720 research outputs found
Products, coproducts and singular value decomposition
Products and coproducts may be recognized as morphisms in a monoidal tensor
category of vector spaces. To gain invariant data of these morphisms, we can
use singular value decomposition which attaches singular values, ie generalized
eigenvalues, to these maps. We show, for the case of Grassmann and Clifford
products, that twist maps significantly alter these data reducing degeneracies.
Since non group like coproducts give rise to non classical behavior of the
algebra of functions, ie make them noncommutative, we hope to be able to learn
more about such geometries. Remarkably the coproduct for positive singular
values of eigenvectors in yields directly corresponding eigenvectors in
A\otimes A.Comment: 17 pages, three eps-figure
Z_2-gradings of Clifford algebras and multivector structures
Let Cl(V,g) be the real Clifford algebra associated to the real vector space
V, endowed with a nondegenerate metric g. In this paper, we study the class of
Z_2-gradings of Cl(V,g) which are somehow compatible with the multivector
structure of the Grassmann algebra over V. A complete characterization for such
Z_2-gradings is obtained by classifying all the even subalgebras coming from
them. An expression relating such subalgebras to the usual even part of Cl(V,g)
is also obtained. Finally, we employ this framework to define spinor spaces,
and to parametrize all the possible signature changes on Cl(V,g) by
Z_2-gradings of this algebra.Comment: 10 pages, LaTeX; v2 accepted for publication in J. Phys.
A Hopf laboratory for symmetric functions
An analysis of symmetric function theory is given from the perspective of the
underlying Hopf and bi-algebraic structures. These are presented explicitly in
terms of standard symmetric function operations. Particular attention is
focussed on Laplace pairing, Sweedler cohomology for 1- and 2-cochains, and
twisted products (Rota cliffordizations) induced by branching operators in the
symmetric function context. The latter are shown to include the algebras of
symmetric functions of orthogonal and symplectic type. A commentary on related
issues in the combinatorial approach to quantum field theory is given.Comment: 29 pages, LaTeX, uses amsmat
On the Decomposition of Clifford Algebras of Arbitrary Bilinear Form
Clifford algebras are naturally associated with quadratic forms. These
algebras are Z_2-graded by construction. However, only a Z_n-gradation induced
by a choice of a basis, or even better, by a Chevalley vector space isomorphism
Cl(V) \bigwedge V and an ordering, guarantees a multi-vector decomposition
into scalars, vectors, tensors, and so on, mandatory in physics. We show that
the Chevalley isomorphism theorem cannot be generalized to algebras if the
Z_n-grading or other structures are added, e.g., a linear form. We work with
pairs consisting of a Clifford algebra and a linear form or a Z_n-grading which
we now call 'Clifford algebras of multi-vectors' or 'quantum Clifford
algebras'. It turns out, that in this sense, all multi-vector Clifford algebras
of the same quadratic but different bilinear forms are non-isomorphic. The
usefulness of such algebras in quantum field theory and superconductivity was
shown elsewhere. Allowing for arbitrary bilinear forms however spoils their
diagonalizability which has a considerable effect on the tensor decomposition
of the Clifford algebras governed by the periodicity theorems, including the
Atiyah-Bott-Shapiro mod 8 periodicity. We consider real algebras Cl_{p,q} which
can be decomposed in the symmetric case into a tensor product Cl_{p-1,q-1}
\otimes Cl_{1,1}. The general case used in quantum field theory lacks this
feature. Theories with non-symmetric bilinear forms are however needed in the
analysis of multi-particle states in interacting theories. A connection to
q-deformed structures through nontrivial vacuum states in quantum theories is
outlined.Comment: 25 pages, 1 figure, LaTeX, {Paper presented at the 5th International
Conference on Clifford Algebras and their Applications in Mathematical
Physics, Ixtapa, Mexico, June 27 - July 4, 199
Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation
The structure of Green functions in quantum field theory with a general state
In quantum field theory, the Green function is usually calculated as the
expectation value of the time-ordered product of fields over the vacuum. In
some cases, especially in degenerate systems, expectation values over general
states are required. The corresponding Green functions are essentially more
complex than in the vacuum, because they cannot be written in terms of standard
Feynman diagrams. Here, a method is proposed to determine the structure of
these Green functions and to derive nonperturbative equations for them. The
main idea is to transform the cumulants describing correlations into
interaction terms.Comment: 13 pages, 6 figure
Quantum field theory and Hopf algebra cohomology
We exhibit a Hopf superalgebra structure of the algebra of field operators of
quantum field theory (QFT) with the normal product. Based on this we construct
the operator product and the time-ordered product as a twist deformation in the
sense of Drinfeld. Our approach yields formulas for (perturbative) products and
expectation values that allow for a significant enhancement in computational
efficiency as compared to traditional methods. Employing Hopf algebra
cohomology sheds new light on the structure of QFT and allows the extension to
interacting (not necessarily perturbative) QFT. We give a reconstruction
theorem for time-ordered products in the spirit of Streater and Wightman and
recover the distinction between free and interacting theory from a property of
the underlying cocycle. We also demonstrate how non-trivial vacua are described
in our approach solving a problem in quantum chemistry.Comment: 39 pages, no figures, LaTeX + AMS macros; title changed, minor
corrections, references update
Risk-factors of melphalan/fludarabine dose-reduced allogeneic stem cell transplantation in patients with multiple myeloma
Cell-free stem cell-derived extract formulation for treatment of knee osteoarthritis: study protocol for a preliminary non-randomized, open-label, multi-center feasibility and safety study.
BACKGROUND: Musculoskeletal conditions are highly prevalent, and knee OA is most common. Current treatment modalities have limitations and either fail to solve the underlying pathophysiology or are highly invasive. To address these limitations, attention has focused on the use of biologics. The efficacy of these devices is attributed to presence of growth factors (GFs), cytokines (CKs), and extracellular vesicles (EVs). With this in mind, we formulated a novel cell-free stem cell-derived extract (CCM) from human progenitor endothelial stem cells (hPESCs). A preliminary study demonstrated the presence of essential components of regenerative medicine, namely GFs, CKs, and EVs, including exosomes, in CCM. The proposed study aims to evaluate the safety and efficacy of intraarticular injection of the novel cell-free stem cell-derived extract (CCM) for the treatment of knee OA. METHODS AND ANALYSIS: This is a non-randomized, open-label, multi-center, prospective study in which the safety and efficacy of intraarticular CCM in patients suffering from grade II/III knee OA will be evaluated. Up to 20 patients with grade II/III OA who meet the inclusion and exclusion criteria will be consented and screened to recruit 12 patients to receive treatment. The study will be conducted at up to 2 sites within the USA, and the 12 participants will be followed for 24 months. The study participants will be monitored for adverse reactions and assessed using Numeric Pain Rating Scale (NPRS), Patient-Reported Outcomes Measurement Information System (PROMIS) Score, Knee Injury and Osteoarthritis Outcome Score Jr. (KOOS Jr.), 36-ietm short form survey (SF-36), Single Assessment Numeric Evaluation (SANE), physical exams, plain radiography, and magnetic resonance imaging (MRI) with Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score for improvements in pain, function, satisfaction, and cartilage regeneration. DISCUSSION: This prospective study will provide valuable information into the safety and efficacy of intraarticular administration of cell-free stem cell-derived extract (CCM) in patients suffering with grade II/III knee OA. The outcomes from this initial study of novel CCM will lay the foundation for a larger randomized, placebo-controlled, multi-center clinical trial of intraarticular CCM for symptomatic knee OA. TRIAL REGISTRATION: Registered on July 21, 2021. ClinicalTrials.gov NCT04971798
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