Free Movement of Workers and Old-age Benefits: The Court of Justice of the European Union’s Standpoint in Commission v. Cyprus (C-515/14)

La nota commenta la sentenza della Corte di giustizia dell'Unione europea del 21 gennaio 2016 nella causa C-515/14 "Commissione c. Cipro", che riguarda la libera circolazione dei lavoratori dipendenti (pubblici) con riferimento agli articoli 45 e 48 TFUE e che interviene sulle differenze di trattamento in ragione dell’età nel percepimento della pensione di vecchiaia

Sustainability disclosure and IPO performance: exploring the impact of ESG reporting

Investors are increasingly concerned with the sustainability of firms and their impact on global development, resulting in a rise in Socially Responsible Investing (SRI) that considers environmental, social, and governance (ESG) factors. Integrating sustainability into company strategies can affect various aspects of an organization, including IPOs (initial public offerings). Given the growing importance of ESG information disclosure, this study wants to examine the potential effect of an ESG report disclosure on IPO performance, since there are not studies focused on analyzing how ESG factors and IPO performance are correlated. The purpose of this study is to examine how ESG disclosure affects IPO underpricing and increases transparency for stakeholders to reduce information asymmetry. This study explores the impact of disclosing ESG information on IPO underpricing using a sample of 100 European IPOs from 2017 to 2021, with 50 firms disclosing an ESG report prior to the IPO and 50 that did not. The results showed that the publication of a sustainable report before an IPO has a positive effect on underpricing by reducing it. This finding suggests that companies that publish sustainability reports are perceived to be less risky, and investors value ESG disclosure as a tool to reduce the risks associated with ESG issues. The work contributes to the research on firms’ incentives to disclose ESG information. Our study is limited by the size of the sample, which is limited and only focused on European companies; therefore, future studies should consider companies from other parts of the world, and with more data related to IPO performance

Free Movement of Services and the Green Economy within the Law of the European Union

Il fine principale della tesi è di dimostrare che il concetto di economia verde, pur non avendo natura giuridica, ha un rilievo notevole nel diritto dell’Unione europea, in particolare rispetto al mercato dei servizi. L’indagine concerne innanzitutto lo sviluppo sostenibile, del quale l’economia verde rappresenta uno strumento, per poi incentrarsi sul concetto di economia verde, al fine di ricostruire la sua veste giuridica e la sua collocazione nel diritto (primario) dell’Unione europea. In secondo luogo, si analizza come l’Unione stia utilizzando il proprio diritto per favorire la transizione verso un’economia verde e per stimolare la circolazione dei relativi servizi. Da ultimo, vengono prospettate le varie relazioni che si ritiene possano intercorrere tra l’economia verde (nella sua dimensione giuridica a livello sovranazionale) e la libera prestazione dei servizi.The main purpose of the thesis is to demonstrate that the “green economy” concept, although not having a legal nature, can make a remarkable impact within the Law of the European Union, especially with regard to the services market. First, the research considers the sustainable development, since the green economy is a means to reach it; then, the concept of green economy is studied, with a view to provide it with a legal meaning and to link it to the (primary) Law of the European Union. After that, it is assessed how the European Union is using its law in order to define and implement the transition to a green economy and to spur the “green” services movement within the EU’s internal market. Finally, some possible relations between the green economy (considered in its supranational legal dimension) and the free movement of services are advanced and explored

Proprioceptive training and sports performance

One of the current trends in the field of sports training concerns the integration into training programs of exercises defined as "proprioceptive", which also include balance exercises, used to optimize performance, prevention or recovery from injuries. After introducing and describing the main characteristics of proprioceptive training in sports, the present review aims to set out and analyse the various flaws in this type of training as it is commonly practiced, in order to lay the groundwork for future improvements in proprioceptive training. Our research highlights that it is common practice to combine proprioceptive training with training on unstable surfaces, generally meaning the same for both situations. Such practices are indicative of the confusion surrounding the concepts of proprioception and balance. Indeed, until these two concepts and their respective performance benefits are clearly differentiated, it will be difficult to move beyond the controversy surrounding proprioceptive training and hence. to make advances in the field of proprioceptive training research. In conclusion, therefore, against the comforting theories that accompany the use of proprioceptive training in relation to the improvement of performance, unfortunately there is a literature that shows many variables not yet considered or treated in an approximate way

Metabolic response of Insulinoma 1E cells to glucose stimulation studied by fluorescence lifetime imaging

