-doped Y3MgxSiyAl5−x−yO12 garnets with Mg and Si contents in x = 0–0.345 and y = 0–0.31 ranges. The absorbance, luminescence, scintillation, and photocurrent properties of Y3MgxSiyAl5−x−yO12:Ce SCFs were examined in comparison with Y3Al5O12:Ce (YAG:Ce) counterpart. Especially prepared YAG:Ce SCFs with a low (x, y 1000 °C in a reducing atmosphere (95%N2 + 5%H2). Annealed SCF samples exhibited an LY of around 42% and similar scintillation decay kinetics to those of the YAG:Ce SCF counterpart. The photoluminescence studies of Y3MgxSiyAl5−x−yO12:Ce SCFs provide evidence for Ce3+ multicenter formation and the presence of an energy transfer between various Ce3+ multicenters. The Ce3+ multicenters possessed variable crystal field strengths in the nonequivalent dodecahedral sites of the garnet host due to the substitution of the octahedral positions by Mg2+ and the tetrahedral positions by Si4+. In comparison with YAG:Ce SCF, the Ce3+ luminescence spectra of Y3MgxSiyAl5−x−yO12:Ce SCFs greatly expanded in the red region. Using these beneficial trends of changes in the optical and photocurrent properties of Y3MgxSiyAl5−x−yO12:Ce garnets as a result of Mg2+ and Si4+ alloying, a new generation of SCF converters for white LEDs, photovoltaics, and scintillators could be developed