Cosmological constraints from the BOSS DR12 void size function

We present the first cosmological constraints derived from the analysis of the void size function. This work relies on the final BOSS DR12 data set, a large spectroscopic galaxy catalog, ideal for the identification of cosmic voids. We extract a sample of voids from the distribution of galaxies and we apply a cleaning procedure aimed at reaching high levels of purity and completeness. We model the void size function by means of an extension of the popular volume-conserving model, based on two additional nuisance parameters. Relying on mock catalogs specifically designed to reproduce the BOSS DR12 galaxy sample, we calibrate the extended size function model parameters and validate the methodology. We then apply a Bayesian analysis to constrain the $\Lambda$CDM model and one of its simplest extensions, featuring a constant dark energy equation of state parameter, $w$. Following a conservative approach, we put constraints on the total matter density parameter and the amplitude of density fluctuations, finding $\Omega_{\rm m}=0.29 \pm 0.06$ and $\sigma_8=0.79^{+0.09}_{-0.08}$. Testing the alternative scenario, we derive $w=-1.1\pm 0.2$, in agreement with the $\Lambda$CDM model. These results are independent and complementary to those derived from standard cosmological probes, opening up new ways to identify the origin of potential tensions in the current cosmological paradigm.Comment: 24 pages, 13 figures, 3 tables, accepted by Ap

Desarrollo embrionario del cangrejo nadador Ovalipes trimaculatus (Decapoda: Brachyura: Portunoidea)

The embryogenesis of Ovalipes trimaculatus, a member of the highly valued portunid swimming crabs, was studied under nearly constant temperature (13±1°C), salinity (33) and photoperiod (14 h light:10 h dark) conditions. A five-stage scale of embryonic development was defined for the species. Time required to complete development averaged 35.7±2.11 days, showing no significant differences between embryos located in inner, middle and outer portions of the egg mass. The egg chorion was rounded and showed the highest growth in diameter between stages I (morula-blastula-gastrula) and II (primordium of larval structure) and between stages III (appendage formation) and IV (eye formation). Results reported here provide a baseline for optimizing hatchery operations and useful information for management purposes.Se estudió la embriogénesis del cangrejo nadador Ovalipes trimaculatus, miembro de la familia de portúnidos altamente valorados, bajo condiciones constantes de temperatura (13±1°C), salinidad (33) y fotoperíodo (luz 14h:10h oscuridad). Se definió una escala de cinco etapas de desarrollo embrionario para la especie. El tiempo necesario para completar el desarrollo es de 35.7±2.11 días, sin mostrar diferencias significativas entre embriones ubicados en porciones interior, media y exterior de la masa de huevos. Los huevos son esféricos y presentan mayor crecimiento en diámetro entre las etapas I (mórula - blástula - gástrula) y II (primordio de estructuras larvarias) y entre las etapas III (formación de apéndices) y IV (formación de los ojos). Los resultados aquí presentados proporcionan la base para la optimización del cultivo y brindan información útil para el manejo de la especie

characterization of equivalent acoustic sources to reproduce the acoustic field generated by engines on an aircraft fuselage

Abstract This work presents a general procedure to characterize equivalent acoustic sources to reproduce the sound pressure field generated by the engines on an aircraft fuselage. The procedure would allow to set up ground experimental tests on aircraft components, by means of distributed loudspeakers, to obtain their vibro-acoustic performances as if they were tested in flight conditions. A FEM model of an aircraft fuselage mock-up was built up, comprising the structure, the internal acoustic cavities and the external air. The sound pressure field generated by the engines was considered as the reference solution, whereas an equivalent sound field, produced by distributed monopole sources surrounding the structure, was obtained by leveraging on the proposed Multi-Disciplinary Optimization (MDO) procedure. The MDO procedure was based on the mutual interaction between the commercial codes Siemens NX, for the CAE/FEM simulations, and Noesis Optimus, for the optimization framework

A Novel Optimization Framework to Replicate the Vibro-Acoustics Response of an Aircraft Fuselage

In this work, a novel optimization framework, based on a Multi-Disciplinary Optimization (MDO) procedure, applied to the vibro-acoustic Finite Element Method (FEM) model of an aircraft fuselage mock-up, is proposed. The MDO procedure, based on an Efficient Global Optimization (EGO)-like approach, is implemented to characterize acoustic sources that replicate the sound pressure field generated by the engines on the fuselage. A realistic sound pressure field, evaluated by aeroacoustic simulations, was considered as the reference acoustic load, whereas two equivalent sound fields, displayed by two different arrays of microphones and generated by the same configuration of monopoles, were calculated by the proposed vibro-acoustic FEM-MDO procedure. The proposed FEM-MDO framework enables to set up ground experimental tests on aircraft components, useful to replicate their vibro-acoustic performances as if tested in flight. More in general, such a procedure can also be used as a reference tool to design simplified tests starting from more complex ones

Boundaries in the Moyal plane

We study the oscillations of a scalar field on a noncommutative disc implementing the boundary as the limit case of an interaction with an appropriately chosen confining background. The space of quantum fluctuations of the field is finite dimensional and displays the rotational and parity symmetry of the disc. We perform a numerical evaluation of the (finite) Casimir energy and obtain similar results as for the fuzzy sphere and torus.Instituto de Física La Plat

On the algebraic structure of rotationally invariant two-dimensional Hamiltonians on the noncommutative phase space