A cascade of highly regulated biochemical processes connects glucose stimulation to insulin secretion in specialized cells of mammalian pancreas, the β-cells. Given the importance of this process for systemic glucose homeostasis, noninvasive and fast strategies capable to monitor the response to glucose in living cells are highly desirable. Here, we use the phasor-based approach to Fluorescence Lifetime IMaging (FLIM) microscopy to quantify the ratio between protein-bound and free Nicotinamide adenine dinucleotide (phosphate) species in their reduced form (NAD(P)H), and the Insulinoma cell line INS-1E as a β-like cellular model. Phasor-FLIM analysis shows that the bound/free ratio of NAD(P)H species increases upon pulsed glucose stimulation. Such response is impaired by 48-hours preincubation of cells under hyperglycemic conditions. Phasor-FLIM concomitantly monitors the appearance of long-lifetime species (LLS) as characteristic products of hyperglycemia-induced oxidative stress

Studying social cognition using near-infrared spectroscopy: the case of social Simon effect

In order to understand the so-called "social brain," we need to monitor social interactions in face-to-face paradigms. Near-infrared spectroscopy (NIRS) is a promising technique to achieve this goal. We investigate the neuronal underpinnings of sharing a task in a proper social context. We record cortical activity by means of NIRS, while participants perform a joint Simon task. Different from other hemodynamic techniques, NIRS allows us to have both participants sit comfortably close to each other in a realistic and ecological environment. We found higher activation in the sensorimotor cortex while processing compatible trials as compared to incompatible ones referring to one's own action alternative. Strikingly, when the participant was not responding because it was the turn of the other member of the pair, the inferior parietal was activated. This study provides twofold findings: first, they suggest that the joint Simon effect relies more on shared attentional mechanisms than a proper mapping of the other's motor response. Second, they highlight the invaluable contribution NIRS can afford to social neuroscience in order to preserve ecological and naturalistic settings. © 2013 Society of Photo-Optical Instrumentation Engineers (SPIE) (DOI: 1

Neurological features of 14q24-q32 interstitial deletion: report of a new case

Background: Interstitial deletions of the long arm of chromosome 14 involving the 14q24-q32 region have been reported in less than 20 patients. Previous studies mainly attempted to delineate recognizable facial dysmorphisms; conversely, descriptions on neurological features are limited to the presence of cognitive and motor delay, but no better characterization exists. Case presentation: In this paper we report on a patient with a de novo interstitial deletion of 5.5 Mb at 14q24.3-q31.1. The deletion encompasses 84 genes, including fourteen Mendelian genes. He presented with dysmorphic face, developmental delay, paroxysmal non-epileptic events and, subsequently, epilepsy. Conclusions: The clinical and molecular evaluation of this patient and the review of the literature expand the phenotype of 14q23-q32 deletion syndrome to include paroxysmal non-epileptic events and infantile-onset focal seizures. © 2015 Nicita et al

Risk of second primary malignancy in breast cancer survivors: A nested population-based case-control study

Purpose: Evolving therapies have improved the prognoses of patients with breast cancer; and currently, the number of long-term survivors is continuously increasing. However, these patients are at increased risk of developing a second cancer. Thus, late side effects are becoming an important issue. In this study, we aimed to investigate whether patient and tumor characteristics, and treatment type correlate with secondary tumor risk. Methods: This case-control study included 305 patients with a diagnosed second malignancy after almost 6 months after the diagnosis of primary breast cancer and 1,525 controls (ratio 1:5 of cases to controls) from a population-based cohort of 6,325 women. The control patients were randomly selected from the cohort and matched to the cases according to age at diagnosis, calendar period of diagnosis, disease stage, and time of follow-up. Results: BRCA1 or BRCA2 mutation, human epidermal growth factor receptor 2 (HER2)+ status, chemotherapy, and radiotherapy were related to increased risk of developing a second cancer, whereas hormonotherapy showed a protective effect. Chemotherapy, radiotherapy, and estrogenic receptor level <10% increased the risk of controlateral breast cancer. HER2+ status increased the risk of digestive system and thyroid tumors, while BRCA1 or BRCA2 mutation increased the risk of cancer in the genital system. Conclusion: Breast cancer survivors are exposed to an excess of risk of developing a second primary cancer. The development of excess of malignancies may be related either to patient and tumor characteristics, such as BRCA1 or BRCA2 mutation and HER2+ status, or to treatments factors