We study two-dimensional Hamiltonians in phase space with noncommutativity both in coordinates and momenta. We consider the generator of rotations on the noncommutative plane and the Lie algebra generated by Hermitian rotationally invariant quadratic forms of noncommutative dynamical variables. We show that two quantum phases are possible, characterized by the Lie algebras sl (2, ℝ) or su(2) according to the relation between the noncommutativity parameters, with the rotation generator related with the Casimir operator. From this algebraic perspective, we analyze the spectrum of some simple models with nonrelativistic rotationally invariant Hamiltonians in this noncommutative phase space, such as the isotropic harmonic oscillator, the Landau problem and the cylindrical well potential.Instituto de Física La Plat

On the algebraic structure of rotationally invariant two-dimensional Hamiltonians on the noncommutative phase space

We study two-dimensional Hamiltonians in phase space with noncommutativity both in coordinates and momenta. We consider the generator of rotations on the noncommutative plane and the Lie algebra generated by Hermitian rotationally invariant quadratic forms of noncommutative dynamical variables. We show that two quantum phases are possible, characterized by the Lie algebras sl (2, ℝ) or su(2) according to the relation between the noncommutativity parameters, with the rotation generator related with the Casimir operator. From this algebraic perspective, we analyze the spectrum of some simple models with nonrelativistic rotationally invariant Hamiltonians in this noncommutative phase space, such as the isotropic harmonic oscillator, the Landau problem and the cylindrical well potential.Instituto de Física La Plat

Enzyme replacement therapy with agalsidase beta improves cardiac involvement in Fabry's disease.

Fabry's disease is an X-linked lysosomal storage disease caused by a deficiency of alpha-galactosidase that results in an accumulation of neutral glycosphingolipids throughout the body, including the cardiovascular system. Fabry cardiomyopathy, characterized by progressive severe concentric left ventricular (LV) hypertrophy, is very frequent and is the most important cause of death in affected patients. Enzyme replacement therapy (ERT) allows a specific treatment for this disease, however, there are very few data on the effectiveness of therapy on cardiac involvement. Nine patients with Fabry cardiac disease were studied on basal condition and after 6 and 12 months of treatment with algasidase beta (Fabrazyme). A complete clinical, electrocardiographic and echocardiographic evaluation was performed in all patients. Interpretable Doppler recordings of transmitral flow and pulmonary flow velocity curves were also acquired. At baseline, the patients with Fabry's disease had increased LV septum and posterior wall thickness, normal LV fractional shortening, LV ejection fraction, normal Doppler parameters of mitral inflow but a duration of pulmonary vein flow velocity wave exceeding that of the mitral wave at atrial systole. ERT did not affect heart rate and arterial pressure. LV internal diameters did not change, there was a slight but not significant decrease in the LV posterior wall thickening and a progressive decrease in the interventricular septum thickening (p < 0.025) and in LV mass (p < 0.001) The difference in duration between pulmonary vein flow velocity wave and mitral wave at atrial systole significantly decreased (p < 0.001). These results suggest that ERT in patients with Fabry cardiomyopathy is able to reduce the LV mass and ameliorate the LV stiffness

The Outcome of Cholangitis After Percutaneous Biliary Drainage in Neoplastic Jaundice

The purpose of this paper is to evaluate factors affecting the outcome of cholangitis after PTBD in jaundiced cancer patients. Twenty nine patients with neoplastic jaundice (male/female ratio 13/16, median age 55 years) with full clinical data, were treated by PTBD and developed cholangitis at a median of 9 days later. Four patients (14%) died of biliary sepsis a median of one month after PTBD while the other 25 survived a median of 6 months, with one week median duration of cholangitis. The probability of the cholangitis resolving was analyzed by time to resolution and it was found that 50% and 100% of the recoveries occurred 5 and 9 months respectively from the onset of the complication

Effect of a Short-Course Treatment with Synbiotics on Plasma p-Cresol Concentration in Kidney Transplant Recipients.

We evaluated whether a short-term course with synbiotics may lower plasma p-Cresol concentrations in kidney transplant patients (KTRs) who accumulate this uremic toxin both because of increased production by their dysbiotic gut microbiome and because of reduced elimination by the transplanted kidneys. METHODS: Thirty-six KTRs (29 males, mean age 49.6 ± 9.1 years) with transplant vintage > 12 months, stable graft function, and no episode of acute rejection or infection in the last 3 months were enrolled in this single-center, parallel-group, double-blinded, randomized (2:1 synbiotic to placebo) study. Synbiotic (Probinul Neutro, CadiGroup, Rome, Italy) or placebo was taken at home for 30 days, as 5 g powder packets dissolved in water three times a day far from meals. The main outcome measure was the decrease in total plasma p-Cresol measured by high-performance liquid chromatography at baseline and after 15 and 30 days of placebo or synbiotic treatment. RESULTS: After 15 and 30 days of treatment, plasma p-Cresol decreased by 40% and 33% from baseline (both p < 0.05), respectively, in the synbiotic group, whereas it remained stable in the placebo group. After 30 days of treatment, no significant change was observed in either group in renal function, glycemia, plasma lipids, or albumin concentration. Treatment was well tolerated and did not induce any change in stool characteristics. CONCLUSION: The results of this pilot study suggest that treatment with synbiotics may be effective to lower plasma p-Cresol concentrations in KTRs. Prospective larger scale, longer term studies are needed to establish whether cardiovascular prognosis could also be improved with this nutritional intervention